KR20180041269A - 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 - Google Patents
조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 Download PDFInfo
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| US6202208P | 2008-01-22 | 2008-01-22 | |
| US6201208P | 2008-01-22 | 2008-01-22 | |
| US6204508P | 2008-01-22 | 2008-01-22 | |
| US61/062,045 | 2008-01-22 | ||
| US61/062,022 | 2008-01-22 | ||
| US61/062,012 | 2008-01-22 | ||
| US13391208P | 2008-07-03 | 2008-07-03 | |
| US61/133,912 | 2008-07-03 | ||
| US20389008P | 2008-12-30 | 2008-12-30 | |
| US61/203,890 | 2008-12-30 | ||
| PCT/US2009/000424 WO2009094172A2 (en) | 2008-01-22 | 2009-01-22 | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
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| KR1020197020103A Division KR20190085187A (ko) | 2008-01-22 | 2009-01-22 | 조직 손상 관련 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
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Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9585932B2 (en) | 2005-04-29 | 2017-03-07 | Peter C. Dowling | Use of EPO-derived peptide fragments for the treatment of neurodegenerative disorders |
| US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
| WO2007052154A2 (en) | 2005-04-29 | 2007-05-10 | University Of Medicine And Dentistry Of New Jersey | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
| PT2371855E (pt) | 2005-08-05 | 2015-11-03 | Araim Pharmaceuticals Inc | Péptidos protetores de tecidos e suas utilizações |
| SG10201604530SA (en) | 2008-01-22 | 2016-07-28 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
| EP2555760B1 (en) | 2010-04-06 | 2019-10-16 | Synedgen, Inc. | Chitosan derivatives for the treatment of mucositis or ulceration |
| US9999702B2 (en) * | 2010-04-09 | 2018-06-19 | Kci Licensing Inc. | Apparatuses, methods, and compositions for the treatment and prophylaxis of chronic wounds |
| US9526648B2 (en) | 2010-06-13 | 2016-12-27 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US10010439B2 (en) | 2010-06-13 | 2018-07-03 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| US8628554B2 (en) | 2010-06-13 | 2014-01-14 | Virender K. Sharma | Intragastric device for treating obesity |
| US10420665B2 (en) | 2010-06-13 | 2019-09-24 | W. L. Gore & Associates, Inc. | Intragastric device for treating obesity |
| WO2012069474A2 (en) | 2010-11-24 | 2012-05-31 | H. Lundbeck A/S | A method for reducing potential virus burden in a sample by cyanate treatment |
| WO2012084895A2 (en) * | 2010-12-20 | 2012-06-28 | Universiteit Gent | Crystal structure of flt3 ligand-receptor complex |
| AU2012271781C1 (en) * | 2011-06-13 | 2017-09-21 | The Board Of Trustees Of The University Of Illinois | Peptide compositions and methods for treating lung injury, asthma, anaphylaxis, angioedema, systemic vascular permeability syndromes, and nasal congestion |
| FR2978964B1 (fr) * | 2011-08-09 | 2015-02-20 | Conservatoire Nat Arts | Composition vaccinale anti-il-6 |
| JP6426001B2 (ja) | 2011-11-17 | 2018-11-21 | グリア エスピー ゼット．オー．オー． | 神経膠腫を治療するための組成物および方法 |
| CA2883704C (en) * | 2012-09-20 | 2021-09-28 | Synedgen, Inc. | Methods for treatment or prevention of damage resulting from radiation, trauma or shock |
