CN107922392B - 1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 - Google Patents

1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 Download PDF

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CN107922392B
CN107922392B CN201680009724.XA CN201680009724A CN107922392B CN 107922392 B CN107922392 B CN 107922392B CN 201680009724 A CN201680009724 A CN 201680009724A CN 107922392 B CN107922392 B CN 107922392B
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alkyl
haloalkyl
cycloalkyl
disorder
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CN107922392A (zh
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安东尼·埃斯特拉德
马修·沃尔格拉夫
陈慧芬
亚历山大·科列斯尼科夫
伊莱沙·维尔缪
维沙尔·维尔马
王兰
丹尼尔·肖尔
史蒂芬·多
袁步伟
胡百华
吴国胜
林星雨
陆爱军
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F Hoffmann La Roche AG
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
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  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201680009724.XA 2015-02-15 2016-02-12 1-(杂)芳基磺酰基-(吡咯烷或哌啶)-2-甲酰胺衍生物及其用途 Active CN107922392B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2015/073102 2015-02-15
CN2015073102 2015-02-15
CNPCT/CN2015/076318 2015-04-10
CN2015076318 2015-04-10
CN2016071061 2016-01-15
CNPCT/CN2016/071061 2016-01-15
PCT/EP2016/052950 WO2016128529A1 (en) 2015-02-15 2016-02-12 1-(het)arylsulfonyl-(pyrrolidine or piperidine)-2-carboxamide derivatives and their use as trpa1 antagonists

Publications (2)

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CN107922392A CN107922392A (zh) 2018-04-17
CN107922392B true CN107922392B (zh) 2020-07-21

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US (1) US10179782B2 (https=)
EP (1) EP3256463B1 (https=)
JP (1) JP6700291B2 (https=)
KR (1) KR20170118166A (https=)
CN (1) CN107922392B (https=)
AU (1) AU2016217851A1 (https=)
BR (1) BR112017017052A2 (https=)
CA (1) CA2975196A1 (https=)
CL (1) CL2017001987A1 (https=)
CO (1) CO2017007679A2 (https=)
CR (1) CR20170367A (https=)
EA (1) EA033497B1 (https=)
IL (1) IL253478A0 (https=)
MX (1) MX2017010300A (https=)
PE (1) PE20180177A1 (https=)
PH (1) PH12017501478A1 (https=)
PT (1) PT3256463T (https=)
SG (1) SG11201706451TA (https=)
TW (1) TW201639829A (https=)
WO (1) WO2016128529A1 (https=)

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