CL2019000149A1 - Composiciones y métodos para disminuir la expresión de tau, útiles para tratar enfermedades asociadas a tau. (divisional solicitud 201801652) - Google Patents
Composiciones y métodos para disminuir la expresión de tau, útiles para tratar enfermedades asociadas a tau. (divisional solicitud 201801652)Info
- Publication number
- CL2019000149A1 CL2019000149A1 CL2019000149A CL2019000149A CL2019000149A1 CL 2019000149 A1 CL2019000149 A1 CL 2019000149A1 CL 2019000149 A CL2019000149 A CL 2019000149A CL 2019000149 A CL2019000149 A CL 2019000149A CL 2019000149 A1 CL2019000149 A1 CL 2019000149A1
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- tau
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
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Abstract
SE PROPORCIONAN EN ESTA SOLICITUD COMPOSICIONES Y MÉTODOS PARA DISMINUIR LA EXPRESIÓN DE PROTEÍNA Y ARNM TAU. ESTAS COMPOSICIONES Y MÉTODOS SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES Y TRASTORNOS RELACIONADOS CON TAU. PARTICULARMENTE, SE PROPORCIONAN EN LA PRESENTE SOLICITUD OLIGONUCLEÓTIDOS ANTISENTIDO QUE SE DIRIGEN A LA PROTEÍNA TAU ASOCIADA A MICROTÚBULO HUMANA (MAPT, CONFORME A SUS SIGLAS EN INGLÉS), COMPOSICIONES QUE COMPRENDEN LOS OLIGONUCLEÓTIDOS ANTISENTIDO, Y MÉTODOS PARA DISMINUIR LA EXPRESIÓN DE PROTEÍNA Y ARNM DE TAU USANDO ESTOS OLIGONUCLEÓTIDOS ANTISENTIDO. LAS COMPOSICIONES Y LOS MÉTODOS PROPORCIONADOS EN ESTE DOCUMENTO SON ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES ASOCIADAS A TAU.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562270165P | 2015-12-21 | 2015-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019000149A1 true CL2019000149A1 (es) | 2019-06-07 |
Family
ID=57758674
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001652A CL2018001652A1 (es) | 2015-12-21 | 2018-06-18 | Composiciones y métodos para disminuir la expresión de tau |
CL2019000149A CL2019000149A1 (es) | 2015-12-21 | 2019-01-18 | Composiciones y métodos para disminuir la expresión de tau, útiles para tratar enfermedades asociadas a tau. (divisional solicitud 201801652) |
CL2019003420A CL2019003420A1 (es) | 2015-12-21 | 2019-11-25 | Composiciones y métodos para disminuir la expresión de tau, útiles para tratar enfermedades asociados a tau. (divisional solicitud 201801652) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2018001652A CL2018001652A1 (es) | 2015-12-21 | 2018-06-18 | Composiciones y métodos para disminuir la expresión de tau |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019003420A CL2019003420A1 (es) | 2015-12-21 | 2019-11-25 | Composiciones y métodos para disminuir la expresión de tau, útiles para tratar enfermedades asociados a tau. (divisional solicitud 201801652) |
Country Status (35)
Country | Link |
---|---|
US (2) | US11473083B2 (es) |
EP (1) | EP3394259B1 (es) |
JP (3) | JP7027328B2 (es) |
KR (1) | KR20180089517A (es) |
CN (2) | CN116218848A (es) |
AR (1) | AR107579A1 (es) |
AU (2) | AU2016376034B2 (es) |
BR (1) | BR112018012304A2 (es) |
CA (1) | CA3008094A1 (es) |
CL (3) | CL2018001652A1 (es) |
CO (1) | CO2018006297A2 (es) |
CR (1) | CR20200609A (es) |
CU (1) | CU24574B1 (es) |
DK (1) | DK3394259T3 (es) |
DO (1) | DOP2018000151A (es) |
EA (2) | EA202091865A1 (es) |
EC (1) | ECSP18050575A (es) |
FI (1) | FI3394259T3 (es) |
HK (1) | HK1254822A1 (es) |
IL (3) | IL296844B2 (es) |
JO (2) | JOP20200228A1 (es) |
LT (1) | LT3394259T (es) |
MA (1) | MA44426B1 (es) |
MX (2) | MX2018007726A (es) |
MY (1) | MY191737A (es) |
PE (1) | PE20181448A1 (es) |
PH (1) | PH12018501207A1 (es) |
PT (1) | PT3394259T (es) |
RU (1) | RU2747734C2 (es) |
SA (1) | SA518391831B1 (es) |
SG (2) | SG11201804704PA (es) |
SV (1) | SV2018005714A (es) |
TW (2) | TWI787163B (es) |
UY (1) | UY37038A (es) |
