KR20080008378A - 크로만 및 크로멘 유도체 및 이의 용도 - Google Patents
크로만 및 크로멘 유도체 및 이의 용도 Download PDFInfo
- Publication number
- KR20080008378A KR20080008378A KR1020077027247A KR20077027247A KR20080008378A KR 20080008378 A KR20080008378 A KR 20080008378A KR 1020077027247 A KR1020077027247 A KR 1020077027247A KR 20077027247 A KR20077027247 A KR 20077027247A KR 20080008378 A KR20080008378 A KR 20080008378A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- methyl
- compound
- mmol
- chromen
- Prior art date
Links
- 0 C*C(C)(C=C)Oc1c(CC=C)cc(C)cc1[Al] Chemical compound C*C(C)(C=C)Oc1c(CC=C)cc(C)cc1[Al] 0.000 description 2
- UBGCITIGQHGMHV-OAHLLOKOSA-N CC(C)Oc1cc(F)ccc1-c1cccc2c1O[C@@H](CN)CC2 Chemical compound CC(C)Oc1cc(F)ccc1-c1cccc2c1O[C@@H](CN)CC2 UBGCITIGQHGMHV-OAHLLOKOSA-N 0.000 description 1
- JXMLNDVCUABJPW-UHFFFAOYSA-N CCc1cccc(C)c1-c1c2OCCCc2ccc1 Chemical compound CCc1cccc(C)c1-c1c2OCCCc2ccc1 JXMLNDVCUABJPW-UHFFFAOYSA-N 0.000 description 1
- POWDDLYJHKKDAY-UHFFFAOYSA-N COc(cc(cc1)F)c1-c1cccc2c1OCCC2 Chemical compound COc(cc(cc1)F)c1-c1cccc2c1OCCC2 POWDDLYJHKKDAY-UHFFFAOYSA-N 0.000 description 1
- YNAGCCKYAGVFAR-CYBMUJFWSA-N COc(cc1)cc(Cl)c1-c1cc(F)cc2c1O[C@@H](CN)CC2 Chemical compound COc(cc1)cc(Cl)c1-c1cc(F)cc2c1O[C@@H](CN)CC2 YNAGCCKYAGVFAR-CYBMUJFWSA-N 0.000 description 1
- NYQFZDLCSXLHKU-UHFFFAOYSA-N Cc(cc(cc1)OC)c1-c1c2OCCCc2cc(F)c1 Chemical compound Cc(cc(cc1)OC)c1-c1c2OCCCc2cc(F)c1 NYQFZDLCSXLHKU-UHFFFAOYSA-N 0.000 description 1
- UCHYVRJUUWPOQR-UHFFFAOYSA-N Cc(cc1C(F)(F)F)ccc1-c1cc(F)cc2c1OCCC2 Chemical compound Cc(cc1C(F)(F)F)ccc1-c1cc(F)cc2c1OCCC2 UCHYVRJUUWPOQR-UHFFFAOYSA-N 0.000 description 1
- GDLNAGWXZRQZPC-UHFFFAOYSA-N FC(c(cccc1)c1-c1cccc2c1OCCC2)(F)F Chemical compound FC(c(cccc1)c1-c1cccc2c1OCCC2)(F)F GDLNAGWXZRQZPC-UHFFFAOYSA-N 0.000 description 1
- NLNMXMNZJZXFAG-UHFFFAOYSA-N N#Cc(cc(cc1)F)c1-c1c2OCCCc2ccc1 Chemical compound N#Cc(cc(cc1)F)c1-c1c2OCCCc2ccc1 NLNMXMNZJZXFAG-UHFFFAOYSA-N 0.000 description 1
- PXFVSUMXEOMMOS-LLVKDONJSA-N NC[C@@H](CC1)Oc(c(-c(c(Cl)ccc2)c2F)c2)c1cc2F Chemical compound NC[C@@H](CC1)Oc(c(-c(c(Cl)ccc2)c2F)c2)c1cc2F PXFVSUMXEOMMOS-LLVKDONJSA-N 0.000 description 1
- FZNBEDOOVRSKMV-GFCCVEGCSA-N NC[C@@H](CC1)Oc(c(-c(cccc2)c2OC(F)(F)F)c2)c1cc2F Chemical compound NC[C@@H](CC1)Oc(c(-c(cccc2)c2OC(F)(F)F)c2)c1cc2F FZNBEDOOVRSKMV-GFCCVEGCSA-N 0.000 description 1
- JNLSYXZVFCMCKO-GFCCVEGCSA-N NC[C@@H](CC1)Oc2c1cccc2-c1cc(C(F)(F)F)ccc1C(F)(F)F Chemical compound NC[C@@H](CC1)Oc2c1cccc2-c1cc(C(F)(F)F)ccc1C(F)(F)F JNLSYXZVFCMCKO-GFCCVEGCSA-N 0.000 description 1
- ZXNDXFTZHZTQNU-GFCCVEGCSA-N NC[C@@H](CC1)Oc2c1cccc2-c1ccccc1Cl Chemical compound NC[C@@H](CC1)Oc2c1cccc2-c1ccccc1Cl ZXNDXFTZHZTQNU-GFCCVEGCSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67382005P | 2005-04-22 | 2005-04-22 | |
| US60/673,820 | 2005-04-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080008378A true KR20080008378A (ko) | 2008-01-23 |
Family
ID=36888961
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020077027247A KR20080008378A (ko) | 2005-04-22 | 2006-04-21 | 크로만 및 크로멘 유도체 및 이의 용도 |
Country Status (19)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014204064A1 (ko) * | 2013-06-21 | 2014-12-24 | 제주대학교 산학협력단 | 신규 플라보노이드 및 그 용도 |
| EP3923919A4 (en) * | 2019-02-17 | 2022-12-07 | Neurawell Therapeutics | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION AND OTHER DISORDERS |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7435837B2 (en) * | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
| GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
| PE20061327A1 (es) * | 2005-04-22 | 2007-01-02 | Wyeth Corp | Combinaciones de derivados de benzofurano y un antidepresivo para el tratamiento o la prevencion de la depresion |
| MX2007013021A (es) * | 2005-04-22 | 2008-01-11 | Wyeth Corp | Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c. |
| EP1874756A1 (en) * | 2005-04-22 | 2008-01-09 | Wyeth | Chromane and chromene derivatives and uses thereof |
| BRPI0607536A2 (pt) * | 2005-04-22 | 2009-09-15 | Wyeth Corp | tratamento de dor |
| JP2008538577A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ジヒドロベンゾフラン誘導体およびその使用 |
| GT200600164A (es) * | 2005-04-22 | 2007-03-14 | Derivados de dihidrobenzofuranos y usos de los mismos | |
| BRPI0610046A2 (pt) * | 2005-04-22 | 2010-05-25 | Wyeth Corp | derivados de benzodioxano e benzodioxolano e usos destes |
| BRPI0610028A2 (pt) * | 2005-04-22 | 2010-05-18 | Wyeth Corp | combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos |
| BRPI0609988A2 (pt) * | 2005-04-22 | 2010-05-18 | Wyeth Corp | derivados de diidrobenzofurano e usos dos mesmos |
| CA2606064A1 (en) * | 2005-04-24 | 2006-11-02 | Wyeth | Methods for modulating bladder function |
| MX2008012212A (es) * | 2006-03-24 | 2008-10-02 | Wyeth Corp | Metodos para tratar trastornos cognitivos y otros afines. |
| TW200815388A (en) * | 2006-04-18 | 2008-04-01 | Wyeth Corp | Chromane and chromene derivatives and uses thereof |
| EP2018863B9 (en) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound and use thereof |
| CL2007003043A1 (es) * | 2006-10-24 | 2008-05-30 | Wyeth Corp | Compuestos derivados de cromano; composicion farmaceutica que los comprende; y uso para el tratamiento de un trastorno psicotico, bipolar, depresivo y ansiedad entre otros. |
| AR063372A1 (es) * | 2006-10-25 | 2009-01-21 | Wyeth Corp | Derivados de cromano, su sintesis e intermediarios |
| RU2472539C2 (ru) | 2007-08-06 | 2013-01-20 | Аллерган, Инк. | Способы и устройства для доставки препарата десмопрессина |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| US8914112B2 (en) | 2008-01-23 | 2014-12-16 | Boston Scienctific Neuromodulation Corporation | Methods and systems of treating pancreatitis pain caused by sphincter of Oddi dysfunction |
| US8676322B2 (en) | 2008-01-30 | 2014-03-18 | Boston Scientific Neuromodulation Corporation | Methods and systems of treating pancreatitis pain |
| SG176464A1 (en) * | 2008-05-09 | 2011-12-29 | Agency Science Tech & Res | Diagnosis and treatment of kawasaki disease |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| LT3225249T (lt) | 2008-05-21 | 2019-01-10 | Ferring B.V. | Burnoje disperguojamas desmopresinas, skirtas pirminio miego periodo, nepertraukiamo nikturija, pailginimui |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
| CN101921252B (zh) * | 2010-07-02 | 2012-05-09 | 中国科学院上海有机化学研究所 | 1-氧杂苯并杂环类化合物、合成方法和用途 |
