KR20250112919A - 타우 발현을 감소시키기 위한 조성물 및 방법 - Google Patents

타우 발현을 감소시키기 위한 조성물 및 방법

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Publication number
KR20250112919A
KR20250112919A KR1020257023205A KR20257023205A KR20250112919A KR 20250112919 A KR20250112919 A KR 20250112919A KR 1020257023205 A KR1020257023205 A KR 1020257023205A KR 20257023205 A KR20257023205 A KR 20257023205A KR 20250112919 A KR20250112919 A KR 20250112919A
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Prior art keywords
oligonucleotide
artificial sequence
dna
note
source
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Pending
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KR1020257023205A
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English (en)
Korean (ko)
Inventor
마누엘라 폴리도로 오펜가임
얀 바일러
Original Assignee
노파르티스 아게
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Publication of KR20250112919A publication Critical patent/KR20250112919A/ko
Pending legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020257023205A 2015-12-21 2016-12-19 타우 발현을 감소시키기 위한 조성물 및 방법 Pending KR20250112919A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562270165P 2015-12-21 2015-12-21
US62/270,165 2015-12-21
KR1020187020632A KR102834468B1 (ko) 2015-12-21 2016-12-19 타우 발현을 감소시키기 위한 조성물 및 방법
PCT/IB2016/057794 WO2017109679A1 (en) 2015-12-21 2016-12-19 Compositions and methods for decreasing tau expression

Related Parent Applications (1)

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KR1020187020632A Division KR102834468B1 (ko) 2015-12-21 2016-12-19 타우 발현을 감소시키기 위한 조성물 및 방법

Publications (1)

Publication Number Publication Date
KR20250112919A true KR20250112919A (ko) 2025-07-24

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KR1020187020632A Active KR102834468B1 (ko) 2015-12-21 2016-12-19 타우 발현을 감소시키기 위한 조성물 및 방법

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EP (2) EP4406541A3 (enExample)
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