KR880012505A - 신규 염소화 방법 - Google Patents
신규 염소화 방법 Download PDFInfo
- Publication number
- KR880012505A KR880012505A KR1019880004705A KR880004705A KR880012505A KR 880012505 A KR880012505 A KR 880012505A KR 1019880004705 A KR1019880004705 A KR 1019880004705A KR 880004705 A KR880004705 A KR 880004705A KR 880012505 A KR880012505 A KR 880012505A
- Authority
- KR
- South Korea
- Prior art keywords
- methoxynicotinic acid
- alkali metal
- molar ratio
- reaction
- chlorination method
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 6
- 238000005660 chlorination reaction Methods 0.000 title claims 2
- FTEZJSXSARPZHJ-UHFFFAOYSA-N 2-methoxypyridine-3-carboxylic acid Chemical compound COC1=NC=CC=C1C(O)=O FTEZJSXSARPZHJ-UHFFFAOYSA-N 0.000 claims 3
- 239000005708 Sodium hypochlorite Substances 0.000 claims 2
- 229910052783 alkali metal Inorganic materials 0.000 claims 2
- -1 alkali metal hypochlorite Chemical class 0.000 claims 2
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical group [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims 2
- DPIJNAABZCWXFD-UHFFFAOYSA-N 5-chloro-2-methoxypyridine-3-carboxylic acid Chemical compound COC1=NC=C(Cl)C=C1C(O)=O DPIJNAABZCWXFD-UHFFFAOYSA-N 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000012320 chlorinating reagent Substances 0.000 claims 1
- 238000009841 combustion method Methods 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B39/00—Halogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 2-메톡시니코틴산을 염소화 반응이 실질적으로 종료될 때까지 약 10°내지 최대로 약 30°C의 온도에서, 균일한 수용성 용매계 중에서 알칼리금속 차아염소산염으로 염소화 시키는 것으로 되는 2-메톡시니코틴산 분자의 5번 위치의 연소화 방법.
- 제1항에 있어서, 염소화제로 사용되는 알칼리금속 차아염소산염이 차아염소산염나트륨인 방법.
- 제1항에 있어서, 출발물질인 2-메톡시니코틴산 대 차아염소산나트륨의 몰 비가 약 1.0:1.0 내지 약 1.0:6.0인 방법.
- 제3항에 있어서, 상기 몰 비가 약 1.0:1.2 내지 약 1.0:2.0인 방법.
- 제1항에 있어서, 반응을 실온에서 적어도 약 16시간 동안 행하는 방법.
- 제1항에 있어서, 생성된 5-클로로-2-메톡시니코틴산을 반응 혼합물에서 회수하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US043,056 | 1987-04-27 | ||
| US07/043,056 US4716231A (en) | 1987-04-27 | 1987-04-27 | Chlorination of 2-methoxynicotinic acid |
| US43056 | 1987-04-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR880012505A true KR880012505A (ko) | 1988-11-28 |
| KR900006208B1 KR900006208B1 (ko) | 1990-08-25 |
Family
ID=21925225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880004705A KR900006208B1 (ko) | 1987-04-27 | 1988-04-25 | 신규 염소화 방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4716231A (ko) |
| EP (1) | EP0289180B1 (ko) |
| JP (1) | JPH0625117B2 (ko) |
| KR (1) | KR900006208B1 (ko) |
| AT (1) | ATE82965T1 (ko) |
| AU (1) | AU581829B2 (ko) |
| CA (1) | CA1297114C (ko) |
| DE (1) | DE3876277T2 (ko) |
| DK (1) | DK168624B1 (ko) |
| ES (1) | ES2035917T3 (ko) |
| FI (1) | FI89044C (ko) |
| GR (1) | GR3006528T3 (ko) |
| HU (1) | HU202206B (ko) |
| IE (1) | IE61278B1 (ko) |
| IL (1) | IL86115A (ko) |
| NZ (1) | NZ224376A (ko) |
| PT (1) | PT87334B (ko) |
| ZA (1) | ZA882937B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6133447A (en) * | 1998-02-27 | 2000-10-17 | Novartis Crop Protection, Inc. | Process for the preparation of substituted pyridines |
| JP5148836B2 (ja) * | 2005-04-21 | 2013-02-20 | 石原産業株式会社 | ニコチン酸誘導体又はその塩の製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1832484A (en) * | 1928-10-11 | 1931-11-17 | Dow Chemical Co | Derivatives of para-hydroxy-diphenyl |
| US2365981A (en) * | 1941-12-20 | 1944-12-26 | Commercial Solvents Corp | Production of chlorinated nitro hydrocarbons |
| US3879403A (en) * | 1973-05-04 | 1975-04-22 | Pfizer | Benzenesulfonylurea derivatives |
-
1987
- 1987-04-27 US US07/043,056 patent/US4716231A/en not_active Expired - Fee Related
-
1988
- 1988-04-18 ES ES198888303449T patent/ES2035917T3/es not_active Expired - Lifetime
- 1988-04-18 EP EP88303449A patent/EP0289180B1/en not_active Expired - Lifetime
