KR20170096112A - Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 - Google Patents

Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 Download PDF

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KR20170096112A
KR20170096112A KR1020177016253A KR20177016253A KR20170096112A KR 20170096112 A KR20170096112 A KR 20170096112A KR 1020177016253 A KR1020177016253 A KR 1020177016253A KR 20177016253 A KR20177016253 A KR 20177016253A KR 20170096112 A KR20170096112 A KR 20170096112A
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antibody
binding
cancer
agonist
binding antagonist
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진 청
마루크 후세니
정 킴
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제넨테크, 인크.
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    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61P37/00Drugs for immunological or allergic disorders
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/507Comprising a combination of two or more separate antibodies
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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KR1020177016253A 2014-11-17 2015-11-16 Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 Withdrawn KR20170096112A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462080991P 2014-11-17 2014-11-17
US62/080,991 2014-11-17
US201462093400P 2014-12-17 2014-12-17
US62/093,400 2014-12-17
PCT/US2015/060941 WO2016081384A1 (en) 2014-11-17 2015-11-16 Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists

Publications (1)

Publication Number Publication Date
KR20170096112A true KR20170096112A (ko) 2017-08-23

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KR1020177016253A Withdrawn KR20170096112A (ko) 2014-11-17 2015-11-16 Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법

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US (2) US20160166685A1 (OSRAM)
EP (1) EP3221360A1 (OSRAM)
JP (1) JP2017537090A (OSRAM)
KR (1) KR20170096112A (OSRAM)
CN (1) CN106999583A (OSRAM)
AU (1) AU2015350242A1 (OSRAM)
BR (1) BR112017010198A2 (OSRAM)
CA (1) CA2967368A1 (OSRAM)
IL (1) IL252251A0 (OSRAM)
MX (1) MX2017006320A (OSRAM)
RU (1) RU2017121096A (OSRAM)
SG (2) SG10201807625PA (OSRAM)
WO (1) WO2016081384A1 (OSRAM)

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