MX2016012056A - Procedimiento de compuesto antifungico. - Google Patents

Procedimiento de compuesto antifungico.

Info

Publication number
MX2016012056A
MX2016012056A MX2016012056A MX2016012056A MX2016012056A MX 2016012056 A MX2016012056 A MX 2016012056A MX 2016012056 A MX2016012056 A MX 2016012056A MX 2016012056 A MX2016012056 A MX 2016012056A MX 2016012056 A MX2016012056 A MX 2016012056A
Authority
MX
Mexico
Prior art keywords
antifungal compound
compound process
preparing compound
useful
antifungal
Prior art date
Application number
MX2016012056A
Other languages
English (en)
Other versions
MX365494B (es
Inventor
J Hoekstra William
m yates Christopher
Behnke Mark
Alimardanov Asaf
A David Scott
Franklin FRY Douglas
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of MX2016012056A publication Critical patent/MX2016012056A/es
Publication of MX365494B publication Critical patent/MX365494B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Artificial Filaments (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La presente invención proporciona un procedimiento para preparar un compuesto 1 que es útil como un agente antifúngico. En particular, la invención busca proporcionar una nueva metodología para preparar el compuesto 1 y derivados substituidos del mismo.
MX2016012056A 2014-03-19 2015-03-19 Procedimiento de compuesto antifungico. MX365494B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461955615P 2014-03-19 2014-03-19
PCT/US2015/021491 WO2015143172A1 (en) 2014-03-19 2015-03-19 Antifungal compound process

Publications (2)

Publication Number Publication Date
MX2016012056A true MX2016012056A (es) 2017-04-27
MX365494B MX365494B (es) 2019-06-05

Family

ID=54145323

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012056A MX365494B (es) 2014-03-19 2015-03-19 Procedimiento de compuesto antifungico.

Country Status (14)

Country Link
US (2) US10173998B2 (es)
EP (1) EP3119745B1 (es)
JP (1) JP6509897B2 (es)
KR (1) KR102151082B1 (es)
CN (2) CN106458900B (es)
AU (1) AU2015231226B2 (es)
BR (1) BR112016020937B1 (es)
CA (1) CA2942968C (es)
EA (1) EA037587B1 (es)
ES (1) ES2815373T3 (es)
HU (1) HUE052446T2 (es)
MX (1) MX365494B (es)
PL (1) PL3119745T3 (es)
WO (1) WO2015143172A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9988365B2 (en) 2014-03-19 2018-06-05 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
US10017494B2 (en) 2014-03-19 2018-07-10 Mycovia Pharmaceuticals, Inc. Antifungal compound process
AU2015231216B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119755B1 (en) 2014-03-19 2019-03-06 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
MX369357B (es) 2014-03-19 2019-11-06 Mycovia Pharmaceuticals Inc Procedimiento de compuesto antifungico.
EP3119754A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
KR102441242B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오로페닐)-1,1-디플루오로-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법
EP3271347B1 (en) * 2015-03-19 2022-06-22 Mycovia Pharmaceuticals, Inc. Antifungal compounds and processes for making
MX2018003357A (es) * 2015-09-18 2018-08-16 Mycovia Pharmaceuticals Inc Proceso de compuesto antifungico.
US11213031B2 (en) 2017-11-13 2022-01-04 Bayer Aktiengesellschaft Tetrazolylpropyl derivatives and their use as fungicides
CN114573557B (zh) * 2022-03-28 2024-03-08 浙江天宇药业股份有限公司 一种奥特康唑的制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854015B2 (de) 1978-12-14 1980-10-09 Dynamit Nobel Ag, 5210 Troisdorf Verfahren zur Herstellung von !H-TetrazoI-1-essigsauren und bestimmter Ester derselben
JP2000344744A (ja) 1999-06-04 2000-12-12 Ss Pharmaceut Co Ltd アセトフェノン誘導体およびその製法
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
KR100889937B1 (ko) 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
BRPI1010096A2 (pt) 2009-06-18 2016-03-15 Basf Se compostos de formulas i e ii, composição agrícola, uso de um composto, método de controle de fungos nocivos, semente, composição farmacêutica, uso de um composto e método de tratamento contra o câncer ou infecções por vírus ou para combater a fungos zoopatogênicos ou humanopatogênicos
CA2837400C (en) * 2010-04-24 2017-12-12 Viamet Pharmaceuticals, Inc. 5-(optionally substituted phenyl) pyridin-2-yl compounds as metalloenzyme inhibitors
BR102012015179B1 (pt) 2011-06-19 2021-09-14 Mycovia Pharmaceuticals, Inc Métodos para tratar ou prevenir uma doença ou desordem mediada por metaloenzima ou fúngica, tratar ou prevenir o crescimento fúngico ou inibir micro-organismos em ou sobre uma planta e composições que compreendem compostos inibidores de metaloenzima
CN103764646A (zh) * 2011-06-19 2014-04-30 威尔金制药有限公司 金属酶抑制剂化合物
EA025266B1 (ru) 2011-06-23 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
EA025437B1 (ru) 2011-12-11 2016-12-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
EA201491386A1 (ru) 2012-01-20 2014-11-28 Вайамет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
IN2014DN06792A (es) 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
EP2894981B1 (en) 2012-09-12 2019-12-04 Dow AgroSciences LLC Metalloenzyme inhibitor compounds
JP2016508487A (ja) 2013-01-28 2016-03-22 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害剤化合物
US9598340B2 (en) 2013-04-05 2017-03-21 The Regents Of The University Of California Metal-catalyzed coupling of aryl and vinyl halides with alpha, alpha-difluorocarbonyl compounds
US9447073B2 (en) 2013-05-28 2016-09-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
CA2915054A1 (en) 2013-06-12 2014-12-18 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US9988365B2 (en) 2014-03-19 2018-06-05 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
KR102441242B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오로페닐)-1,1-디플루오로-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법
EP3119749A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119755B1 (en) 2014-03-19 2019-03-06 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
US10017494B2 (en) 2014-03-19 2018-07-10 Mycovia Pharmaceuticals, Inc. Antifungal compound process
MX369357B (es) 2014-03-19 2019-11-06 Mycovia Pharmaceuticals Inc Procedimiento de compuesto antifungico.
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119754A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231216B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3271347B1 (en) 2015-03-19 2022-06-22 Mycovia Pharmaceuticals, Inc. Antifungal compounds and processes for making
US11051514B2 (en) 2015-05-18 2021-07-06 Mycovia Pharmaceuticals, Inc. Antifungal compounds
MX2018003357A (es) 2015-09-18 2018-08-16 Mycovia Pharmaceuticals Inc Proceso de compuesto antifungico.
BR112018009915A2 (pt) 2015-11-17 2018-11-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
CN108882709A (zh) 2015-11-17 2018-11-23 美国陶氏益农公司 4-((6-(2-(2,4-二氟苯基)-1,1-二氟-2-氧代乙基)吡啶-3-基)氧基)苄腈以及制备方法
EP3377475A4 (en) 2015-11-17 2019-04-10 Dow Agrosciences Llc 4 - ((6-2- (2,4-difluorophenyl) -1,1-DIFLUORO-2-HYDROXY-3- (1H-1,2,4-TRIAZOL-1-YL) PROPYL) PYRIDIN-3-YL ) OXY) BENZONITRILE AND METHODS OF PREPARATION
BR112018009920A2 (pt) 2015-11-17 2018-11-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
WO2017117393A1 (en) 2015-12-30 2017-07-06 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds

