KR20090109102A - 바이러스 감염의 치료를 위한 신규 뉴클레오시드 유사체 - Google Patents
바이러스 감염의 치료를 위한 신규 뉴클레오시드 유사체 Download PDFInfo
- Publication number
- KR20090109102A KR20090109102A KR1020097016580A KR20097016580A KR20090109102A KR 20090109102 A KR20090109102 A KR 20090109102A KR 1020097016580 A KR1020097016580 A KR 1020097016580A KR 20097016580 A KR20097016580 A KR 20097016580A KR 20090109102 A KR20090109102 A KR 20090109102A
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- South Korea
- Prior art keywords
- virus
- compound
- ethynyl
- alkynyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- 238000005507 spraying Methods 0.000 description 1
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- YRALAIOMGQZKOW-UHFFFAOYSA-N sulfated caerulein Natural products C=1C=CC=CC=1CC(C(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C1NC(=O)CC1)CC1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-UHFFFAOYSA-N 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
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- 229960000894 sulindac Drugs 0.000 description 1
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- 230000002195 synergetic effect Effects 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- NHKZSTHOYNWEEZ-AFCXAGJDSA-N taribavirin Chemical compound N1=C(C(=N)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NHKZSTHOYNWEEZ-AFCXAGJDSA-N 0.000 description 1
- 229950006081 taribavirin Drugs 0.000 description 1
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- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 description 1
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- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229960001017 tolmetin Drugs 0.000 description 1
- UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
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- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000004072 triols Chemical class 0.000 description 1
- 229940093257 valacyclovir Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
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- 235000019871 vegetable fat Nutrition 0.000 description 1
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- 229960003636 vidarabine Drugs 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
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- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07102027.5 | 2007-02-09 | ||
| EP07102027 | 2007-02-09 | ||
| EP08150003 | 2008-01-02 | ||
| EP08150003.5 | 2008-01-02 | ||
| PCT/EP2008/051527 WO2008095993A1 (en) | 2007-02-09 | 2008-02-07 | Novel nucleoside analogs for treatment of viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20090109102A true KR20090109102A (ko) | 2009-10-19 |
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|---|---|---|---|
| KR1020097016580A Ceased KR20090109102A (ko) | 2007-02-09 | 2008-02-07 | 바이러스 감염의 치료를 위한 신규 뉴클레오시드 유사체 |
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|---|---|
| US (1) | US8278282B2 (enExample) |
| EP (1) | EP2132216B1 (enExample) |
| JP (1) | JP2010518047A (enExample) |
| KR (1) | KR20090109102A (enExample) |
| CN (1) | CN101600726B (enExample) |
| AR (1) | AR065249A1 (enExample) |
| AT (1) | ATE533774T1 (enExample) |
| AU (1) | AU2008212752A1 (enExample) |
| BR (1) | BRPI0807222A2 (enExample) |
| CA (1) | CA2675462A1 (enExample) |
| CL (1) | CL2008000409A1 (enExample) |
| EA (1) | EA200901080A1 (enExample) |
| ES (1) | ES2381093T3 (enExample) |
| MX (1) | MX2009008495A (enExample) |
| PE (1) | PE20090070A1 (enExample) |
| PT (1) | PT2132216E (enExample) |
| TW (1) | TW200838550A (enExample) |
| WO (1) | WO2008095993A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR072906A1 (es) * | 2008-08-06 | 2010-09-29 | Novartis Ag | Nucleosidos modificados utiles como antivirales |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| MX2018001073A (es) | 2015-08-06 | 2018-06-12 | Chimerix Inc | Nucleosidos de pirrolopirimidina y analogos de los mismos utiles como agentes antivirales. |
| US10953029B2 (en) | 2015-09-23 | 2021-03-23 | Merck Sharp & Dohme Corp. | 4′-Substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
| CA3022119A1 (en) * | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| WO2018031818A2 (en) * | 2016-08-12 | 2018-02-15 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| WO2019060692A1 (en) | 2017-09-21 | 2019-03-28 | Chimerix, Inc. | MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES |
| US11718534B2 (en) | 2019-04-23 | 2023-08-08 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| AU2022422062B2 (en) * | 2021-12-22 | 2025-08-14 | Cj Cheiljedang Corporation | Antiviral composition comprising nucleoside analogues derived from nucleic acid and pharmaceutically acceptable salt thereof |
| CN117430571B (zh) * | 2022-07-15 | 2025-08-29 | 宜昌东阳光长江药业股份有限公司 | 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| SK286630B6 (sk) * | 2001-01-22 | 2009-02-05 | Merck & Co., Inc. | Nukleozidové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| JP2005511764A (ja) * | 2001-12-14 | 2005-04-28 | アルコン，インコーポレイテッド | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
| WO2003068244A1 (en) | 2002-02-13 | 2003-08-21 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| CA2484921A1 (en) | 2002-05-06 | 2003-11-13 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| EP1572097A4 (en) | 2002-09-30 | 2010-02-17 | Smithkline Beecham Corp | NUCLEOSIDE DERIVATIVES FOR THE TREATMENT OF INFECTIONS WITH THE HEPATITIS C-VIRUS |
| US20040259934A1 (en) * | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| EP1680436A1 (en) * | 2003-10-27 | 2006-07-19 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
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- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
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- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100227833A1 (en) | 2010-09-09 |
| PE20090070A1 (es) | 2009-03-19 |
| MX2009008495A (es) | 2009-08-20 |
| EP2132216B1 (en) | 2011-11-16 |
| CA2675462A1 (en) | 2008-08-14 |
| ES2381093T3 (es) | 2012-05-23 |
| AR065249A1 (es) | 2009-05-27 |
| EP2132216A1 (en) | 2009-12-16 |
| EA200901080A1 (ru) | 2010-02-26 |
| CL2008000409A1 (es) | 2008-08-29 |
| AU2008212752A1 (en) | 2008-08-14 |
| TW200838550A (en) | 2008-10-01 |
| CN101600726A (zh) | 2009-12-09 |
| PT2132216E (pt) | 2012-02-20 |
| US8278282B2 (en) | 2012-10-02 |
| BRPI0807222A2 (pt) | 2014-04-29 |
| CN101600726B (zh) | 2013-03-27 |
| JP2010518047A (ja) | 2010-05-27 |
| ATE533774T1 (de) | 2011-12-15 |
| WO2008095993A1 (en) | 2008-08-14 |
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