| EP2655304B1 (en) | 2010-12-21 | 2017-12-06 | Colgate-Palmolive Company | Halogenated biphenols as antibacterial agents |
| CN109970533B (zh) * | 2012-12-18 | 2022-06-14 | 帝斯曼知识产权资产管理有限公司 | 由(r)-6，10，14-三甲基十五碳-5-烯-2-酮制备的(6r，10r)-6，10，14-三甲基十五烷-2-酮 |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| MX371404B (es) | 2015-02-11 | 2020-01-29 | Sunovion Pharmaceuticals Inc | Compuestos y analogos de 1-heterociclil isocromanilo para el tratamiento de trastornos del sistema nervioso central (snc). |
| CN116283877A (zh) | 2016-07-29 | 2023-06-23 | 赛诺维信制药公司 | 化合物、组合物及其用途 |
| EA201990399A1 (ru) | 2016-07-29 | 2019-07-31 | Суновион Фармасьютикалз, Инк. | Соединения, композиции и их применение |
| EA202090414A1 (ru) | 2017-08-02 | 2020-05-28 | Суновион Фармасьютикалз Инк. | Соединения и их применение |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| AU2020236225A1 (en) | 2019-03-14 | 2021-09-16 | Sunovion Pharmaceuticals Inc. | Salts of a isochromanyl compound and crystalline forms, processes for preparing, therapeutic uses, and pharmaceutical compositions thereof |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1262078A (en) | 1968-05-24 | 1972-02-02 | Fisons Pharmaceuticals Ltd | Preparation of phenoxy fumaric acid compounds and chromone-2-carboxylic acid compounds therefrom |
| US4536518A (en) * | 1979-11-01 | 1985-08-20 | Pfizer Inc. | Antidepressant derivatives of cis-4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamine |
| US4654362A (en) * | 1983-12-05 | 1987-03-31 | Janssen Pharmaceutica, N.V. | Derivatives of 2,2'-iminobisethanol |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| US5089637A (en) * | 1990-03-21 | 1992-02-18 | Pfizer Inc. | Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde |
| JP3283114B2 (ja) * | 1992-09-07 | 2002-05-20 | クミアイ化学工業株式会社 | 縮合ヘテロ環誘導体及び農園芸用殺菌剤 |
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| CZ287771B6 (en) * | 1993-08-19 | 2001-01-17 | Janssen Pharmaceutica Nv | Dihydrobenzopyran derivatives, process and intermediates for their preparation, their use and pharmaceutical preparations based thereon |
| US6150402A (en) * | 1994-08-15 | 2000-11-21 | Loma Linda University Medical Center | Natriuretic compounds |
| DE4430089A1 (de) | 1994-08-25 | 1996-02-29 | Bayer Ag | Verfahren zur enzymatischen Herstellung von enantiomerenreinen Chroman-2-carbonsäuren und deren Derivaten |
| DK0707007T3 (da) * | 1994-10-14 | 2002-03-18 | Merck Patent Gmbh | Amino(thio)etherderivater som CNS-aktive midler |
| US5658796A (en) * | 1995-06-07 | 1997-08-19 | Seprachem, Inc. | Optical resolution of alkyl chroman-2-carboxylates |
| CA2276278C (en) * | 1997-02-27 | 2009-04-07 | Takeda Chemical Industries, Ltd. | Amine compounds, their production and use |
| FR2763335B1 (fr) * | 1997-05-16 | 2000-11-24 | Adir | Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6133277A (en) * | 1997-12-05 | 2000-10-17 | Janssen Pharmaceutica N.V. | (Benzodioxan, benzofuran or benzopyran) derivatives having fundic relaxation properties |
| US20060258176A1 (en) * | 1998-02-05 | 2006-11-16 | Asm Japan K.K. | Method for forming insulation film |
| US6011035A (en) * | 1998-06-30 | 2000-01-04 | Neuromed Technologies Inc. | Calcium channel blockers |
