KR20190104405A - Magl 억제제로서의 1,1,1-트리플루오로-3-히드록시프로판-2-일 카르바메이트 유도체 - Google Patents
Magl 억제제로서의 1,1,1-트리플루오로-3-히드록시프로판-2-일 카르바메이트 유도체 Download PDFInfo
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- KR20190104405A KR20190104405A KR1020197023870A KR20197023870A KR20190104405A KR 20190104405 A KR20190104405 A KR 20190104405A KR 1020197023870 A KR1020197023870 A KR 1020197023870A KR 20197023870 A KR20197023870 A KR 20197023870A KR 20190104405 A KR20190104405 A KR 20190104405A
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- 0 *OCC(C(F)(F)F)OC(N(CC1)CCC11CCCCCCC1)=O Chemical compound *OCC(C(F)(F)F)OC(N(CC1)CCC11CCCCCCC1)=O 0.000 description 11
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762448498P | 2017-01-20 | 2017-01-20 | |
| US62/448,498 | 2017-01-20 | ||
| PCT/IB2018/050103 WO2018134695A1 (en) | 2017-01-20 | 2018-01-08 | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
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| RU2720203C1 (ru) | 2017-01-20 | 2020-04-27 | Пфайзер Инк. | 1,1,1-трифтор-3-гидроксипропан-2-илкарбаматные производные как ингибиторы magl |
| US10662159B2 (en) * | 2017-11-22 | 2020-05-26 | Makscientific, Llc | ABHD6 and dual ABHD6/MGL inhibitors and their uses |
| BR112021014389A2 (pt) * | 2019-01-25 | 2021-09-28 | NodThera Limited | Derivados de carbamato e usos dos mesmos |
| CN115362153B (zh) * | 2020-03-26 | 2025-01-07 | 詹森药业有限公司 | 作为单酰基甘油脂肪酶调节剂的氮杂螺环 |
| MX2022015706A (es) * | 2020-06-09 | 2023-01-24 | Pfizer | Antagonistas del receptor de melanocortina 4 y usos de estos. |
| JP2023541601A (ja) | 2020-09-10 | 2023-10-03 | プレシリックス・ナームローゼ・ベンノートシヤープ | Fapに対する抗体フラグメント |
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| WO2022135462A1 (zh) * | 2020-12-22 | 2022-06-30 | 鲁南制药集团股份有限公司 | Magl抑制剂的医药用途 |
| CA3242372A1 (en) | 2021-12-29 | 2023-07-06 | Psy Therapeutics, Inc. | Inhibiting monoacylglycerol lipase (magl) |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
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| EP4665718A1 (en) | 2023-02-13 | 2025-12-24 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
| CN116621792B (zh) * | 2023-05-16 | 2025-02-25 | 常州大学 | 一种制备n-正丁基-1,2-苯并异噻唑啉-3-酮-1-氧化物的方法 |
| CN118191332B (zh) * | 2024-03-19 | 2024-10-29 | 暨南大学 | 一种用于诊断术后认知功能障碍的血浆生物标志物及其应用 |
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| EP3571191A1 (en) | 2019-11-27 |
| CA3050625C (en) | 2021-07-20 |
| WO2018134695A1 (en) | 2018-07-26 |
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| US10626125B2 (en) | 2020-04-21 |
| US20180208607A1 (en) | 2018-07-26 |
| JP2020506899A (ja) | 2020-03-05 |
| TW201838975A (zh) | 2018-11-01 |
| MX2019008626A (es) | 2019-09-19 |
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