ES2381093T3 - Nuevos analogos de nucleosido para el tratamiento de infecciones virales - Google Patents
Nuevos analogos de nucleosido para el tratamiento de infecciones virales Download PDFInfo
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- ES2381093T3 ES2381093T3 ES08708805T ES08708805T ES2381093T3 ES 2381093 T3 ES2381093 T3 ES 2381093T3 ES 08708805 T ES08708805 T ES 08708805T ES 08708805 T ES08708805 T ES 08708805T ES 2381093 T3 ES2381093 T3 ES 2381093T3
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- Prior art keywords
- virus
- compound
- ethynyl
- pyrrolo
- compounds
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
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| EP07102027 | 2007-02-09 | ||
| EP07102027 | 2007-02-09 | ||
| EP08150003 | 2008-01-02 | ||
| EP08150003 | 2008-01-02 | ||
| PCT/EP2008/051527 WO2008095993A1 (en) | 2007-02-09 | 2008-02-07 | Novel nucleoside analogs for treatment of viral infections |
Publications (1)
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|---|---|
| ES2381093T3 true ES2381093T3 (es) | 2012-05-23 |
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| ES08708805T Active ES2381093T3 (es) | 2007-02-09 | 2008-02-07 | Nuevos analogos de nucleosido para el tratamiento de infecciones virales |
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|---|---|
| US (1) | US8278282B2 (enExample) |
| EP (1) | EP2132216B1 (enExample) |
| JP (1) | JP2010518047A (enExample) |
| KR (1) | KR20090109102A (enExample) |
| CN (1) | CN101600726B (enExample) |
| AR (1) | AR065249A1 (enExample) |
| AT (1) | ATE533774T1 (enExample) |
| AU (1) | AU2008212752A1 (enExample) |
| BR (1) | BRPI0807222A2 (enExample) |
| CA (1) | CA2675462A1 (enExample) |
| CL (1) | CL2008000409A1 (enExample) |
| EA (1) | EA200901080A1 (enExample) |
| ES (1) | ES2381093T3 (enExample) |
| MX (1) | MX2009008495A (enExample) |
| PE (1) | PE20090070A1 (enExample) |
| PT (1) | PT2132216E (enExample) |
| TW (1) | TW200838550A (enExample) |
| WO (1) | WO2008095993A1 (enExample) |
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| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| US9708359B2 (en) | 2015-08-06 | 2017-07-18 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof |
| RU2720811C2 (ru) | 2015-09-23 | 2020-05-13 | Мерк Шарп И Доум Лимитед | 4'-замещенные нуклеозидные ингибиторы обратной транскриптазы и их получение |
| US11192914B2 (en) | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| WO2018031818A2 (en) * | 2016-08-12 | 2018-02-15 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| ES3011607T3 (en) | 2017-09-21 | 2025-04-07 | Chimerix Inc | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| WO2020219447A1 (en) | 2019-04-23 | 2020-10-29 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| JP2024545703A (ja) * | 2021-12-22 | 2024-12-10 | シージェイ チェルジェダン コーポレイション | 核酸由来ヌクレオシドアナログおよびこれらの薬学的に許容可能な塩を含む抗ウイルス用組成物 |
| CN117430571B (zh) * | 2022-07-15 | 2025-08-29 | 宜昌东阳光长江药业股份有限公司 | 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法 |
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| US7005448B2 (en) | 2001-12-14 | 2006-02-28 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| US7323453B2 (en) * | 2002-02-13 | 2008-01-29 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| CA2484921A1 (en) * | 2002-05-06 | 2003-11-13 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| NZ538457A (en) * | 2002-09-30 | 2008-04-30 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| US20040259934A1 (en) * | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| JP2007509939A (ja) * | 2003-10-27 | 2007-04-19 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染を治療するためのヌクレオシド化合物 |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
- 2008-02-07 MX MX2009008495A patent/MX2009008495A/es active IP Right Grant
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
- 2008-02-07 US US12/526,079 patent/US8278282B2/en not_active Expired - Fee Related
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2008000409A1 (es) | 2008-08-29 |
| KR20090109102A (ko) | 2009-10-19 |
| PT2132216E (pt) | 2012-02-20 |
| US8278282B2 (en) | 2012-10-02 |
| BRPI0807222A2 (pt) | 2014-04-29 |
| US20100227833A1 (en) | 2010-09-09 |
| AR065249A1 (es) | 2009-05-27 |
| PE20090070A1 (es) | 2009-03-19 |
| CA2675462A1 (en) | 2008-08-14 |
| TW200838550A (en) | 2008-10-01 |
| ATE533774T1 (de) | 2011-12-15 |
| MX2009008495A (es) | 2009-08-20 |
| EA200901080A1 (ru) | 2010-02-26 |
| AU2008212752A1 (en) | 2008-08-14 |
| WO2008095993A1 (en) | 2008-08-14 |
| EP2132216B1 (en) | 2011-11-16 |
| JP2010518047A (ja) | 2010-05-27 |
| CN101600726A (zh) | 2009-12-09 |
| EP2132216A1 (en) | 2009-12-16 |
| CN101600726B (zh) | 2013-03-27 |
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