| FR2791675B1 (fr) | 1999-03-30 | 2001-05-04 | Synthelabo | Derives de n-[2-(4-aminophenyl) ethyl] -2,3-dihydro-1,4- benzodioxinne-2-methanamine, leur preparation et leur application en therapeutique |
| DE10044091A1 (de) * | 2000-09-07 | 2002-04-04 | Merck Patent Gmbh | Chromanonderivate |
| US20040029788A1 (en) * | 2000-11-01 | 2004-02-12 | Hans-Markus Bender | Methods and compositions for the treatment of diseases of the eye |
| DE10120619A1 (de) * | 2001-04-26 | 2002-10-31 | Merck Patent Gmbh | 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman |
| US20040198644A1 (en) * | 2001-08-01 | 2004-10-07 | Hans-Markus Bender | Integrin inhibitors for the treatment of eye diseases |
| JP2005505586A (ja) * | 2001-10-04 | 2005-02-24 | ワイス | ５−ヒドロキシトリプタミン−６リガンドとしてのクロマン誘導体 |
| WO2003029239A1 (en) * | 2001-10-04 | 2003-04-10 | Wyeth | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands |
| WO2003031429A1 (en) * | 2001-10-05 | 2003-04-17 | Wyeth | A process for the stereoselective synthesis of 2-hydroxymethyl-chromans |
| US6667322B2 (en) * | 2001-10-05 | 2003-12-23 | Wyeth | Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole |
| US6716998B2 (en) * | 2001-10-05 | 2004-04-06 | Wyeth | Process for synthesis of 2-yl chroman derivatives |
| EP1445324A4 (en) * | 2001-11-09 | 2005-02-16 | Kaneka Corp | PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE PRODUCT |
| US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| AU2003291012A1 (en) | 2002-11-15 | 2004-06-15 | Galileo Pharmaceuticals, Inc. | Chroman derivatives for the reduction of inflammation symptoms |
| US20050065099A1 (en) | 2003-09-19 | 2005-03-24 | Gail Walkinshaw | Treatment of mitochondrial diseases |
| DE10348257A1 (de) | 2003-10-16 | 2005-05-25 | Merck Patent Gmbh | Verfahren zur Herstellung von enantiomereneinen in 2-Position substituierten Chromanderivaten |
| US20050261347A1 (en) * | 2003-10-24 | 2005-11-24 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7435837B2 (en) | 2003-10-24 | 2008-10-14 | Wyeth | Dihydrobenzofuranyl alkanamine derivatives and methods for using same |
| US7728155B2 (en) * | 2003-10-24 | 2010-06-01 | Wyeth Llc | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents |
| DE102004011265A1 (de) | 2004-03-09 | 2005-09-29 | Lutz F. Prof. Dr. Tietze | Synthese von Vitamin E |
| GT200500297A (es) * | 2004-10-21 | 2006-10-27 | Sintesis asimetrica de dehidrobenzofuranos sustituidos | |
| GT200500296A (es) * | 2004-10-21 | 2006-10-02 | Sintesis asimetrica de derivados del dehidrobenzofurano | |
| EP2527339A1 (en) | 2004-11-24 | 2012-11-28 | Abbott Laboratories | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof |
| BRPI0610046A2 (pt) * | 2005-04-22 | 2010-05-25 | Wyeth Corp | derivados de benzodioxano e benzodioxolano e usos destes |
| PE20061319A1 (es) * | 2005-04-22 | 2006-12-28 | Wyeth Corp | Cristales formados de clorhidrato de {[(2r)-7-(2,6-diclorofenil)-5-fluoro-2-3-dihidro-1-benzofurano-2-il]metil}amina |
| JP2008538577A (ja) * | 2005-04-22 | 2008-10-30 | ワイス | ジヒドロベンゾフラン誘導体およびその使用 |
| BRPI0607536A2 (pt) * | 2005-04-22 | 2009-09-15 | Wyeth Corp | tratamento de dor |
