KR20120053052A - 헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법 - Google Patents

헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법 Download PDF

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KR20120053052A
KR20120053052A KR1020127007526A KR20127007526A KR20120053052A KR 20120053052 A KR20120053052 A KR 20120053052A KR 1020127007526 A KR1020127007526 A KR 1020127007526A KR 20127007526 A KR20127007526 A KR 20127007526A KR 20120053052 A KR20120053052 A KR 20120053052A
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cancer
effective amount
composition
taxane
nanoparticles
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Korean (ko)
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춘린 타오
닐 피. 데사이
패트릭 순-시옹
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아브락시스 바이오사이언스, 엘엘씨
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127007526A 2009-08-25 2010-08-25 헤지호그 억제제 및 탁산의 나노입자 조성물로의 조합 요법 Ceased KR20120053052A (ko)

Applications Claiming Priority (2)

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US23681309P 2009-08-25 2009-08-25
US61/236,813 2009-08-25

Publications (1)

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KR20120053052A true KR20120053052A (ko) 2012-05-24

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US (2) US20130045240A1 (enExample)
EP (2) EP3103452A1 (enExample)
JP (1) JP2013503174A (enExample)
KR (1) KR20120053052A (enExample)
CN (1) CN102573832B (enExample)
AU (1) AU2010286670B2 (enExample)
BR (1) BR112012004149A2 (enExample)
CA (1) CA2772301A1 (enExample)
CR (1) CR20120115A (enExample)
DK (1) DK2470173T3 (enExample)
ES (1) ES2577024T3 (enExample)
HR (1) HRP20160551T8 (enExample)
HU (1) HUE029094T2 (enExample)
IL (1) IL218316A (enExample)
IN (1) IN2012DN02018A (enExample)
MX (1) MX340670B (enExample)
MY (1) MY162514A (enExample)
NI (1) NI201200030A (enExample)
NZ (1) NZ598588A (enExample)
PL (1) PL2470173T3 (enExample)
PT (1) PT2470173E (enExample)
RU (1) RU2561055C2 (enExample)
SG (2) SG178873A1 (enExample)
UA (1) UA110196C2 (enExample)
WO (1) WO2011025838A1 (enExample)
ZA (1) ZA201201531B (enExample)

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KR20160017039A (ko) * 2013-06-05 2016-02-15 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
KR20160030403A (ko) * 2013-07-11 2016-03-17 아지오스 파마슈티컬스 아이엔씨. 치료학적 활성 화합물 및 이들의 사용 방법
WO2023080575A1 (ko) * 2021-11-03 2023-05-11 주식회사 에스엔바이오사이언스 입도분포 유지 안정성이 개선된 알부민 결합 탄산 나노입자 제조방법
RU2846262C2 (ru) * 2021-11-03 2025-09-02 ЭсЭнБИОСАЙЕНС ИНК. Способ производства наночастиц таксана, связанного с альбумином, с повышенной стабильностью в отношении сохранения распределения частиц по размерам

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KR20160017039A (ko) * 2013-06-05 2016-02-15 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
KR20160030403A (ko) * 2013-07-11 2016-03-17 아지오스 파마슈티컬스 아이엔씨. 치료학적 활성 화합물 및 이들의 사용 방법
WO2023080575A1 (ko) * 2021-11-03 2023-05-11 주식회사 에스엔바이오사이언스 입도분포 유지 안정성이 개선된 알부민 결합 탄산 나노입자 제조방법
RU2846262C2 (ru) * 2021-11-03 2025-09-02 ЭсЭнБИОСАЙЕНС ИНК. Способ производства наночастиц таксана, связанного с альбумином, с повышенной стабильностью в отношении сохранения распределения частиц по размерам

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