WO (1) | WO2017109679A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6492003B2 (ja) | 2012-03-30 | 2019-03-27 | ワシントン・ユニバーシティWashington University | 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 |
TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
JP2021515784A (ja) * | 2018-03-13 | 2021-06-24 | ヤンセン ファーマシューティカ エヌ.ベー. | 修飾オリゴヌクレオチド及びタウオパチーにおける使用方法 |
JP7102557B2 (ja) | 2018-07-03 | 2022-07-19 | エフ.ホフマン-ラ ロシュ アーゲー | Tau発現調節用オリゴヌクレオチド |
US20230203486A1 (en) * | 2020-03-30 | 2023-06-29 | Alnylam Pharmaceuticals, Inc. | MICROTUBULE ASSOCIATED PROTEIN TAU (MAPT) iRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF |
CN113817728A (zh) * | 2020-06-19 | 2021-12-21 | 四川大学华西医院 | 一种有效干扰Tau蛋白表达的重组慢病毒及其应用 |
CA3221625A1 (en) * | 2021-06-16 | 2022-12-22 | Omri GOTTESMAN | Treatment of mtres1 related diseases and disorders |
WO2024091874A1 (en) * | 2022-10-25 | 2024-05-02 | Empirico Inc. | Gene therapy treatment of mtres1 related diseases and disorders |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
WO1991010671A1 (en) | 1990-01-11 | 1991-07-25 | Isis Pharmaceuticals, Inc. | Compositions and methods for detecting and modulating rna activity and gene expression |
US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
US20020052331A1 (en) | 1990-08-14 | 2002-05-02 | Brenda Baker | Compositions and methods for antisense inhibition of protein translation |
US5789573A (en) | 1990-08-14 | 1998-08-04 | Isis Pharmaceuticals, Inc. | Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2 |
DE69233767D1 (de) | 1991-12-06 | 2009-09-17 | Max Planck Gesellschaft | Verwendung von Protein-Kinasen zur Diagnose und Behandlung der Alzheimer-Krankheit |
US7408027B1 (en) | 1991-12-06 | 2008-08-05 | Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften | Tools for the diagnosis and treatment of Alzheimer's disease |
US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
KR940021073A (ko) | 1993-03-02 | 1994-10-17 | 미야베 요시가즈 | 알쯔하이머병의 예방 또는 치료제, 그 스크리닝 방법 및 인간 유래의 타우 단백질 키나아제 i |
CA2116460A1 (en) | 1993-03-02 | 1994-09-03 | Mitsubishi Chemical Corporation | Preventive or therapeutic agents for alzheimer's disease, a screening method of alzheimer's disease and tau-protein kinase i originated from human being |
CA2162361C (en) | 1993-05-11 | 2008-10-21 | Ryszard Kole | Antisense oligonucleotides which combat aberrant splicing and methods of using the same |
DE69729179T2 (de) | 1996-02-14 | 2004-12-30 | Isis Pharmaceuticals, Inc., Carlsbad | Lückenhaft Zucker-modifizierte Oligonukleotide |
JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
CN1273476C (zh) | 1997-09-12 | 2006-09-06 | 埃克西康有限公司 | 寡核苷酸类似物 |
US20040186071A1 (en) | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
US6664443B1 (en) | 1998-05-01 | 2003-12-16 | Mayo Foundation For Medical Education And Research | Pathogenic Tau mutations in transgenic mice |
JP2002513551A (ja) | 1998-05-01 | 2002-05-14 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 病原性タウ突然変異 |
AU762812B2 (en) * | 1998-07-14 | 2003-07-03 | Corixa Corporation | Compositions and methods for therapy and diagnosis of prostate cancer |
US7098192B2 (en) * | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
US6350868B1 (en) | 1999-04-26 | 2002-02-26 | University Of North Carolina At Chapel Hill | Antisense human fucosyltransferase sequences and methods of use thereof |
CN101284873A (zh) * | 1999-06-30 | 2008-10-15 | 科里克萨有限公司 | 用于肺癌治疗和诊断的组合物和方法 |
AU2001229619A1 (en) | 2000-01-21 | 2001-07-31 | Pharmacia And Upjohn Company | Transgenic mouse model of human neurodegenerative disease |
CA2400595A1 (en) * | 2000-02-28 | 2001-09-07 | Decode Genetics Ehf | Human schizophrenia gene |
WO2002055681A2 (en) | 2001-01-11 | 2002-07-18 | Bayer Ag | Regulation of human tau-tubulin kinase |
US20050130924A1 (en) | 2002-06-26 | 2005-06-16 | Monia Brett P. | Antisense inhibition via RNAse H-independent reduction in mRNA |
