KR20140097529A - 항암 융합 단백질 - Google Patents
항암 융합 단백질 Download PDFInfo
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- KR20140097529A KR20140097529A KR1020147018001A KR20147018001A KR20140097529A KR 20140097529 A KR20140097529 A KR 20140097529A KR 1020147018001 A KR1020147018001 A KR 1020147018001A KR 20147018001 A KR20147018001 A KR 20147018001A KR 20140097529 A KR20140097529 A KR 20140097529A
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| WO2014141094A1 (en) | 2013-03-14 | 2014-09-18 | Adamed Sp. Z O.O. | Anticancer conjugate |
| KR20160113158A (ko) | 2014-01-27 | 2016-09-28 | 몰레큘러 템플레이츠, 인코퍼레이션. | 폴리펩티드를 전달하는 mhc 클래스 i 항원결정기 |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| WO2015138435A1 (en) * | 2014-03-11 | 2015-09-17 | Molecular Templates, Inc. | Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs |
| JP6444486B2 (ja) | 2015-02-05 | 2018-12-26 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 志賀毒素ａサブユニットエフェクター領域を含む多価ｃｄ２０結合分子及びそれらの強化組成物 |
| WO2016127346A1 (zh) * | 2015-02-11 | 2016-08-18 | 四川大学华西医院 | 一种肿瘤坏死因子相关凋亡诱导配体变异体及其制备方法和用途 |
| JP6771492B2 (ja) * | 2015-05-30 | 2020-10-21 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | 脱免疫化された志賀毒素ａサブユニット足場及びそれを含む細胞標的化分子 |
| CN106380521B (zh) | 2015-07-02 | 2020-12-29 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
| KR101732126B1 (ko) | 2015-11-05 | 2017-05-02 | 한국생명공학연구원 | 췌장암 치료용 융합 단백질 및 이의 용도 |
| PL233352B1 (pl) * | 2016-09-15 | 2019-10-31 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe białko fuzyjne |
| JP7075134B2 (ja) | 2016-12-07 | 2022-05-25 | モレキュラー テンプレーツ，インク． | 部位特異的コンジュゲーションのための志賀毒素ａサブユニットエフェクターポリペプチド、志賀毒素エフェクター足場、及び細胞標的化分子 |
| CN106632680A (zh) * | 2016-12-27 | 2017-05-10 | 上海交通大学 | 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建 |
| KR102590672B1 (ko) | 2017-01-25 | 2023-10-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| WO2019173478A2 (en) * | 2018-03-06 | 2019-09-12 | The Johns Hopkins University | Methods of treating or preventing cancer with an agent that depletes tregs and a checkpoint inhibitor |
| MX2019009726A (es) | 2018-04-17 | 2020-02-05 | Molecular Templates Inc | Moleculas con direccion hacia her2 que comprenden andamiajes de la sub-unidad a de la toxina shiga desinmunizados. |
| US20220211872A1 (en) * | 2019-05-15 | 2022-07-07 | Universidad De Granada | Gene therapy with the genes hokd and ldrb for cancer treatments |
| CN113354738B (zh) * | 2020-03-05 | 2022-09-09 | 绍兴德方华生物技术有限公司 | 融合毒素VEGF165b/mGEL及其编码基因与应用 |
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| ATE501256T1 (de) | 2003-11-03 | 2011-03-15 | Beijing Sunbio Biotech Co Ltd | Rekombinantes protein mit krebsunterdrückender wirkung, sein codierendes gen und seine verwendung |
| US7252993B2 (en) | 2004-03-12 | 2007-08-07 | Battelle Energy Alliance, Llc | Plasmids encoding therapeutic agents |
| EP3006456B1 (en) | 2005-07-29 | 2018-09-19 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Mutated pseudomonas exotoxins with reduced antigenicity |
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| WO2009002947A2 (en) | 2007-06-22 | 2008-12-31 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| GB0723059D0 (en) | 2007-11-23 | 2008-01-02 | Nat Univ Ireland | Improved cytokine design |
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| WO2009094634A1 (en) * | 2008-01-24 | 2009-07-30 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
| WO2009140469A2 (en) | 2008-05-14 | 2009-11-19 | Genentech, Inc. | Methods of using apo2l/trail to treat cancer |
| JP5475766B2 (ja) * | 2008-06-30 | 2014-04-16 | ユニバーシティ オブ ペンシルベニア | Ｆｎ１４／ＴＲＡＩＬ融合タンパク質 |
-
2011
- 2011-11-28 PL PL397167A patent/PL397167A1/pl unknown
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2012
- 2012-11-28 AU AU2012345494A patent/AU2012345494A1/en not_active Abandoned
- 2012-11-28 EA EA201491049A patent/EA201491049A1/ru unknown
- 2012-11-28 KR KR1020147018001A patent/KR20140097529A/ko not_active Withdrawn
- 2012-11-28 JP JP2014544020A patent/JP2015500228A/ja active Pending
- 2012-11-28 MX MX2014006369A patent/MX2014006369A/es unknown
- 2012-11-28 SG SG11201402312WA patent/SG11201402312WA/en unknown
- 2012-11-28 US US14/361,279 patent/US20150044162A1/en not_active Abandoned
- 2012-11-28 HK HK15102260.2A patent/HK1201727A1/xx unknown
- 2012-11-28 WO PCT/IB2012/056806 patent/WO2013080147A2/en not_active Ceased
- 2012-11-28 BR BR112014012808A patent/BR112014012808A2/pt not_active IP Right Cessation
- 2012-11-28 IN IN4498CHN2014 patent/IN2014CN04498A/en unknown
- 2012-11-28 EP EP12816127.0A patent/EP2785362A2/en not_active Withdrawn
- 2012-11-28 CA CA2856480A patent/CA2856480A1/en not_active Abandoned
- 2012-11-28 CN CN201280058346.6A patent/CN103974711A/zh active Pending
-
2014
- 2014-05-14 PH PH12014501083A patent/PH12014501083A1/en unknown
- 2014-05-21 IL IL232743A patent/IL232743A0/en unknown
- 2014-06-25 ZA ZA2014/04667A patent/ZA201404667B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170010896A (ko) * | 2014-06-11 | 2017-02-01 | 몰레큘러 템플레이츠, 인코퍼레이션. | 프로테아제-절단 저항성의 시가 독소 a 서브유닛 작동체 폴리펩티드 및 이를 포함하는 세포-표적화 분자 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2015500228A (ja) | 2015-01-05 |
| BR112014012808A2 (pt) | 2019-09-24 |
| IN2014CN04498A (enExample) | 2015-09-11 |
| WO2013080147A2 (en) | 2013-06-06 |
| MX2014006369A (es) | 2014-07-09 |
| EP2785362A2 (en) | 2014-10-08 |
| PL397167A1 (pl) | 2013-06-10 |
| AU2012345494A1 (en) | 2014-07-10 |
| ZA201404667B (en) | 2015-09-30 |
| EA201491049A1 (ru) | 2014-10-30 |
| US20150044162A1 (en) | 2015-02-12 |
| WO2013080147A3 (en) | 2014-02-13 |
| IL232743A0 (en) | 2014-07-31 |
| CN103974711A (zh) | 2014-08-06 |
| SG11201402312WA (en) | 2014-06-27 |
| HK1201727A1 (en) | 2015-09-11 |
| PH12014501083A1 (en) | 2014-08-04 |
| CA2856480A1 (en) | 2013-06-06 |
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