KR20180077198A - 이오시메놀의 혁신적인 제조 및 결정화 - Google Patents

이오시메놀의 혁신적인 제조 및 결정화 Download PDF

Info

Publication number
KR20180077198A
KR20180077198A KR1020187014635A KR20187014635A KR20180077198A KR 20180077198 A KR20180077198 A KR 20180077198A KR 1020187014635 A KR1020187014635 A KR 1020187014635A KR 20187014635 A KR20187014635 A KR 20187014635A KR 20180077198 A KR20180077198 A KR 20180077198A
Authority
KR
South Korea
Prior art keywords
iosimenol
process according
crystals
crystallization
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020187014635A
Other languages
English (en)
Korean (ko)
Inventor
이리 말리나크
이반 흘라바체크
이리 프로코프
요시토 마스다
Original Assignee
오츠카 세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 오츠카 세이야쿠 가부시키가이샤 filed Critical 오츠카 세이야쿠 가부시키가이샤
Publication of KR20180077198A publication Critical patent/KR20180077198A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0081—Use of vibrations, e.g. ultrasound
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
    • B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D2009/0086—Processes or apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00049—Controlling or regulating processes
    • B01J2219/00051—Controlling the temperature
    • B01J2219/00139—Controlling the temperature using electromagnetic heating
    • B01J2219/00141—Microwaves
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
KR1020187014635A 2015-11-04 2016-11-02 이오시메놀의 혁신적인 제조 및 결정화 Withdrawn KR20180077198A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250720P 2015-11-04 2015-11-04
US62/250,720 2015-11-04
PCT/JP2016/004798 WO2017077710A1 (en) 2015-11-04 2016-11-02 Innovative preparation and crystallization of iosimenol

Publications (1)

Publication Number Publication Date
KR20180077198A true KR20180077198A (ko) 2018-07-06

Family

ID=57354423

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187014635A Withdrawn KR20180077198A (ko) 2015-11-04 2016-11-02 이오시메놀의 혁신적인 제조 및 결정화

Country Status (23)

Country Link
US (1) US10544089B2 (cg-RX-API-DMAC7.html)
EP (1) EP3371147B1 (cg-RX-API-DMAC7.html)
JP (1) JP6778746B2 (cg-RX-API-DMAC7.html)
KR (1) KR20180077198A (cg-RX-API-DMAC7.html)
CN (1) CN108368031B (cg-RX-API-DMAC7.html)
AU (2) AU2016350219B2 (cg-RX-API-DMAC7.html)
CA (1) CA3002502A1 (cg-RX-API-DMAC7.html)
CY (1) CY1124164T1 (cg-RX-API-DMAC7.html)
DK (1) DK3371147T3 (cg-RX-API-DMAC7.html)
ES (1) ES2873828T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20210820T1 (cg-RX-API-DMAC7.html)
HU (1) HUE054876T2 (cg-RX-API-DMAC7.html)
LT (1) LT3371147T (cg-RX-API-DMAC7.html)
MY (1) MY186399A (cg-RX-API-DMAC7.html)
NZ (1) NZ742104A (cg-RX-API-DMAC7.html)
PH (1) PH12018500872A1 (cg-RX-API-DMAC7.html)
PL (1) PL3371147T3 (cg-RX-API-DMAC7.html)
PT (1) PT3371147T (cg-RX-API-DMAC7.html)
SA (1) SA518391413B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201803241YA (cg-RX-API-DMAC7.html)
SI (1) SI3371147T1 (cg-RX-API-DMAC7.html)
TW (1) TWI724049B (cg-RX-API-DMAC7.html)
WO (1) WO2017077710A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200002720A (ko) * 2019-10-11 2020-01-08 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102128423B1 (ko) * 2018-09-17 2020-07-01 (주)유케이케미팜 조영제 이오메프롤의 제조방법
CN111777525B (zh) * 2019-04-04 2021-08-27 成都西岭源药业有限公司 一种碘克沙醇的精制方法
CN115931935A (zh) * 2022-12-28 2023-04-07 深圳晶泰科技有限公司 一种提高微晶电子衍射数据质量的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5698739A (en) 1989-07-05 1997-12-16 Schering Aktiengesellschaft Carboxamide non-ionic contrast media
US6072069A (en) * 1998-11-04 2000-06-06 Biophysica, Inc. Biodegradable nonionic contrast media
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
WO2009091758A1 (en) 2008-01-14 2009-07-23 Mallinckrodt Inc. Process for the preparation of iosimenol

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200002720A (ko) * 2019-10-11 2020-01-08 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법
WO2021071033A1 (ko) * 2019-10-11 2021-04-15 (주)에이에스텍 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법

Also Published As

Publication number Publication date
TW201722906A (zh) 2017-07-01
DK3371147T3 (da) 2021-05-25
HK1257821A1 (en) 2019-11-01
SA518391413B1 (ar) 2022-03-06
PT3371147T (pt) 2021-05-24
AU2016350219B2 (en) 2021-04-29
ES2873828T3 (es) 2021-11-04
LT3371147T (lt) 2021-08-10
HUE054876T2 (hu) 2021-10-28
NZ742104A (en) 2023-01-27
AU2021205101B2 (en) 2022-11-24
CN108368031A (zh) 2018-08-03
MY186399A (en) 2021-07-22
JP2018536654A (ja) 2018-12-13
EP3371147B1 (en) 2021-04-07
SI3371147T1 (sl) 2021-08-31
PL3371147T3 (pl) 2021-10-25
US20190177266A1 (en) 2019-06-13
TWI724049B (zh) 2021-04-11
AU2021205101A1 (en) 2021-08-19
PH12018500872A1 (en) 2018-11-05
CN108368031B (zh) 2022-05-03
AU2016350219A1 (en) 2018-05-17
US10544089B2 (en) 2020-01-28
HRP20210820T1 (hr) 2021-06-25
JP6778746B2 (ja) 2020-11-04
WO2017077710A1 (en) 2017-05-11
EP3371147A1 (en) 2018-09-12
CY1124164T1 (el) 2022-05-27
CA3002502A1 (en) 2017-05-11
SG11201803241YA (en) 2018-05-30

Similar Documents

Publication Publication Date Title
AU2021205101B2 (en) Innovative preparation and crystallization of iosimenol
US20180155300A1 (en) Solid state forms of trisodium valsartan: sacubitril
JP2011503185A (ja) ヘミフマル酸アリスキレンの多形形態及びその調製プロセス
CN114096519B (zh) 亚稳态晶变体及其制备方法(i)
KR20120032538A (ko) 핀골리모드 염의 제조 방법
RU2586117C2 (ru) Кристаллизация гидрохлорида эпирубицина
KR20160099655A (ko) 테노포비르의 고체 형태
HK1257821B (en) Innovative preparation and crystallization of iosimenol
KR20050033525A (ko) 가바펜틴의 새로운 무수 결정질 형태
KR102709537B1 (ko) 초순수 트레프로스티닐의 효율적인 결정화 방법 및 그로부터 제조된 결정
TW202409034A (zh) 度洛巴坦（Ｄｕｒｌｏｂａｃｔａｍ）結晶型
KR101287422B1 (ko) 글리세릴 포스포릴 콜린의 i형 결정
RU2849774C2 (ru) Метастабильная кристаллическая модификация и способ ее получения
EP3594210B1 (en) Lubiprostone crystals and methods for preparing the same
WO2018203525A1 (en) Process of preparing iosimenol
CA2989364C (en) Process for the preparation of enclomiphene citrate having needle shaped crystal habit.
KR20120104781A (ko) 글리세릴 포스포릴 콜린의 이형 결정 및 그 제조방법
EA044016B1 (ru) Твердые формы трет-бутил(s)-2-((2s,3r)-1-амино-3-гидрокси-1-оксобутан-2-ил)-1-оксо-2,5-диазаспиро[3.4]октан-5-карбоксилата и способы их получения

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PC1202 Submission of document of withdrawal before decision of registration

St.27 status event code: N-1-6-B10-B11-nap-PC1202