RU2561055C2 - Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог - Google Patents

Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог Download PDF

Info

Publication number
RU2561055C2
RU2561055C2 RU2012111235/15A RU2012111235A RU2561055C2 RU 2561055 C2 RU2561055 C2 RU 2561055C2 RU 2012111235/15 A RU2012111235/15 A RU 2012111235/15A RU 2012111235 A RU2012111235 A RU 2012111235A RU 2561055 C2 RU2561055 C2 RU 2561055C2
Authority
RU
Russia
Prior art keywords
cancer
effective amount
albumin
taxane
nanoparticles
Prior art date
Application number
RU2012111235/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2012111235A (ru
Inventor
Чуньлинь ТАО
Нейл П. ДИСЭЙ
Патрик СООН-ШИОНГ
Original Assignee
АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи filed Critical АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи
Publication of RU2012111235A publication Critical patent/RU2012111235A/ru
Application granted granted Critical
Publication of RU2561055C2 publication Critical patent/RU2561055C2/ru

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5169Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2012111235/15A 2009-08-25 2010-08-25 Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог RU2561055C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23681309P 2009-08-25 2009-08-25
US61/236,813 2009-08-25
PCT/US2010/046684 WO2011025838A1 (en) 2009-08-25 2010-08-25 Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors

Publications (2)

Publication Number Publication Date
RU2012111235A RU2012111235A (ru) 2013-10-10
RU2561055C2 true RU2561055C2 (ru) 2015-08-20

Family

ID=43628371

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012111235/15A RU2561055C2 (ru) 2009-08-25 2010-08-25 Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог

Country Status (26)

Country Link
US (2) US20130045240A1 (enExample)
EP (2) EP3103452A1 (enExample)
JP (1) JP2013503174A (enExample)
KR (1) KR20120053052A (enExample)
CN (1) CN102573832B (enExample)
AU (1) AU2010286670B2 (enExample)
BR (1) BR112012004149A2 (enExample)
CA (1) CA2772301A1 (enExample)
CR (1) CR20120115A (enExample)
DK (1) DK2470173T3 (enExample)
ES (1) ES2577024T3 (enExample)
HR (1) HRP20160551T8 (enExample)
HU (1) HUE029094T2 (enExample)
IL (1) IL218316A (enExample)
IN (1) IN2012DN02018A (enExample)
MX (1) MX340670B (enExample)
MY (1) MY162514A (enExample)
NI (1) NI201200030A (enExample)
NZ (1) NZ598588A (enExample)
PL (1) PL2470173T3 (enExample)
PT (1) PT2470173E (enExample)
RU (1) RU2561055C2 (enExample)
SG (2) SG178873A1 (enExample)
UA (1) UA110196C2 (enExample)
WO (1) WO2011025838A1 (enExample)
ZA (1) ZA201201531B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2773750C2 (ru) * 2017-06-14 2022-06-09 Крититек, Инк. Способы лечения нарушений легких

