CA2675462A1 - Novel nucleoside analogs for treatment of viral infections - Google Patents
Novel nucleoside analogs for treatment of viral infections Download PDFInfo
- Publication number
- CA2675462A1 CA2675462A1 CA002675462A CA2675462A CA2675462A1 CA 2675462 A1 CA2675462 A1 CA 2675462A1 CA 002675462 A CA002675462 A CA 002675462A CA 2675462 A CA2675462 A CA 2675462A CA 2675462 A1 CA2675462 A1 CA 2675462A1
- Authority
- CA
- Canada
- Prior art keywords
- virus
- compound
- ethynyl
- alkynyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000011282 treatment Methods 0.000 title abstract description 40
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- 150000003833 nucleoside derivatives Chemical class 0.000 title description 10
- -1 nucleoside compounds Chemical class 0.000 claims abstract description 77
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- 238000000034 method Methods 0.000 claims description 89
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
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| EP07102027 | 2007-02-09 | ||
| EP07102027.5 | 2007-02-09 | ||
| EP08150003.5 | 2008-01-02 | ||
| EP08150003 | 2008-01-02 | ||
| PCT/EP2008/051527 WO2008095993A1 (en) | 2007-02-09 | 2008-02-07 | Novel nucleoside analogs for treatment of viral infections |
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| CA2675462A1 true CA2675462A1 (en) | 2008-08-14 |
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| CA002675462A Abandoned CA2675462A1 (en) | 2007-02-09 | 2008-02-07 | Novel nucleoside analogs for treatment of viral infections |
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| JP (1) | JP2010518047A (enExample) |
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| CN (1) | CN101600726B (enExample) |
| AR (1) | AR065249A1 (enExample) |
| AT (1) | ATE533774T1 (enExample) |
| AU (1) | AU2008212752A1 (enExample) |
| BR (1) | BRPI0807222A2 (enExample) |
| CA (1) | CA2675462A1 (enExample) |
| CL (1) | CL2008000409A1 (enExample) |
| EA (1) | EA200901080A1 (enExample) |
| ES (1) | ES2381093T3 (enExample) |
| MX (1) | MX2009008495A (enExample) |
| PE (1) | PE20090070A1 (enExample) |
| PT (1) | PT2132216E (enExample) |
| TW (1) | TW200838550A (enExample) |
| WO (1) | WO2008095993A1 (enExample) |
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| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| AU2016301188A1 (en) | 2015-08-06 | 2018-02-15 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
| JP6768796B2 (ja) | 2015-09-23 | 2020-10-14 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ４’−置換ヌクレオシド逆転写酵素阻害剤及びその調製 |
| JP7129703B2 (ja) * | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| JP2019524795A (ja) * | 2016-08-12 | 2019-09-05 | ヤンセン バイオファーマ インク． | 置換ヌクレオシド、ヌクレオチド、及びそのアナログ |
| US11111264B2 (en) | 2017-09-21 | 2021-09-07 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide and uses thereof |
| WO2020219447A1 (en) | 2019-04-23 | 2020-10-29 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| EP4454650A4 (en) * | 2021-12-22 | 2025-10-22 | Cj Cheiljedang Corp | ANTIVIRAL COMPOSITION COMPRISING NUCLEOSIDE ANALOGUES DERIVED FROM A NUCLEIC ACID AND A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF |
| WO2024012568A1 (en) * | 2022-07-15 | 2024-01-18 | Sunshine Lake Pharma Co., Ltd. | A key intermediate for preparing glucopyranosyl derivatives and preparation method thereof |
| WO2026042861A1 (ja) * | 2024-08-21 | 2026-02-26 | セトラスホールディングス株式会社 | ジアセトングルコースのケトン体及びジアセトンアロースの製造方法 |
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| MXPA03006514A (es) * | 2001-01-22 | 2004-12-02 | Merck & Co Inc | Derivados de nucleosidos como inhibidores de polimerasa de acido ribonucleico viral dependiente de acido ribonucleico. |
| JP2005511764A (ja) * | 2001-12-14 | 2005-04-28 | アルコン，インコーポレイテッド | 緑内障の処置のためのアミノアルキルベンゾフラン−５−オール化合物 |
| US7323453B2 (en) * | 2002-02-13 | 2008-01-29 | Merck & Co., Inc. | Methods of inhibiting orthopoxvirus replication with nucleoside compounds |
| BR0309581A (pt) * | 2002-05-06 | 2005-03-29 | Genelabs Tech Inc | Derivados de nucleosìdeo para tratamento de infecção por vìrus de hepatite c |
| TW200418498A (en) * | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| US20040259934A1 (en) * | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| JP2007509939A (ja) * | 2003-10-27 | 2007-04-19 | ジェネラブズ テクノロジーズ インコーポレーティッド | ウイルス感染を治療するためのヌクレオシド化合物 |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-07 MX MX2009008495A patent/MX2009008495A/es active IP Right Grant
- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 US US12/526,079 patent/US8278282B2/en not_active Expired - Fee Related
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009008495A (es) | 2009-08-20 |
| TW200838550A (en) | 2008-10-01 |
| AR065249A1 (es) | 2009-05-27 |
| EP2132216A1 (en) | 2009-12-16 |
| CN101600726B (zh) | 2013-03-27 |
| PT2132216E (pt) | 2012-02-20 |
| US8278282B2 (en) | 2012-10-02 |
| PE20090070A1 (es) | 2009-03-19 |
| CL2008000409A1 (es) | 2008-08-29 |
| ES2381093T3 (es) | 2012-05-23 |
| EP2132216B1 (en) | 2011-11-16 |
| JP2010518047A (ja) | 2010-05-27 |
| ATE533774T1 (de) | 2011-12-15 |
| EA200901080A1 (ru) | 2010-02-26 |
| BRPI0807222A2 (pt) | 2014-04-29 |
| WO2008095993A1 (en) | 2008-08-14 |
| KR20090109102A (ko) | 2009-10-19 |
| CN101600726A (zh) | 2009-12-09 |
| US20100227833A1 (en) | 2010-09-09 |
| AU2008212752A1 (en) | 2008-08-14 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20130110 |
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| FZDE | Discontinued |
Effective date: 20150209 |