Also Published As

Publication number Publication date
JP6509897B2 (ja) 2019-05-08
US20190161469A1 (en) 2019-05-30
US10392365B2 (en) 2019-08-27
EA201691649A1 (ru) 2016-12-30
CA2942968A1 (en) 2015-09-24
EP3119745A4 (en) 2017-08-23
CN106458900B (zh) 2019-01-01
EA037587B1 (ru) 2021-04-19
HUE052446T2 (hu) 2021-04-28
US20170088539A1 (en) 2017-03-30
BR112016020937B1 (pt) 2022-09-20
BR112016020937A2 (es) 2017-08-15
AU2015231226B2 (en) 2019-04-04
KR102151082B1 (ko) 2020-09-03
CN109970629B (zh) 2023-04-11
CN109970629A (zh) 2019-07-05
KR20160138012A (ko) 2016-12-02
JP2017509644A (ja) 2017-04-06
ES2815373T3 (es) 2021-03-29
MX365494B (es) 2019-06-05
WO2015143172A1 (en) 2015-09-24
AU2015231226A1 (en) 2016-10-06
EP3119745B1 (en) 2020-08-05
PL3119745T3 (pl) 2021-01-25
CA2942968C (en) 2022-03-15
US10173998B2 (en) 2019-01-08
EP3119745A1 (en) 2017-01-25
CN106458900A (zh) 2017-02-22

Similar Documents

Publication Publication Date Title
MX365494B (es) Procedimiento de compuesto antifungico.
MX2016012053A (es) Procedimiento de compuesto antifungico.
MX2018003280A (es) Proceso de compuesto antifungico.
GB201512314D0 (en) Use of a composition containing 1,3-propanediol as an e-liquid
MX2016016143A (es) Compuestos de [1,2,4]triazol sustituido.
HRP20190107T1 (hr) Supstituirani 2,4 diamino-kinolin kao novi antikancerogeni agens
PH12017500833A1 (en) Synthesis of copanlisib and its dihydrochloride salt
MX2017008414A (es) Composiciones inhibidoras de nitrificacion y metodos para preparar las mismas.
JO3487B1 (ar) تخليق كوبانليسيب وملح الدايهيدروكلوريد الخاص به
MX360496B (es) Compuestos tetrahidropiridopirimidina novedoso o una sal del mismo.
PH12016501865A1 (en) Pyridine-2-amides useful as cb2 agonists
MX2018002416A (es) Derivados de 1,7-diaril-1,6-heptadien-3,5-diona, procedimiento para la preparación y uso de los mismos.
MX2016009117A (es) Pigmentos a base de compuestos de bismuto.
IN2014MU00455A (es)
MX2017003550A (es) Uso de cisteamina en tratamiento de infecciones causadas por levaduras/mohos.
MX2017011389A (es) Proceso para la preparacion de 3-cloro-2-vinilfenilsulfonatos.
MX2017002015A (es) Ligando del receptor 2 de canabinoide radiomarcado.
MX2016015624A (es) Proceso para la preparacion de derivados de tiazol.
MX2021000508A (es) Extracto de sabadilla seco y fluido.
EA201692246A1 (ru) Способ получения 2,6-диметилбензохинона
MX2016015623A (es) Proceso para la preparacion de derivados dihidroisoxazol.
MX2021000509A (es) Extracto concentrado de sabadilla.
MX2017011388A (es) Proceso para la preparacion de derivados de fenilisoxazolina sustituida.
GB201707234D0 (en) Composition & Process
UA97937U (uk) Матеріал для інтерференційних покриттів

Legal Events

Date Code Title Description
HC Change of company name or juridical status

Owner name: REMOTE MEDIA, LLC

FG Grant or registration