BR112014012808A2 - proteína de fusão anticâncer - Google Patents
proteína de fusão anticâncerInfo
- Publication number
- BR112014012808A2 BR112014012808A2 BR112014012808A BR112014012808A BR112014012808A2 BR 112014012808 A2 BR112014012808 A2 BR 112014012808A2 BR 112014012808 A BR112014012808 A BR 112014012808A BR 112014012808 A BR112014012808 A BR 112014012808A BR 112014012808 A2 BR112014012808 A2 BR 112014012808A2
- Authority
- BR
- Brazil
- Prior art keywords
- fusion protein
- domain
- sequence
- protein
- terminus
- Prior art date
Links
- 108020001507 fusion proteins Proteins 0.000 title abstract 4
- 102000037865 fusion proteins Human genes 0.000 title abstract 4
- 230000001093 anti-cancer Effects 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000001243 protein synthesis Methods 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL397167A PL397167A1 (pl) | 2011-11-28 | 2011-11-28 | Przeciwnowotworowe bialko fuzyjne |
| PCT/IB2012/056806 WO2013080147A2 (en) | 2011-11-28 | 2012-11-28 | Anticancer fusion protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014012808A2 true BR112014012808A2 (pt) | 2019-09-24 |
Family
ID=47561689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014012808A BR112014012808A2 (pt) | 2011-11-28 | 2012-11-28 | proteína de fusão anticâncer |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20150044162A1 (enExample) |
| EP (1) | EP2785362A2 (enExample) |
| JP (1) | JP2015500228A (enExample) |
| KR (1) | KR20140097529A (enExample) |
| CN (1) | CN103974711A (enExample) |
| AU (1) | AU2012345494A1 (enExample) |
| BR (1) | BR112014012808A2 (enExample) |
| CA (1) | CA2856480A1 (enExample) |
| EA (1) | EA201491049A1 (enExample) |
| HK (1) | HK1201727A1 (enExample) |
| IL (1) | IL232743A0 (enExample) |
| IN (1) | IN2014CN04498A (enExample) |
| MX (1) | MX2014006369A (enExample) |
| PH (1) | PH12014501083A1 (enExample) |
| PL (1) | PL397167A1 (enExample) |
| SG (1) | SG11201402312WA (enExample) |
| WO (1) | WO2013080147A2 (enExample) |
| ZA (1) | ZA201404667B (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101990341B1 (ko) | 2013-03-12 | 2019-06-19 | 몰레큘러 템플레이츠, 인코퍼레이션. | 세포 내재화를 유도하기 위한 ｃｄ20-결합 면역독소 및 이의 사용 방법 |
| WO2014141094A1 (en) | 2013-03-14 | 2014-09-18 | Adamed Sp. Z O.O. | Anticancer conjugate |
| JP6655017B2 (ja) | 2014-01-27 | 2020-02-26 | モレキュラー テンプレーツ, インク.Molecular Templates, Inc. | Ｍｈｃクラスｉエピトープ送達ポリペプチド |
| EP3502134B1 (en) * | 2014-03-11 | 2020-12-16 | Molecular Templates, Inc. | Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs |
| US11142584B2 (en) | 2014-03-11 | 2021-10-12 | Molecular Templates, Inc. | CD20-binding proteins comprising Shiga toxin A subunit effector regions for inducing cellular internalization and methods using same |
| EP3137488B1 (en) * | 2014-06-11 | 2019-01-02 | Molecular Templates, Inc. | Protease-cleavage resistant, shiga toxin a subunit effector polypeptides and cell-targeting molecules comprising the same |
| WO2016126950A1 (en) | 2015-02-05 | 2016-08-11 | Molecular Templates, Inc. | Multivalent cd20-binding molecules comprising shiga toxin a subunit effector regions and enriched compositions thereof |
| US10428132B2 (en) | 2015-02-11 | 2019-10-01 | West China Hospital, Sichuan University | Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof |
| LT3303373T (lt) | 2015-05-30 | 2020-07-10 | Molecular Templates, Inc. | Deimunizuoto shiga toksino a subvieneto karkasai ir juos apimančios ląstelės taikinio molekulės |
| CN112574316A (zh) * | 2015-07-02 | 2021-03-30 | 博际生物医药科技(杭州)有限公司 | 用于肿瘤靶向治疗的白细胞介素-15融合蛋白 |
| KR101732126B1 (ko) | 2015-11-05 | 2017-05-02 | 한국생명공학연구원 | 췌장암 치료용 융합 단백질 및 이의 용도 |
| PL233352B1 (pl) * | 2016-09-15 | 2019-10-31 | Adamed Spolka Z Ograniczona Odpowiedzialnoscia | Przeciwnowotworowe białko fuzyjne |
| IL302130A (en) | 2016-12-07 | 2023-06-01 | Molecular Templates Inc | Shiga toxin a subunit effector polypeptides, shiga toxin effector scaffolds, and cell-targeting molecules for site-specific conjugation |
| CN106632680A (zh) * | 2016-12-27 | 2017-05-10 | 上海交通大学 | 植物体系表达人源化抗agr2单克隆抗体18a4的质粒构建 |
| KR102590672B1 (ko) | 2017-01-25 | 2023-10-18 | 몰레큘러 템플레이츠, 인코퍼레이션. | 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자 |
| JP2021515774A (ja) * | 2018-03-06 | 2021-06-24 | ザ・ジョンズ・ホプキンス・ユニバーシティ | 制御性ｔ細胞を枯渇する薬剤、及びチェックポイント阻害剤を使用してがんを治療、又は予防する方法 |
| CN110612117B (zh) | 2018-04-17 | 2024-04-12 | 分子模板公司 | 包含去免疫化的志贺毒素a亚基支架的her2靶向分子 |
| WO2020234498A2 (es) * | 2019-05-15 | 2020-11-26 | Universidad De Granada | Terapia génica con los genes hokd y ldrb para el tratamiento del cáncer |
| CN113354738B (zh) * | 2020-03-05 | 2022-09-09 | 绍兴德方华生物技术有限公司 | 融合毒素VEGF165b/mGEL及其编码基因与应用 |
| US20230310557A1 (en) * | 2020-08-17 | 2023-10-05 | Atb Therapeutics | Recombinant immunotoxin comprising a ribotoxin or rnase |
| CN114681599B (zh) * | 2020-12-31 | 2024-07-02 | 中国科学院上海药物研究所 | 一种阳离子脂质体疫苗及其制备方法和用途 |
| EP4382607A4 (en) * | 2021-08-06 | 2025-11-19 | Kao Corp | NUCLEIC ACID STRUCTURE INVOLVING SNARE PROTEINS |
| CN117384859B (zh) * | 2023-12-13 | 2024-03-22 | 北京翊博生物集团有限公司 | 一种树突状细胞来源的外泌体的制备方法及应用 |
| CN118792375B (zh) * | 2024-06-25 | 2025-09-23 | 华南农业大学 | 一种具有补肾壮阳功效的瓜蒌多肽及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2253753T3 (es) | 1995-06-29 | 2006-06-01 | Immunex Corporation | Citocina que induce apoptosis. |
| WO2001060393A1 (en) | 2000-02-16 | 2001-08-23 | Bechtel Bwxt Idaho, Llc | Selective destruction of cells infected with human immunodeficiency virus |
| ZA200305980B (en) | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| CN1257187C (zh) * | 2003-10-22 | 2006-05-24 | 上海恰尔生物技术有限公司 | 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途 |
| JP4688678B2 (ja) | 2003-11-03 | 2011-05-25 | 北京沙東生物技術有限公司 | 抗癌作用を有する組換えタンパク質、それをコードする遺伝子、及びそれらの使用 |
| US7252993B2 (en) | 2004-03-12 | 2007-08-07 | Battelle Energy Alliance, Llc | Plasmids encoding therapeutic agents |
| EP1910407B1 (en) | 2005-07-29 | 2011-09-14 | The Government of the United States of America, as represented by the Secretary of Health and Human Services | Mutated pseudomonas exotoxins with reduced antigenicity |
| PT1915626E (pt) | 2005-08-16 | 2012-02-03 | Genentech Inc | Sensibilidade da apoptose a apo2l/trail por ensaio de expressão de galnac-t14 em células/tecidos |
| WO2008052322A1 (en) | 2006-10-30 | 2008-05-08 | Viventia Biotech Inc. | Immunotoxγn fusions comprising an antibody fragment and a plant toxin linked by protease cleavable linkers |
| SG163558A1 (en) | 2006-12-29 | 2010-08-30 | Osprey Pharmaceuticals Usa Inc | Methods of selecting and producing modified toxins, conjugates containing modified toxins and uses thereof |
| US20090131317A1 (en) | 2007-06-22 | 2009-05-21 | Affymax, Inc. | Compounds and peptides that bind the trail receptor |
| GB0723059D0 (en) | 2007-11-23 | 2008-01-02 | Nat Univ Ireland | Improved cytokine design |
| GB0724532D0 (en) | 2007-12-17 | 2008-01-30 | Nat Univ Ireland | Trail variants for treating cancer |
| KR101863136B1 (ko) * | 2008-01-24 | 2018-05-31 | 에스퍼란스 파마슈티컬스, 인코포레이티드 | 용해 도메인 융합 구성물 및 이를 제조하고 사용하는 방법 |
| CL2009001191A1 (es) | 2008-05-14 | 2010-07-02 | Genentech Inc | Uso del peptido apo2l/trail porque sirve para preparar un medicamento para tratar el cancer de pulmon y el linfoma de hodkin. |
| JP5475766B2 (ja) * | 2008-06-30 | 2014-04-16 | ユニバーシティ オブ ペンシルベニア | Ｆｎ１４／ＴＲＡＩＬ融合タンパク質 |
-
2011
- 2011-11-28 PL PL397167A patent/PL397167A1/pl unknown
-
2012
- 2012-11-28 MX MX2014006369A patent/MX2014006369A/es unknown
- 2012-11-28 WO PCT/IB2012/056806 patent/WO2013080147A2/en not_active Ceased
- 2012-11-28 US US14/361,279 patent/US20150044162A1/en not_active Abandoned
- 2012-11-28 SG SG11201402312WA patent/SG11201402312WA/en unknown
- 2012-11-28 KR KR1020147018001A patent/KR20140097529A/ko not_active Withdrawn
- 2012-11-28 BR BR112014012808A patent/BR112014012808A2/pt not_active IP Right Cessation
- 2012-11-28 EA EA201491049A patent/EA201491049A1/ru unknown
- 2012-11-28 JP JP2014544020A patent/JP2015500228A/ja active Pending
- 2012-11-28 HK HK15102260.2A patent/HK1201727A1/xx unknown
- 2012-11-28 IN IN4498CHN2014 patent/IN2014CN04498A/en unknown
- 2012-11-28 AU AU2012345494A patent/AU2012345494A1/en not_active Abandoned
- 2012-11-28 EP EP12816127.0A patent/EP2785362A2/en not_active Withdrawn
- 2012-11-28 CN CN201280058346.6A patent/CN103974711A/zh active Pending
- 2012-11-28 CA CA2856480A patent/CA2856480A1/en not_active Abandoned
-
2014
- 2014-05-14 PH PH12014501083A patent/PH12014501083A1/en unknown
- 2014-05-21 IL IL232743A patent/IL232743A0/en unknown
- 2014-06-25 ZA ZA2014/04667A patent/ZA201404667B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201402312WA (en) | 2014-06-27 |
| WO2013080147A2 (en) | 2013-06-06 |
| US20150044162A1 (en) | 2015-02-12 |
| AU2012345494A1 (en) | 2014-07-10 |
| MX2014006369A (es) | 2014-07-09 |
| ZA201404667B (en) | 2015-09-30 |
| IN2014CN04498A (enExample) | 2015-09-11 |
| KR20140097529A (ko) | 2014-08-06 |
| CN103974711A (zh) | 2014-08-06 |
| PL397167A1 (pl) | 2013-06-10 |
| EA201491049A1 (ru) | 2014-10-30 |
| IL232743A0 (en) | 2014-07-31 |
| EP2785362A2 (en) | 2014-10-08 |
| CA2856480A1 (en) | 2013-06-06 |
| HK1201727A1 (en) | 2015-09-11 |
| JP2015500228A (ja) | 2015-01-05 |
| WO2013080147A3 (en) | 2014-02-13 |
| PH12014501083A1 (en) | 2014-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |