KR20120034613A - 키나아제 억제제로서 사용을 위한 이미다조피라진 - Google Patents

키나아제 억제제로서 사용을 위한 이미다조피라진 Download PDF

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KR20120034613A
KR20120034613A KR1020117027154A KR20117027154A KR20120034613A KR 20120034613 A KR20120034613 A KR 20120034613A KR 1020117027154 A KR1020117027154 A KR 1020117027154A KR 20117027154 A KR20117027154 A KR 20117027154A KR 20120034613 A KR20120034613 A KR 20120034613A
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호아킨 패스토르 페르난데즈
소니아 마르티네즈 콘잘레스
율렌 오야르자발 산타마리나
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센트로 내셔널 드 인베스티가시오네스 온콜로지카스 (씨엔아이오)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
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  • AIDS & HIV (AREA)
KR1020117027154A 2009-04-16 2010-04-16 키나아제 억제제로서 사용을 위한 이미다조피라진 Ceased KR20120034613A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09380079 2009-04-16
EP09380079.5 2009-04-16

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KR1020177028146A Division KR101792837B1 (ko) 2009-04-16 2010-04-16 키나아제 억제제로서 사용을 위한 이미다조피라진

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KR1020117027154A Ceased KR20120034613A (ko) 2009-04-16 2010-04-16 키나아제 억제제로서 사용을 위한 이미다조피라진
KR1020177028146A Active KR101792837B1 (ko) 2009-04-16 2010-04-16 키나아제 억제제로서 사용을 위한 이미다조피라진

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US (1) US8778935B2 (enExample)
EP (1) EP2419429B1 (enExample)
JP (1) JP5805623B2 (enExample)
KR (2) KR20120034613A (enExample)
CN (1) CN102428087B (enExample)
AU (1) AU2010238361B2 (enExample)
BR (1) BRPI1014572B8 (enExample)
CA (1) CA2756759C (enExample)
DK (1) DK2419429T3 (enExample)
EA (1) EA022629B1 (enExample)
ES (1) ES2475091T3 (enExample)
IL (1) IL215297A (enExample)
MX (1) MX2011010915A (enExample)
NZ (1) NZ596185A (enExample)
SG (1) SG175195A1 (enExample)
WO (1) WO2010119264A1 (enExample)
ZA (1) ZA201107717B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
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KR20190005876A (ko) * 2016-04-15 2019-01-16 블루프린트 메디신즈 코포레이션 액티빈 수용체 유사 키나아제의 저해제
KR20190095403A (ko) * 2016-12-21 2019-08-14 아세르타 파마. 비.브이. 브루톤 티로신 키나제의 이미다조피라진 저해제

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RU2569678C2 (ru) 2010-04-22 2015-11-27 Вертекс Фармасьютикалз Инкорпорейтед Способ получения циклоалкилкарбоксамидо-индольных соединений
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WO2012052745A1 (en) 2010-10-21 2012-04-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Combinations of pi3k inhibitors with a second anti -tumor agent
EP2444084A1 (en) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Use of PI3K inibitors for the treatment of obesity
TWI617559B (zh) 2010-12-22 2018-03-11 江蘇恆瑞醫藥股份有限公司 ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物
EP2524918A1 (en) 2011-05-19 2012-11-21 Centro Nacional de Investigaciones Oncológicas (CNIO) Imidazopyrazines derivates as kinase inhibitors
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
PL2841075T3 (pl) 2012-04-26 2020-09-21 The General Hospital Corporation Środki i sposoby leczenia i zapobiegania rogowaceniu łojotokowemu
CN103450204B (zh) * 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
CN102675323B (zh) * 2012-06-01 2014-04-09 南京药石药物研发有限公司 吡咯并[2,1-f][1,2,4]三嗪衍生物及其抗肿瘤用途
WO2014001314A1 (en) 2012-06-26 2014-01-03 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en) 2012-07-09 2017-03-30 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
US9145411B2 (en) 2012-08-02 2015-09-29 Asana Biosciences, Llc Substituted amino-pyrimidine derivatives
WO2014186663A2 (en) * 2013-05-17 2014-11-20 The General Hospital Corporation Methods for detecting and treating variants of seborrheic keratoses
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
LT3105218T (lt) 2014-02-13 2019-12-10 Incyte Corp Ciklopropilaminai kaip lsd1 inhibitoriai
EP3392244A1 (en) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2015123424A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
PL3925607T5 (pl) 2014-04-15 2026-06-01 Vertex Pharmaceuticals Incorporated Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
WO2016007736A1 (en) * 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
PL236355B1 (pl) * 2015-04-02 2021-01-11 Celon Pharma Spolka Akcyjna Pochodne 7-(morfolin-4-ylo)pirazolo[1,5-α]pirymidyny jako inhibitory kinazy PI3
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