WO2004003134A2 (en) | 2002-06-26 | 2004-01-08 | Isis Pharmaceuticals, Inc. | Antisense inhibition via rnase h-independent reduction in mrna |
US20080176812A1 (en) | 2002-08-05 | 2008-07-24 | Davidson Beverly L | Allele-specific silencing of disease genes |
US20040241854A1 (en) | 2002-08-05 | 2004-12-02 | Davidson Beverly L. | siRNA-mediated gene silencing |
US20050106731A1 (en) | 2002-08-05 | 2005-05-19 | Davidson Beverly L. | siRNA-mediated gene silencing with viral vectors |
JP4393382B2 (ja) | 2002-08-14 | 2010-01-06 | 三菱化学株式会社 | 中枢性タウ蛋白質特異的抗体 |
US8163896B1 (en) | 2002-11-14 | 2012-04-24 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
US7906326B2 (en) | 2003-05-07 | 2011-03-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides associated with alzheimer's disease and uses thereof |
US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
US20130130231A1 (en) | 2002-11-26 | 2013-05-23 | Isaac Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
US20060257851A1 (en) | 2002-11-26 | 2006-11-16 | Itzhak Bentwich | Bioinformatically detectable group of novel viral regulatory genes and uses thereof |
US7790867B2 (en) | 2002-12-05 | 2010-09-07 | Rosetta Genomics Inc. | Vaccinia virus-related nucleic acids and microRNA |
US7696334B1 (en) | 2002-12-05 | 2010-04-13 | Rosetta Genomics, Ltd. | Bioinformatically detectable human herpesvirus 5 regulatory gene |
US20070077553A1 (en) | 2003-10-30 | 2007-04-05 | Rosetta Genomics | Bioinformatically detectable group of novel vaccinia regulatory genes and uses thereof |
AU2003904328A0 (en) | 2003-08-13 | 2003-08-28 | Garvan Institute Of Medical Research | Diagnosis and treatment of neurodegenerative disorders |
US7888497B2 (en) | 2003-08-13 | 2011-02-15 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof |
KR20110007263A (ko) | 2003-08-28 | 2011-01-21 | 노파르티스 아게 | 블런트-말단 및 3'-변형체를 갖는 간섭 rna 이중나선 |
WO2005040382A2 (de) | 2003-10-28 | 2005-05-06 | Alexander Cherkasky | Cherkasky - fusionsproteine enthaltend antikorperbinde-, antigenbinde - mikrotubulibinde und immunantwortauslosende |
US20050244851A1 (en) | 2004-01-13 | 2005-11-03 | Affymetrix, Inc. | Methods of analysis of alternative splicing in human |
US7687616B1 (en) | 2004-05-14 | 2010-03-30 | Rosetta Genomics Ltd | Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof |
CA2566519C (en) * | 2004-05-14 | 2020-04-21 | Rosetta Genomics Ltd. | Micrornas and uses thereof |
EP3228711A1 (en) | 2004-06-28 | 2017-10-11 | The University Of Western Australia | Antisense oligonucleotides for inducing exon skipping and methods of use thereof |
US7312035B2 (en) | 2004-09-03 | 2007-12-25 | Affymetrix, Inc. | Methods of genetic analysis of yeast |
US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
US7838657B2 (en) | 2004-12-03 | 2010-11-23 | University Of Massachusetts | Spinal muscular atrophy (SMA) treatment via targeting of SMN2 splice site inhibitory sequences |
CA2587601C (en) | 2004-12-03 | 2017-11-07 | Rhode Island Hospital | Diagnosis and treatment of alzheimer's disease |
US20070048756A1 (en) | 2005-04-18 | 2007-03-01 | Affymetrix, Inc. | Methods for whole genome association studies |
EP1937312B1 (en) | 2005-08-30 | 2016-06-29 | Ionis Pharmaceuticals, Inc. | Chimeric oligomeric compounds for modulation of splicing |
WO2007047913A2 (en) | 2005-10-20 | 2007-04-26 | Isis Pharmaceuticals, Inc | Compositions and methods for modulation of lmna expression |
GB0605337D0 (en) * | 2006-03-17 | 2006-04-26 | Genomica Sau | Treatment of CNS conditions |
US7901882B2 (en) | 2006-03-31 | 2011-03-08 | Affymetrix, Inc. | Analysis of methylation using nucleic acid arrays |
ES2715625T3 (es) | 2006-04-03 | 2019-06-05 | Roche Innovation Ct Copenhagen As | Composición farmacéutica que comprende oligonucleótidos antisentido anti-miARN |
WO2008002620A2 (en) | 2006-06-27 | 2008-01-03 | University Of Virginia Patent Foundation | Cell model for alzheimer's disease pathology |
JP2010509923A (ja) | 2006-11-23 | 2010-04-02 | ミルクス セラピューティクス アンパーツゼルスカブ | 標的rnaの活性を変化させるためのオリゴヌクレオチド |
EP2578692B1 (en) | 2007-04-05 | 2016-06-08 | The J. David Gladstone Institutes | Agents that reduce neuronal overexcitation |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
CA2717792A1 (en) | 2008-03-07 | 2009-09-11 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
EP2421970B1 (en) | 2009-04-24 | 2016-09-07 | Roche Innovation Center Copenhagen A/S | Pharmaceutical compositions for treatment of hcv patients that are non-responders to interferon |
JP5963678B2 (ja) | 2009-11-12 | 2016-08-03 | ジ ユニバーシティ オブ ウェスタン オーストラリア | 病状を治療するためのアンチセンス分子及び方法 |
US20150018223A1 (en) | 2010-01-28 | 2015-01-15 | University Of Massachusetts Lowell | Methods of diagnosing tau-associated neurodegenerative diseases |
WO2011117353A1 (en) | 2010-03-24 | 2011-09-29 | Mirrx Therapeutics A/S | Bivalent antisense oligonucleotides |
EP3702460A1 (en) | 2010-11-12 | 2020-09-02 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
US9145557B2 (en) | 2010-11-23 | 2015-09-29 | Mirrx Therapeutics A/S | Oligonucleotides for modulation of target RNA activity |
CA2822462A1 (en) | 2010-12-20 | 2012-06-28 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
US9957558B2 (en) * | 2011-04-28 | 2018-05-01 | Life Technologies Corporation | Methods and compositions for multiplex PCR |
WO2013013165A2 (en) | 2011-07-21 | 2013-01-24 | The Trustees Of The University Of Pennsylvania | Use of lna compounds for therapeutic inhibition of mir-21 in systemic lupus erythematosus |
JP6492003B2 (ja) * | 2012-03-30 | 2019-03-27 | ワシントン・ユニバーシティWashington University | 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法 |
AU2013243951A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of secreted proteins |
EP2855520B1 (en) | 2012-06-04 | 2018-09-26 | Novartis AG | Site-specific labeling methods and molecules produced thereby |
WO2014064187A1 (en) | 2012-10-24 | 2014-05-01 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | A microtubuli-modifying compound |
US9200068B2 (en) | 2012-12-18 | 2015-12-01 | Regents Of The University Of Minnesota | Compositions and methods related to tauopathy |
JP2016502858A (ja) | 2012-12-20 | 2016-02-01 | サレプタ セラピューティクス, インコーポレイテッド | 筋ジストロフィを処置するための改善されたエキソンスキッピング組成物 |
US20160040162A1 (en) | 2013-03-14 | 2016-02-11 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
JP6449231B2 (ja) | 2013-03-14 | 2019-01-09 | サレプタ セラピューティクス, インコーポレイテッド | 筋ジストロフィを処置するためのエキソンスキッピング組成物 |
CN111254145A (zh) | 2013-03-14 | 2020-06-09 | Ionis制药公司 | 用于调节tau表达的组合物和方法 |
WO2014201306A1 (en) | 2013-06-12 | 2014-12-18 | Oncoimmunin, Inc. | Systemic in vivo delivery of oligonucleotides |
TW202246503A (zh) * | 2013-07-19 | 2022-12-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
WO2015068075A2 (en) | 2013-10-24 | 2015-05-14 | Institut National De La Sante Et De La Recherche Medicale | Detection of tau |
WO2016011123A1 (en) * | 2014-07-16 | 2016-01-21 | Arrowhead Research Corporation | Organic compositions to treat apoc3-related diseases |
WO2016019063A1 (en) | 2014-07-29 | 2016-02-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating tau expression |
EP3653712B1 (en) | 2015-02-04 | 2022-11-30 | F. Hoffmann-La Roche AG | Tau antisense oligomers and uses thereof |
CN107636159B (zh) | 2015-02-04 | 2022-06-14 | 百时美施贵宝公司 | 选择治疗性分子的方法 |
WO2016127002A1 (en) | 2015-02-04 | 2016-08-11 | Bristol-Myers Squibb Company | Lna oligonucleotides with alternating flanks |
US20170035860A1 (en) * | 2015-04-02 | 2017-02-09 | Alexander C. Flynn | Compositions and methods for treatment of neurogenerative diseases |
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