KR20140097529A - 항암 융합 단백질 - Google Patents
항암 융합 단백질 Download PDFInfo
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- KR20140097529A KR20140097529A KR1020147018001A KR20147018001A KR20140097529A KR 20140097529 A KR20140097529 A KR 20140097529A KR 1020147018001 A KR1020147018001 A KR 1020147018001A KR 20147018001 A KR20147018001 A KR 20147018001A KR 20140097529 A KR20140097529 A KR 20140097529A
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20170010896A (ko) * | 2014-06-11 | 2017-02-01 | 몰레큘러 템플레이츠, 인코퍼레이션. | 프로테아제-절단 저항성의 시가 독소 a 서브유닛 작동체 폴리펩티드 및 이를 포함하는 세포-표적화 분자 |
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| US10450354B2 (en) | 2013-03-12 | 2019-10-22 | Molecular Templates, Inc. | CD20-binding immunotoxins for inducing cellular internalization and methods using same |
| WO2014141094A1 (en) | 2013-03-14 | 2014-09-18 | Adamed Sp. Z O.O. | Anticancer conjugate |
| KR102692200B1 (ko) | 2014-01-27 | 2024-08-06 | 몰레큘러 템플레이츠, 인코퍼레이션. | 포유류에 적용하기 위한 탈면역된 시가 독소 a 서브유닛 작동체 폴리펩티드 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| CA2940252C (en) * | 2014-03-11 | 2022-10-18 | Molecular Templates, Inc. | Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs |
| US10392425B2 (en) | 2015-02-05 | 2019-08-27 | Molecular Templates, Inc. | Multivalent CD20-binding molecules comprising Shiga toxin A subunit effector regions and enriched compositions thereof |
| US10428132B2 (en) | 2015-02-11 | 2019-10-01 | West China Hospital, Sichuan University | Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof |
| RS60441B1 (sr) * | 2015-05-30 | 2020-07-31 | Molecular Templates Inc | De-imunizovane, strukture shiga toksin a podjedinice i ciljani ćelijski molekuli koji sadrže isti |
| CN112574316A (zh) | 2015-07-02 | 2021-03-30 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
| KR101732126B1 (ko) | 2015-11-05 | 2017-05-02 | 한국생명공학연구원 | 췌장암 치료용 융합 단백질 및 이의 용도 |
| PL233352B1 (pl) * | 2016-09-15 | 2019-10-31 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe białko fuzyjne |
| CN114773439A (zh) | 2016-12-07 | 2022-07-22 | 分子模板公司 | 用于位点特异性缀合的志贺毒素a亚基效应子多肽、志贺毒素效应子支架和细胞靶向分子 |
| CN106632680A (zh) * | 2016-12-27 | 2017-05-10 | 上海交通大学 | 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建 |
| AU2018213194B2 (en) | 2017-01-25 | 2023-01-12 | Molecular Templates, Inc. | Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes |
| WO2019173478A2 (en) * | 2018-03-06 | 2019-09-12 | The Johns Hopkins University | Methods of treating or preventing cancer with an agent that depletes tregs and a checkpoint inhibitor |
| WO2019204272A1 (en) | 2018-04-17 | 2019-10-24 | Molecular Templates, Inc. | Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds |
| US20220211872A1 (en) * | 2019-05-15 | 2022-07-07 | Universidad De Granada | Gene therapy with the genes hokd and ldrb for cancer treatments |
| CN113354738B (zh) * | 2020-03-05 | 2022-09-09 | 绍兴德方华生物技术有限公司 | 融合毒素VEGF165b/mGEL及其编码基因与应用 |
| JP2023538563A (ja) * | 2020-08-17 | 2023-09-08 | エーティービー セラピューティクス | リボトキシンまたはＲＮＡｓｅを含む組換え免疫毒素 |
| CN114681599B (zh) * | 2020-12-31 | 2024-07-02 | 中国科学院上海药物研究所 | 一种阳离子脂质体疫苗及其制备方法和用途 |
| CN117795079A (zh) * | 2021-08-06 | 2024-03-29 | 花王株式会社 | 利用snare的核酸构建体 |
| CN117384859B (zh) * | 2023-12-13 | 2024-03-22 | 北京翊博生物集团有限公司 | 一种树突状细胞来源的外泌体的制备方法及应用 |
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| CN1257187C (zh) * | 2003-10-22 | 2006-05-24 | 上海恰尔生物技术有限公司 | 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途 |
| CA2544473C (en) | 2003-11-03 | 2013-08-13 | Beijing Sunbio Biotech Co., Ltd. | A recombinant protein having an anti-cancer effect, its encoding gene and uses thereof |
| US7252993B2 (en) | 2004-03-12 | 2007-08-07 | Battelle Energy Alliance, Llc | Plasmids encoding therapeutic agents |
| US8907060B2 (en) | 2005-07-29 | 2014-12-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mutated Pseudomonas exotoxins with reduced antigenicity |
| EP1915626B1 (en) | 2005-08-16 | 2011-11-09 | Genentech, Inc. | Apoptosis sensitivity to apo2l/trail by testing for galnac-t14 expression in cells/tissues |
| US20100215670A1 (en) | 2006-10-30 | 2010-08-26 | Jeannick Cizeau | Immunotoxin Fusions Comprising An Antibody Fragment and a Plant Toxin Linked by Protease Cleavable Linkers |
| SG163558A1 (en) | 2006-12-29 | 2010-08-30 | Osprey Pharmaceuticals Usa Inc | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof |
| WO2009002947A2 (en) | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| GB0723059D0 (en) | 2007-11-23 | 2008-01-02 | Nat Univ Ireland | Improved cytokine design |
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| PT2252627T (pt) * | 2008-01-24 | 2017-07-24 | Esperance Pharmaceuticals | Constructos de fusão de domínio lítico e métodos para produzir e utilizar os mesmos |
| TW200950778A (en) | 2008-05-14 | 2009-12-16 | Genentech Inc | Methods of using Apo2L/TRAIL to treat cancer |
| EP2297198B1 (en) * | 2008-06-30 | 2014-12-17 | University Of Pennsylvania | Fn14/trail fusion proteins |
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2012
- 2012-11-28 EA EA201491049A patent/EA201491049A1/ru unknown
- 2012-11-28 JP JP2014544020A patent/JP2015500228A/ja active Pending
- 2012-11-28 IN IN4498CHN2014 patent/IN2014CN04498A/en unknown
- 2012-11-28 HK HK15102260.2A patent/HK1201727A1/xx unknown
- 2012-11-28 WO PCT/IB2012/056806 patent/WO2013080147A2/en not_active Ceased
- 2012-11-28 CA CA2856480A patent/CA2856480A1/en not_active Abandoned
- 2012-11-28 BR BR112014012808A patent/BR112014012808A2/pt not_active IP Right Cessation
- 2012-11-28 SG SG11201402312WA patent/SG11201402312WA/en unknown
- 2012-11-28 EP EP12816127.0A patent/EP2785362A2/en not_active Withdrawn
- 2012-11-28 AU AU2012345494A patent/AU2012345494A1/en not_active Abandoned
- 2012-11-28 CN CN201280058346.6A patent/CN103974711A/zh active Pending
- 2012-11-28 MX MX2014006369A patent/MX2014006369A/es unknown
- 2012-11-28 US US14/361,279 patent/US20150044162A1/en not_active Abandoned
- 2012-11-28 KR KR1020147018001A patent/KR20140097529A/ko not_active Withdrawn
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2014
- 2014-05-14 PH PH12014501083A patent/PH12014501083A1/en unknown
- 2014-05-21 IL IL232743A patent/IL232743A0/en unknown
- 2014-06-25 ZA ZA2014/04667A patent/ZA201404667B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170010896A (ko) * | 2014-06-11 | 2017-02-01 | 몰레큘러 템플레이츠, 인코퍼레이션. | 프로테아제-절단 저항성의 시가 독소 a 서브유닛 작동체 폴리펩티드 및 이를 포함하는 세포-표적화 분자 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150044162A1 (en) | 2015-02-12 |
| CA2856480A1 (en) | 2013-06-06 |
| CN103974711A (zh) | 2014-08-06 |
| ZA201404667B (en) | 2015-09-30 |
| HK1201727A1 (en) | 2015-09-11 |
| EP2785362A2 (en) | 2014-10-08 |
| IN2014CN04498A (enExample) | 2015-09-11 |
| PL397167A1 (pl) | 2013-06-10 |
| EA201491049A1 (ru) | 2014-10-30 |
| JP2015500228A (ja) | 2015-01-05 |
| PH12014501083A1 (en) | 2014-08-04 |
| AU2012345494A1 (en) | 2014-07-10 |
| MX2014006369A (es) | 2014-07-09 |
| IL232743A0 (en) | 2014-07-31 |
| BR112014012808A2 (pt) | 2019-09-24 |
| WO2013080147A2 (en) | 2013-06-06 |
| SG11201402312WA (en) | 2014-06-27 |
| WO2013080147A3 (en) | 2014-02-13 |
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