AR065249A1 - Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales. - Google Patents
Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales.Info
- Publication number
- AR065249A1 AR065249A1 ARP080100529A ARP080100529A AR065249A1 AR 065249 A1 AR065249 A1 AR 065249A1 AR P080100529 A ARP080100529 A AR P080100529A AR P080100529 A ARP080100529 A AR P080100529A AR 065249 A1 AR065249 A1 AR 065249A1
- Authority
- AR
- Argentina
- Prior art keywords
- nitrogenate
- condensed
- treat
- derivatives
- pharmaceutical compositions
- Prior art date
Links
- VZQXUWKZDSEQRR-UHFFFAOYSA-N Nucleosid Natural products C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1C1OC(CO)C(O)C1O VZQXUWKZDSEQRR-UHFFFAOYSA-N 0.000 title 1
- 208000036142 Viral infection Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000000304 alkynyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 nitro, hydroxyl Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07102027 | 2007-02-09 | ||
| EP08150003 | 2008-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065249A1 true AR065249A1 (es) | 2009-05-27 |
Family
ID=39462074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100529A AR065249A1 (es) | 2007-02-09 | 2008-02-07 | Derivados nitrogenados condensados de analogos de nucleosidos, composiciones farmaceuticas que los contienen y usos para tratar y/o prevenir infecciones virales. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8278282B2 (enExample) |
| EP (1) | EP2132216B1 (enExample) |
| JP (1) | JP2010518047A (enExample) |
| KR (1) | KR20090109102A (enExample) |
| CN (1) | CN101600726B (enExample) |
| AR (1) | AR065249A1 (enExample) |
| AT (1) | ATE533774T1 (enExample) |
| AU (1) | AU2008212752A1 (enExample) |
| BR (1) | BRPI0807222A2 (enExample) |
| CA (1) | CA2675462A1 (enExample) |
| CL (1) | CL2008000409A1 (enExample) |
| EA (1) | EA200901080A1 (enExample) |
| ES (1) | ES2381093T3 (enExample) |
| MX (1) | MX2009008495A (enExample) |
| PE (1) | PE20090070A1 (enExample) |
| PT (1) | PT2132216E (enExample) |
| TW (1) | TW200838550A (enExample) |
| WO (1) | WO2008095993A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| KR102630013B1 (ko) | 2015-08-06 | 2024-01-25 | 키메릭스 인크. | 항바이러스제로서 유용한 피롤로피리미딘 뉴클레오시드 및 그의 유사체 |
| KR102185996B1 (ko) | 2015-09-23 | 2020-12-02 | 머크 샤프 앤드 돔 코포레이션 | 4'-치환된 뉴클레오시드 리버스 트랜스크립타제 억제제 및 그의 제조법 |
| EA201892448A1 (ru) * | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| MA45925A (fr) * | 2016-08-12 | 2019-06-19 | Janssen Biopharma Inc | Nucléosides et nucléotides substitués et leurs analogues |
| US11111264B2 (en) | 2017-09-21 | 2021-09-07 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof |
| WO2020219447A1 (en) | 2019-04-23 | 2020-10-29 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| JP2024545703A (ja) * | 2021-12-22 | 2024-12-10 | シージェイ チェルジェダン コーポレイション | 核酸由来ヌクレオシドアナログおよびこれらの薬学的に許容可能な塩を含む抗ウイルス用組成物 |
| WO2024012568A1 (en) * | 2022-07-15 | 2024-01-18 | Sunshine Lake Pharma Co., Ltd. | A key intermediate for preparing glucopyranosyl derivatives and preparation method thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DZ3487A1 (fr) * | 2001-01-22 | 2002-07-25 | Merck Sharp & Dohme | Derives de nucleoside comme inhibiteurs de l'arn polymerase virale d'arn-dependant |
| JP2005511764A (ja) | 2001-12-14 | 2005-04-28 | アルコン，インコーポレイテッド | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
| US7323453B2 (en) | 2002-02-13 | 2008-01-29 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| US20040063658A1 (en) * | 2002-05-06 | 2004-04-01 | Roberts Christopher Don | Nucleoside derivatives for treating hepatitis C virus infection |
| TW200418498A (en) * | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| US20040259934A1 (en) | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| MXPA06004680A (es) * | 2003-10-27 | 2007-04-17 | Genelabs Tech Inc | Compuestos de nucleosido para el tratamiento de infecciones virales. |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 US US12/526,079 patent/US8278282B2/en not_active Expired - Fee Related
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 MX MX2009008495A patent/MX2009008495A/es active IP Right Grant
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2132216A1 (en) | 2009-12-16 |
| ATE533774T1 (de) | 2011-12-15 |
| PE20090070A1 (es) | 2009-03-19 |
| CN101600726B (zh) | 2013-03-27 |
| KR20090109102A (ko) | 2009-10-19 |
| US20100227833A1 (en) | 2010-09-09 |
| BRPI0807222A2 (pt) | 2014-04-29 |
| CL2008000409A1 (es) | 2008-08-29 |
| CA2675462A1 (en) | 2008-08-14 |
| TW200838550A (en) | 2008-10-01 |
| PT2132216E (pt) | 2012-02-20 |
| MX2009008495A (es) | 2009-08-20 |
| EP2132216B1 (en) | 2011-11-16 |
| JP2010518047A (ja) | 2010-05-27 |
| US8278282B2 (en) | 2012-10-02 |
| EA200901080A1 (ru) | 2010-02-26 |
| WO2008095993A1 (en) | 2008-08-14 |
| CN101600726A (zh) | 2009-12-09 |
| AU2008212752A1 (en) | 2008-08-14 |
| ES2381093T3 (es) | 2012-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |