KR830001854A - 1,1-비페닐-2-일 프로필 및 부틸아민과 조성물 및 항부정맥제 - Google Patents
1,1-비페닐-2-일 프로필 및 부틸아민과 조성물 및 항부정맥제 Download PDFInfo
- Publication number
- KR830001854A KR830001854A KR1019800001023A KR800001023A KR830001854A KR 830001854 A KR830001854 A KR 830001854A KR 1019800001023 A KR1019800001023 A KR 1019800001023A KR 800001023 A KR800001023 A KR 800001023A KR 830001854 A KR830001854 A KR 830001854A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- hydrogen
- alkyl
- hydroxy
- Prior art date
Links
- HQABUPZFAYXKJW-UHFFFAOYSA-N butan-1-amine Chemical compound CCCCN HQABUPZFAYXKJW-UHFFFAOYSA-N 0.000 title 2
- -1 1,1-biphenyl-2-yl propyl Chemical group 0.000 title 1
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- 239000003416 antiarrhythmic agent Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000002576 ketones Chemical class 0.000 claims 2
- 150000002825 nitriles Chemical class 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 239000007818 Grignard reagent Substances 0.000 claims 1
- 150000001336 alkenes Chemical class 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 150000004795 grignard reagents Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 구조식(Ⅱ)의 케톤을 다음 구조식(A)의 그리나드 시약과 반응시켜서 R1이 하이드록시이고 Z가 -(CH2)n-이며 n이 2내지 4인 구조식(Ⅰ)의 화합물을 얻거나 다음 구조식(Ⅱ-1)의 화합물을 환원시켜서 R1이 하이드록시이고 Z가 -(CH2)n-이며 n이 3 또는 4인 구조식(Ⅰ)의 화합물을 얻거나 다음 구조식(Ⅲ)의 케톤을 환원시켜서 R1이 하이드록시이고 R2가 수소인 구조식(Ⅰ)의 화합물을 얻거나 다음 구조식(Ⅳ)의 니트릴을 다음 구조식(B)의 아미노알킬화제로 알킬화 시켜서 R1이 -C=N인 구조식(Ⅰ)의 화합물을 얻거나 다음 구조식(Ⅴ)의 니트릴을 가수분해 시켜서 R1이 -CONH2또는 -COOH인 구조식(Ⅰ)의 화합물을 얻거나 다음 구조식(Ⅵ)의 에폭시드를 구조식 HNR3R4의 아민과 축합시키고 R1이 보호된 하이드록실 그룹일 경우 필요하다면 보호그룹을 제거시키거나 다음 구조식(C)의 올레핀을 환원시켜서 R1이 수소이고, Z가 -(CH2)n이며 n이 2내지 4인 구조식(Ⅰ)의 화합물을 제조함을 포함하는 다음 구조식(Ⅰ)의 화합물 또는 그의 염을 제조하는 방법.상기 구조식에서X는 수소거나 페닐환의 어느 위치라도 좋은 할로치환체이고,R1은 수소, 하이드록시, CN, CONR5R6(R5및 R6는 각각 수소 또는 C1-6알킬을 나타낸다) 또는 COR8(R8은 수소 또는 C1-4알킬이다),R2는 수소 또는 C1-3알킬,Z는 -(CH2)n또는(n은 2, 3 또는 4),R3및 R4는 독립적으로 수소, C1-6알킬, CH2C2-5알케닐, 페닐 C1-3알킬이거나 인접질소원자와 함께 5내지 7환 원자를 함유하며 임의로 산소 및 질소중에서 선택된 한 헤테로 원자를 함유하는 헤테로 사이클 그룹을 형성하며,X1는 클로로, 브로모 또는 요오도이고 n은 3 또는 4이며(구조식 (A)에서),A는 이탈그룹이고,구조식(Ⅵ)에서R1은 전술된 바와 같거나 보호된 하이드록실그룹이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1953479A | 1979-03-12 | 1979-03-12 | |
| US19.534 | 1979-03-12 | ||
| US19534 | 1979-03-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830001854A true KR830001854A (ko) | 1983-05-19 |
| KR840000103B1 KR840000103B1 (ko) | 1984-02-11 |
Family
ID=21793713
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019800001023A KR840000103B1 (ko) | 1979-03-12 | 1980-03-12 | 1, 1'-비페닐-2-일 알킬아민 유도체의 제조방법 |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0015776B1 (ko) |
| JP (1) | JPS55127347A (ko) |
| KR (1) | KR840000103B1 (ko) |
| AR (1) | AR228852A1 (ko) |
| AT (1) | AT367395B (ko) |
| AU (1) | AU528060B2 (ko) |
| BE (1) | BE882167A (ko) |
| CA (1) | CA1144926A (ko) |
| CH (1) | CH644094A5 (ko) |
| CS (1) | CS215052B2 (ko) |
| DD (1) | DD149664A5 (ko) |
| DE (1) | DE3060611D1 (ko) |
| DK (1) | DK103480A (ko) |
| ES (6) | ES489469A0 (ko) |
| FI (1) | FI800736A (ko) |
| FR (1) | FR2451363A1 (ko) |
| GB (1) | GB2046256B (ko) |
| GR (1) | GR68036B (ko) |
| HU (1) | HU180334B (ko) |
| IE (1) | IE49552B1 (ko) |
| IL (1) | IL59557A (ko) |
| IT (1) | IT1140773B (ko) |
| LU (1) | LU82237A1 (ko) |
| MX (1) | MX6219E (ko) |
| NZ (1) | NZ193079A (ko) |
| PH (1) | PH14749A (ko) |
| PL (1) | PL121662B1 (ko) |
| PT (1) | PT70928A (ko) |
| RO (1) | RO79906A (ko) |
| SU (2) | SU940645A3 (ko) |
