KR20140042933A - 프로테아좀 억제제 - Google Patents

프로테아좀 억제제 Download PDF

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Publication number
KR20140042933A
KR20140042933A KR1020147007078A KR20147007078A KR20140042933A KR 20140042933 A KR20140042933 A KR 20140042933A KR 1020147007078 A KR1020147007078 A KR 1020147007078A KR 20147007078 A KR20147007078 A KR 20147007078A KR 20140042933 A KR20140042933 A KR 20140042933A
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KR
South Korea
Prior art keywords
compound
formula
reagent
group
ring
Prior art date
Application number
KR1020147007078A
Other languages
English (en)
Korean (ko)
Inventor
에드워드 제이. 올하바
미헤라 디. 단카
Original Assignee
밀레니엄 파머슈티컬스 인코퍼레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20140042933(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 밀레니엄 파머슈티컬스 인코퍼레이티드 filed Critical 밀레니엄 파머슈티컬스 인코퍼레이티드
Publication of KR20140042933A publication Critical patent/KR20140042933A/ko

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147007078A 2007-08-06 2007-08-06 프로테아좀 억제제 KR20140042933A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020107003809A Division KR101474831B1 (ko) 2007-08-06 2007-08-06 프로테아좀 억제제

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020157000064A Division KR20150010802A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020167008358A Division KR20160040735A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제

Publications (1)

Publication Number Publication Date
KR20140042933A true KR20140042933A (ko) 2014-04-07

Family

ID=38691782

Family Applications (6)

Application Number Title Priority Date Filing Date
KR1020167008358A KR20160040735A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020167036758A KR101831674B1 (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020107003809A KR101474831B1 (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020157000064A KR20150010802A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020147007078A KR20140042933A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020147007077A KR20140042932A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제

Family Applications Before (4)

Application Number Title Priority Date Filing Date
KR1020167008358A KR20160040735A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020167036758A KR101831674B1 (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020107003809A KR101474831B1 (ko) 2007-08-06 2007-08-06 프로테아좀 억제제
KR1020157000064A KR20150010802A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147007077A KR20140042932A (ko) 2007-08-06 2007-08-06 프로테아좀 억제제

Country Status (33)

Country Link
EP (3) EP2527347A1 (ru)
JP (1) JP5261488B2 (ru)
KR (6) KR20160040735A (ru)
CN (1) CN101772507B (ru)
AU (1) AU2007357338B2 (ru)
BR (1) BRPI0721905B8 (ru)
CA (1) CA2695082C (ru)
CY (2) CY1113386T1 (ru)
DK (1) DK2178888T3 (ru)
EA (1) EA028622B1 (ru)
EC (1) ECSP10010015A (ru)
ES (1) ES2390606T3 (ru)
FR (1) FR17C1011I2 (ru)
GE (1) GEP20125599B (ru)
HK (2) HK1143595A1 (ru)
HR (1) HRP20120745T1 (ru)
HU (1) HUS1700018I1 (ru)
IL (4) IL203641A (ru)
LT (1) LTC2178888I2 (ru)
LU (1) LUC00013I2 (ru)
MY (1) MY161991A (ru)
NL (1) NL300871I2 (ru)
NZ (1) NZ582693A (ru)
PH (1) PH12014500053B1 (ru)
PL (1) PL2178888T3 (ru)
PT (1) PT2178888E (ru)
RS (1) RS52435B (ru)
SG (1) SG10201508712QA (ru)
SI (1) SI2178888T1 (ru)
TN (1) TN2010000060A1 (ru)
UA (1) UA97536C2 (ru)
WO (1) WO2009020448A1 (ru)
ZA (1) ZA201000348B (ru)