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8853260B2 (en) * 1997-06-27 2014-10-07 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
EP1585548B1 (en) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
SI3248600T1 (sl) 2005-02-18 2020-09-30 Abraxis Bioscience, Llc Kombinacije in načini dajanja terapevtskih sredstev in kombinacijska terapija
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
PL1931321T3 (pl) 2005-08-31 2019-08-30 Abraxis Bioscience, Llc Kompozycje zawierające słabo rozpuszczalne w wodzie środki farmaceutyczne i środki przeciwdrobnoustrojowe
EP3470071A1 (en) * 2006-12-14 2019-04-17 Abraxis BioScience, LLC Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane
LT2481402T (lt) * 2007-03-07 2018-10-25 Abraxis Bioscience, Llc Nanodalelė, apimanti rapamiciną ir albuminą, kaip priešvėžinį agentą
WO2008150532A1 (en) * 2007-06-01 2008-12-11 Abraxis Bioscience, Llc Methods and compositions for treating recurrent cancer
EP2942346B1 (en) 2009-02-17 2020-05-06 Syntrix Biosystems, Inc. Pyridinecarboxamides as cxcr2 modulators
MX378130B (es) * 2009-04-15 2025-03-10 Abraxis Bioscience Llc Métodos y composiciones de nanopartículas sin priones.
PT2552438T (pt) 2010-03-26 2016-07-07 Abraxis Bioscience Llc Métodos de tratamento de carcinoma hepatocelular
AU2011232862B2 (en) 2010-03-29 2016-03-03 Abraxis Bioscience, Llc Methods of enhancing drug delivery and effectiveness of therapeutic agents
EP3141245A1 (en) 2010-03-29 2017-03-15 Abraxis BioScience, LLC Methods of treating cancer
US20130109672A1 (en) 2010-04-29 2013-05-02 The United States Of America,As Represented By The Secretary, Department Of Health And Human Service Activators of human pyruvate kinase
ES2639038T3 (es) * 2010-06-02 2017-10-25 Abraxis Bioscience, Llc Métodos para el tratamiento de cáncer de vejiga
BR112012030909A2 (pt) * 2010-06-04 2020-08-18 Abraxis Bioscience, Llc métodos de tratamento de câncer pancreático
AU2011264590B2 (en) * 2010-06-07 2016-12-15 Abraxis Bioscience, Llc Combination therapy methods for treating proliferative diseases
WO2012027289A1 (en) * 2010-08-23 2012-03-01 Syntrix Biosystems Inc. Aminopyridine- and aminopyrimidinecarboxamides as cxcr2 modulators
AU2012249371B2 (en) 2011-04-28 2017-06-08 Abraxis Bioscience, Llc Intravascular delivery of nanoparticle compositions and uses thereof
US8945627B2 (en) 2011-05-05 2015-02-03 Wisconsin Alumni Research Foundation Micelles for the solubilization of gossypol
RU2705998C2 (ru) 2011-12-14 2019-11-13 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Применение полимерных эксципиентов для лиофилизации или заморозки частиц
WO2013112859A1 (en) 2012-01-27 2013-08-01 New York University Method for enhancing remyelination using gli1 inhibitors
CN103570625A (zh) 2012-07-19 2014-02-12 南京英派药业有限公司 N-(3-杂芳基芳基)-4-芳基芳基甲酰胺和类似物作为Hedgehog通路抑制剂及其应用
WO2014062511A1 (en) * 2012-10-15 2014-04-24 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
US9149455B2 (en) 2012-11-09 2015-10-06 Abraxis Bioscience, Llc Methods of treating melanoma
WO2014087413A1 (en) * 2012-12-03 2014-06-12 Vishwa Vidya Peetham University Amrita Nanoparticles comprising sorafenib
US20140186447A1 (en) * 2012-12-28 2014-07-03 Abraxis Bioscience, Llc Nanoparticle compositions of albumin and paclitaxel
US20140199405A1 (en) * 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
US9511046B2 (en) 2013-01-11 2016-12-06 Abraxis Bioscience, Llc Methods of treating pancreatic cancer
US10744110B2 (en) * 2013-03-12 2020-08-18 Abraxis Bioscience, Llc Methods of treating lung cancer
CA2903548A1 (en) 2013-03-14 2014-09-25 Abraxis Bioscience, Llc Methods of treating bladder cancer
US9776996B2 (en) * 2013-03-15 2017-10-03 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
US9045477B2 (en) 2013-03-15 2015-06-02 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
WO2014179678A1 (en) * 2013-05-03 2014-11-06 Angiostrass Llc Methods of treating cancer and angioproliferative disorders
MX367554B (es) * 2013-06-05 2019-08-27 C&C Res Lab Derivados heterocíclicos y sus usos.
US9914740B2 (en) 2013-07-02 2018-03-13 Bristol-Myers Squibb Company Tricyclic pyrido-carboxamide derivatives as rock inhibitors
ES2634628T3 (es) 2013-07-02 2017-09-28 Bristol-Myers Squibb Company Derivados tricíclicos de pirido-carboxamida como inhibidores ROCK
WO2015003360A2 (en) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
US10561676B2 (en) 2013-08-02 2020-02-18 Syntrix Biosystems Inc. Method for treating cancer using dual antagonists of CXCR1 and CXCR2
US10046002B2 (en) 2013-08-02 2018-08-14 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
US8969365B2 (en) 2013-08-02 2015-03-03 Syntrix Biosystems, Inc. Thiopyrimidinecarboxamides as CXCR1/2 modulators
CA2922889A1 (en) 2013-09-17 2015-03-26 Genentech, Inc. Methods of using anti-lgr5 antibodies
GB201416513D0 (en) 2014-09-18 2014-11-05 Astex Therapeutics Ltd And Cancer Res Technology Ltd Pharmaceutical compounds
CN111170998B (zh) * 2014-11-05 2023-04-11 益方生物科技(上海)股份有限公司 嘧啶或吡啶类化合物、其制备方法和医药用途
KR20160066490A (ko) * 2014-12-02 2016-06-10 주식회사 씨앤드씨신약연구소 헤테로사이클 유도체 및 그의 용도
SG11201706989SA (en) 2015-02-27 2017-09-28 Curtana Pharmaceuticals Inc Inhibition of olig2 activity
US10705070B1 (en) 2015-03-05 2020-07-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and poorly water soluble drug
US10527604B1 (en) 2015-03-05 2020-01-07 Abraxis Bioscience, Llc Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
JP2018521021A (ja) 2015-06-11 2018-08-02 バジリア・ファルマスーチカ・インターナショナル・アーゲーBasilea Pharmaceutica International Ag 排出ポンプ阻害剤及びその治療的使用
KR102606071B1 (ko) 2015-06-29 2023-11-27 아브락시스 바이오사이언스, 엘엘씨 상피양 세포 종양을 치료하는 방법
CN106421786A (zh) * 2015-08-06 2017-02-22 复旦大学 Hedgehog通路抑制剂和纳米药物递送系统的药物组合物及其用途
JP2018052878A (ja) * 2016-09-29 2018-04-05 第一三共株式会社 ピリジン化合物
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
KR102837015B1 (ko) 2018-03-20 2025-07-23 아브락시스 바이오사이언스, 엘엘씨 mTOR 억제제 및 알부민의 나노입자의 투여를 통한 중추 신경계 장애의 치료 방법
CN114126656A (zh) 2019-05-29 2022-03-01 内卢姆公司 治疗癌症的方法和用途
CA3158764A1 (en) 2019-10-28 2021-05-06 Abraxis Bioscience, Llc Pharmaceutical compositions of albumin and rapamycin
CN112755042A (zh) * 2019-11-06 2021-05-07 绍兴维帆生物技术有限公司 一种抗肿瘤药物的联合使用治疗白血病的方法
KR102526793B1 (ko) * 2021-11-03 2023-04-28 주식회사 에스엔바이오사이언스 입도분포 유지 안정성이 개선된 알부민 결합 탁산 나노입자 제조방법
WO2025120550A1 (ko) * 2023-12-08 2025-06-12 제이더블유중외제약 주식회사 헤테로사이클 유도체 제조에 사용되는 중간체 화합물, 이의 제조 방법 및 이를 이용한 헤테로사이클 유도체의 제조 방법
TW202540116A (zh) * 2023-12-08 2025-10-16 韓商Jw製藥公司 用於製備雜環衍生物之中間化合物、其製備方法及使用其製備雜環衍生物之方法
CN120177781B (zh) * 2025-05-22 2025-08-12 南京师范大学 生物传感器及其应用和高通量筛选花姜酮生产菌的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187062A1 (en) * 2002-03-29 2003-10-02 Acs Dobfar S.P.A. Paclitaxel-based antitumor formulation
WO2004103369A1 (en) * 2003-05-26 2004-12-02 Schering Aktiengesellschaft Pharmaceutical composition containing histone deacetylase inhibitor
WO2006039569A1 (en) * 2004-09-30 2006-04-13 The University Of Chicago Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents
WO2007082978A1 (es) * 2006-01-20 2007-07-26 Eriochem S.A. Una formulación farmacéutica de taxano, una composición sólida de taxano, un procedimiento para la preparación de dicha composición sólida de taxano, una composición solubilizante de dicha composición sólida de taxano, y un conjunto de elementos (kit) par

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6537579B1 (en) 1993-02-22 2003-03-25 American Bioscience, Inc. Compositions and methods for administration of pharmacologically active compounds
US5916596A (en) 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US20070116761A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6749868B1 (en) 1993-02-22 2004-06-15 American Bioscience, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
NZ502500A (en) * 1997-06-27 2002-03-28 Vivorx Pharmaceuticals Inc Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
IL142905A0 (en) 1998-11-02 2002-04-21 Biogen Inc Functional antagonists of hedgehog activity
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
EP1119368A2 (en) 1999-03-03 2001-08-01 Biogen, Inc. Methods of modulating lipid metabolism and storage
EP1183271A1 (en) 1999-06-01 2002-03-06 Biogen, Inc. Polymer conjugates of hedgehog proteins and uses
US7708998B2 (en) 2000-10-13 2010-05-04 Curis, Inc. Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
US20050192262A1 (en) * 2001-03-13 2005-09-01 Tomas Hagstrom Treatment of tumours
AU2002327390B2 (en) 2001-07-27 2008-06-26 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
US7655674B2 (en) 2002-04-22 2010-02-02 The Johns Hopkins University Modulators of hedgehog signaling pathways, compositions and uses related thereto
EP1585548B1 (en) 2002-12-09 2018-06-27 Abraxis BioScience, LLC Compositions and methods of delivery of pharmacological agents
FR2850022B1 (fr) * 2003-01-22 2006-09-08 Centre Nat Rech Scient Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications
EP1807074B1 (en) * 2004-11-03 2013-10-23 Curis, Inc. Mediators of hedgehog signaling pathways, compositions and uses related thereto
SI3248600T1 (sl) * 2005-02-18 2020-09-30 Abraxis Bioscience, Llc Kombinacije in načini dajanja terapevtskih sredstev in kombinacijska terapija
EP3527202A1 (en) 2005-08-31 2019-08-21 Abraxis BioScience, LLC Compositions and methods for preparation of poorly water soluble drugs with increased stability
WO2007056135A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Method of treating cancers with saha and pemetrexed
EP1998785A4 (en) 2006-02-21 2009-06-17 Univ Michigan TREATMENT OF CANCER BY AN ANTAGONIST OF THE HEDGEHOG SIGNALING PATH
DE102006038747A1 (de) 2006-08-17 2008-03-20 Khs Ag Dichtanordnung für eine Drehlagervorrichtung
JP4897518B2 (ja) 2007-03-02 2012-03-14 株式会社ニチベイ ブラインドの操作装置
AU2008224941C1 (en) * 2007-03-14 2013-06-27 Exelixis Patent Company Llc Inhibitors of the hedgehog pathway
KR101473504B1 (ko) * 2007-03-15 2014-12-16 노파르티스 아게 유기 화합물 및 그의 용도
CA2686736A1 (en) 2007-05-03 2008-11-13 Abraxis Bioscience, Llc Nanoparticle compositions comprising rapamycin for treating pulmonary hypertension
AU2008262056A1 (en) * 2007-06-07 2008-12-18 Irm Llc Biphenylcarboxamide derivatives as hedgehog pathway modulators
US20090123932A1 (en) * 2007-11-09 2009-05-14 Anne-Marie Mes-Masson Quantitative test to detect disease progression markers of epithelial ovarian cancer patients
CA2710377A1 (en) * 2007-12-27 2009-07-09 Infinity Pharmaceuticals, Inc. Therapeutic cancer treatments
US8030454B2 (en) * 2007-12-28 2011-10-04 Genentech, Inc. Anti-hedgehog antibodies