| WO2014121063A1 (en) * | 2013-01-31 | 2014-08-07 | The Trustees Of The University Of Pennsylvania | Repair of peripheral nerve injury |
| WO2014144095A2 (en) * | 2013-03-15 | 2014-09-18 | The Board Of Regents Of The University Of Oklahoma | Compositions comprising d-amino acid peptides and methods of production and use thereof for inhibiting autoantibodies |
| KR20160052537A (ko) * | 2013-07-17 | 2016-05-12 | 아라임 파마슈티칼즈, 인크. | 조직 손상과 연관된 질환 및 장애를 예방 및 치료하기 위한 조직 보호 펩티드 및 펩티드 유사체 |
| KR101510743B1 (ko) * | 2013-07-23 | 2015-04-10 | (주)케어젠 | 파골 세포 분화 억제용 펩타이드 및 이의 용도 |
| MX386702B (es) | 2014-02-10 | 2025-03-19 | Fred Hutchinson Cancer Center | Tratamiento con halogeno de ataque cardiaco y lesion isquemica. |
| CN108125965B (zh) * | 2014-04-25 | 2020-04-10 | 广州市赛普特医药科技股份有限公司 | 5α-雄甾-3β,5,6β-三醇及其类似物在高原病中的应用 |
| US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
| GB2539161A (en) * | 2014-11-26 | 2016-12-14 | Neuro-Bio Ltd | Neurodegenerative disorders |
| US20180292390A1 (en) * | 2015-04-23 | 2018-10-11 | Rowan University | Novel slice cultures and methods for diagnosing neuronal degeneration diseases |
| CN105233256A (zh) * | 2015-10-28 | 2016-01-13 | 中国人民解放军第三军医大学 | 促红细胞生成素及其衍生物在制备治疗疾病中促进凋亡细胞清除的药物中的应用 |
| RU2613308C1 (ru) * | 2015-11-23 | 2017-03-15 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ прогнозирования предрасположенности к послеоперационному кровотечению при раке головки поджелудочной железы |
| US20190126043A1 (en) | 2016-04-14 | 2019-05-02 | The Trustees Of The University Of Pennsylvania | Implantable living electrodes and methods for use thereof |
| US10779980B2 (en) | 2016-04-27 | 2020-09-22 | Synerz Medical, Inc. | Intragastric device for treating obesity |
| JP2019523633A (ja) * | 2016-04-29 | 2019-08-29 | アライム ファーマシューティカルズ，インコーポレーテッド | 組織の損傷に関連した疾患及び障害を予防及び治療する組織保護ペプチド |
| CN106075392B (zh) * | 2016-07-18 | 2020-07-07 | 滨州医学院 | 促红细胞生成素衍生物在听力保护上的应用 |
| IL247369B (en) * | 2016-08-18 | 2018-08-30 | B G Negev Tech And Applications Ltd | Polypeptides derived from CSF-m and their uses |
| EP4316595A3 (en) * | 2016-09-02 | 2024-04-17 | Christopher J. Soares | Use of cgrp receptor antagonists in treating glaucoma |
| US10456346B2 (en) | 2016-11-10 | 2019-10-29 | Asc Regenity Ltd. | Cosmetic formulations for topical applications containing erythropoietin-derived molecules |
| KR101965814B1 (ko) * | 2017-02-27 | 2019-08-13 | 재단법인 대구경북과학기술원 | 에리스로포이에틴 유래 펩티드의 세포손상방지에 효과를 통한 활용 |
| JP6450999B2 (ja) * | 2017-03-31 | 2019-01-16 | 国立大学法人群馬大学 | Ｂ型ボツリヌス毒素を用いたレイノー現象の治療 |
| EP4621067A3 (en) * | 2017-05-05 | 2025-11-19 | Trefoil Therapeutics, Inc. | Recombinant modified fibroblast growth factors and therapeutic uses thereof |
| CN110590919B (zh) * | 2017-05-24 | 2022-05-24 | 中国海洋大学 | 含鸟氨酸的短肽及其应用 |
| AU2018321825A1 (en) * | 2017-08-19 | 2020-03-05 | Ohio State Innovation Foundation | Novel peptide-based cancer imaging agents |
| WO2019058263A1 (en) * | 2017-09-19 | 2019-03-28 | Auckland Uniservices Limited | PEPTIDES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH DYSFUNCTION OF ADIPONECTIN |
| CN107880109B (zh) * | 2017-11-01 | 2019-08-30 | 复旦大学附属中山医院 | 一种促红细胞生成素来源肽及其制备方法和用途 |
| US10975124B2 (en) | 2018-02-23 | 2021-04-13 | The Board Of Regents Of The University Of Oklahoma | Methods and compositions for treating diseases and conditions associated with gonadotropin releasing hormone receptor |
| KR102167641B1 (ko) * | 2018-08-27 | 2020-10-19 | 주식회사 사이루스 | 에리스로포이에틴 유래 펩티드를 함유하는 세포증식 촉진용 조성물 |
| CN120267815A (zh) | 2018-09-10 | 2025-07-08 | 冷泉港实验室 | 用于治疗胰腺炎的方法 |
| KR20200080179A (ko) * | 2018-12-26 | 2020-07-06 | 아미코젠주식회사 | 아세틸콜린 수용체 저해 펩타이드 및 이의 용도 |
| CN113993523A (zh) * | 2019-04-17 | 2022-01-28 | 指南针探路者有限公司 | 用赛洛西宾治疗抑郁症和其他各种病症 |
| JP2023500702A (ja) * | 2019-11-04 | 2023-01-10 | ファラデイ ファーマシューティカルズ， インコーポレイテッド | 化学療法に関連した悪液質および心毒性の治療ならびに予防のためのヨウ化化合物の使用 |
| CA3170057A1 (en) | 2020-02-06 | 2021-09-10 | Austin Star Detonator Company | Integrated detonator sensors |
| KR102387136B1 (ko) * | 2020-04-06 | 2022-04-14 | 재단법인대구경북과학기술원 | 탈모의 예방 또는 치료용 펩티드 및 이의 이용 |
| WO2021245677A1 (en) * | 2020-06-05 | 2021-12-09 | Digestix Bioscience Inc. | Compositions and methods for treating dysplastic and early-stage neoplastic conditions |
| CN111863118B (zh) * | 2020-07-20 | 2023-09-05 | 湖南莱博赛医用机器人有限公司 | 基于tct制片进行tct和dna倍体分析的方法 |
| CN112557347B (zh) * | 2020-11-12 | 2023-10-24 | 渤海大学 | 一种黏液层中乳糜粒子迁移模型的制备及检测方法 |
| CA3226259A1 (en) * | 2021-07-23 | 2023-01-26 | Lateral IP Pty Ltd | Peptide compositions capable of binding lanthionine synthetase c-like protein (lancl) and uses thereof |
| US12492223B2 (en) | 2021-07-23 | 2025-12-09 | Lateral IP Pty Ltd | Peptide compositions capable of binding lanthionine synthetase C-like protein (LanCl) and uses thereof |
| CN114606317B (zh) * | 2022-03-22 | 2022-12-02 | 中山大学附属第一医院 | 一种预测胃癌淋巴结转移的菌群标志物及其应用 |
| CN117106057B (zh) * | 2022-08-19 | 2024-11-01 | 南京汉欣医药科技有限公司 | 一种高纯的人促肾上腺皮质激素或其类似物及其规模化制备方法 |
| GB202215797D0 (en) | 2022-10-25 | 2022-12-07 | Solasta Bio Ltd | Insect neuropeptide analogues |
| CN116983469B (zh) * | 2023-08-03 | 2025-11-21 | 东华大学 | 一种水凝胶支架及其制备方法和应用 |
| US12302908B2 (en) | 2023-10-23 | 2025-05-20 | Solasta Bio Limited | Insect neuropeptides 4 |
| US12245596B1 (en) * | 2023-10-23 | 2025-03-11 | Solasta Bio Limited | Insect neuropeptides 8 |
| US12279621B1 (en) | 2023-10-23 | 2025-04-22 | Solasta Bio Limited | Insect neuropeptides 3 |
| US12245588B1 (en) | 2023-10-23 | 2025-03-11 | Solasta Bio Limited | Insect neuropeptides 2 |
| US12356995B2 (en) | 2023-10-23 | 2025-07-15 | Solasta Bio Limited | Insect neuropeptides 9 |
| US12281143B1 (en) | 2023-10-23 | 2025-04-22 | Solasta Bio Limited | Insect neuropeptides 1 |
| CN118085024A (zh) * | 2024-02-29 | 2024-05-28 | 南通大学 | 一种牦牛脾脏小分子多肽及其制备方法和应用 |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1479268A (en) | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
| CH596313A5 (enExample) | 1975-05-30 | 1978-03-15 | Battelle Memorial Institute | |
| NO812612L (no) | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
| US4414147A (en) | 1981-04-17 | 1983-11-08 | Massachusetts Institute Of Technology | Methods of decreasing the hydrophobicity of fibroblast and other interferons |
| US4558006A (en) | 1983-02-04 | 1985-12-10 | Kirin-Amgen, Inc. | A.T.C.C. HB8209 and its monoclonal antibody to erythropoietin |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US5051448A (en) | 1984-07-24 | 1991-09-24 | The Mclean Hospital Corporation | GABA esters and GABA analog esters |
| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| DE3676670D1 (de) | 1985-06-26 | 1991-02-07 | Cetus Corp | Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung. |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US6932968B1 (en) | 1989-07-26 | 2005-08-23 | Dade Behring Marburg Gmbh | Erythropoietin (EPO) peptides and antibodies directed against these |
| DE3924746A1 (de) * | 1989-07-26 | 1991-01-31 | Behringwerke Ag | Erythropoietin (epo)-peptide und dagegen gerichtete antikoerper |
| WO1991004014A1 (en) | 1989-09-21 | 1991-04-04 | Synergen, Inc. | Method for transporting compositions across the blood brain barrier |
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| AU5098193A (en) | 1992-09-01 | 1994-03-29 | Berlex Laboratories, Inc. | Glycolation of glycosylated macromolecules |
| US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
| US5571787A (en) | 1993-07-30 | 1996-11-05 | Myelos Corporation | Prosaposin as a neurotrophic factor |
| US5700909A (en) | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| US5576423A (en) | 1994-12-02 | 1996-11-19 | Schering Corporation | Antibodies to the slam protein expressed on activated T cells |
| US6849602B1 (en) | 1996-03-05 | 2005-02-01 | The Regents Of The University Of California | Compositions for alleviating neuropathic pain with prosaposin receptor agonists |
| US6271196B1 (en) | 1996-03-05 | 2001-08-07 | Regents Of The University Of Ca | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
| US5952293A (en) | 1996-03-08 | 1999-09-14 | Receptron | Receptor derived peptides involved in inhibition of receptor internalization in response to ligand binding |
| US6346390B1 (en) | 1996-03-08 | 2002-02-12 | Receptron, Inc. | Receptor derived peptides involved in modulation of response to ligand binding |
| US5835382A (en) | 1996-04-26 | 1998-11-10 | The Scripps Research Institute | Small molecule mimetics of erythropoietin |
| US6437216B1 (en) | 1997-11-13 | 2002-08-20 | Interleukin Genetics Inc. | Transgenic models of inflammatory disease |
| IL124015A0 (en) | 1998-04-08 | 1999-01-26 | Yeda Res & Dev | Pharmaceutical compositions comprising a protein |
| US6307024B1 (en) * | 1999-03-09 | 2001-10-23 | Zymogenetics, Inc. | Cytokine zalpha11 Ligand |
| PL352223A1 (en) | 1999-04-13 | 2003-08-11 | Kenneth S Warren Inst | Modulation of excitable tissue function by peripherally administered erythropoietin |
| WO2001083548A1 (en) | 2000-04-28 | 2001-11-08 | Effector Cell Institute | Novel derivative of cell chemotactic factor |
| US7259146B2 (en) | 2000-05-26 | 2007-08-21 | Ortho-Mcneil Pharmaceutical, Inc. | Neuroprotective peptides |
| IL153079A0 (en) * | 2000-05-26 | 2003-06-24 | Ortho Mcneil Pharm Inc | Neuroprotective peptides |
| US7432051B2 (en) | 2000-11-30 | 2008-10-07 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Erythropoietin and erythropoietin receptor expression in human cancer |
| US20030072737A1 (en) | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| PA8536201A1 (es) | 2000-12-29 | 2002-08-29 | Kenneth S Warren Inst Inc | Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| EP1575499A2 (en) | 2002-06-28 | 2005-09-21 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