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EP1948678B1 (en) 2005-11-09 2013-05-01 Onyx Therapeutics, Inc. Compounds for enzyme inhibition
AU2007261345B2 (en) 2006-06-19 2012-02-23 Onyx Therapeutics, Inc. Peptide epoxyketones for proteasome inhibition
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
MX2010003732A (es) 2007-10-04 2010-08-09 Onyx Therapeutics Inc Inhibidores de peptido cetona epoxi de proteasa cristalina y la sintesis de ceto-epoxidos de aminoacido.
US20090325903A1 (en) 2008-06-17 2009-12-31 Millennium Pharmaceuticals, Inc. Boronate ester compounds and pharmaceutical compositions thereof
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
MX2011004225A (es) 2008-10-21 2011-06-21 Onyx Therapeutics Inc Terapia de combinacion con epoxicetonas peptidicas.
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2498793B1 (en) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib for use in metastasis suppression
WO2011087822A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
MX2012011298A (es) 2010-03-31 2012-11-06 Millennium Pharm Inc Derivados del acido 1-amino-2-ciclopropiletilboronico.
JP5944986B2 (ja) * 2011-06-22 2016-07-05 セファロン、インク. プロテアソーム阻害剤、ならびにそれらの調製、精製、および使用のためのプロセス
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CN104822689B (zh) * 2012-12-03 2016-11-02 弗·哈夫曼-拉罗切有限公司 取代的三唑硼酸化合物
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WO2017198194A1 (zh) * 2016-05-19 2017-11-23 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
EA201990069A1 (ru) 2016-06-21 2019-06-28 ОРИОН ОФТАЛМОЛОДЖИ ЭлЭлСи Производные гетероциклического пролинамида
JP7164521B2 (ja) 2016-06-21 2022-11-01 オリオン・オフサルモロジー・エルエルシー 炭素環式プロリンアミド誘導体
WO2018019196A1 (zh) * 2016-07-25 2018-02-01 深圳市塔吉瑞生物医药有限公司 一种取代的硼酸化合物及包含该化合物的药物组合物及其用途
CN108440583B (zh) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 一种新的硼酸衍生物及其药物组合物
EP3589659A4 (en) 2017-02-28 2021-03-24 Mayo Foundation for Medical Education and Research CANCER TREATMENT COMPOUNDS AND METHODS
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
WO2019020099A1 (zh) * 2017-07-28 2019-01-31 成都地奥九泓制药厂 一种硼酸酯化合物、其合成方法及其用途
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Also Published As

Publication number Publication date
AU2007357338A1 (en) 2009-02-12
NZ582693A (en) 2012-01-12
PL2178888T3 (pl) 2012-11-30
FR17C1011I2 (fr) 2018-04-27
PH12014500053A1 (en) 2015-03-30
IL242292A0 (en) 2015-11-30
KR20160040735A (ko) 2016-04-14
FR17C1011I1 (ru) 2017-05-26
RS52435B (en) 2013-02-28
KR20150010802A (ko) 2015-01-28
CY1113386T1 (el) 2016-06-22
GEP20125599B (en) 2012-08-10
SG10201508712QA (en) 2015-11-27
DK2178888T3 (da) 2012-10-01
BRPI0721905B8 (pt) 2021-05-25
LUC00013I1 (ru) 2017-04-06
CY2017016I2 (el) 2017-07-12
LUC00013I2 (ru) 2017-06-19
IL242292A (en) 2017-12-31
KR20140042932A (ko) 2014-04-07
KR20100059811A (ko) 2010-06-04
PH12014500053B1 (en) 2015-03-30
CN101772507B (zh) 2012-12-12
IL242290A0 (en) 2015-11-30
MY161991A (en) 2017-05-31
HK1182924A1 (zh) 2013-12-13
HK1143595A1 (en) 2011-01-07
HUS1700018I1 (hu) 2017-05-29
WO2009020448A1 (en) 2009-02-12
EP2527347A1 (en) 2012-11-28
ECSP10010015A (es) 2010-04-30
CN101772507A (zh) 2010-07-07
EA201070247A1 (ru) 2010-06-30
CA2695082C (en) 2015-07-28
BRPI0721905B1 (pt) 2020-11-17
LTPA2017010I1 (lt) 2017-05-10
IL203641A (en) 2015-11-30
ZA201000348B (en) 2011-03-30
IL242291A (en) 2017-12-31
CY2017016I1 (el) 2017-07-12
JP2010535759A (ja) 2010-11-25
KR101474831B1 (ko) 2014-12-19
SI2178888T1 (sl) 2012-11-30
AU2007357338B2 (en) 2014-03-20
KR20170004031A (ko) 2017-01-10
PT2178888E (pt) 2012-10-04
LTC2178888I2 (lt) 2018-03-12
KR101831674B1 (ko) 2018-02-23
UA97536C2 (en) 2012-02-27
CA2695082A1 (en) 2009-02-12
EP2178888A1 (en) 2010-04-28
IL242291A0 (en) 2015-11-30
IL242290A (en) 2017-12-31
EA028622B1 (ru) 2017-12-29
TN2010000060A1 (en) 2011-09-26
JP5261488B2 (ja) 2013-08-14
BRPI0721905A2 (pt) 2014-02-25
ES2390606T3 (es) 2012-11-14
EP3210987A1 (en) 2017-08-30
EP2178888B1 (en) 2012-07-04
NL300871I2 (nl) 2017-12-07
HRP20120745T1 (hr) 2012-10-31

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