KR20110042153A - 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 - Google Patents

퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 Download PDF

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Publication number
KR20110042153A
KR20110042153A KR1020107026673A KR20107026673A KR20110042153A KR 20110042153 A KR20110042153 A KR 20110042153A KR 1020107026673 A KR1020107026673 A KR 1020107026673A KR 20107026673 A KR20107026673 A KR 20107026673A KR 20110042153 A KR20110042153 A KR 20110042153A
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South Korea
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purin
morpholino
compound
alkylene
methyl
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Korean (ko)
Inventor
조젯트 카스타네도
이리나 추코우리
아드리안 폴케스
다니엘 피. 서덜린
난 치 완
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제넨테크, 인크.
에프. 호프만-라 로슈 아게
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Publication of KR20110042153A publication Critical patent/KR20110042153A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107026673A 2008-05-30 2009-05-29 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법 Ceased KR20110042153A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5755908P 2008-05-30 2008-05-30
US61/057,559 2008-05-30

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KR20110042153A true KR20110042153A (ko) 2011-04-25

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KR1020107026673A Ceased KR20110042153A (ko) 2008-05-30 2009-05-29 퓨린 ｐｉ３ｋ 억제 화합물 및 사용 방법

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US (2) US8158624B2 (https=)
EP (1) EP2279188B1 (https=)
JP (1) JP2011521968A (https=)
KR (1) KR20110042153A (https=)
CN (1) CN102105474B (https=)
AU (1) AU2009251291B2 (https=)
BR (1) BRPI0909614A2 (https=)
CA (1) CA2721851A1 (https=)
ES (1) ES2533788T3 (https=)
IL (1) IL208838A0 (https=)
MX (1) MX2010012583A (https=)
RU (1) RU2509081C2 (https=)
WO (1) WO2009146406A1 (https=)
ZA (1) ZA201007524B (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180011068A (ko) * 2015-04-21 2018-01-31 구이저우 바이링 엔터프라이즈 그룹 파마슈티컬 컴퍼니 리미티드 퓨리닐-n-하이드록실 피리미딘 포름아미드 유도체, 이의 제조 방법 및 용도
KR20210069664A (ko) * 2018-09-27 2021-06-11 상하이 잉리 파마슈티컬 컴퍼니 리미티드 모르폴리노 퀴나졸린계 화합물의 결정형태, 이의 제조방법 및 용도

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JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
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US8158625B2 (en) * 2009-05-27 2012-04-17 Genentech, Inc. Bicyclic indole-pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use
JP5579864B2 (ja) * 2009-11-12 2014-08-27 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Ｎ−９−置換プリン化合物、組成物及び使用の方法
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JP2013545749A (ja) 2010-11-10 2013-12-26 インフィニティー ファーマシューティカルズ， インコーポレイテッド 複素環化合物及びその使用
TW201500358A (zh) 2010-12-16 2015-01-01 赫夫門羅氏藥廠股份有限公司 三環ｐｉ３ｋ抑制劑化合物及其使用方法
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US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
KR20160027219A (ko) 2012-05-23 2016-03-09 에프. 호프만-라 로슈 아게 내배엽 및 간세포를 수득하고 사용하는 조성물 및 방법
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
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CN103936742B (zh) * 2013-01-17 2017-05-03 程鹏 含嘌呤基的新型pi3k抑制剂及其制备方法和应用
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
CN105209466B (zh) * 2013-05-02 2018-05-18 豪夫迈·罗氏有限公司 作为cb2受体激动剂的嘌呤衍生物
TW201520215A (zh) * 2013-05-13 2015-06-01 Daiichi Sankyo Co Ltd Ｎ－□啉基嘌呤衍生物之製造方法
PT3052485T (pt) 2013-10-04 2021-10-22 Infinity Pharmaceuticals Inc Compostos heterocíclicos e suas utilizações
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CN104557872B (zh) * 2013-10-16 2017-05-24 上海璎黎药业有限公司 稠合杂环化合物、其制备方法、药物组合物和用途
CN103804380B (zh) * 2014-01-24 2016-05-18 温州医科大学 以IKK-β为靶点的2-氨基-8-取代鸟嘌呤衍生物、应用及其制备方法
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JP6871919B2 (ja) 2015-06-16 2021-05-19 ナノファギックス エルエルシー 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
KR20180011068A (ko) * 2015-04-21 2018-01-31 구이저우 바이링 엔터프라이즈 그룹 파마슈티컬 컴퍼니 리미티드 퓨리닐-n-하이드록실 피리미딘 포름아미드 유도체, 이의 제조 방법 및 용도
KR20210069664A (ko) * 2018-09-27 2021-06-11 상하이 잉리 파마슈티컬 컴퍼니 리미티드 모르폴리노 퀴나졸린계 화합물의 결정형태, 이의 제조방법 및 용도

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Publication number Publication date
ZA201007524B (en) 2012-01-25
AU2009251291A1 (en) 2009-12-03
WO2009146406A1 (en) 2009-12-03
CN102105474A (zh) 2011-06-22
US8445487B2 (en) 2013-05-21
RU2010154428A (ru) 2012-07-10
US20090318411A1 (en) 2009-12-24
EP2279188A1 (en) 2011-02-02
AU2009251291B2 (en) 2013-05-02
ES2533788T3 (es) 2015-04-14
CN102105474B (zh) 2014-01-08
RU2509081C2 (ru) 2014-03-10
CA2721851A1 (en) 2009-12-03
BRPI0909614A2 (pt) 2015-09-22
IL208838A0 (en) 2011-01-31
US8158624B2 (en) 2012-04-17
JP2011521968A (ja) 2011-07-28
EP2279188B1 (en) 2015-01-28
MX2010012583A (es) 2011-02-24
US20120135988A1 (en) 2012-05-31

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