AR086241A1 - Proteinas repetitivas de union a il4/il13 y usos - Google Patents
Proteinas repetitivas de union a il4/il13 y usosInfo
- Publication number
- AR086241A1 AR086241A1 ARP120101543A ARP120101543A AR086241A1 AR 086241 A1 AR086241 A1 AR 086241A1 AR P120101543 A ARP120101543 A AR P120101543A AR P120101543 A ARP120101543 A AR P120101543A AR 086241 A1 AR086241 A1 AR 086241A1
- Authority
- AR
- Argentina
- Prior art keywords
- binding
- domain
- protein
- diseases
- binding domain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Reivindicación 1: Una proteína de unión que comprende un dominio de unión, en donde el dominio de unión es un dominio con repeticiones de anquirina que se une a la IL4 humana e inhibe la unión de IL4 a IL4Ra in vitro o in vivo y en donde el dominio con repeticiones de anquirina comprende por lo menos un módulo con repeticiones de anquirina.Reivindicación 32: La composición farmacéutica de conformidad con la reivindicación 28, en donde la composición está formulada para el suministro con el uso de un nebulizador. Reivindicación 40: Una proteína de unión que comprende un dominio de unión, en donde el dominio de unión es un dominio con repeticiones de anquirina, en donde la proteína de unión compite para unirse a la proteína IL4 que tiene la secuencia de aminoácidos de la sec. con núm. de ident.: 4 y/o la proteína IL13 tiene la secuencia de aminoácidos de la sec. con núm. de ident.: 101, con la proteína de unión de cualquiera de la reivindicaciones 1 - 7, 9 - 18 y 20 - 27. Reivindicación 47: El uso de un dominio de unión de conformidad con cualquiera de las reivindicaciones 1 - 7, 9 - 18, 20 - 27 y 41 para elaborar un medicamento para tratar enfermedades cardiovasculares, enfermedades respiratorias, cáncer, enfermedades dermatológicas y enfermedades fibróticas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161481008P | 2011-04-29 | 2011-04-29 | |
US201161480999P | 2011-04-29 | 2011-04-29 | |
US201161481021P | 2011-04-29 | 2011-04-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR086241A1 true AR086241A1 (es) | 2013-11-27 |
Family
ID=47068346
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120101543A AR086241A1 (es) | 2011-04-29 | 2012-05-02 | Proteinas repetitivas de union a il4/il13 y usos |
Country Status (14)
Country | Link |
---|---|
US (2) | US8722618B2 (es) |
EP (1) | EP2702069A4 (es) |
JP (1) | JP2014519808A (es) |
KR (1) | KR20140039203A (es) |
CN (1) | CN104105704A (es) |
AR (1) | AR086241A1 (es) |
AU (1) | AU2012249359A1 (es) |
BR (1) | BR112013027766A2 (es) |
CA (1) | CA2834624A1 (es) |
EA (1) | EA201391607A1 (es) |
IL (1) | IL229093A0 (es) |
TW (1) | TW201305337A (es) |
UY (1) | UY34048A (es) |
WO (1) | WO2012149439A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR081361A1 (es) | 2010-04-30 | 2012-08-29 | Molecular Partners Ag | Proteinas de union modificadas que inhiben la interaccion de receptor del factor de crecimiento endotelial vascular de glicoproteina a vegf-a |
ES2758352T3 (es) * | 2010-11-26 | 2020-05-05 | Molecular Partners Ag | Proteínas de repetición diseñadas que se une a la seroalbúmina |
AU2013283296A1 (en) * | 2012-06-28 | 2015-02-05 | Molecular Partners Ag | Designed ankyrin repeat proteins binding to platelet-derived growth factor |
EP2738180A1 (en) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
EP3004152B1 (en) * | 2013-05-31 | 2020-09-30 | Molecular Partners AG | Designed ankyrin repeat proteins binding to hepatocyte growth factor |
KR20150097304A (ko) | 2014-02-18 | 2015-08-26 | 삼성전자주식회사 | 항 EGFR DARPin을 포함하는 EGFR/HER2 이중 특이 항체 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
BR112017020986A2 (pt) | 2015-04-02 | 2018-08-14 | Molecular Partners Ag. | proteínas de ligação recombinantes e seu uso |
US10717772B2 (en) | 2016-09-22 | 2020-07-21 | Molecular Partners Ag | Recombinant binding proteins targeting HER2 and serum albumin, and their uses |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
WO2018195388A1 (en) * | 2017-04-21 | 2018-10-25 | Kindred Biosciences, Inc. | Il4/il13 receptor molecule for veterinary use |
KR20200011685A (ko) * | 2018-07-25 | 2020-02-04 | 주식회사유한양행 | 갑상선 자극 호르몬 수용기(thyrotropin receptor, TSHR) 단편을 포함하는 융합 단백질 및 이의 용도 |
WO2020190852A2 (en) * | 2019-03-17 | 2020-09-24 | Jorge Fallas | Topological control of receptor signaling using synthetic homo- and hetero-dimeric cytokine mimetics |
MX2021014601A (es) * | 2019-06-04 | 2022-02-11 | Molecular Partners Ag | Proteinas recombinantes de union a fap y su uso. |
AU2020345943A1 (en) | 2019-09-10 | 2022-03-31 | Obsidian Therapeutics, Inc. | CA2-IL15 fusion proteins for tunable regulation |
MX2022007122A (es) | 2019-12-11 | 2022-09-09 | Molecular Partners Ag | Dominios de repetición de anquirina diseñados con residuos de superficie alterados. |
CA3176845A1 (en) | 2020-05-06 | 2021-11-11 | Patrick AMSTUTZ | Novel ankyrin repeat binding proteins and their uses |
WO2022190016A1 (en) | 2021-03-09 | 2022-09-15 | Molecular Partners Ag | Novel darpin based multi-specific t-cell engagers |
CN116789843A (zh) * | 2022-03-16 | 2023-09-22 | 伯桢生物科技(杭州)有限公司 | Wnt重组蛋白及其应用 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3771253B2 (ja) | 1988-09-02 | 2006-04-26 | ダイアックス コープ. | 新規な結合タンパク質の生成と選択 |
US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
US5348867A (en) | 1991-11-15 | 1994-09-20 | George Georgiou | Expression of proteins on bacterial surface |
CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
CA2289691C (en) | 1997-04-23 | 2008-01-15 | Andreas Pluckthun | Methods for identifying nucleic acid molecules encoding (poly)peptides that interact with target molecules |
AU775997B2 (en) | 1998-12-02 | 2004-08-19 | Bristol-Myers Squibb Company | DNA-protein fusions and uses thereof |
ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
US7875465B2 (en) | 2005-05-31 | 2011-01-25 | Canon Kabushiki Kaisha | Target substance capturing molecule |
CA2614512C (en) | 2005-07-08 | 2014-01-07 | University Of Zuerich | Phage display using cotranslational translocation of fusion polypeptides |
WO2009138413A1 (en) * | 2008-05-15 | 2009-11-19 | Domantis Limited | Single domain antibodies that bind il-13 |
KR20090064559A (ko) | 2006-10-16 | 2009-06-19 | (주)제이슨알앤디 | 콘텐츠 부가정보를 전송하는 시스템 및 이용방법 |
EP2263088A2 (en) * | 2008-03-19 | 2010-12-22 | Institut Pasteur | Reagentless fluorescent biosensors comprising a designed ankyrin repeat protein module, rational design methods to create reagentless fluorescent biosensors and methods of their use |
WO2010060748A1 (en) | 2008-11-03 | 2010-06-03 | Molecular Partners Ag | Binding proteins inhibiting the vegf-a receptor interaction |
-
2012
- 2012-04-27 AU AU2012249359A patent/AU2012249359A1/en not_active Abandoned
- 2012-04-27 CA CA2834624A patent/CA2834624A1/en not_active Abandoned
- 2012-04-27 CN CN201280032217.XA patent/CN104105704A/zh active Pending
- 2012-04-27 US US13/458,578 patent/US8722618B2/en active Active
- 2012-04-27 EP EP20120776643 patent/EP2702069A4/en not_active Withdrawn
- 2012-04-27 EA EA201391607A patent/EA201391607A1/ru unknown
- 2012-04-27 JP JP2014508142A patent/JP2014519808A/ja active Pending
- 2012-04-27 BR BR112013027766A patent/BR112013027766A2/pt not_active IP Right Cessation
- 2012-04-27 KR KR1020137031219A patent/KR20140039203A/ko not_active Application Discontinuation
- 2012-04-27 WO PCT/US2012/035613 patent/WO2012149439A2/en active Application Filing
