KR20210005031A - Pten 억제제를 포함하는 소포 및 이의 용도 - Google Patents

Pten 억제제를 포함하는 소포 및 이의 용도 Download PDF

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KR20210005031A
KR20210005031A KR1020207031043A KR20207031043A KR20210005031A KR 20210005031 A KR20210005031 A KR 20210005031A KR 1020207031043 A KR1020207031043 A KR 1020207031043A KR 20207031043 A KR20207031043 A KR 20207031043A KR 20210005031 A KR20210005031 A KR 20210005031A
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sirna
pten
pharmaceutical composition
cells
extracellular vesicle
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KR1020207031043A
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Korean (ko)
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슐라미트 레벤베르크
샤오웨이 구오
다니엘 오펜
니심 페레츠
Original Assignee
테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디.
라모트 앳 텔-아비브 유니버시티 리미티드
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Publication of KR20210005031A publication Critical patent/KR20210005031A/ko

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KR1020207031043A 2018-03-29 2019-03-27 Pten 억제제를 포함하는 소포 및 이의 용도 KR20210005031A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862649648P 2018-03-29 2018-03-29
US62/649,648 2018-03-29
PCT/IL2019/050355 WO2019186558A1 (en) 2018-03-29 2019-03-27 Vesicles comprising a pten inhibitor and uses of same

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KR20210005031A true KR20210005031A (ko) 2021-01-13

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US (2) US11648260B2 (de)
EP (1) EP3773506A4 (de)
JP (1) JP2021519283A (de)
KR (1) KR20210005031A (de)
CN (1) CN112236131A (de)
IL (1) IL277605A (de)
WO (1) WO2019186558A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11504390B2 (en) 2019-03-20 2022-11-22 Regeneron Pharmaceuticals, Inc. Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors
CN112972702A (zh) * 2019-12-17 2021-06-18 南京大学 用于治疗耐药菌感染的外泌体制剂
CN111467372B (zh) * 2020-03-03 2022-09-30 中山大学附属第一医院 间充质干细胞外泌体在制备延缓脊髓小脑性共济失调3型病程进展的药物中的应用
EP4132479A1 (de) 2020-04-07 2023-02-15 Ramot at Tel-Aviv University Ltd. Cannabidiolhaltige zusammensetzungen und verwendungen davon
CN111748520B (zh) * 2020-06-30 2021-02-19 四川大学 牙囊干细胞外泌体、制法及应用、其组合物及制法
WO2022215078A1 (en) * 2021-04-07 2022-10-13 Ramot At Tel-Aviv University Ltd. Modified cannabinoids and uses thereof
CN113303280B (zh) * 2021-05-26 2022-11-01 中国人民解放军陆军特色医学中心 建立小鼠腹透腹膜损伤模型的方法及BMSCs外泌体的应用
CN114410632A (zh) * 2022-01-28 2022-04-29 江苏大学 特异性抑制PTEN基因的shRNA及应用
WO2023178500A1 (en) * 2022-03-22 2023-09-28 Beijing Theraxyte Bioscience Co. Ltd. Therapeutic vesicles and methods of processing the same
WO2023223312A1 (en) 2022-05-15 2023-11-23 Nurexone Biologic Ltd. Anti-pten rna interference oligonucleotides and uses thereof
WO2024013734A1 (en) 2022-07-10 2024-01-18 Nurexone Biologic Ltd. Rna interference oligonucleotides for inhibiting perineuronal network formation

