KR20150127199A - 항-b7-h4 항체 및 면역접합체 - Google Patents

항-b7-h4 항체 및 면역접합체 Download PDF

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KR20150127199A
KR20150127199A KR1020157028126A KR20157028126A KR20150127199A KR 20150127199 A KR20150127199 A KR 20150127199A KR 1020157028126 A KR1020157028126 A KR 1020157028126A KR 20157028126 A KR20157028126 A KR 20157028126A KR 20150127199 A KR20150127199 A KR 20150127199A
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South Korea
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seq
amino acid
acid sequence
hvr
sequence
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Korean (ko)
Inventor
스티븐 알. 렁
앤드류 폴슨
폴 폴라키스
얀 우
웨이-칭 리앙
론 파이어스타인
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제넨테크, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
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  • Physics & Mathematics (AREA)
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  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
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  • General Physics & Mathematics (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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KR1020157028126A 2013-03-14 2014-03-13 항-b7-h4 항체 및 면역접합체 Withdrawn KR20150127199A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201361785811P 2013-03-14 2013-03-14
US201361784877P 2013-03-14 2013-03-14
US61/784,877 2013-03-14
US61/785,811 2013-03-14
US201361874175P 2013-09-05 2013-09-05
US61/874,175 2013-09-05
PCT/US2014/025285 WO2014159835A1 (en) 2013-03-14 2014-03-13 Anti-b7-h4 antibodies and immunoconjugates

Publications (1)

Publication Number Publication Date
KR20150127199A true KR20150127199A (ko) 2015-11-16

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KR1020157028126A Withdrawn KR20150127199A (ko) 2013-03-14 2014-03-13 항-b7-h4 항체 및 면역접합체

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US (3) US10150813B2 (enExample)
EP (2) EP3299391B1 (enExample)
JP (2) JP6436965B2 (enExample)
KR (1) KR20150127199A (enExample)
CN (1) CN105189552B (enExample)
AU (1) AU2014244424A1 (enExample)
BR (1) BR112015022019A2 (enExample)
CA (1) CA2902865A1 (enExample)
CL (1) CL2015002562A1 (enExample)
CR (1) CR20150482A (enExample)
EA (1) EA201591750A1 (enExample)
IL (1) IL240517A0 (enExample)
MX (1) MX2015010777A (enExample)
PE (1) PE20151672A1 (enExample)
PH (1) PH12015501954A1 (enExample)
SG (1) SG11201507037XA (enExample)
WO (1) WO2014159835A1 (enExample)

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WO2014159835A1 (en) 2013-03-14 2014-10-02 Genentech, Inc. Anti-b7-h4 antibodies and immunoconjugates
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
CA2954508A1 (en) 2014-07-15 2016-01-21 Genentech, Inc. Compositions for treating cancer using pd-1 axis binding antagonists and mek inhibitors
WO2016040724A1 (en) 2014-09-12 2016-03-17 Genentech, Inc. Anti-b7-h4 antibodies and immunoconjugates
EP3223865A4 (en) 2014-10-31 2018-10-03 Jounce Therapeutics, Inc. Methods of treating conditions with antibodies that bind b7-h4
US20180118831A1 (en) * 2015-03-27 2018-05-03 University Of Southern California Car t-cells for the treatment of b7-h4 expressing solid tumors
MY198562A (en) 2015-11-03 2023-09-05 Janssen Biotech Inc Antibodies specifically binding pd-1 and their uses
SG11201808994YA (en) 2016-04-15 2018-11-29 Bioatla Llc Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof
ES2930255T3 (es) 2016-05-13 2022-12-09 Bioatla Inc Anticuerpos anti-Ror2, fragmentos de anticuerpos, sus inmunoconjugados y usos de los mismos
KR102346988B1 (ko) * 2016-07-26 2022-01-03 시즈오카켄 항 b7-h4 항체
BR112019011186A2 (pt) 2016-12-01 2019-10-08 Regeneron Pharmaceuticals, Inc. conjugado de anticorpo radiomarcado, composto, e, métodos de imageamento e para tratamento de um tumor.
CN110650974B (zh) 2017-02-10 2024-04-19 瑞泽恩制药公司 用于免疫-pet成像的放射性标记的抗-lag3抗体
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