- 2012-04-30 TW TW101115382A patent/TW201305337A/zh unknown
- 2012-04-30 UY UY0001034048A patent/UY34048A/es unknown
- 2012-05-02 AR ARP120101543A patent/AR086241A1/es unknown
-
2013
- 2013-10-27 IL IL229093A patent/IL229093A0/en unknown
-
2014
- 2014-03-26 US US14/225,821 patent/US9206244B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
UY34048A (es) | 2012-10-31 |
KR20140039203A (ko) | 2014-04-01 |
TW201305337A (zh) | 2013-02-01 |
WO2012149439A2 (en) | 2012-11-01 |
EP2702069A4 (en) | 2015-04-29 |
US8722618B2 (en) | 2014-05-13 |
JP2014519808A (ja) | 2014-08-21 |
AU2012249359A1 (en) | 2013-11-14 |
CA2834624A1 (en) | 2012-11-01 |
US9206244B2 (en) | 2015-12-08 |
CN104105704A (zh) | 2014-10-15 |
BR112013027766A2 (pt) | 2016-11-29 |
EP2702069A2 (en) | 2014-03-05 |
EA201391607A1 (ru) | 2014-04-30 |
IL229093A0 (en) | 2013-12-31 |
US20140206599A1 (en) | 2014-07-24 |
WO2012149439A3 (en) | 2014-05-30 |
US20120277143A1 (en) | 2012-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR086241A1 (es) | Proteinas repetitivas de union a il4/il13 y usos | |
CY1122466T1 (el) | Σκευασμα αντισωματος αντι il-17ra και θεραπευτικα σχηματα για την αγωγη της ψωριασης | |
CO6680687A2 (es) | Inmunoglobinas con dominio variable dual capaces de unirse a il 1 beta e il-17, composiciones farmaceúticas y conjugados de proteína de unión de las mismas | |
CY1119410T1 (el) | Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi) | |
CY1118691T1 (el) | Συνθεσεις και μεθοδοι χρησης για αντισωματα κατα σκληροστινης | |
DOP2014000083A (es) | Inmunoenlazadores dirigidos contra el tnf | |
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
SV2011003828A (es) | Anticuerpos monoclonales contra el inhibidor de la via del factor tisular (tfpi) | |
BR112012001984B8 (pt) | anticorpos humanos com alta afinidade para angiopoietina-2 humana, uso dos mesmos e composição farmacêutica | |
CR20130134A (es) | Inmunoglobulinas con dominio variable dual y usos de las mismas | |
CO6351751A2 (es) | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos | |
CO6400149A2 (es) | Proteínas de enlace a miostatina | |
BR112015004734A2 (pt) | proteínas de fusão para tratar uma síndrome metabólica | |
CL2011002482A1 (es) | Anticuerpo biespecificos que se une especificamente a las proteinas erbb-3 humana y c-met humana; acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar cancer | |
EA201290570A1 (ru) | Конструкты, связывающиеся с ron, и способы их использования | |
ECSP12012272A (es) | Proteínas que se unen al tnf-? | |
UA116194C2 (uk) | Антитіло, яке специфічно зв'язується з людським альфа-синуклеїном | |
CO6551686A2 (es) | Inmunoglobinas con dominio variable dual y usos de las mismas | |
BR112012030664A2 (pt) | proteína de ligação de antígeno humanizada, molécula de ácido nucleico, vetor de expressão, célula hospedeira recombinante, métodos para a produção de uma proteína de ligação de antígeno, para tratar um indivíduo afligido com uma doença e para aumentar a massa muscular, aumentar a força muscular, e/ou melhorar a função muscular em um paciente, e, composição farmacêutica. | |
CO6280500A2 (es) | Anticuerpos humanizados especificos pare l factor von willebrand | |
BR112014007675A2 (pt) | tratamento de doença articular degenerativa | |
EA201301107A1 (ru) | Моноклональные антитела против ингибитора пути тканевого фактора (tfpi) | |
CY1118044T1 (el) | Παρασκευασμα συνδυασμου με ανταγωνιστη και κορτικοστεροειδες | |
EA201591133A1 (ru) | СОСТАВЫ В ВИДЕ РАСТВОРА СКОНСТРУИРОВАННЫХ АНТИТЕЛ К IL-23p19 | |
BR112014012459A2 (pt) | 2h-indazóis como antagonistas do receptor de ep2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |