SA518391413B1 - عملية تحضير وتبلر لليوزيمينول - Google Patents
عملية تحضير وتبلر لليوزيمينولInfo
- Publication number
- SA518391413B1 SA518391413B1 SA518391413A SA518391413A SA518391413B1 SA 518391413 B1 SA518391413 B1 SA 518391413B1 SA 518391413 A SA518391413 A SA 518391413A SA 518391413 A SA518391413 A SA 518391413A SA 518391413 B1 SA518391413 B1 SA 518391413B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- iosimenol
- preparing
- crystallization
- formula
- cvi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/005—Selection of auxiliary, e.g. for control of crystallisation nuclei, of crystal growth, of adherence to walls; Arrangements for introduction thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/0081—Use of vibrations, e.g. ultrasound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/10—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing sonic or ultrasonic vibrations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/08—Preparation of carboxylic acid amides from amides by reaction at nitrogen atoms of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D2009/0086—Processes or apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00139—Controlling the temperature using electromagnetic heating
- B01J2219/00141—Microwaves
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Abstract
يتعلق الاختراع الحالي بصفة عامة بعملية لتحضير الأيزو إيمينول iosimenol من الصيغة: المحضرة بتفاعل 5،5'-[(1،3-داي أوكسو-1،3-بروبان داي يل) داي ايمينو]بيس[N-(2،3-داي هيدروكسي بروبيل)-2،4،6-تراي يودو-1،3-بنزين داي كربوكساميد] 5,5'-[(1,3-dioxo-1,3-propanediyl)diimino]bis[N-(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide] (يُشار إليه باسم "CVI") له الصيغة: مع عامل مؤلكل alkylating agent بإدخال مجموعة 2، 3- داي هيدروكسي بروبيل 2,3-dihydroxypropyl في وجود قاعدة غير عضوية inorganic base في مذيب solvent يحتوي على 2- ميثوكسي إيثانول 2-methoxyethanol.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562250720P | 2015-11-04 | 2015-11-04 | |
PCT/JP2016/004798 WO2017077710A1 (en) | 2015-11-04 | 2016-11-02 | Innovative preparation and crystallization of iosimenol |
Publications (1)
Publication Number | Publication Date |
---|---|
SA518391413B1 true SA518391413B1 (ar) | 2022-03-06 |
Family
ID=57354423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA518391413A SA518391413B1 (ar) | 2015-11-04 | 2018-04-22 | عملية تحضير وتبلر لليوزيمينول |
Country Status (24)
Country | Link |
---|---|
US (1) | US10544089B2 (ar) |
EP (1) | EP3371147B1 (ar) |
JP (1) | JP6778746B2 (ar) |
KR (1) | KR20180077198A (ar) |
CN (1) | CN108368031B (ar) |
AU (2) | AU2016350219B2 (ar) |
CA (1) | CA3002502A1 (ar) |
CY (1) | CY1124164T1 (ar) |
DK (1) | DK3371147T3 (ar) |
ES (1) | ES2873828T3 (ar) |
HK (1) | HK1257821A1 (ar) |
HR (1) | HRP20210820T1 (ar) |
HU (1) | HUE054876T2 (ar) |
LT (1) | LT3371147T (ar) |
MY (1) | MY186399A (ar) |
NZ (1) | NZ742104A (ar) |
PH (1) | PH12018500872A1 (ar) |
PL (1) | PL3371147T3 (ar) |
PT (1) | PT3371147T (ar) |
SA (1) | SA518391413B1 (ar) |
SG (1) | SG11201803241YA (ar) |
SI (1) | SI3371147T1 (ar) |
TW (1) | TWI724049B (ar) |
WO (1) | WO2017077710A1 (ar) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102128423B1 (ko) * | 2018-09-17 | 2020-07-01 | (주)유케이케미팜 | 조영제 이오메프롤의 제조방법 |
CN111777525B (zh) * | 2019-04-04 | 2021-08-27 | 成都西岭源药业有限公司 | 一种碘克沙醇的精制方法 |
KR102179649B1 (ko) * | 2019-10-11 | 2020-11-18 | (주)에이에스텍 | 디에틸아미노하이드록시벤조일헥실벤조에이트의 제조 방법 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5698739A (en) | 1989-07-05 | 1997-12-16 | Schering Aktiengesellschaft | Carboxamide non-ionic contrast media |
US6072069A (en) * | 1998-11-04 | 2000-06-06 | Biophysica, Inc. | Biodegradable nonionic contrast media |
NO20053687D0 (no) * | 2005-07-29 | 2005-07-29 | Amersham Health As | Crystallisation Process. |
EP2240432B1 (en) | 2008-01-14 | 2012-07-04 | Mallinckrodt LLC | Process for the preparation of iosimenol |
-
2016
- 2016-11-02 MY MYPI2018701574A patent/MY186399A/en unknown
- 2016-11-02 DK DK16798573.8T patent/DK3371147T3/da active
- 2016-11-02 US US15/772,710 patent/US10544089B2/en not_active Expired - Fee Related
- 2016-11-02 HU HUE16798573A patent/HUE054876T2/hu unknown
- 2016-11-02 EP EP16798573.8A patent/EP3371147B1/en active Active
- 2016-11-02 TW TW105135469A patent/TWI724049B/zh not_active IP Right Cessation
- 2016-11-02 JP JP2018522702A patent/JP6778746B2/ja active Active
- 2016-11-02 SG SG11201803241YA patent/SG11201803241YA/en unknown
- 2016-11-02 CN CN201680066838.8A patent/CN108368031B/zh active Active
- 2016-11-02 PL PL16798573T patent/PL3371147T3/pl unknown
- 2016-11-02 LT LTEP16798573.8T patent/LT3371147T/lt unknown
- 2016-11-02 CA CA3002502A patent/CA3002502A1/en not_active Abandoned
- 2016-11-02 NZ NZ742104A patent/NZ742104A/en unknown
- 2016-11-02 WO PCT/JP2016/004798 patent/WO2017077710A1/en active Application Filing
- 2016-11-02 AU AU2016350219A patent/AU2016350219B2/en not_active Ceased
- 2016-11-02 SI SI201631172T patent/SI3371147T1/sl unknown
- 2016-11-02 KR KR1020187014635A patent/KR20180077198A/ko unknown
- 2016-11-02 PT PT167985738T patent/PT3371147T/pt unknown
- 2016-11-02 ES ES16798573T patent/ES2873828T3/es active Active
-
2018
- 2018-04-22 SA SA518391413A patent/SA518391413B1/ar unknown
- 2018-04-23 PH PH12018500872A patent/PH12018500872A1/en unknown
-
2019
- 2019-01-04 HK HK19100172.9A patent/HK1257821A1/zh unknown
-
2021
- 2021-05-18 CY CY20211100428T patent/CY1124164T1/el unknown
- 2021-05-21 HR HRP20210820TT patent/HRP20210820T1/hr unknown
- 2021-07-16 AU AU2021205101A patent/AU2021205101B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2021205101B2 (en) | 2022-11-24 |
LT3371147T (lt) | 2021-08-10 |
PL3371147T3 (pl) | 2021-10-25 |
EP3371147A1 (en) | 2018-09-12 |
SI3371147T1 (sl) | 2021-08-31 |
HK1257821A1 (zh) | 2019-11-01 |
AU2016350219A1 (en) | 2018-05-17 |
HRP20210820T1 (hr) | 2021-06-25 |
PH12018500872A1 (en) | 2018-11-05 |
MY186399A (en) | 2021-07-22 |
KR20180077198A (ko) | 2018-07-06 |
US20190177266A1 (en) | 2019-06-13 |
CY1124164T1 (el) | 2022-05-27 |
WO2017077710A1 (en) | 2017-05-11 |
ES2873828T3 (es) | 2021-11-04 |
CA3002502A1 (en) | 2017-05-11 |
PT3371147T (pt) | 2021-05-24 |
CN108368031B (zh) | 2022-05-03 |
EP3371147B1 (en) | 2021-04-07 |
JP6778746B2 (ja) | 2020-11-04 |
AU2016350219B2 (en) | 2021-04-29 |
US10544089B2 (en) | 2020-01-28 |
HUE054876T2 (hu) | 2021-10-28 |
TW201722906A (zh) | 2017-07-01 |
SG11201803241YA (en) | 2018-05-30 |
NZ742104A (en) | 2023-01-27 |
DK3371147T3 (da) | 2021-05-25 |
CN108368031A (zh) | 2018-08-03 |
JP2018536654A (ja) | 2018-12-13 |
TWI724049B (zh) | 2021-04-11 |
AU2021205101A1 (en) | 2021-08-19 |
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