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030187062A1 (en) * 2002-03-29 2003-10-02 Acs Dobfar S.P.A. Paclitaxel-based antitumor formulation
WO2004103369A1 (en) * 2003-05-26 2004-12-02 Schering Aktiengesellschaft Pharmaceutical composition containing histone deacetylase inhibitor
WO2006039569A1 (en) * 2004-09-30 2006-04-13 The University Of Chicago Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents
WO2007082978A1 (es) * 2006-01-20 2007-07-26 Eriochem S.A. Una formulación farmacéutica de taxano, una composición sólida de taxano, un procedimiento para la preparación de dicha composición sólida de taxano, una composición solubilizante de dicha composición sólida de taxano, y un conjunto de elementos (kit) par

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LOBO C. et al., Paclitaxel albumin-bound particles (abraxane) in combination with bevacizumab with or without gemcitabine: early experience at the University of Miami/Braman Family Breast Cancer Institute.Biomed Pharmacother. 2007 Oct;61(9):531-3. Epub 2007 Sep 12. Найдено из Интернета [он-лайн] 8.12.2014 на сайте http://www.ncbi.nlm.nih.gov/pubmed/17913443 -реферат *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2773750C2 (ru) * 2017-06-14 2022-06-09 Крититек, Инк. Способы лечения нарушений легких

Also Published As

Publication number Publication date
SG178873A1 (en) 2012-04-27
IN2012DN02018A (enExample) 2015-07-31
JP2013503174A (ja) 2013-01-31
EP2470173A1 (en) 2012-07-04
CN102573832A (zh) 2012-07-11
CN102573832B (zh) 2015-07-22
NI201200030A (es) 2012-12-06
HRP20160551T1 (hr) 2016-09-23
RU2012111235A (ru) 2013-10-10
MY162514A (en) 2017-06-15
US20140072630A1 (en) 2014-03-13
CA2772301A1 (en) 2011-03-03
DK2470173T3 (en) 2016-06-06
ES2577024T3 (es) 2016-07-12
BR112012004149A2 (pt) 2016-03-22
AU2010286670B2 (en) 2016-04-21
EP2470173A4 (en) 2013-06-19
AU2010286670A1 (en) 2012-03-29
IL218316A0 (en) 2012-04-30
PL2470173T3 (pl) 2016-11-30
IL218316A (en) 2016-04-21
SG10201609290PA (en) 2016-12-29
ZA201201531B (en) 2013-05-29
CR20120115A (es) 2012-09-04
MX340670B (es) 2016-07-20
HUE029094T2 (hu) 2017-02-28
MX2012002460A (es) 2012-05-08
WO2011025838A1 (en) 2011-03-03
US20130045240A1 (en) 2013-02-21
HK1172550A1 (zh) 2013-04-26
EP2470173B1 (en) 2016-04-27
KR20120053052A (ko) 2012-05-24
HRP20160551T8 (hr) 2016-11-18
PT2470173E (pt) 2016-06-15
NZ598588A (en) 2014-05-30
EP3103452A1 (en) 2016-12-14
UA110196C2 (uk) 2015-12-10

Similar Documents

Publication Publication Date Title
RU2561055C2 (ru) Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог
AU2018201514B2 (en) Combinations and modes of administration of therapeutic agents and combination therapy
CA2793536C (en) Use of nanoparticles comprising a taxane and albumin in the treatment of hepatocellular carcinoma
AU2011264590B2 (en) Combination therapy methods for treating proliferative diseases
JP5725563B2 (ja) チオコルヒチン誘導体との組み合わせ療法
SG186112A1 (en) Methods of treatment of pancreatic cancer
HK1172550B (en) Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
HK1181665B (en) Methods of treatment of hepatocellular carcinoma
HK1165957B (en) Combination therapy with thiocolchicine derivatives
HK1165957A (en) Combination therapy with thiocolchicine derivatives