| ZA (1) | ZA801421B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470454B1 (ko) * | 2002-05-14 | 2005-02-05 | 대한민국 | 돼지 사료공급을 위한 자동조절급이기 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005265164A1 (en) * | 2004-06-17 | 2006-01-26 | Musc Foundation For Research Development | Non-natural amino acids |
| ES2742261T3 (es) * | 2011-04-15 | 2020-02-13 | Hivih | Inhibidores de la replicación viral, su proceso de preparación y sus usos terapéuticos |
| EP2821104A1 (en) | 2013-07-05 | 2015-01-07 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES236010A1 (es) * | 1956-06-29 | 1957-12-16 | Lab Pharmaceutica Dr C Janssen | UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS PARASIMPATICOLiTICAMENTE ACTIVOS DE ALFAS-DEFENIL PROPANO |
| US3433836A (en) * | 1966-01-14 | 1969-03-18 | Rexall Drug Chemical | Alpha-diaryl alpha,omega-alkylene glycol-dilower-alkylamines |
| GB1475314A (en) * | 1973-11-02 | 1977-06-01 | Cm Ind | Phenyl-propylamine derivatives |
| IL48319A0 (en) * | 1974-10-26 | 1975-12-31 | Merck Patent Gmbh | Araliphatic nitrogen compounds and a process for their preparation |
| GB1523655A (en) * | 1975-02-10 | 1978-09-06 | Armour Pharma | 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith |
-
1980
- 1980-03-09 IL IL59557A patent/IL59557A/xx unknown
- 1980-03-10 CH CH186880A patent/CH644094A5/fr not_active IP Right Cessation
- 1980-03-10 PH PH23743A patent/PH14749A/en unknown
- 1980-03-10 GR GR61387A patent/GR68036B/el unknown
- 1980-03-10 HU HU8080563A patent/HU180334B/hu unknown
- 1980-03-10 FR FR8005311A patent/FR2451363A1/fr active Granted
- 1980-03-10 NZ NZ193079A patent/NZ193079A/xx unknown
- 1980-03-10 AU AU56302/80A patent/AU528060B2/en not_active Ceased
- 1980-03-10 RO RO80100427A patent/RO79906A/ro unknown
- 1980-03-10 CA CA000347365A patent/CA1144926A/en not_active Expired
- 1980-03-10 PT PT70928A patent/PT70928A/pt unknown
- 1980-03-10 LU LU82237A patent/LU82237A1/fr unknown
- 1980-03-11 FI FI800736A patent/FI800736A/fi not_active Application Discontinuation
- 1980-03-11 AT AT0134580A patent/AT367395B/de not_active IP Right Cessation
- 1980-03-11 GB GB8008170A patent/GB2046256B/en not_active Expired
- 1980-03-11 IE IE493/80A patent/IE49552B1/en unknown
- 1980-03-11 DE DE8080300744T patent/DE3060611D1/de not_active Expired
- 1980-03-11 JP JP3256880A patent/JPS55127347A/ja active Pending
- 1980-03-11 DK DK103480A patent/DK103480A/da not_active Application Discontinuation
- 1980-03-11 BE BE1/9747A patent/BE882167A/fr not_active IP Right Cessation
- 1980-03-11 EP EP80300744A patent/EP0015776B1/en not_active Expired
- 1980-03-11 PL PL1980222601A patent/PL121662B1/pl unknown
- 1980-03-11 CS CS801665A patent/CS215052B2/cs unknown
- 1980-03-11 IT IT20503/80A patent/IT1140773B/it active
- 1980-03-11 ZA ZA00801421A patent/ZA801421B/xx unknown
- 1980-03-12 MX MX808706U patent/MX6219E/es unknown
- 1980-03-12 ES ES489469A patent/ES489469A0/es active Granted
- 1980-03-12 AR AR280280A patent/AR228852A1/es active
- 1980-03-12 DD DD80219615A patent/DD149664A5/de unknown
- 1980-03-12 SU SU802892804A patent/SU940645A3/ru active
- 1980-03-12 KR KR1019800001023A patent/KR840000103B1/ko active
- 1980-11-27 ES ES497210A patent/ES497210A0/es active Granted
- 1980-11-27 ES ES497208A patent/ES497208A0/es active Granted
- 1980-11-27 ES ES497206A patent/ES8201525A1/es not_active Expired
- 1980-11-27 ES ES497207A patent/ES497207A0/es active Granted
- 1980-11-27 ES ES497209A patent/ES497209A0/es active Granted
-
1981
- 1981-01-14 SU SU813229052A patent/SU1022655A3/ru active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100470454B1 (ko) * | 2002-05-14 | 2005-02-05 | 대한민국 | 돼지 사료공급을 위한 자동조절급이기 |
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