KR20210005031A - Pten 억제제를 포함하는 소포 및 이의 용도 - Google Patents
Pten 억제제를 포함하는 소포 및 이의 용도 Download PDFInfo
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- KR20210005031A KR20210005031A KR1020207031043A KR20207031043A KR20210005031A KR 20210005031 A KR20210005031 A KR 20210005031A KR 1020207031043 A KR1020207031043 A KR 1020207031043A KR 20207031043 A KR20207031043 A KR 20207031043A KR 20210005031 A KR20210005031 A KR 20210005031A
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- sirna
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02004—Chondroitin ABC lyase (4.2.2.4), i.e. chondroitinase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03067—Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (3.1.3.67)
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- Bioinformatics & Cheminformatics (AREA)
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- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862649648P | 2018-03-29 | 2018-03-29 | |
US62/649,648 | 2018-03-29 | ||
PCT/IL2019/050355 WO2019186558A1 (en) | 2018-03-29 | 2019-03-27 | Vesicles comprising a pten inhibitor and uses of same |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20210005031A true KR20210005031A (ko) | 2021-01-13 |
Family
ID=68058075
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020207031043A KR20210005031A (ko) | 2018-03-29 | 2019-03-27 | Pten 억제제를 포함하는 소포 및 이의 용도 |
Country Status (7)
Country | Link |
---|---|
US (2) | US11648260B2 (de) |
EP (1) | EP3773506A4 (de) |
JP (1) | JP2021519283A (de) |
KR (1) | KR20210005031A (de) |
CN (1) | CN112236131A (de) |
IL (1) | IL277605A (de) |
WO (1) | WO2019186558A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11504390B2 (en) | 2019-03-20 | 2022-11-22 | Regeneron Pharmaceuticals, Inc. | Treatment of increased lipid levels with sterol regulatory element binding transcription factor 1 (SREBF1) inhibitors |
CN112972702A (zh) * | 2019-12-17 | 2021-06-18 | 南京大学 | 用于治疗耐药菌感染的外泌体制剂 |
CN111467372B (zh) * | 2020-03-03 | 2022-09-30 | 中山大学附属第一医院 | 间充质干细胞外泌体在制备延缓脊髓小脑性共济失调3型病程进展的药物中的应用 |
EP4132479A1 (de) | 2020-04-07 | 2023-02-15 | Ramot at Tel-Aviv University Ltd. | Cannabidiolhaltige zusammensetzungen und verwendungen davon |
CN111748520B (zh) * | 2020-06-30 | 2021-02-19 | 四川大学 | 牙囊干细胞外泌体、制法及应用、其组合物及制法 |
WO2022215078A1 (en) * | 2021-04-07 | 2022-10-13 | Ramot At Tel-Aviv University Ltd. | Modified cannabinoids and uses thereof |
CN113303280B (zh) * | 2021-05-26 | 2022-11-01 | 中国人民解放军陆军特色医学中心 | 建立小鼠腹透腹膜损伤模型的方法及BMSCs外泌体的应用 |
CN114410632A (zh) * | 2022-01-28 | 2022-04-29 | 江苏大学 | 特异性抑制PTEN基因的shRNA及应用 |
WO2023178500A1 (en) * | 2022-03-22 | 2023-09-28 | Beijing Theraxyte Bioscience Co. Ltd. | Therapeutic vesicles and methods of processing the same |
WO2023223312A1 (en) | 2022-05-15 | 2023-11-23 | Nurexone Biologic Ltd. | Anti-pten rna interference oligonucleotides and uses thereof |
WO2024013734A1 (en) | 2022-07-10 | 2024-01-18 | Nurexone Biologic Ltd. | Rna interference oligonucleotides for inhibiting perineuronal network formation |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
CA2006008C (en) | 1988-12-20 | 2000-02-15 | Donald J. Kessler | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
US20020123476A1 (en) | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
US5721138A (en) | 1992-12-15 | 1998-02-24 | Sandford University | Apolipoprotein(A) promoter and regulatory sequence constructs and methods of use |
PT1527176E (pt) | 2002-08-05 | 2007-04-30 | Atugen Ag | Novas formas de muléculas de arn de interferência |
EP1560931B1 (de) * | 2002-11-14 | 2011-07-27 | Dharmacon, Inc. | Funktionelle und hyperfunktionelle sirna |
EP1638580A2 (de) | 2003-06-27 | 2006-03-29 | atugen AG | Verwendung von doppelsträngiger ribonucleinsäure zur induktion von zelllyse |
US20070297985A1 (en) | 2006-04-11 | 2007-12-27 | Williams Bart O | Method and composition for enhancing bone formation |
EP2129397B1 (de) | 2007-03-02 | 2018-10-31 | Amgen, Inc. | Verfahren und zusammensetzungen zur behandlung von tumorerkrankungen |
US20110003008A1 (en) | 2008-02-22 | 2011-01-06 | Agency For Science, Technology And Research (A*Star) | Mesenchymal stem cell particles |
US20110189308A1 (en) | 2008-03-17 | 2011-08-04 | Asa Abeliovich | Methods to treat neurodegenerative conditions or diseases by targeting components of a pten signaling pathway |
