KR830001821B1 - 할로겐 치환된 벤조피란 및 벤조 티오피란 4 카복실산의 제조방법 - Google Patents
할로겐 치환된 벤조피란 및 벤조 티오피란 4 카복실산의 제조방법 Download PDFInfo
- Publication number
- KR830001821B1 KR830001821B1 KR1019790003889A KR790003889A KR830001821B1 KR 830001821 B1 KR830001821 B1 KR 830001821B1 KR 1019790003889 A KR1019790003889 A KR 1019790003889A KR 790003889 A KR790003889 A KR 790003889A KR 830001821 B1 KR830001821 B1 KR 830001821B1
- Authority
- KR
- South Korea
- Prior art keywords
- chloro
- dihydro
- acid
- benzopyran
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 238000004519 manufacturing process Methods 0.000 title claims description 5
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- 150000001562 benzopyrans Chemical class 0.000 title description 2
- 125000005843 halogen group Chemical group 0.000 title description 2
- 229910052736 halogen Inorganic materials 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 39
- 229910052739 hydrogen Inorganic materials 0.000 claims description 16
- 239000001257 hydrogen Substances 0.000 claims description 16
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 13
- 239000002253 acid Substances 0.000 claims description 12
- 125000001153 fluoro group Chemical group F* 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000001246 bromo group Chemical group Br* 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 6
- 229910052717 sulfur Chemical group 0.000 claims description 6
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- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000011593 sulfur Chemical group 0.000 claims description 5
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- 150000003839 salts Chemical class 0.000 description 5
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- GCUCIFQCGJIRNT-UHFFFAOYSA-N alrestatin Chemical compound C1=CC(C(N(CC(=O)O)C2=O)=O)=C3C2=CC=CC3=C1 GCUCIFQCGJIRNT-UHFFFAOYSA-N 0.000 description 1
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- 244000309466 calf Species 0.000 description 1
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- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
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- 239000000463 material Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- MUZXPWUBHAGLJX-UHFFFAOYSA-N methyl 2-(6-chloro-3,4-dihydro-2h-chromen-4-yl)acetate Chemical compound C1=C(Cl)C=C2C(CC(=O)OC)CCOC2=C1 MUZXPWUBHAGLJX-UHFFFAOYSA-N 0.000 description 1
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- 150000002825 nitriles Chemical class 0.000 description 1
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- LWHYKTAISUZRAD-UHFFFAOYSA-L palladium(2+);carbonate Chemical compound [Pd+2].[O-]C([O-])=O LWHYKTAISUZRAD-UHFFFAOYSA-L 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US959023 | 1978-11-08 | ||
| US05/959,023 US4210663A (en) | 1978-11-08 | 1978-11-08 | Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids |
| US959,023 | 1992-10-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830001273A KR830001273A (ko) | 1983-04-30 |
| KR830001821B1 true KR830001821B1 (ko) | 1983-09-12 |
Family
ID=25501572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019790003889A Expired KR830001821B1 (ko) | 1978-11-08 | 1979-11-07 | 할로겐 치환된 벤조피란 및 벤조 티오피란 4 카복실산의 제조방법 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4210663A (https=) |
| EP (1) | EP0011426B1 (https=) |
| JP (2) | JPS6033433B2 (https=) |
| KR (1) | KR830001821B1 (https=) |
| AR (1) | AR223195A1 (https=) |
| AT (1) | AT366680B (https=) |
| AU (1) | AU513399B2 (https=) |
| CA (1) | CA1132584A (https=) |
| DE (1) | DE2965755D1 (https=) |
| DK (1) | DK153947C (https=) |
| ES (1) | ES485798A1 (https=) |
| FI (1) | FI71139C (https=) |
| IE (1) | IE49109B1 (https=) |
| IL (1) | IL58656A (https=) |
| PT (1) | PT70420A (https=) |
| YU (1) | YU41675B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4305955A (en) * | 1980-10-21 | 1981-12-15 | Pfizer Inc. | Carboxylic acid therapeutic agents |
| US4486428A (en) * | 1982-03-16 | 1984-12-04 | Pfizer Inc. | Bicyclic benzo fused compounds |
| US4537920A (en) * | 1983-08-18 | 1985-08-27 | Ethyl Corporation | 4H-1-benzopyrans and lubricant compositions containing same |
