KR830006185A - p-이소부틸-페닐-프로피온산의 아미드유도체의 제조방법 - Google Patents
p-이소부틸-페닐-프로피온산의 아미드유도체의 제조방법 Download PDFInfo
- Publication number
- KR830006185A KR830006185A KR1019810002639A KR810002639A KR830006185A KR 830006185 A KR830006185 A KR 830006185A KR 1019810002639 A KR1019810002639 A KR 1019810002639A KR 810002639 A KR810002639 A KR 810002639A KR 830006185 A KR830006185 A KR 830006185A
- Authority
- KR
- South Korea
- Prior art keywords
- isobutyl
- propionic acid
- phenyl
- substituted amine
- chloride
- Prior art date
Links
- -1 amide derivative of p-isobutyl-phenyl-propionic acid Chemical class 0.000 title claims 2
- 238000004519 manufacturing process Methods 0.000 title claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical group ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012320 chlorinating reagent Substances 0.000 claims 1
- 238000005660 chlorination reaction Methods 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- OHZZTXYKLXZFSZ-UHFFFAOYSA-I manganese(3+) 5,10,15-tris(1-methylpyridin-1-ium-4-yl)-20-(1-methylpyridin-4-ylidene)porphyrin-22-ide pentachloride Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Mn+3].C1=CN(C)C=CC1=C1C(C=C2)=NC2=C(C=2C=C[N+](C)=CC=2)C([N-]2)=CC=C2C(C=2C=C[N+](C)=CC=2)=C(C=C2)N=C2C(C=2C=C[N+](C)=CC=2)=C2N=C1C=C2 OHZZTXYKLXZFSZ-UHFFFAOYSA-I 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Rheumatology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- p-이소부틸-페닐-프로피온산을 과잉의 염소화제로써 염소화시켜서 생성된 그 염화물을 적당한 치환아민으로써 반응시키는 것이 특징인 하기 일반식을 가진 p-이소부틸-페닐-프로피온산의 아미드 유도체의 제조방법.상기 일반식에서 x는 리진, 메타르플루오로톨루이딘, 글루타민산 및 아스파트산으로 구성되는 그룹의 치환아민기를 나타낸다.
- 특허청구의 범위 제1항 기재에 있어서 전기 염소화제가 염화티오닐 또는 5염화인 것이 특징인 방법.
- 특허청구의 범위 제1항 기재에 있어서, 치환아민과 p-이소부틸-페틸-프로피온산의 염화물의 반응이 저온에서 알칼리성 수용액의 매질내에서 행해지는 것이 특징인 방법.
- 특허청구의 범위 제1항 기재에 있어서 치환아민과 p-이소부틸-페닐-프로피온산의 염화물의 반응이 피리딘내에서 수행되는 것이 특징인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT23601/80A IT1193955B (it) | 1980-07-22 | 1980-07-22 | Derivati ammidici dell'acido p-isobutilfenilpropionico, procedimento per la loro preparazione e relative composizioni farmaceutici |
| IT23601 | 1980-07-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830006185A true KR830006185A (ko) | 1983-09-20 |
| KR840001072B1 KR840001072B1 (ko) | 1984-07-31 |
Family
ID=11208465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810002639A KR840001072B1 (ko) | 1980-07-22 | 1981-07-21 | P-이소부틸-페닐-프로피온산의 아미드 유도체의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| JP (1) | JPS5742663A (ko) |
| KR (1) | KR840001072B1 (ko) |
| AR (1) | AR226734A1 (ko) |
| BE (1) | BE889699A (ko) |
| BR (1) | BR8104728A (ko) |
| CA (1) | CA1181419A (ko) |
| CH (1) | CH648292A5 (ko) |
| DE (1) | DE3128676C2 (ko) |
| ES (1) | ES504156A0 (ko) |
| FR (1) | FR2491456B1 (ko) |
| GB (1) | GB2080797B (ko) |
| IN (1) | IN153746B (ko) |
| IT (1) | IT1193955B (ko) |
| LU (1) | LU83497A1 (ko) |
| MX (1) | MX7038E (ko) |
| PT (1) | PT73400B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4536346A (en) * | 1983-05-06 | 1985-08-20 | American Cyanamid Company | Aralkanamidophenyl compounds |
| HU198446B (en) * | 1987-09-25 | 1989-10-30 | Richter Gedeon Vegyeszet | Process for production of new amids of buten acid and medical compositions containing such active substances |
| IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
| IT1318466B1 (it) * | 2000-04-14 | 2003-08-25 | Dompe Spa | Ammidi di acidi r-2-(amminoaril)-propionici, utili nella prevenzionedell'attivazione leucocitaria. |
| ITMI20010395A1 (it) | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
| EP1457485A1 (en) | 2003-03-14 | 2004-09-15 | Dompé S.P.A. | Sulfonic acids, their derivatives and pharmaceutical compositions containing them |
-
1980
- 1980-07-22 IT IT23601/80A patent/IT1193955B/it active
-
1981
- 1981-07-14 GB GB8121623A patent/GB2080797B/en not_active Expired
- 1981-07-17 CA CA000381957A patent/CA1181419A/en not_active Expired
- 1981-07-20 DE DE3128676A patent/DE3128676C2/de not_active Expired
- 1981-07-20 PT PT73400A patent/PT73400B/pt unknown
- 1981-07-20 IN IN809/CAL/81A patent/IN153746B/en unknown
- 1981-07-20 LU LU83497A patent/LU83497A1/de unknown
- 1981-07-21 CH CH4755/81A patent/CH648292A5/it not_active IP Right Cessation
- 1981-07-21 AR AR286159A patent/AR226734A1/es active
- 1981-07-21 KR KR1019810002639A patent/KR840001072B1/ko active IP Right Grant
- 1981-07-21 ES ES504156A patent/ES504156A0/es active Granted
- 1981-07-21 JP JP56113098A patent/JPS5742663A/ja active Pending
- 1981-07-21 MX MX819564U patent/MX7038E/es unknown
- 1981-07-22 BE BE0/205465A patent/BE889699A/fr not_active IP Right Cessation
- 1981-07-22 BR BR8104728A patent/BR8104728A/pt unknown
- 1981-07-22 FR FR8114252A patent/FR2491456B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2491456A1 (ko) | 1982-04-09 |
| GB2080797B (en) | 1984-01-18 |
| ES8204414A1 (es) | 1982-05-16 |
| CH648292A5 (it) | 1985-03-15 |
| BR8104728A (pt) | 1982-04-13 |
| LU83497A1 (de) | 1981-10-29 |
| BE889699A (fr) | 1981-11-16 |
| PT73400B (en) | 1982-10-01 |
| MX7038E (es) | 1987-03-18 |
| IN153746B (ko) | 1984-08-18 |
| GB2080797A (en) | 1982-02-10 |
| DE3128676A1 (de) | 1982-04-22 |
| JPS5742663A (en) | 1982-03-10 |
| CA1181419A (en) | 1985-01-22 |
| KR840001072B1 (ko) | 1984-07-31 |
| PT73400A (en) | 1981-08-01 |
| IT8023601A0 (it) | 1980-07-22 |
| IT1193955B (it) | 1988-08-31 |
| FR2491456B1 (ko) | 1985-11-15 |
| AR226734A1 (es) | 1982-08-13 |
| DE3128676C2 (de) | 1983-12-01 |
| ES504156A0 (es) | 1982-05-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| E701 | Decision to grant or registration of patent right |