TW200838550A - Organic compounds - Google Patents

Organic compounds Download PDF

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Publication number
TW200838550A
TW200838550A TW097104689A TW97104689A TW200838550A TW 200838550 A TW200838550 A TW 200838550A TW 097104689 A TW097104689 A TW 097104689A TW 97104689 A TW97104689 A TW 97104689A TW 200838550 A TW200838550 A TW 200838550A
Authority
TW
Taiwan
Prior art keywords
group
virus
compound
doc
alkynyl
Prior art date
Application number
TW097104689A
Other languages
English (en)
Chinese (zh)
Inventor
Zheng Yin
Jeyaraj Duraiswamy
Yen-Liang Chen
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39462074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200838550(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TW200838550A publication Critical patent/TW200838550A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW097104689A 2007-02-09 2008-02-05 Organic compounds TW200838550A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07102027 2007-02-09
EP08150003 2008-01-02

Publications (1)

Publication Number Publication Date
TW200838550A true TW200838550A (en) 2008-10-01

Family

ID=39462074

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097104689A TW200838550A (en) 2007-02-09 2008-02-05 Organic compounds

Country Status (18)

Country Link
US (1) US8278282B2 (enExample)
EP (1) EP2132216B1 (enExample)
JP (1) JP2010518047A (enExample)
KR (1) KR20090109102A (enExample)
CN (1) CN101600726B (enExample)
AR (1) AR065249A1 (enExample)
AT (1) ATE533774T1 (enExample)
AU (1) AU2008212752A1 (enExample)
BR (1) BRPI0807222A2 (enExample)
CA (1) CA2675462A1 (enExample)
CL (1) CL2008000409A1 (enExample)
EA (1) EA200901080A1 (enExample)
ES (1) ES2381093T3 (enExample)
MX (1) MX2009008495A (enExample)
PE (1) PE20090070A1 (enExample)
PT (1) PT2132216E (enExample)
TW (1) TW200838550A (enExample)
WO (1) WO2008095993A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015643A1 (en) * 2008-08-06 2010-02-11 Novartis Ag New antiviral modified nucleosides
CN102526087B (zh) * 2010-12-30 2014-09-03 南开大学 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用
CN105669783B (zh) * 2014-12-03 2019-11-12 广东东阳光药业有限公司 一种制备呋喃糖的方法
JP2018523665A (ja) 2015-08-06 2018-08-23 キメリックス インコーポレイテッド 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体
JP6768796B2 (ja) 2015-09-23 2020-10-14 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製
EA201892448A1 (ru) * 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения
TW201815821A (zh) * 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
TW201811339A (zh) * 2016-08-12 2018-04-01 美商艾洛斯生物製藥公司 經取代之核苷、核苷酸及其類似物
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
US11718534B2 (en) 2019-04-23 2023-08-08 Elementis Specialties, Inc. Slurry compositions containing mixed branched alkyl organoclay compositions
EP4454650A4 (en) * 2021-12-22 2025-10-22 Cj Cheiljedang Corp ANTIVIRAL COMPOSITION COMPRISING NUCLEOSIDE ANALOGUES DERIVED FROM A NUCLEIC ACID AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
CN117430571B (zh) * 2022-07-15 2025-08-29 宜昌东阳光长江药业股份有限公司 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1355916T1 (sl) * 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
AU2002346671B2 (en) 2001-12-14 2005-08-11 Alcon, Inc. Aminoalkyl-benzofuran-5-OL compounds for the treatment of glaucoma
US7323453B2 (en) * 2002-02-13 2008-01-29 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
MXPA04010983A (es) * 2002-05-06 2005-02-14 Genelabs Tech Inc Derivados de nucleosidos para tratar infecciones por el virus de la hepatitis c.
NZ538457A (en) * 2002-09-30 2008-04-30 Genelabs Tech Inc Nucleoside derivatives for treating hepatitis C virus infection
US20040259934A1 (en) * 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
KR20060096487A (ko) * 2003-10-27 2006-09-11 진랩스 테크놀러지스, 인크. 바이러스 감염증들을 치료하기 위한 뉴클레오시드 화합물

Also Published As

Publication number Publication date
MX2009008495A (es) 2009-08-20
EP2132216A1 (en) 2009-12-16
KR20090109102A (ko) 2009-10-19
US8278282B2 (en) 2012-10-02
PE20090070A1 (es) 2009-03-19
PT2132216E (pt) 2012-02-20
US20100227833A1 (en) 2010-09-09
CN101600726B (zh) 2013-03-27
EP2132216B1 (en) 2011-11-16
CN101600726A (zh) 2009-12-09
CL2008000409A1 (es) 2008-08-29
ES2381093T3 (es) 2012-05-23
CA2675462A1 (en) 2008-08-14
EA200901080A1 (ru) 2010-02-26
ATE533774T1 (de) 2011-12-15
AR065249A1 (es) 2009-05-27
BRPI0807222A2 (pt) 2014-04-29
WO2008095993A1 (en) 2008-08-14
AU2008212752A1 (en) 2008-08-14
JP2010518047A (ja) 2010-05-27

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