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154600B (nl) 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
NL154599B (nl) 1970-12-28 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking.
US3901654A (en) 1971-06-21 1975-08-26 Biological Developments Receptor assays of biologically active compounds employing biologically specific receptors
US3853987A (en) 1971-09-01 1974-12-10 W Dreyer Immunological reagent and radioimmuno assay
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
NL171930C (nl) 1972-05-11 1983-06-01 Akzo Nv Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen.
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4034074A (en) 1974-09-19 1977-07-05 The Board Of Trustees Of Leland Stanford Junior University Universal reagent 2-site immunoradiometric assay using labelled anti (IgG)
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4098876A (en) 1976-10-26 1978-07-04 Corning Glass Works Reverse sandwich immunoassay
US4879219A (en) 1980-09-19 1989-11-07 General Hospital Corporation Immunoassay utilizing monoclonal high affinity IgM antibodies
US5011771A (en) 1984-04-12 1991-04-30 The General Hospital Corporation Multiepitopic immunometric assay
US4666828A (en) 1984-08-15 1987-05-19 The General Hospital Corporation Test for Huntington's disease
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4801531A (en) 1985-04-17 1989-01-31 Biotechnology Research Partners, Ltd. Apo AI/CIII genomic polymorphisms predictive of atherosclerosis
US5272057A (en) 1988-10-14 1993-12-21 Georgetown University Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase
CA2006008C (en) 1988-12-20 2000-02-15 Donald J. Kessler Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5192659A (en) 1989-08-25 1993-03-09 Genetype Ag Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US6933286B2 (en) 1991-03-19 2005-08-23 R. Martin Emanuele Therapeutic delivery compositions and methods of use thereof
US20020123476A1 (en) 1991-03-19 2002-09-05 Emanuele R. Martin Therapeutic delivery compositions and methods of use thereof
US6235887B1 (en) 1991-11-26 2001-05-22 Isis Pharmaceuticals, Inc. Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
US5281521A (en) 1992-07-20 1994-01-25 The Trustees Of The University Of Pennsylvania Modified avidin-biotin technique
US5721138A (en) 1992-12-15 1998-02-24 Sandford University Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use
PT1527176E (pt) 2002-08-05 2007-04-30 Atugen Ag Novas formas de muléculas de arn de interferência
EP1560931B1 (de) * 2002-11-14 2011-07-27 Dharmacon, Inc. Funktionelle und hyperfunktionelle sirna
EP1638580A2 (de) 2003-06-27 2006-03-29 atugen AG Verwendung von doppelsträngiger ribonucleinsäure zur induktion von zelllyse
US20070297985A1 (en) 2006-04-11 2007-12-27 Williams Bart O Method and composition for enhancing bone formation
EP2129397B1 (de) 2007-03-02 2018-10-31 Amgen, Inc. Verfahren und zusammensetzungen zur behandlung von tumorerkrankungen
US20110003008A1 (en) 2008-02-22 2011-01-06 Agency For Science, Technology And Research (A*Star) Mesenchymal stem cell particles
US20110189308A1 (en) 2008-03-17 2011-08-04 Asa Abeliovich Methods to treat neurodegenerative conditions or diseases by targeting components of a pten signaling pathway
EP2323695B1 (de) 2008-08-19 2018-12-05 Nektar Therapeutics Komplexe von small-interfering nukleinsäuren
CA2746527A1 (en) 2008-09-22 2010-03-25 Rxi Pharmaceuticals Corporation Rna interference in skin indications
CA2745811C (en) 2008-12-04 2021-07-13 Joseph Collard Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
EP2400973B1 (de) 2009-02-17 2016-11-30 The Trustees of Columbia University in the City of New York Identifizierung einer extrazellularen pten-form zur behandlung von tumoren
US20130079382A1 (en) 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro
US9127079B2 (en) * 2009-10-16 2015-09-08 The University Of British Columbia Inhibitors of phosphatase and tensin homolog (PTEN) conjugates
WO2011088058A1 (en) * 2010-01-12 2011-07-21 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expressions of factor vii and pten genes
US9080171B2 (en) 2010-03-24 2015-07-14 RXi Parmaceuticals Corporation Reduced size self-delivering RNAi compounds
GB201011589D0 (en) 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US10227593B2 (en) 2011-12-13 2019-03-12 Henry Ford Health System Methods, systems, and compositions for cell-derived/vesicle-based microRNA delivery
ES2691296T3 (es) 2012-04-03 2018-11-26 Reneuron Limited Micropartículas de células madre
WO2013186735A2 (en) 2012-06-14 2013-12-19 Bar-Ilan Research And Development Company Ltd. Photothermal detection
MX2015013141A (es) * 2013-03-15 2016-06-21 Univ Texas Biogénesis de miarn en exosomas para diagnóstico y terapia.
SG11201603506PA (en) * 2013-11-04 2016-05-30 Tissuegene Inc Treatment of damaged nerve with pten inhibitor
WO2015105957A1 (en) 2014-01-08 2015-07-16 Shriners Hospitals For Children Pten antagonist peptides and methods of using the same
WO2015161184A1 (en) 2014-04-18 2015-10-22 University Of Massachusetts Exosomal loading using hydrophobically modified oligonucleotides
KR101834841B1 (ko) * 2015-06-01 2018-03-06 아주대학교 산학협력단 줄기세포의 고활성 유도 방법
JP2018520125A (ja) * 2015-06-10 2018-07-26 ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム 疾患の処置のためのエキソソームの使用
MX2018011202A (es) * 2016-03-15 2019-03-28 Codiak Biosciences Inc Vesiculas de membrana terapeuticas.
US11458097B2 (en) 2016-03-30 2022-10-04 The University Of North Carolina At Chapel Hill Biological agent-exosome compositions and uses thereof
CN108602849B (zh) * 2016-04-06 2022-10-21 俄亥俄州国家创新基金会 用于通过rna纳米技术将治疗剂特异性递送至细胞的rna配体展示外来体
SG11201810161RA (en) * 2016-05-16 2018-12-28 Exostem Biotec Ltd Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases
GB2552460A (en) 2016-07-11 2018-01-31 Evox Therapeutics Ltd CPP-Mediated EV Loading
WO2018022927A1 (en) * 2016-07-27 2018-02-01 BioAxone BioSciences, Inc. TREATMENT OF CNS INJURY WITH RNAi THERAPEUTICS
JP7014449B2 (ja) 2016-08-14 2022-02-01 ラモット アット テル アビブ ユニバーシティ, リミテッド 神経障害を処置するための間葉系細胞由来エキソソーム
CN110402146A (zh) 2016-11-03 2019-11-01 埃克森蒂姆生物技术公司 间充质干细胞群、其产物及其用途
JP2020527038A (ja) 2017-07-16 2020-09-03 ラモット アット テル アビブ ユニバーシティ, リミテッド ヒト口腔粘膜幹細胞セクレトーム

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EP3773506A4 (de) 2021-12-22
US20230330130A1 (en) 2023-10-19
WO2019186558A1 (en) 2019-10-03
EP3773506A1 (de) 2021-02-17
JP2021519283A (ja) 2021-08-10
RU2020132733A (ru) 2022-04-29
US20210077520A1 (en) 2021-03-18
CN112236131A (zh) 2021-01-15
US11648260B2 (en) 2023-05-16

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