FR2451363A1 - (1,1-biphenyl-2-yl)-propyl- et butylamines, leur preparation et leur utilisation therapeutique - Google Patents

(1,1-biphenyl-2-yl)-propyl- et butylamines, leur preparation et leur utilisation therapeutique

Info

Publication number
FR2451363A1
FR2451363A1 FR8005311A FR8005311A FR2451363A1 FR 2451363 A1 FR2451363 A1 FR 2451363A1 FR 8005311 A FR8005311 A FR 8005311A FR 8005311 A FR8005311 A FR 8005311A FR 2451363 A1 FR2451363 A1 FR 2451363A1
Authority
FR
France
Prior art keywords
butylamines
biphenyl
propyl
preparation
therapeutic use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8005311A
Other languages
English (en)
Other versions
FR2451363B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2451363A1 publication Critical patent/FR2451363A1/fr
Application granted granted Critical
Publication of FR2451363B1 publication Critical patent/FR2451363B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES DE FORMULE: (CF DESSIN DANS BOPI) OU X EST UN ATOME D'HYDROGENE OU UN SUBSTITUANT HALO; R EST H, OH, CN OU UN GROUPEMENT AMIDE OU ACIDE OU EVENTUELLEMENT CERTAINS DE LEURS DERIVES; R EST UN ATOME D'HYDROGENE OU UN GROUPEMENT ALKYLE EN C-C; Z EST UN GROUPEMENT ALKYLENE OU ALKYLENE HYDROXYLE; R ET R SONT INDEPENDAMMENT DES ATOMES D'HYDROGENE OU DES GROUPEMENTS ALKYLE EN C-C, ALCENYLE, PHENYLALKYLE OU PEUVENT FORMER AVEC L'ATOME D'AZOTE UN NOYAU HETEROCYCLIQUE, ET LEURS SELS PHARMACEUTIQUEMENT ACCEPTABLES. CES COMPOSES SONT UTILES COMME AGENTS PHARMACOLOGIQUES, EN PARTICULIER DANS LE TRAITEMENT DES TROUBLES CARDIOVASCULAIRES.
FR8005311A 1979-03-12 1980-03-10 (1,1-biphenyl-2-yl)-propyl- et butylamines, leur preparation et leur utilisation therapeutique Granted FR2451363A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1953479A 1979-03-12 1979-03-12

Publications (2)

Publication Number Publication Date
FR2451363A1 true FR2451363A1 (fr) 1980-10-10
FR2451363B1 FR2451363B1 (fr) 1983-01-14

Family

ID=21793713

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8005311A Granted FR2451363A1 (fr) 1979-03-12 1980-03-10 (1,1-biphenyl-2-yl)-propyl- et butylamines, leur preparation et leur utilisation therapeutique

Country Status (31)

Country Link
EP (1) EP0015776B1 (fr)
JP (1) JPS55127347A (fr)
KR (1) KR840000103B1 (fr)
AR (1) AR228852A1 (fr)
AT (1) AT367395B (fr)
AU (1) AU528060B2 (fr)
BE (1) BE882167A (fr)
CA (1) CA1144926A (fr)
CH (1) CH644094A5 (fr)
CS (1) CS215052B2 (fr)
DD (1) DD149664A5 (fr)
DE (1) DE3060611D1 (fr)
DK (1) DK103480A (fr)
ES (6) ES489469A0 (fr)
FI (1) FI800736A (fr)
FR (1) FR2451363A1 (fr)
GB (1) GB2046256B (fr)
GR (1) GR68036B (fr)
HU (1) HU180334B (fr)
IE (1) IE49552B1 (fr)
IL (1) IL59557A (fr)
IT (1) IT1140773B (fr)
LU (1) LU82237A1 (fr)
MX (1) MX6219E (fr)
NZ (1) NZ193079A (fr)
PH (1) PH14749A (fr)
PL (1) PL121662B1 (fr)
PT (1) PT70928A (fr)
RO (1) RO79906A (fr)
SU (2) SU940645A3 (fr)
ZA (1) ZA801421B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100470454B1 (ko) * 2002-05-14 2005-02-05 대한민국 돼지 사료공급을 위한 자동조절급이기
AU2005265164A1 (en) * 2004-06-17 2006-01-26 Musc Foundation For Research Development Non-natural amino acids
ES2742261T3 (es) * 2011-04-15 2020-02-13 Hivih Inhibidores de la replicación viral, su proceso de preparación y sus usos terapéuticos
EP2821104A1 (fr) 2013-07-05 2015-01-07 Laboratoire Biodim Inhibiteurs de la réplication virale, leur procédé de préparation et leurs utilisations thérapeutiques

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES236010A1 (es) * 1956-06-29 1957-12-16 Lab Pharmaceutica Dr C Janssen UN PROCEDIMIENTO PARA PREPARAR NUEVOS DERIVADOS PARASIMPATICOLiTICAMENTE ACTIVOS DE ALFAS-DEFENIL PROPANO
US3433836A (en) * 1966-01-14 1969-03-18 Rexall Drug Chemical Alpha-diaryl alpha,omega-alkylene glycol-dilower-alkylamines
GB1475314A (en) * 1973-11-02 1977-06-01 Cm Ind Phenyl-propylamine derivatives
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
GB1523655A (en) * 1975-02-10 1978-09-06 Armour Pharma 4-(4-biphenylyl) butylamines and treatment of the animal organism therewith

Also Published As

Publication number Publication date
BE882167A (fr) 1980-09-11
GR68036B (fr) 1981-10-27
KR830001854A (ko) 1983-05-19
LU82237A1 (fr) 1980-06-06
FI800736A (fi) 1980-09-13
DK103480A (da) 1980-09-13
DD149664A5 (de) 1981-07-22
AU5630280A (en) 1980-09-18
ES8105262A1 (es) 1981-05-16
GB2046256A (en) 1980-11-12
IE800493L (en) 1980-09-12
ES8201528A1 (es) 1981-12-16
AT367395B (de) 1982-06-25
IL59557A0 (en) 1980-06-30
EP0015776B1 (fr) 1982-06-30
IT1140773B (it) 1986-10-10
ES8201526A1 (es) 1981-12-16
ES8201527A1 (es) 1981-12-16
IL59557A (en) 1983-10-31
ES497207A0 (es) 1981-12-16
FR2451363B1 (fr) 1983-01-14
ES497206A0 (es) 1981-12-16
DE3060611D1 (en) 1982-08-19
JPS55127347A (en) 1980-10-02
ES8201529A1 (es) 1981-12-16
EP0015776A1 (fr) 1980-09-17
MX6219E (es) 1984-12-21
ES497209A0 (es) 1981-12-16
HU180334B (en) 1983-02-28
GB2046256B (en) 1983-04-20
AU528060B2 (en) 1983-04-14
ES489469A0 (es) 1981-05-16
PL222601A1 (fr) 1981-01-30
SU940645A3 (ru) 1982-06-30
ATA134580A (de) 1981-11-15
PH14749A (en) 1981-11-20
ZA801421B (en) 1981-10-28
CA1144926A (fr) 1983-04-19
ES8201525A1 (es) 1981-12-16
ES497208A0 (es) 1981-12-16
ES497210A0 (es) 1981-12-16
IT8020503A0 (it) 1980-03-11
AR228852A1 (es) 1983-04-29
RO79906A (fr) 1982-10-11
IE49552B1 (en) 1985-10-30
SU1022655A3 (ru) 1983-06-07
PT70928A (en) 1980-04-01
CH644094A5 (fr) 1984-07-13
CS215052B2 (en) 1982-07-30
KR840000103B1 (ko) 1984-02-11
NZ193079A (en) 1982-05-31
PL121662B1 (en) 1982-05-31

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