ES485798A1 - Un procedimiento para la preparacion de nuevos acidos benzo-piran y benzotiopiran-4-carboxilicos y derivados de los mis-mos. - Google Patents

Un procedimiento para la preparacion de nuevos acidos benzo-piran y benzotiopiran-4-carboxilicos y derivados de los mis-mos.

Info

Publication number
ES485798A1
ES485798A1 ES485798A ES485798A ES485798A1 ES 485798 A1 ES485798 A1 ES 485798A1 ES 485798 A ES485798 A ES 485798A ES 485798 A ES485798 A ES 485798A ES 485798 A1 ES485798 A1 ES 485798A1
Authority
ES
Spain
Prior art keywords
benzothiopyran
pharmaceutical compositions
compositions containing
bromo
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485798A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES485798A1 publication Critical patent/ES485798A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Se describen nuevos ácidos benzopiran-4-carboxílicos, ácidos benzotiopiran-4-carboxílicos y derivados de los mismos, sustituidos con halógenos, útiles como inhibidores de la aldosa- reductasa y como agentes terapéuticos para el tratamiento de las complicaciones diabéticas crónicas. Entre los compuestos específicos descritos se encuentran el ácido-6-fenil-8-cloro- 3,4-dihidro-2h,1-benzopiran-4-carboxílico, ácido 6,7-dicloro.3,4-dihidrobenzotiopiran-4- carboxílico, ácido 6-cloro-8-metil-3,4-dihidrobenzotiopiran-4-carboxílico, ácido 6,8-dicloro- 3,4-dihidro-2H-1,benzopiran-4-carboxílico, ácido 6-flúor-3,4-dihidro-2H-1-benzopiran-4- carboxílico, ácido 6-cloro-3,4-dihidro-2H-1-beenzopiran-4-carboxílico, ácido 6-cloro 3,4- dihidro-2H-nafto[1,2-b]piran-4-carboxílico, ácido 6-cloro -3,4-dihidro-2H-1-benzotiopiran-4- carboxílico y ácido 6-cloro-3,4-dihidro-2H-1-benzopiran-4-acético. También se describen composiciones farmacéuticas que contienen los nuevos compuestos y un método de utilización de losnuevos compuestos para el tratamiento de las complicaciones diabéticas crónicas.
ES485798A 1978-11-08 1979-11-07 Un procedimiento para la preparacion de nuevos acidos benzo-piran y benzotiopiran-4-carboxilicos y derivados de los mis-mos. Expired ES485798A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/959,023 US4210663A (en) 1978-11-08 1978-11-08 Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids

Publications (1)

Publication Number Publication Date
ES485798A1 true ES485798A1 (es) 1980-10-01

Family

ID=25501572

Family Applications (1)

Application Number Title Priority Date Filing Date
ES485798A Expired ES485798A1 (es) 1978-11-08 1979-11-07 Un procedimiento para la preparacion de nuevos acidos benzo-piran y benzotiopiran-4-carboxilicos y derivados de los mis-mos.

Country Status (16)

Country Link
US (1) US4210663A (es)
EP (1) EP0011426B1 (es)
JP (2) JPS6033433B2 (es)
KR (1) KR830001821B1 (es)
AR (1) AR223195A1 (es)
AT (1) AT366680B (es)
AU (1) AU513399B2 (es)
CA (1) CA1132584A (es)
DE (1) DE2965755D1 (es)
DK (1) DK153947C (es)
ES (1) ES485798A1 (es)
FI (1) FI71139C (es)
IE (1) IE49109B1 (es)
IL (1) IL58656A (es)
PT (1) PT70420A (es)
YU (1) YU41675B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4305955A (en) * 1980-10-21 1981-12-15 Pfizer Inc. Carboxylic acid therapeutic agents
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
US4537920A (en) * 1983-08-18 1985-08-27 Ethyl Corporation 4H-1-benzopyrans and lubricant compositions containing same
US4551542A (en) * 1984-09-26 1985-11-05 Pfizer Inc. Regeneration of 6-fluoro-4-chromanone from 6-fluoro-4-ureidochroman-4-carboxylic acid
HU206618B (en) * 1986-01-17 1992-12-28 Pfizer Process for producing hydroxyacetic acid derivatives for treating complications of diabetes and pharmaceutical compositions containing them
DE3737195A1 (de) * 1987-11-03 1989-05-18 Bayer Ag Chromanderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US5039672A (en) * 1990-04-05 1991-08-13 Pfizer Inc. Heterocyclic compounds as aldose reductase inhibitors
ES2111572T3 (es) * 1990-07-27 1998-03-16 Chugai Pharmaceutical Co Ltd Nuevo derivado de benzopirano.
JP3255411B2 (ja) * 1991-02-18 2002-02-12 中外製薬株式会社 発毛促進剤
US5407897A (en) * 1993-03-03 1995-04-18 American Cyanamid Company Method for safening herbicides in crops using substituted benzopyran and tetrahydronaphthalene compounds
AU2440599A (en) * 1998-02-25 1999-09-15 Shionogi & Co., Ltd. Therapeutic agent for complication of diabetes
US7288279B2 (en) * 2001-12-21 2007-10-30 Michael Foods Of Delaware, Inc. Formulated fried egg product
JP4742215B2 (ja) * 2003-06-23 2011-08-10 Ｊｎｃ株式会社 クロマン化合物、この化合物を含有する液晶組成物およびこの液晶組成物を含有する液晶表示素子
JP5956920B2 (ja) 2012-12-14 2016-07-27 株式会社コガネイ 液体供給装置

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications

Also Published As

Publication number Publication date
ATA719279A (de) 1981-09-15
IL58656A0 (en) 1980-02-29
FI71139C (fi) 1986-11-24
EP0011426B1 (en) 1983-06-22
JPS56103176A (en) 1981-08-18
AR223195A1 (es) 1981-07-31
DK153947B (da) 1988-09-26
IE792136L (en) 1980-05-08
KR830001821B1 (ko) 1983-09-12
AU513399B2 (en) 1980-11-27
IL58656A (en) 1983-06-15
EP0011426A1 (en) 1980-05-28
JPS6113716B2 (es) 1986-04-15
YU41675B (en) 1987-12-31
DK153947C (da) 1989-02-20
DK471079A (da) 1980-05-09
AU5258279A (en) 1980-05-15
CA1132584A (en) 1982-09-28
YU269779A (en) 1983-02-28
PT70420A (de) 1979-12-01
FI793487A (fi) 1980-05-09
JPS6033433B2 (ja) 1985-08-02
KR830001273A (ko) 1983-04-30
JPS5585582A (en) 1980-06-27
FI71139B (fi) 1986-08-14
IE49109B1 (en) 1985-08-07
AT366680B (de) 1982-04-26
US4210663A (en) 1980-07-01
DE2965755D1 (en) 1983-07-28

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