MX2023008211A - Composiciones y metodos para disminuir la expresion de tau. - Google Patents
Composiciones y metodos para disminuir la expresion de tau.Info
- Publication number
- MX2023008211A MX2023008211A MX2023008211A MX2023008211A MX2023008211A MX 2023008211 A MX2023008211 A MX 2023008211A MX 2023008211 A MX2023008211 A MX 2023008211A MX 2023008211 A MX2023008211 A MX 2023008211A MX 2023008211 A MX2023008211 A MX 2023008211A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- methods
- tau expression
- decreasing tau
- decreasing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000003247 decreasing effect Effects 0.000 title abstract 2
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Wood Science & Technology (AREA)
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- Biochemistry (AREA)
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- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
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- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se proporciona en esta solicitud composiciones y métodos para disminuir la expresión de proteína y ARNm tau. Estas composiciones y métodos son útiles en el tratamiento de enfermedades y trastornos relacionados con tau.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270165P | 2015-12-21 | 2015-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023008211A true MX2023008211A (es) | 2023-07-18 |
Family
ID=57758674
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007726A MX2018007726A (es) | 2015-12-21 | 2016-12-19 | Composiciones y metodos para disminuir la expresion de tau. |
MX2023008211A MX2023008211A (es) | 2015-12-21 | 2018-06-21 | Composiciones y metodos para disminuir la expresion de tau. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007726A MX2018007726A (es) | 2015-12-21 | 2016-12-19 | Composiciones y metodos para disminuir la expresion de tau. |
Country Status (30)
Country | Link |
---|---|
US (2) | US11473083B2 (es) |
EP (1) | EP3394259B1 (es) |
JP (3) | JP7027328B2 (es) |
KR (1) | KR20180089517A (es) |
CN (2) | CN116218848A (es) |
AR (1) | AR107579A1 (es) |
AU (2) | AU2016376034B2 (es) |
BR (1) | BR112018012304A2 (es) |
CA (1) | CA3008094A1 (es) |
CL (3) | CL2018001652A1 (es) |
CO (1) | CO2018006297A2 (es) |
CR (1) | CR20200609A (es) |
CU (1) | CU24574B1 (es) |
DO (1) | DOP2018000151A (es) |
EA (2) | EA202091865A1 (es) |
EC (1) | ECSP18050575A (es) |
HK (1) | HK1254822A1 (es) |
IL (3) | IL296844B2 (es) |
JO (2) | JOP20200228A1 (es) |
MX (2) | MX2018007726A (es) |
MY (1) | MY191737A (es) |
PE (1) | PE20181448A1 (es) |
PH (1) | PH12018501207A1 (es) |
RU (1) | RU2747734C2 (es) |
SA (1) | SA518391831B1 (es) |
SG (2) | SG11201804704PA (es) |
SV (1) | SV2018005714A (es) |
TW (1) | TWI787163B (es) |
UY (1) | UY37038A (es) |
WO (1) | WO2017109679A1 (es) |
Families Citing this family (9)
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US10273474B2 (en) | 2012-03-30 | 2019-04-30 | Washington University | Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome |
TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
KR20200131263A (ko) * | 2018-03-13 | 2020-11-23 | 얀센 파마슈티카 엔.브이. | 변형 올리고뉴클레오티드 및 타우병증에서의 사용 방법 |
TW202020151A (zh) | 2018-07-03 | 2020-06-01 | 瑞士商赫孚孟拉羅股份公司 | 用於調制 Tau 表現之寡核苷酸 |
WO2021202511A2 (en) * | 2020-03-30 | 2021-10-07 | Alnylam Pharmaceuticals, Inc. | MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
CN113817728A (zh) * | 2020-06-19 | 2021-12-21 | 四川大学华西医院 | 一种有效干扰Tau蛋白表达的重组慢病毒及其应用 |
AU2022293669A1 (en) * | 2021-06-16 | 2024-01-18 | Empirico Inc. | Treatment of mtres1 related diseases and disorders |
WO2024091874A1 (en) * | 2022-10-25 | 2024-05-02 | Empirico Inc. | Gene therapy treatment of mtres1 related diseases and disorders |
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