CN103974711A - 抗癌融合蛋白 - Google Patents

抗癌融合蛋白 Download PDF

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Publication number
CN103974711A
CN103974711A CN201280058346.6A CN201280058346A CN103974711A CN 103974711 A CN103974711 A CN 103974711A CN 201280058346 A CN201280058346 A CN 201280058346A CN 103974711 A CN103974711 A CN 103974711A
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CN
China
Prior art keywords
seq
sequence
fusion protein
domain
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280058346.6A
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English (en)
Chinese (zh)
Inventor
J·S·皮耶奇克兰
S·帕夫拉克
M·希玛尼克
A·M·皮耶切科兰
B·M·泽雷克
P·鲁兹加
A·R·亚沃尔斯基
M·I·特斯克-卡明斯卡
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Adamed Sp zoo
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Adamed Sp zoo
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Publication date
Application filed by Adamed Sp zoo filed Critical Adamed Sp zoo
Publication of CN103974711A publication Critical patent/CN103974711A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201280058346.6A 2011-11-28 2012-11-28 抗癌融合蛋白 Pending CN103974711A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PLP.397167 2011-11-28
PL397167A PL397167A1 (pl) 2011-11-28 2011-11-28 Przeciwnowotworowe bialko fuzyjne
PCT/IB2012/056806 WO2013080147A2 (en) 2011-11-28 2012-11-28 Anticancer fusion protein

Publications (1)

Publication Number Publication Date
CN103974711A true CN103974711A (zh) 2014-08-06

Family

ID=47561689

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280058346.6A Pending CN103974711A (zh) 2011-11-28 2012-11-28 抗癌融合蛋白

Country Status (18)

Country Link
US (1) US20150044162A1 (enExample)
EP (1) EP2785362A2 (enExample)
JP (1) JP2015500228A (enExample)
KR (1) KR20140097529A (enExample)
CN (1) CN103974711A (enExample)
AU (1) AU2012345494A1 (enExample)
BR (1) BR112014012808A2 (enExample)
CA (1) CA2856480A1 (enExample)
EA (1) EA201491049A1 (enExample)
HK (1) HK1201727A1 (enExample)
IL (1) IL232743A0 (enExample)
IN (1) IN2014CN04498A (enExample)
MX (1) MX2014006369A (enExample)
PH (1) PH12014501083A1 (enExample)
PL (1) PL397167A1 (enExample)
SG (1) SG11201402312WA (enExample)
WO (1) WO2013080147A2 (enExample)
ZA (1) ZA201404667B (enExample)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127346A1 (zh) * 2015-02-11 2016-08-18 四川大学华西医院 一种肿瘤坏死因子相关凋亡诱导配体变异体及其制备方法和用途
WO2017000913A1 (zh) * 2015-07-02 2017-01-05 马卫红 用于肿瘤靶向治疗的白细胞介素15融合蛋白
CN106632680A (zh) * 2016-12-27 2017-05-10 上海交通大学 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建
CN112105631A (zh) * 2018-03-06 2020-12-18 约翰霍普金斯大学 Treg耗尽和检查点抑制剂的组合
CN113354738A (zh) * 2020-03-05 2021-09-07 宁波德方华生物技术有限公司 融合毒素VEGF165b/mGEL及其编码基因与应用
CN114681599A (zh) * 2020-12-31 2022-07-01 中国科学院上海药物研究所 一种阳离子脂质体疫苗及其制备方法和用途
CN117384859A (zh) * 2023-12-13 2024-01-12 北京翊博生物集团有限公司 一种树突状细胞来源的外泌体的制备方法及应用

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3666795A1 (en) 2013-03-12 2020-06-17 Molecular Templates, Inc. Cytotoxic proteins comprising cell-targeting binding regions and shiga toxin a subunit regions for selective killing of specific cell types
WO2014141094A1 (en) 2013-03-14 2014-09-18 Adamed Sp. Z O.O. Anticancer conjugate
EP3575312A1 (en) 2014-01-27 2019-12-04 Molecular Templates, Inc. De-immunized shiga toxin a subunit effector polypeptides for applications in mammals
ES2723774T3 (es) * 2014-03-11 2019-09-02 Molecular Templates Inc Proteínas que comprenden regiones de unión, regiones efectoras de la subunidad A de toxina Shiga y motivos señal de localización de retículo endoplasmático carboxi terminal
US11142584B2 (en) 2014-03-11 2021-10-12 Molecular Templates, Inc. CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same
EP3137488B1 (en) 2014-06-11 2019-01-02 Molecular Templates, Inc. Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same
EP3253799B1 (en) 2015-02-05 2020-12-02 Molecular Templates, Inc. Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof
MX2017015493A (es) * 2015-05-30 2018-02-09 Molecular Templates Inc Andamiajes de la subunidad a de la toxina shiga desinmunizados y moleculas con direccion a las celulas que los comprenden.
KR101732126B1 (ko) 2015-11-05 2017-05-02 한국생명공학연구원 췌장암 치료용 융합 단백질 및 이의 용도
PL233352B1 (pl) * 2016-09-15 2019-10-31 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe białko fuzyjne
AU2017373962B2 (en) 2016-12-07 2022-03-31 Molecular Templates, Inc. Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation
AU2018213194B2 (en) 2017-01-25 2023-01-12 Molecular Templates, Inc. Cell-targeting molecules comprising de-immunized, Shiga toxin A Subunit effectors and CD8+ T-cell epitopes
CA3097178A1 (en) 2018-04-17 2019-10-24 Molecular Templates, Inc. Her2-targeting molecules comprising de-immunized, shiga toxin a subunit scaffolds
EP3984546A4 (en) * 2019-05-15 2023-09-27 Universidad de Granada GENE THERAPY WITH THE HOKD AND LDRB GENES FOR CANCER TREATMENTS
IL300701A (en) * 2020-08-17 2023-04-01 Atb Therapeutics Immunotoxin-containing immunotoxin-containing or renase
AU2022321126A1 (en) * 2021-08-06 2024-02-29 Kao Corporation Nucleic acid structure utilizing snare
CN118792375B (zh) * 2024-06-25 2025-09-23 华南农业大学 一种具有补肾壮阳功效的瓜蒌多肽及其制备方法和应用

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CN1609124A (zh) * 2003-10-22 2005-04-27 上海恰尔生物技术有限公司 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途
WO2009094634A1 (en) * 2008-01-24 2009-07-30 Esperance Pharmaceuticals Lytic domain fusion constructs and methods of making and using same
WO2010005519A1 (en) * 2008-06-30 2010-01-14 University Of Pennsylvania Fn14/trail fusion proteins

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AU2001238501A1 (en) 2000-02-16 2001-08-27 Bechtel Bwxt Idaho, Llc Selective destruction of cells infected with human immunodeficiency virus
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US7666989B2 (en) 2003-11-03 2010-02-23 Beijing Sunbio Biotech Co., Ltd. Recombinant protein having an anti-cancer effect, its encoding gene and uses thereof
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CN101287990B (zh) 2005-08-16 2012-07-04 健泰科生物技术公司 通过检测细胞/组织中galnac-t14的表达判定对apo2l/trail的凋亡敏感性
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WO2009094634A1 (en) * 2008-01-24 2009-07-30 Esperance Pharmaceuticals Lytic domain fusion constructs and methods of making and using same
WO2010005519A1 (en) * 2008-06-30 2010-01-14 University Of Pennsylvania Fn14/trail fusion proteins

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Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016127346A1 (zh) * 2015-02-11 2016-08-18 四川大学华西医院 一种肿瘤坏死因子相关凋亡诱导配体变异体及其制备方法和用途
WO2017000913A1 (zh) * 2015-07-02 2017-01-05 马卫红 用于肿瘤靶向治疗的白细胞介素15融合蛋白
US10611812B2 (en) 2015-07-02 2020-04-07 Numab Biopharmaceuticals (Hangzhou) Ltd. Interleukin 15 fusion protein for tumor targeting therapy
US11236140B2 (en) 2015-07-02 2022-02-01 Bj Bioscience Inc. Interleukin 15 fusion protein for tumor targeting therapy
CN106632680A (zh) * 2016-12-27 2017-05-10 上海交通大学 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建
CN112105631A (zh) * 2018-03-06 2020-12-18 约翰霍普金斯大学 Treg耗尽和检查点抑制剂的组合
CN113354738A (zh) * 2020-03-05 2021-09-07 宁波德方华生物技术有限公司 融合毒素VEGF165b/mGEL及其编码基因与应用
CN113354738B (zh) * 2020-03-05 2022-09-09 绍兴德方华生物技术有限公司 融合毒素VEGF165b/mGEL及其编码基因与应用
CN114681599A (zh) * 2020-12-31 2022-07-01 中国科学院上海药物研究所 一种阳离子脂质体疫苗及其制备方法和用途
CN114681599B (zh) * 2020-12-31 2024-07-02 中国科学院上海药物研究所 一种阳离子脂质体疫苗及其制备方法和用途
CN117384859A (zh) * 2023-12-13 2024-01-12 北京翊博生物集团有限公司 一种树突状细胞来源的外泌体的制备方法及应用
CN117384859B (zh) * 2023-12-13 2024-03-22 北京翊博生物集团有限公司 一种树突状细胞来源的外泌体的制备方法及应用

Also Published As

Publication number Publication date
AU2012345494A1 (en) 2014-07-10
HK1201727A1 (en) 2015-09-11
EA201491049A1 (ru) 2014-10-30
WO2013080147A3 (en) 2014-02-13
WO2013080147A2 (en) 2013-06-06
SG11201402312WA (en) 2014-06-27
IL232743A0 (en) 2014-07-31
JP2015500228A (ja) 2015-01-05
CA2856480A1 (en) 2013-06-06
IN2014CN04498A (enExample) 2015-09-11
KR20140097529A (ko) 2014-08-06
EP2785362A2 (en) 2014-10-08
PL397167A1 (pl) 2013-06-10
US20150044162A1 (en) 2015-02-12
PH12014501083A1 (en) 2014-08-04
BR112014012808A2 (pt) 2019-09-24
ZA201404667B (en) 2015-09-30
MX2014006369A (es) 2014-07-09

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Application publication date: 20140806