- 1988-04-18 AT AT88303449T patent/ATE82965T1/de not_active IP Right Cessation
- 1988-04-18 DE DE8888303449T patent/DE3876277T2/de not_active Expired - Fee Related
- 1988-04-19 IL IL86115A patent/IL86115A/xx not_active IP Right Cessation
- 1988-04-25 CA CA000564980A patent/CA1297114C/en not_active Expired - Fee Related
- 1988-04-25 KR KR1019880004705A patent/KR900006208B1/ko not_active IP Right Cessation
- 1988-04-25 JP JP63102352A patent/JPH0625117B2/ja not_active Expired - Lifetime
- 1988-04-26 DK DK225888A patent/DK168624B1/da not_active IP Right Cessation
- 1988-04-26 PT PT87334A patent/PT87334B/pt not_active IP Right Cessation
- 1988-04-26 ZA ZA882937A patent/ZA882937B/xx unknown
- 1988-04-26 FI FI881949A patent/FI89044C/fi not_active IP Right Cessation
- 1988-04-26 AU AU15144/88A patent/AU581829B2/en not_active Ceased
- 1988-04-26 HU HU882104A patent/HU202206B/hu not_active IP Right Cessation
- 1988-04-26 NZ NZ224376A patent/NZ224376A/xx unknown
- 1988-04-26 IE IE124688A patent/IE61278B1/en not_active IP Right Cessation
-
1992
- 1992-12-14 GR GR920402902T patent/GR3006528T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0289180A2 (en) | 1988-11-02 |
| FI881949A0 (fi) | 1988-04-26 |
| EP0289180B1 (en) | 1992-12-02 |
| DK225888A (da) | 1988-10-28 |
| DK168624B1 (da) | 1994-05-09 |
| DE3876277T2 (de) | 1993-04-01 |
| PT87334A (pt) | 1988-05-01 |
| ATE82965T1 (de) | 1992-12-15 |
| PT87334B (pt) | 1992-08-31 |
| KR900006208B1 (ko) | 1990-08-25 |
| NZ224376A (en) | 1989-12-21 |
| FI89044B (fi) | 1993-04-30 |
| AU1514488A (en) | 1988-10-27 |
| DK225888D0 (da) | 1988-04-26 |
| DE3876277D1 (de) | 1993-01-14 |
| ES2035917T3 (es) | 1993-05-01 |
| GR3006528T3 (ko) | 1993-06-30 |
| JPH0625117B2 (ja) | 1994-04-06 |
| HUT49331A (en) | 1989-09-28 |
| IL86115A (en) | 1992-02-16 |
| IE61278B1 (en) | 1994-10-19 |
| CA1297114C (en) | 1992-03-10 |
| AU581829B2 (en) | 1989-03-02 |
| HU202206B (en) | 1991-02-28 |
| EP0289180A3 (en) | 1989-12-13 |
| US4716231A (en) | 1987-12-29 |
| FI89044C (fi) | 1993-08-10 |
| IE881246L (en) | 1988-10-27 |
| ZA882937B (en) | 1989-12-27 |
| FI881949A (fi) | 1988-10-28 |
| JPS63280065A (ja) | 1988-11-17 |
| IL86115A0 (en) | 1988-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR880003909A (ko) | 5-클로로메틸피리딘의 제조방법 | |
| KR890015962A (ko) | 희석된 염산으로 부터의 염화 제 2 철의 제조방법 | |
| KR840000541A (ko) | N-디히드로티아졸릴-3-퀴놀린 카복사미드 유도체의 제조방법 | |
| KR880012505A (ko) | 신규 염소화 방법 | |
| KR830006191A (ko) | 살균제로 유용한 n-알키닐-2-(치환된 페녹시)부틸아미드의 제조방법 | |
| KR860008174A (ko) | 항정신질환성 벤지소티아졸 s-산화물의 제조방법 | |
| KR880009937A (ko) | 치환된 3-알킬퀴놀린-8-카르복실산의 제조방법 | |
| KR890701516A (ko) | 하이드록시방향족 및 아미노방향족 화합물을 요오드화하는 방법 | |
| KR830001948A (ko) | 페니실린 설폭사이드의 제조방법 | |
| KR927003509A (ko) | 할로-니트로-페놀의 수성 환원방법 | |
| KR830008993A (ko) | 메르캅토아실-카르니틴의 제조방법 | |
| KR900018032A (ko) | 2,3-디클로로-5-아세틸피리딘의 제조방법 | |
| KR890000440A (ko) | 2-퀴녹살린의 제조 방법 | |
| KR900017971A (ko) | 할로겐화된 시클로부테노아렌의 제조 방법 | |
| KR970006276A (ko) | 6-클로로-2,4-디니트로 아닐린의 제조방법 | |
| KR900000325A (ko) | 벤조일 아세틱 에스테르 유도체 및 그 제조방법 | |
| Coleman et al. | CHLORINATION AND THE FORMATION OF CHLORO-AMINES BY MEANS OF NITROGEN TRICHLORIDE. | |
| SU571061A1 (ru) | Способ получени N-бензил- @ -хлорпропионамида | |
| KR950018012A (ko) | 6,6-디할로페니실란산 1,1-디옥시드 및 그 유도체의 탈할로겐화 방법 | |
| KR870003039A (ko) | 1,3,6,8-데트라브로모피렌의 제조방법 | |
| KR830005175A (ko) | 치환된 트리아릴티아졸 화합물의 제조방법 | |
| KR870005964A (ko) | 파라-페닐렌디아민의 제조 방법 | |
| KR830005173A (ko) | 벤즈옥사졸론의 염소화 유도체의 제조방법 | |
| JPS6245862B2 (ko) | ||
| KR860008966A (ko) | 벤젠 디카복실산 할라이드의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| G160 | Decision to publish patent application | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant | ||
| FPAY | Annual fee payment |
Payment date: 19960523 Year of fee payment: 7 |
|
| LAPS | Lapse due to unpaid annual fee |