KR840004412A - 치환된 하이드록시 알킬-아졸의 제조방법 - Google Patents
치환된 하이드록시 알킬-아졸의 제조방법 Download PDFInfo
- Publication number
- KR840004412A KR840004412A KR1019830001358A KR830001358A KR840004412A KR 840004412 A KR840004412 A KR 840004412A KR 1019830001358 A KR1019830001358 A KR 1019830001358A KR 830001358 A KR830001358 A KR 830001358A KR 840004412 A KR840004412 A KR 840004412A
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- optionally substituted
- alkyl
- hydroxy alkyl
- formula
- Prior art date
Links
- 125000002887 hydroxy group Chemical group [H]O* 0.000 title claims 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Chemical group 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 1
- 125000002071 phenylalkoxy group Chemical group 0.000 claims 1
- 125000003884 phenylalkyl group Chemical group 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/08—Compounds containing oxirane rings with hydrocarbon radicals, substituted by halogen atoms, nitro radicals or nitroso radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 일반식(Ⅱ)의 옥시란을 일반식(Ⅲ)의 아졸과 희석제의 존재하에서, 필요시 염기의 존재하에서 반응시키고, 필요시 생성된 일반식(a)의 하이드록시 알킬-아졸을 통상의 방법으로, 산화시켜 일반식(Ⅰ)의 치환된 하이드록시 알킬-아졸을 제조하는 방법.상기식에서, R1은 페닐, -0-페닐, -S-페닐-SC-페닐, -SO2-페닐, -CH2-페닐, -CH2-0-페닐-, CH2-S-페닐, -CH2-SC-페닐 또는 -CH2-SC2페닐로 이들은 각각 임의로 치환되며, R2는 알킬이며, R3는 알킬이며, R4는 임의로 치환된 페닐이며, X는 질소원자 또는 CH 그룹이며, Y는 할로겐, 알킬, 시클로알킬, 알콕시, 알킬티오, 할로게노알킬,할로게노알콕시, 할로게노알킬티오, 임의로 치환된 페닐, 임의로 치환된 페녹시, 임의로 치환된 페닐알킬 또는 임의로 치환된 페닐알콕시이며, M은 수소 또는 알카리금속이며, m은 0,1,2 또는 3의 정수이며, n은 0 또는 1의 정수이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823212388 DE3212388A1 (de) | 1982-04-02 | 1982-04-02 | Substituierte hydroxyalkyl-azole, verfahren zu ihrer herstellung und ihre verwendung als antimykotika |
DEP3212388.4 | 1982-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR840004412A true KR840004412A (ko) | 1984-10-15 |
Family
ID=6160129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019830001358A KR840004412A (ko) | 1982-04-02 | 1983-04-01 | 치환된 하이드록시 알킬-아졸의 제조방법 |
Country Status (8)
Country | Link |
---|---|
US (1) | US4879385A (ko) |
EP (1) | EP0090993B1 (ko) |
JP (1) | JPS58183674A (ko) |
KR (1) | KR840004412A (ko) |
AT (1) | ATE19626T1 (ko) |
DE (2) | DE3212388A1 (ko) |
HU (1) | HU186677B (ko) |
ZA (1) | ZA832328B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3402166A1 (de) * | 1984-01-23 | 1985-07-25 | Hoechst Ag, 6230 Frankfurt | Azolyl-aryl-alkanol-derivate, verfahren zu ihrer herstellung und ihre verwendung |
WO1989005801A1 (en) * | 1987-12-17 | 1989-06-29 | E.I. Du Pont De Nemours And Company | Antifungal carbinols |
US5087620A (en) * | 1990-05-17 | 1992-02-11 | Bristol-Myers Squibb Co. | Controlled dermal penetration enhancement using imidazoles |
CA2145458A1 (en) * | 1994-03-28 | 1995-09-29 | Hiroki Kodama | Triazole compound and production process and use thereof |
BR112014012588A2 (pt) * | 2011-11-25 | 2017-06-13 | Bayer Ip Gmbh | novos derivados heterocíclicos de alcanol |
AR109545A1 (es) | 2016-09-29 | 2018-12-19 | Bayer Cropscience Ag | Derivados de triazol |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2736122A1 (de) * | 1977-08-11 | 1979-02-22 | Basf Ag | Fungizide |
US4414210A (en) * | 1979-10-02 | 1983-11-08 | Rohm And Haas Company | 2-Hydroxyarylethyltriazole fungicides |
DE2946956A1 (de) * | 1979-11-21 | 1981-06-19 | Bayer Ag, 5090 Leverkusen | Hydroxybutyl-imidazol-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
DE3018865A1 (de) * | 1980-05-16 | 1981-11-26 | Bayer Ag, 5090 Leverkusen | Antimikrobielle mittel |
EP0052424B2 (en) * | 1980-11-19 | 1990-02-28 | Imperial Chemical Industries Plc | Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them |
AR228764A1 (es) * | 1980-12-20 | 1983-04-15 | Bayer Ag | 1-azolil-3,3-dimetilalcan(c3-4)-2-onas y-2-oles,sustituidos,procedimiento para su produccion y composiciones protectoras de plantas fungicidas y reguladoras del crecimiento de las plantas a base de dichos compuestos |
JPS57165370A (en) * | 1981-03-18 | 1982-10-12 | Ici Ltd | Triazole or imidazole compounds, manufacture and fungicidal or plant growth regulant agent |
DE3279417D1 (en) * | 1981-03-18 | 1989-03-09 | Ici Plc | Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them |
GR78217B (ko) * | 1981-07-02 | 1984-09-26 | Ciba Geigy Ag | |
DE3202601A1 (de) * | 1982-01-27 | 1983-08-04 | Bayer Ag, 5090 Leverkusen | Substituierte 1 -hydroxyalkyl-azolyl-derivate, verfahren zu ihrer herstellung sowie ihrer verwendung als fungizide und pflanzenwachstumsregulatoren |
-
1982
- 1982-04-02 DE DE19823212388 patent/DE3212388A1/de not_active Withdrawn
-
1983
- 1983-03-21 DE DE8383102754T patent/DE3363364D1/de not_active Expired
- 1983-03-21 AT AT83102754T patent/ATE19626T1/de not_active IP Right Cessation
- 1983-03-21 EP EP83102754A patent/EP0090993B1/de not_active Expired
- 1983-03-31 ZA ZA832328A patent/ZA832328B/xx unknown
- 1983-04-01 HU HU831141A patent/HU186677B/hu not_active IP Right Cessation
- 1983-04-01 KR KR1019830001358A patent/KR840004412A/ko not_active Application Discontinuation
- 1983-04-01 JP JP58055365A patent/JPS58183674A/ja active Pending
-
1987
- 1987-06-15 US US07/062,251 patent/US4879385A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE19626T1 (de) | 1986-05-15 |
EP0090993A3 (en) | 1984-05-30 |
DE3363364D1 (en) | 1986-06-12 |
DE3212388A1 (de) | 1983-10-13 |
ZA832328B (en) | 1983-12-28 |
HU186677B (en) | 1985-09-30 |
EP0090993B1 (de) | 1986-05-07 |
JPS58183674A (ja) | 1983-10-26 |
US4879385A (en) | 1989-11-07 |
EP0090993A2 (de) | 1983-10-12 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |