KR20150090038A - 충전재를 함유한 생분해성 미세캡슐 - Google Patents

충전재를 함유한 생분해성 미세캡슐 Download PDF

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Publication number
KR20150090038A
KR20150090038A KR1020157010168A KR20157010168A KR20150090038A KR 20150090038 A KR20150090038 A KR 20150090038A KR 1020157010168 A KR1020157010168 A KR 1020157010168A KR 20157010168 A KR20157010168 A KR 20157010168A KR 20150090038 A KR20150090038 A KR 20150090038A
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KR
South Korea
Prior art keywords
composition
shell
microcapsules
therapeutic agent
filler
Prior art date
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Ceased
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KR1020157010168A
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English (en)
Korean (ko)
Inventor
기남 박
크리스토퍼 에이. 로데스
Original Assignee
아키나, 인크.
오에이치알 파마, 엘엘씨.
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Application filed by 아키나, 인크., 오에이치알 파마, 엘엘씨. filed Critical 아키나, 인크.
Publication of KR20150090038A publication Critical patent/KR20150090038A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Dermatology (AREA)
KR1020157010168A 2012-09-20 2013-09-20 충전재를 함유한 생분해성 미세캡슐 Ceased KR20150090038A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261703723P 2012-09-20 2012-09-20
US61/703,723 2012-09-20
PCT/US2013/060922 WO2014047439A1 (en) 2012-09-20 2013-09-20 Biodegradable microcapsules containing filling material

Publications (1)

Publication Number Publication Date
KR20150090038A true KR20150090038A (ko) 2015-08-05

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157010168A Ceased KR20150090038A (ko) 2012-09-20 2013-09-20 충전재를 함유한 생분해성 미세캡슐

Country Status (9)

Country Link
US (3) US20150265541A1 (https=)
EP (1) EP2897593A4 (https=)
JP (2) JP2015532928A (https=)
KR (1) KR20150090038A (https=)
AU (3) AU2013317899A1 (https=)
BR (1) BR112015006087A2 (https=)
HK (1) HK1214127A1 (https=)
MX (2) MX2015003665A (https=)
WO (1) WO2014047439A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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KR20200089819A (ko) * 2019-01-18 2020-07-28 주식회사 대하맨텍 인체에 자극이 없어 안전하고 생분해가 가능한 캡슐 및 그의 제조방법
WO2020149684A3 (ko) * 2019-01-18 2020-10-22 주식회사 대하맨텍 인체에 자극이 없어 안전하고 생분해가 가능한 캡슐 및 그의 제조방법

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WO2012109363A2 (en) 2011-02-08 2012-08-16 The Johns Hopkins University Mucus penetrating gene carriers
CA2863632C (en) 2012-01-19 2017-07-11 The Johns Hopkins University Nanoparticle formulations with enhanced mucosal penetration
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
JP6138904B2 (ja) 2012-03-16 2017-05-31 ザ・ジョンズ・ホプキンス・ユニバーシティー 活性剤の送達のための非線状マルチブロックコポリマー薬物コンジュゲート
KR102310775B1 (ko) 2012-05-03 2021-10-07 칼라 파마슈티컬스, 인크. 개선된 점막 수송을 나타내는 제약 나노입자
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
AU2013256064B2 (en) 2012-05-03 2018-01-04 Alcon Inc. Pharmaceutical nanoparticles showing improved mucosal transport
AU2013256008B2 (en) 2012-05-04 2016-02-25 The Johns Hopkins University Lipid-based drug carriers for rapid penetration through mucus linings
WO2014124006A1 (en) 2013-02-05 2014-08-14 The Johns Hopkins University Nanoparticles for magnetic resonance imaging tracking and methods of making and using thereof
WO2015127368A1 (en) 2014-02-23 2015-08-27 The Johns Hopkins University Hypotonic microbicidal formulations and methods of use
CN107635545A (zh) 2015-01-27 2018-01-26 约翰霍普金斯大学 用于增强粘膜表面处活性剂的输送的低渗水凝胶制剂
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
US20170273911A1 (en) * 2016-03-23 2017-09-28 Boston Scientific Scimed Inc. Injectable microspheres
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP4491236A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
RU2018145364A (ru) 2016-06-27 2020-07-28 Ачиллион Фармасьютикалс, Инк. Хиназолиновые и индольные соединения для лечения медицинских нарушений
EP3858835A1 (en) 2016-07-01 2021-08-04 G1 Therapeutics, Inc. Pyrimidine-based antiproliferative agents
CN109862945B (zh) * 2016-10-28 2022-03-08 联合利华知识产权控股有限公司 包含颗粒的个人护理组合物
BR112019008463B1 (pt) 2016-10-28 2022-06-07 Unilever Ip Holdings B.V. Composição para a higiene pessoal
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
JP2021519337A (ja) 2018-03-26 2021-08-10 シー４ セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓの分解のためのセレブロン結合剤
WO2020041301A1 (en) 2018-08-20 2020-02-27 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
WO2020051532A2 (en) 2018-09-06 2020-03-12 Achillion Pharmaceuticals, Inc. Macrocyclic compounds for the treatment of medical disorders
EP3866773B1 (en) 2018-10-16 2024-08-28 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
FR3091878B1 (fr) 2019-01-22 2023-06-16 Calyxia Compositions de produits d’entretien avec des propriétés olfactives améliorées
FR3091877B1 (fr) 2019-01-22 2023-06-16 Calyxia Compositions de detergence avec des propriétés olfactives améliorées
US12496279B2 (en) 2019-04-11 2025-12-16 The Johns Hopkins University Nanoparticles for drug delivery to brain
CN120172958A (zh) 2019-04-12 2025-06-20 C4医药公司 Ikaros和aiolos的三环降解物
WO2021168320A1 (en) 2020-02-20 2021-08-26 Achillion Pharmaceuticals, Inc. Heteroaryl compounds for treatment of complement factor d mediated disorders
AU2021231898A1 (en) 2020-03-05 2022-10-27 C4 Therapeutics, Inc. Compounds for targeted degradation of BRD9
ES3048084T3 (en) 2020-05-19 2025-12-09 Pharmacosmos Holding As Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
WO2022066774A1 (en) 2020-09-23 2022-03-31 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement mediated disorders
WO2024184188A1 (en) * 2023-03-03 2024-09-12 Danmarks Tekniske Universitet A method for preparing microparticles for drug delivery

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Publication number Priority date Publication date Assignee Title
KR20200089819A (ko) * 2019-01-18 2020-07-28 주식회사 대하맨텍 인체에 자극이 없어 안전하고 생분해가 가능한 캡슐 및 그의 제조방법
WO2020149684A3 (ko) * 2019-01-18 2020-10-22 주식회사 대하맨텍 인체에 자극이 없어 안전하고 생분해가 가능한 캡슐 및 그의 제조방법
EP3888624A4 (en) * 2019-01-18 2023-02-22 Daeha Mantech Co., Ltd. BIODEGRADABLE CAPSULES WITH SAFETY DUE TO NON-IRRITATION TO THE HUMAN BODY AND MANUFACTURING PROCESSES FOR THEM
US12122886B2 (en) 2019-01-18 2024-10-22 Daeha Mantech Co., Ltd. Biodegradable capsule with safety due to no irritation to human body and manufacturing method therefor

Also Published As

Publication number Publication date
MX2019002575A (es) 2019-10-30
US20200390715A1 (en) 2020-12-17
AU2013317899A1 (en) 2015-05-07
JP2015532928A (ja) 2015-11-16
MX2015003665A (es) 2016-03-08
HK1214127A1 (zh) 2016-10-07
AU2020202735A1 (en) 2020-05-14
WO2014047439A1 (en) 2014-03-27
EP2897593A1 (en) 2015-07-29
BR112015006087A2 (pt) 2017-07-04
US20150265541A1 (en) 2015-09-24
AU2018204552A1 (en) 2018-07-12
EP2897593A4 (en) 2016-04-06
JP2019014729A (ja) 2019-01-31
US20180185296A1 (en) 2018-07-05
AU2013317899A8 (en) 2015-05-28

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