EP2323695B1 (de) | 2008-08-19 | 2018-12-05 | Nektar Therapeutics | Komplexe von small-interfering nukleinsäuren |
CA2746527A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
CA2745811C (en) | 2008-12-04 | 2021-07-13 | Joseph Collard | Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene |
EP2400973B1 (de) | 2009-02-17 | 2016-11-30 | The Trustees of Columbia University in the City of New York | Identifizierung einer extrazellularen pten-form zur behandlung von tumoren |
US20130079382A1 (en) | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
US9127079B2 (en) * | 2009-10-16 | 2015-09-08 | The University Of British Columbia | Inhibitors of phosphatase and tensin homolog (PTEN) conjugates |
WO2011088058A1 (en) * | 2010-01-12 | 2011-07-21 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expressions of factor vii and pten genes |
US9080171B2 (en) | 2010-03-24 | 2015-07-14 | RXi Parmaceuticals Corporation | Reduced size self-delivering RNAi compounds |
GB201011589D0 (en) | 2010-07-09 | 2010-08-25 | Reneuron Ltd | Therapeutic cells |
US10227593B2 (en) | 2011-12-13 | 2019-03-12 | Henry Ford Health System | Methods, systems, and compositions for cell-derived/vesicle-based microRNA delivery |
ES2691296T3 (es) | 2012-04-03 | 2018-11-26 | Reneuron Limited | Micropartículas de células madre |
WO2013186735A2 (en) | 2012-06-14 | 2013-12-19 | Bar-Ilan Research And Development Company Ltd. | Photothermal detection |
MX2015013141A (es) * | 2013-03-15 | 2016-06-21 | Univ Texas | Biogénesis de miarn en exosomas para diagnóstico y terapia. |
SG11201603506PA (en) * | 2013-11-04 | 2016-05-30 | Tissuegene Inc | Treatment of damaged nerve with pten inhibitor |
WO2015105957A1 (en) | 2014-01-08 | 2015-07-16 | Shriners Hospitals For Children | Pten antagonist peptides and methods of using the same |
WO2015161184A1 (en) | 2014-04-18 | 2015-10-22 | University Of Massachusetts | Exosomal loading using hydrophobically modified oligonucleotides |
KR101834841B1 (ko) * | 2015-06-01 | 2018-03-06 | 아주대학교 산학협력단 | 줄기세포의 고활성 유도 방법 |
JP2018520125A (ja) * | 2015-06-10 | 2018-07-26 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患の処置のためのエキソソームの使用 |
MX2018011202A (es) * | 2016-03-15 | 2019-03-28 | Codiak Biosciences Inc | Vesiculas de membrana terapeuticas. |
US11458097B2 (en) | 2016-03-30 | 2022-10-04 | The University Of North Carolina At Chapel Hill | Biological agent-exosome compositions and uses thereof |
CN108602849B (zh) * | 2016-04-06 | 2022-10-21 | 俄亥俄州国家创新基金会 | 用于通过rna纳米技术将治疗剂特异性递送至细胞的rna配体展示外来体 |
SG11201810161RA (en) * | 2016-05-16 | 2018-12-28 | Exostem Biotec Ltd | Mesenchymal stem cell and use thereof for treatment of muscle injury and muscle-associated diseases |
GB2552460A (en) | 2016-07-11 | 2018-01-31 | Evox Therapeutics Ltd | CPP-Mediated EV Loading |
WO2018022927A1 (en) * | 2016-07-27 | 2018-02-01 | BioAxone BioSciences, Inc. | TREATMENT OF CNS INJURY WITH RNAi THERAPEUTICS |
JP7014449B2 (ja) | 2016-08-14 | 2022-02-01 | ラモット アット テル アビブ ユニバーシティ, リミテッド | 神経障害を処置するための間葉系細胞由来エキソソーム |
CN110402146A (zh) | 2016-11-03 | 2019-11-01 | 埃克森蒂姆生物技术公司 | 间充质干细胞群、其产物及其用途 |
JP2020527038A (ja) | 2017-07-16 | 2020-09-03 | ラモット アット テル アビブ ユニバーシティ, リミテッド | ヒト口腔粘膜幹細胞セクレトーム |
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2019
- 2019-03-27 EP EP19775863.4A patent/EP3773506A4/de active Pending
- 2019-03-27 CN CN201980035234.0A patent/CN112236131A/zh active Pending
- 2019-03-27 JP JP2020551470A patent/JP2021519283A/ja active Pending
- 2019-03-27 WO PCT/IL2019/050355 patent/WO2019186558A1/en active Application Filing
- 2019-03-27 US US17/042,441 patent/US11648260B2/en active Active
- 2019-03-27 KR KR1020207031043A patent/KR20210005031A/ko active Search and Examination
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2020
- 2020-09-24 IL IL277605A patent/IL277605A/en unknown
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IL277605A (en) | 2020-11-30 |
EP3773506A4 (de) | 2021-12-22 |
US20230330130A1 (en) | 2023-10-19 |
WO2019186558A1 (en) | 2019-10-03 |
EP3773506A1 (de) | 2021-02-17 |
JP2021519283A (ja) | 2021-08-10 |
RU2020132733A (ru) | 2022-04-29 |
US20210077520A1 (en) | 2021-03-18 |
CN112236131A (zh) | 2021-01-15 |
US11648260B2 (en) | 2023-05-16 |
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