| CA2491567A1 (en) * | 2002-07-01 | 2004-01-08 | The Kenneth S. Warren Institute, Inc. | Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs |
| US7037902B2 (en) | 2002-07-03 | 2006-05-02 | Receptron, Inc. | Affinity small molecules for the EPO receptor |
| ZA200505423B (en) | 2002-09-09 | 2008-08-27 | Warren Pharmaceuticals Inc | Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin |
| JP2004305006A (ja) | 2003-04-01 | 2004-11-04 | Japan Science & Technology Agency | 人工調製肺サーファクタント |
| US7718363B2 (en) | 2003-04-25 | 2010-05-18 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokine receptor complex and assays for identifying tissue protective compounds |
| AU2004238870B8 (en) | 2003-05-12 | 2010-04-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| JP2007512001A (ja) | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Ｅｐｏミメティックペプチドおよび融合タンパク質 |
| CN1882355A (zh) | 2003-09-09 | 2006-12-20 | 沃伦药品公司 | 保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素 |
| KR20070008519A (ko) | 2003-09-29 | 2007-01-17 | 워렌 파마슈티칼즈 인코포레이티드 | 패혈증 및 유착 형성의 치료 및 예방용 조직 보호성사이토카인 |
| US20050090551A1 (en) | 2003-10-27 | 2005-04-28 | Board Of Trustees Of Southern Illinois University | Therapeutic use of methionine for the treatment or prevention of mucositis |
| US7842661B2 (en) * | 2003-11-24 | 2010-11-30 | Novo Nordisk A/S | Glycopegylated erythropoietin formulations |
| CA2788707C (en) * | 2004-02-02 | 2014-02-25 | Engeneic Molecular Delivery Pty Ltd. | Compositions and methods for targeted in vitro and in vivo drug delivery to mammalian cells via bacterially derived intact minicells |
| US20080227696A1 (en) * | 2005-02-22 | 2008-09-18 | Biosurface Engineering Technologies, Inc. | Single branch heparin-binding growth factor analogs |
| EP3138832A1 (en) | 2004-03-16 | 2017-03-08 | Temple University - Of The Commonwealth System of Higher Education | Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders |
| US20050267027A1 (en) | 2004-04-05 | 2005-12-01 | Lounsbury Karen M | Use of erythropoietin for treatment of cancer |
| WO2007010552A2 (en) * | 2005-03-17 | 2007-01-25 | Serum Institute Of India Limited | N- terminal peg conjugate of erythropoietin |
| WO2007052154A2 (en) | 2005-04-29 | 2007-05-10 | University Of Medicine And Dentistry Of New Jersey | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
| US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
| EP2377884A1 (en) | 2005-05-10 | 2011-10-19 | Neoloch Aps | Neuritogenic peptides |
| EP1736481A1 (en) | 2005-05-13 | 2006-12-27 | Charite Universitätsmedizin-Berlin | Erythropoietin variants |
| PT2371855E (pt) | 2005-08-05 | 2015-11-03 | Araim Pharmaceuticals Inc | Péptidos protetores de tecidos e suas utilizações |
| US20100040623A1 (en) | 2005-12-20 | 2010-02-18 | Elisabeth Bock | Neuritogenic and neuronal survival promoting peptides derived from the family of s-100 proteins |
| JP2010513309A (ja) | 2006-12-18 | 2010-04-30 | アルタス ファーマシューティカルズ インコーポレイテッド | ヒト成長ホルモン製剤 |
| SG10201604530SA (en) | 2008-01-22 | 2016-07-28 | Araim Pharmaceuticals Inc | Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage |
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