CA2675462A1 - Novel nucleoside analogs for treatment of viral infections - Google Patents
Novel nucleoside analogs for treatment of viral infections Download PDFInfo
- Publication number
- CA2675462A1 CA2675462A1 CA002675462A CA2675462A CA2675462A1 CA 2675462 A1 CA2675462 A1 CA 2675462A1 CA 002675462 A CA002675462 A CA 002675462A CA 2675462 A CA2675462 A CA 2675462A CA 2675462 A1 CA2675462 A1 CA 2675462A1
- Authority
- CA
- Canada
- Prior art keywords
- virus
- compound
- ethynyl
- alkynyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 238000011282 treatment Methods 0.000 title abstract description 40
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- 150000003833 nucleoside derivatives Chemical class 0.000 title description 10
- -1 nucleoside compounds Chemical class 0.000 claims abstract description 77
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- 238000000034 method Methods 0.000 claims description 89
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
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| EP07102027 | 2007-02-09 | ||
| EP07102027.5 | 2007-02-09 | ||
| EP08150003 | 2008-01-02 | ||
| EP08150003.5 | 2008-01-02 | ||
| PCT/EP2008/051527 WO2008095993A1 (en) | 2007-02-09 | 2008-02-07 | Novel nucleoside analogs for treatment of viral infections |
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| CA2675462A1 true CA2675462A1 (en) | 2008-08-14 |
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| EP (1) | EP2132216B1 (enExample) |
| JP (1) | JP2010518047A (enExample) |
| KR (1) | KR20090109102A (enExample) |
| CN (1) | CN101600726B (enExample) |
| AR (1) | AR065249A1 (enExample) |
| AT (1) | ATE533774T1 (enExample) |
| AU (1) | AU2008212752A1 (enExample) |
| BR (1) | BRPI0807222A2 (enExample) |
| CA (1) | CA2675462A1 (enExample) |
| CL (1) | CL2008000409A1 (enExample) |
| EA (1) | EA200901080A1 (enExample) |
| ES (1) | ES2381093T3 (enExample) |
| MX (1) | MX2009008495A (enExample) |
| PE (1) | PE20090070A1 (enExample) |
| PT (1) | PT2132216E (enExample) |
| TW (1) | TW200838550A (enExample) |
| WO (1) | WO2008095993A1 (enExample) |
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| WO2010015643A1 (en) * | 2008-08-06 | 2010-02-11 | Novartis Ag | New antiviral modified nucleosides |
| CN102526087B (zh) * | 2010-12-30 | 2014-09-03 | 南开大学 | 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用 |
| CN105669783B (zh) * | 2014-12-03 | 2019-11-12 | 广东东阳光药业有限公司 | 一种制备呋喃糖的方法 |
| BR112018002399A2 (pt) | 2015-08-06 | 2018-09-25 | Chimerix, Inc. | nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais |
| WO2017053216A2 (en) | 2015-09-23 | 2017-03-30 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
| US11192914B2 (en) * | 2016-04-28 | 2021-12-07 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
| TW201815821A (zh) * | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| EP3497111A2 (en) * | 2016-08-12 | 2019-06-19 | Janssen BioPharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| EP3684771B1 (en) | 2017-09-21 | 2024-11-27 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| WO2020219447A1 (en) | 2019-04-23 | 2020-10-29 | Elementis Specialties, Inc. | Slurry compositions containing mixed branched alkyl organoclay compositions |
| AU2022422062B2 (en) * | 2021-12-22 | 2025-08-14 | Cj Cheiljedang Corporation | Antiviral composition comprising nucleoside analogues derived from nucleic acid and pharmaceutically acceptable salt thereof |
| WO2024012568A1 (en) * | 2022-07-15 | 2024-01-18 | Sunshine Lake Pharma Co., Ltd. | A key intermediate for preparing glucopyranosyl derivatives and preparation method thereof |
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| US7005448B2 (en) | 2001-12-14 | 2006-02-28 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| EP1476169B1 (en) * | 2002-02-13 | 2013-03-20 | Merck Sharp & Dohme Corp. | Inhibiting orthopoxvirus replication with nucleoside compounds |
| AU2003232071A1 (en) * | 2002-05-06 | 2003-11-17 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| EA200500584A1 (ru) * | 2002-09-30 | 2006-02-24 | Дженелэбс Текнолоджиз, Инк. | Нуклеозидные производные для лечения инфекционных заболеваний, вызванных вирусом гепатита c |
| US20040259934A1 (en) | 2003-05-01 | 2004-12-23 | Olsen David B. | Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds |
| US7157434B2 (en) * | 2003-10-27 | 2007-01-02 | Genelabs Technologies, Inc. | Nucleoside compounds for treating viral infections |
-
2008
- 2008-02-05 TW TW097104689A patent/TW200838550A/zh unknown
- 2008-02-07 EA EA200901080A patent/EA200901080A1/ru unknown
- 2008-02-07 WO PCT/EP2008/051527 patent/WO2008095993A1/en not_active Ceased
- 2008-02-07 PT PT08708805T patent/PT2132216E/pt unknown
- 2008-02-07 CN CN2008800031040A patent/CN101600726B/zh not_active Expired - Fee Related
- 2008-02-07 JP JP2009548691A patent/JP2010518047A/ja active Pending
- 2008-02-07 AR ARP080100529A patent/AR065249A1/es unknown
- 2008-02-07 ES ES08708805T patent/ES2381093T3/es active Active
- 2008-02-07 PE PE2008000274A patent/PE20090070A1/es not_active Application Discontinuation
- 2008-02-07 EP EP08708805A patent/EP2132216B1/en not_active Not-in-force
- 2008-02-07 MX MX2009008495A patent/MX2009008495A/es active IP Right Grant
- 2008-02-07 KR KR1020097016580A patent/KR20090109102A/ko not_active Ceased
- 2008-02-07 AT AT08708805T patent/ATE533774T1/de active
- 2008-02-07 AU AU2008212752A patent/AU2008212752A1/en not_active Abandoned
- 2008-02-07 US US12/526,079 patent/US8278282B2/en not_active Expired - Fee Related
- 2008-02-07 CA CA002675462A patent/CA2675462A1/en not_active Abandoned
- 2008-02-07 BR BRPI0807222-1A2A patent/BRPI0807222A2/pt not_active IP Right Cessation
- 2008-02-08 CL CL200800409A patent/CL2008000409A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090109102A (ko) | 2009-10-19 |
| JP2010518047A (ja) | 2010-05-27 |
| EP2132216A1 (en) | 2009-12-16 |
| EP2132216B1 (en) | 2011-11-16 |
| ATE533774T1 (de) | 2011-12-15 |
| US20100227833A1 (en) | 2010-09-09 |
| EA200901080A1 (ru) | 2010-02-26 |
| TW200838550A (en) | 2008-10-01 |
| CN101600726B (zh) | 2013-03-27 |
| BRPI0807222A2 (pt) | 2014-04-29 |
| AU2008212752A1 (en) | 2008-08-14 |
| ES2381093T3 (es) | 2012-05-23 |
| CL2008000409A1 (es) | 2008-08-29 |
| AR065249A1 (es) | 2009-05-27 |
| MX2009008495A (es) | 2009-08-20 |
| CN101600726A (zh) | 2009-12-09 |
| WO2008095993A1 (en) | 2008-08-14 |
| PT2132216E (pt) | 2012-02-20 |
| PE20090070A1 (es) | 2009-03-19 |
| US8278282B2 (en) | 2012-10-02 |
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| EEER | Examination request |
Effective date: 20130110 |
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| FZDE | Discontinued |
Effective date: 20150209 |