KR20170118166A - 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 - Google Patents

1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 Download PDF

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KR20170118166A
KR20170118166A KR1020177025946A KR20177025946A KR20170118166A KR 20170118166 A KR20170118166 A KR 20170118166A KR 1020177025946 A KR1020177025946 A KR 1020177025946A KR 20177025946 A KR20177025946 A KR 20177025946A KR 20170118166 A KR20170118166 A KR 20170118166A
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rti
alkyl
haloalkyl
cycloalkyl
membered
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앤쏘니 에스트라다
매튜 볼그라프
후이펜 천
알렉산드르 콜레스니코프
엘리시아 빌무어
비샬 베르마
란 왕
다니엘 쇼어
스티븐 두
포-와이 위엔
바이후아 후
궈셩 우
싱위 린
아이쥔 루
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에프. 호프만-라 로슈 아게
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65127—

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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177025946A 2015-02-15 2016-02-12 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도 Withdrawn KR20170118166A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/073102 2015-02-15
CN2015073102 2015-02-15
CNPCT/CN2015/076318 2015-04-10
CN2015076318 2015-04-10
CN2016071061 2016-01-15
CNPCT/CN2016/071061 2016-01-15
PCT/EP2016/052950 WO2016128529A1 (en) 2015-02-15 2016-02-12 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists

Publications (1)

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KR20170118166A true KR20170118166A (ko) 2017-10-24

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KR1020177025946A Withdrawn KR20170118166A (ko) 2015-02-15 2016-02-12 1-헤트(아릴)설폰일-(피롤리딘 또는 피페리딘)-2-카복스아마이드 유도체 및 trpa1 길항제로서의 이의 용도

Country Status (20)

Country Link
US (1) US10179782B2 (https=)
EP (1) EP3256463B1 (https=)
JP (1) JP6700291B2 (https=)
KR (1) KR20170118166A (https=)
CN (1) CN107922392B (https=)
AU (1) AU2016217851A1 (https=)
BR (1) BR112017017052A2 (https=)
CA (1) CA2975196A1 (https=)
CL (1) CL2017001987A1 (https=)
CO (1) CO2017007679A2 (https=)
CR (1) CR20170367A (https=)
EA (1) EA033497B1 (https=)
IL (1) IL253478A0 (https=)
MX (1) MX2017010300A (https=)
PE (1) PE20180177A1 (https=)
PH (1) PH12017501478A1 (https=)
PT (1) PT3256463T (https=)
SG (1) SG11201706451TA (https=)
TW (1) TW201639829A (https=)
WO (1) WO2016128529A1 (https=)

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