KR20250054838A - 옥시스테롤 및 그의 사용 방법 - Google Patents

옥시스테롤 및 그의 사용 방법 Download PDF

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Publication number
KR20250054838A
KR20250054838A KR1020257012306A KR20257012306A KR20250054838A KR 20250054838 A KR20250054838 A KR 20250054838A KR 1020257012306 A KR1020257012306 A KR 1020257012306A KR 20257012306 A KR20257012306 A KR 20257012306A KR 20250054838 A KR20250054838 A KR 20250054838A
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disorder
compound
alkyl
substituted
unsubstituted
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Korean (ko)
Inventor
프란체스코 지. 살리투로
앨버트 제이. 로비쇼
가브리엘 마르티네즈 보텔라
보이드 엘. 해리슨
앤드류 그리핀
대니얼 라
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세이지 테라퓨틱스, 인크.
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Publication of KR20250054838A publication Critical patent/KR20250054838A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
KR1020257012306A 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법 Pending KR20250054838A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201662409756P 2016-10-18 2016-10-18
US201662409768P 2016-10-18 2016-10-18
US62/409,768 2016-10-18
US62/409,756 2016-10-18
KR1020237012221A KR20230051723A (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법
PCT/US2017/057276 WO2018075698A1 (en) 2016-10-18 2017-10-18 Oxysterols and methods of use thereof

Related Parent Applications (1)

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KR1020237012221A Division KR20230051723A (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법

Publications (1)

Publication Number Publication Date
KR20250054838A true KR20250054838A (ko) 2025-04-23

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Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020197014258A Active KR102521573B1 (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법
KR1020237012221A Ceased KR20230051723A (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법
KR1020257012306A Pending KR20250054838A (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법

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KR1020197014258A Active KR102521573B1 (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법
KR1020237012221A Ceased KR20230051723A (ko) 2016-10-18 2017-10-18 옥시스테롤 및 그의 사용 방법

Country Status (14)

Country Link
US (4) US11111266B2 (enExample)
EP (3) EP3529256B1 (enExample)
JP (3) JP2019532079A (enExample)
KR (3) KR102521573B1 (enExample)
CN (3) CN110072874B (enExample)
AU (3) AU2017345399B2 (enExample)
DK (1) DK4105223T3 (enExample)
ES (2) ES2968140T3 (enExample)
IL (3) IL293231B2 (enExample)
MA (1) MA46565A (enExample)
MX (2) MX2019004679A (enExample)
RU (1) RU2019115112A (enExample)
TW (3) TWI836485B (enExample)
WO (1) WO2018075698A1 (enExample)

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CN107936076B (zh) 2011-09-08 2021-10-15 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
MX362544B (es) 2013-03-13 2019-01-24 Sage Therapeutics Inc Esteroides neuroactivos y metodos para su uso.
EP4306114A1 (en) 2014-06-18 2024-01-17 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3828194B1 (en) 2015-07-06 2025-04-16 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PL3319612T3 (pl) 2015-07-06 2021-12-20 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
US20190330259A1 (en) 2016-04-01 2019-10-31 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
MD3481846T2 (ro) 2016-07-07 2021-11-30 Sage Therapeutics Inc 24-Hidroxisteroli 11-substituiți pentru utilizare în tratamentul stărilor legate de NMDA
CN121085986A (zh) 2016-09-30 2025-12-09 萨奇治疗股份有限公司 C7取代的氧固醇及其作为nmda调节剂的方法
KR102521573B1 (ko) * 2016-10-18 2023-04-14 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
TW202444381A (zh) 2016-10-18 2024-11-16 美商賽吉醫療公司 氧固醇(oxysterol)及其使用方法
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN111560045A (zh) * 2020-06-23 2020-08-21 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成石胆酸的方法
CN112375117A (zh) * 2020-11-14 2021-02-19 湖南科瑞生物制药股份有限公司 石胆酸及其中间体的制备方法
CN113651866B (zh) * 2021-08-02 2023-07-04 王涛 一种以21-羟基-20-甲基孕甾-4-烯-3-酮为原料合成胆固醇的新方法
EP4430056A1 (en) * 2021-11-10 2024-09-18 Umecrine AB 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
CN118843500A (zh) 2022-03-30 2024-10-25 唐纳森公司 用于回收溶剂的系统和方法
US20250375459A1 (en) * 2022-07-01 2025-12-11 Intercept Pharmaceuticals, Inc. Methods for ameliorating cognitive impairment using bile acid derivatives
JP2025538551A (ja) * 2022-11-21 2025-11-28 セージ セラピューティクス， エルエルシー 負のｎｍｄａ調節化合物及びその使用方法
CN115974950A (zh) * 2022-12-23 2023-04-18 上海彩迩文生化科技有限公司 一种3-烷基化的甾体中间体及其制备和应用
WO2025020191A1 (zh) * 2023-07-27 2025-01-30 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用
WO2025250816A1 (en) * 2024-05-29 2025-12-04 Sage Therapeutics, Inc. Agents for delivering nmda receptor modulating compounds and methods of use thereof

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