KR20160064230A - Trpa1 조절제로서 유용한 치환된 헤테로환형 설폰아마이드 화합물 - Google Patents

Trpa1 조절제로서 유용한 치환된 헤테로환형 설폰아마이드 화합물 Download PDF

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KR20160064230A
KR20160064230A KR1020167012211A KR20167012211A KR20160064230A KR 20160064230 A KR20160064230 A KR 20160064230A KR 1020167012211 A KR1020167012211 A KR 1020167012211A KR 20167012211 A KR20167012211 A KR 20167012211A KR 20160064230 A KR20160064230 A KR 20160064230A
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alkyl
haloalkyl
halogen
phenyl
cycloalkyl
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Korean (ko)
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후이펀 천
옌옌 추
스티븐 도
안쏘니 에스트라다
바이화 후
알렉산드르 콜레스니코프
싱유 린
조셉 피 라이씨카토스
다니엘 쇼어
비샬 버마
란 왕
구오셩 우
포-와이 위옌
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에프. 호프만-라 로슈 아게
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Publication of KR20160064230A publication Critical patent/KR20160064230A/ko
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
KR1020167012211A 2013-10-11 2014-10-09 Trpa1 조절제로서 유용한 치환된 헤테로환형 설폰아마이드 화합물 Withdrawn KR20160064230A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361890127P 2013-10-11 2013-10-11
US61/890,127 2013-10-11
CN2014086380 2014-09-12
CNPCT/CN2014/086380 2014-09-12
PCT/EP2014/071593 WO2015052264A1 (en) 2013-10-11 2014-10-09 Substituted heterocyclic sulfonamide compounds useful as trpa1 modulators

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KR20160064230A true KR20160064230A (ko) 2016-06-07

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KR1020167012211A Withdrawn KR20160064230A (ko) 2013-10-11 2014-10-09 Trpa1 조절제로서 유용한 치환된 헤테로환형 설폰아마이드 화합물

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US (4) US20160221945A1 (enExample)
EP (1) EP3055302B1 (enExample)
JP (2) JP2016532673A (enExample)
KR (1) KR20160064230A (enExample)
CN (1) CN105612153B (enExample)
BR (1) BR112016002012A2 (enExample)
CA (1) CA2917193A1 (enExample)
DK (1) DK3055302T3 (enExample)
ES (1) ES2713323T3 (enExample)
HR (1) HRP20190329T1 (enExample)
HU (1) HUE041652T2 (enExample)
LT (1) LT3055302T (enExample)
MX (1) MX363457B (enExample)
PL (1) PL3055302T3 (enExample)
PT (1) PT3055302T (enExample)
RS (1) RS58376B1 (enExample)
RU (1) RU2675792C2 (enExample)
SG (1) SG11201609411SA (enExample)
SI (1) SI3055302T1 (enExample)
TR (1) TR201902249T4 (enExample)
TW (1) TWI657076B (enExample)
WO (1) WO2015052264A1 (enExample)

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KR102006158B1 (ko) 2018-03-27 2019-08-01 (주)에스더블유엠 차량 주행유도 장치 및 방법
KR102006157B1 (ko) 2018-03-22 2019-08-01 (주)에스더블유엠 자율주행 차량의 주행 유도선 제공 방법 및 장치
KR20190114496A (ko) 2018-03-30 2019-10-10 주식회사 에스더블유엠 차량 시뮬레이션 방법 및 장치

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JP6906449B2 (ja) * 2016-02-05 2021-07-21 Ｅａファーマ株式会社 複素環スルホンアミド誘導体及びそれを含有する医薬
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EP3487853B1 (en) * 2016-07-20 2022-06-08 F. Hoffmann-La Roche AG Bicyclic proline compounds
JP6975515B2 (ja) * 2016-07-20 2021-12-01 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Ｔｒｐａ１モデュレーターとしてのスルホニルシクロアルキルカルボキサミド化合物
JP7071959B2 (ja) 2016-08-12 2022-05-19 エフ．ホフマン－ラ ロシュ アーゲー スルホニルピリジルｔｒｐ阻害剤
AU2018275552B2 (en) 2017-06-01 2022-01-20 Bristol-Myers Squibb Company Substituted nitrogen containing compounds
JP2019019124A (ja) * 2017-07-19 2019-02-07 日本化薬株式会社 ピラジン化合物
US11465985B2 (en) * 2017-12-08 2022-10-11 Vertex Pharmaceuticals Incorporated Processes for making modulators of cystic fibrosis transmembrane conductance regulator
WO2019164778A1 (en) * 2018-02-20 2019-08-29 Genentech, Inc. Process for preparing 1-arylsulfonyl-pyrrolidine-2-carboxamide transient receptor potential channel antagonist compounds and crystalline forms thereof
JP7367001B2 (ja) 2019-03-28 2023-10-23 住友建機株式会社 ショベル及び施工システム
CN111116456B (zh) * 2019-12-26 2022-01-28 南通华祥医药科技有限公司 一种4,4-二氟哌啶盐酸盐的制备方法
FR3114235A1 (fr) 2020-09-18 2022-03-25 Université Grenoble Alpes Inhibition du canal trpa1 astrocytaire comme nouvelle cible therapeutique neuroprotectrice dans les phases prodromales de la maladie d’alzheimer
CN112624966B (zh) * 2020-12-25 2022-12-23 杭州澳赛诺生物科技有限公司 一种2-氨甲基-4-甲基-5-吡啶羧酸的合成方法
IT202100015098A1 (it) 2021-06-09 2022-12-09 Flonext S R L Composto antagonista del canale trpa1 per uso in patologie degenerative della retina
CN116478076A (zh) * 2023-04-26 2023-07-25 南京优氟医药科技有限公司 一种(2s,4s)-1-叔丁氧羰基-2-(二氟甲基)-4-羟基吡咯烷的制备方法
WO2025132542A1 (en) 2023-12-19 2025-06-26 Idorsia Pharmaceuticals Ltd Macrocyclic orexin agonists
CN119019440A (zh) * 2024-10-24 2024-11-26 浙江雅辰药物科技股份有限公司 一种6-环丙基吡啶-3-硼酸频那醇酯的制备方法

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KR102006157B1 (ko) 2018-03-22 2019-08-01 (주)에스더블유엠 자율주행 차량의 주행 유도선 제공 방법 및 장치
KR102006158B1 (ko) 2018-03-27 2019-08-01 (주)에스더블유엠 차량 주행유도 장치 및 방법
KR20190114496A (ko) 2018-03-30 2019-10-10 주식회사 에스더블유엠 차량 시뮬레이션 방법 및 장치

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