| US4551542A (en) * | 1984-09-26 | 1985-11-05 | Pfizer Inc. | Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid |
| HU206618B (en) * | 1986-01-17 | 1992-12-28 | Pfizer | Process for producing hydroxyacetic acid derivatives for treating complications of diabetes and pharmaceutical compositions containing them |
| DE3737195A1 (de) * | 1987-11-03 | 1989-05-18 | Bayer Ag | Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| US5039672A (en) * | 1990-04-05 | 1991-08-13 | Pfizer Inc. | Heterocyclic compounds as aldose reductase inhibitors |
| DE69128477T2 (de) * | 1990-07-27 | 1998-07-16 | Chugai Seiyaku K.K., Tokio/Tokyo | Benzopyranderivat |
| AU1256192A (en) * | 1991-02-18 | 1992-09-15 | Chugai Seiyaku Kabushiki Kaisha | Hair growth stimulant |
| US5407897A (en) * | 1993-03-03 | 1995-04-18 | American Cyanamid Company | Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds |
| WO1999043315A1 (en) * | 1998-02-25 | 1999-09-02 | Shionogi & Co., Ltd. | Therapeutic agent for complication of diabetes |
| US7288279B2 (en) * | 2001-12-21 | 2007-10-30 | Michael Foods Of Delaware, Inc. | Formulated fried egg product |
| JP4742215B2 (ja) * | 2003-06-23 | 2011-08-10 | Ｊｎｃ株式会社 | クロマン化合物、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子 |
| JP5956920B2 (ja) | 2012-12-14 | 2016-07-27 | 株式会社コガネイ | 液体供給装置 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3821383A (en) * | 1972-07-10 | 1974-06-28 | Ayerst Mckenna & Harrison | Compositions for and a method of treating diabetic complications |
-
1978
- 1978-11-08 US US05/959,023 patent/US4210663A/en not_active Expired - Lifetime
-
1979
- 1979-11-05 YU YU2697/79A patent/YU41675B/xx unknown
- 1979-11-06 DE DE7979302467T patent/DE2965755D1/de not_active Expired
- 1979-11-06 AR AR278784A patent/AR223195A1/es active
- 1979-11-06 EP EP79302467A patent/EP0011426B1/en not_active Expired
- 1979-11-06 CA CA339,283A patent/CA1132584A/en not_active Expired
- 1979-11-07 PT PT70420A patent/PT70420A/pt unknown
- 1979-11-07 ES ES485798A patent/ES485798A1/es not_active Expired
- 1979-11-07 IL IL58656A patent/IL58656A/xx unknown
- 1979-11-07 DK DK471079A patent/DK153947C/da not_active IP Right Cessation
- 1979-11-07 JP JP54144280A patent/JPS6033433B2/ja not_active Expired
- 1979-11-07 IE IE2136/79A patent/IE49109B1/en unknown
- 1979-11-07 KR KR1019790003889A patent/KR830001821B1/ko not_active Expired
- 1979-11-07 FI FI793487A patent/FI71139C/fi not_active IP Right Cessation
- 1979-11-07 AU AU52582/79A patent/AU513399B2/en not_active Ceased
- 1979-11-08 AT AT0719279A patent/AT366680B/de not_active IP Right Cessation
-
1980
- 1980-12-15 JP JP17706780A patent/JPS56103176A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| KR830001273A (ko) | 1983-04-30 |
| DK471079A (da) | 1980-05-09 |
| DE2965755D1 (en) | 1983-07-28 |
| DK153947C (da) | 1989-02-20 |
| PT70420A (de) | 1979-12-01 |
| IL58656A0 (en) | 1980-02-29 |
| YU269779A (en) | 1983-02-28 |
| ATA719279A (de) | 1981-09-15 |
| JPS6113716B2 (https=) | 1986-04-15 |
| AU5258279A (en) | 1980-05-15 |
| CA1132584A (en) | 1982-09-28 |
| AT366680B (de) | 1982-04-26 |
| EP0011426B1 (en) | 1983-06-22 |
| AR223195A1 (es) | 1981-07-31 |
| JPS5585582A (en) | 1980-06-27 |
| ES485798A1 (es) | 1980-10-01 |
| IL58656A (en) | 1983-06-15 |
| FI793487A7 (fi) | 1980-05-09 |
| YU41675B (en) | 1987-12-31 |
| DK153947B (da) | 1988-09-26 |
| FI71139C (fi) | 1986-11-24 |
| FI71139B (fi) | 1986-08-14 |
| IE49109B1 (en) | 1985-08-07 |
| IE792136L (en) | 1980-05-08 |
| US4210663A (en) | 1980-07-01 |
| AU513399B2 (en) | 1980-11-27 |
| JPS56103176A (en) | 1981-08-18 |
| JPS6033433B2 (ja) | 1985-08-02 |
| EP0011426A1 (en) | 1980-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19791107 |
|
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19830114 Patent event code: PE09021S01D |
|
| PG1501 | Laying open of application | ||
| PG1605 | Publication of application before grant of patent |
Comment text: Decision on Publication of Application Patent event code: PG16051S01I Patent event date: 19830809 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
Patent event code: PE07011S01D Comment text: Decision to Grant Registration Patent event date: 19831201 |