| AU2006239917A1 (en) * | 2005-04-22 | 2006-11-02 | Wyeth | (7-arlysubstituted 2, 3-dihydr0-1-benz0furan-2-yl) alkylamines in the treatment' of substance abuse |
| BRPI0609988A2 (pt) * | 2005-04-22 | 2010-05-18 | Wyeth Corp | derivados de diidrobenzofurano e usos dos mesmos |
| PE20061327A1 (es) * | 2005-04-22 | 2007-01-02 | Wyeth Corp | Combinaciones de derivados de benzofurano y un antidepresivo para el tratamiento o la prevencion de la depresion |
| EP1874756A1 (en) * | 2005-04-22 | 2008-01-09 | Wyeth | Chromane and chromene derivatives and uses thereof |
| BRPI0610028A2 (pt) * | 2005-04-22 | 2010-05-18 | Wyeth Corp | combinações terapêuticas para o tratamento ou a prevenção de distúrbios psicóticos |
| MX2007013021A (es) * | 2005-04-22 | 2008-01-11 | Wyeth Corp | Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c. |
| CA2606064A1 (en) * | 2005-04-24 | 2006-11-02 | Wyeth | Methods for modulating bladder function |
-
2006
- 2006-04-21 EP EP06758490A patent/EP1874756A1/en not_active Withdrawn
- 2006-04-21 AR ARP060101590A patent/AR056320A1/es unknown
- 2006-04-21 WO PCT/US2006/015208 patent/WO2006116165A1/en active Application Filing
- 2006-04-21 TW TW095114313A patent/TW200716595A/zh unknown
- 2006-04-21 RU RU2007139541/04A patent/RU2007139541A/ru unknown
- 2006-04-21 CA CA002605587A patent/CA2605587A1/en not_active Abandoned
- 2006-04-21 CN CNA2006800222674A patent/CN101203505A/zh active Pending
- 2006-04-21 BR BRPI0610027-9A patent/BRPI0610027A2/pt not_active Application Discontinuation
- 2006-04-21 PE PE2006000415A patent/PE20061297A1/es not_active Application Discontinuation
- 2006-04-21 MX MX2007013163A patent/MX2007013163A/es unknown
- 2006-04-21 US US11/409,467 patent/US7365095B2/en not_active Expired - Fee Related
- 2006-04-21 KR KR1020077027247A patent/KR20080008378A/ko not_active Application Discontinuation
- 2006-04-21 AU AU2006239937A patent/AU2006239937A1/en not_active Abandoned
- 2006-04-21 GT GT200600166A patent/GT200600166A/es unknown
- 2006-04-21 JP JP2008507952A patent/JP2008538576A/ja active Pending
-
2007
- 2007-10-19 ZA ZA200709052A patent/ZA200709052B/xx unknown
- 2007-10-22 IL IL186837A patent/IL186837A0/en unknown
- 2007-10-22 CO CO07110959A patent/CO6321153A2/es not_active Application Discontinuation
- 2007-11-06 NO NO20075641A patent/NO20075641L/no not_active Application Discontinuation
-
2008
- 2008-03-19 US US12/051,368 patent/US20080182891A1/en not_active Abandoned
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014204064A1 (ko) * | 2013-06-21 | 2014-12-24 | 제주대학교 산학협력단 | 신규 플라보노이드 및 그 용도 |
| EP3923919A4 (en) * | 2019-02-17 | 2022-12-07 | Neurawell Therapeutics | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DEPRESSION AND OTHER DISORDERS |
Also Published As
| Publication number | Publication date |
|---|---|
| GT200600166A (es) | 2007-03-14 |
| EP1874756A1 (en) | 2008-01-09 |
| US7365095B2 (en) | 2008-04-29 |
| AR056320A1 (es) | 2007-10-03 |
| AU2006239937A1 (en) | 2006-11-02 |
| CA2605587A1 (en) | 2006-11-02 |
| NO20075641L (no) | 2007-11-20 |
| CO6321153A2 (es) | 2011-09-20 |
| TW200716595A (en) | 2007-05-01 |
| PE20061297A1 (es) | 2006-12-24 |
| RU2007139541A (ru) | 2009-05-27 |
| BRPI0610027A2 (pt) | 2010-05-18 |
| ZA200709052B (en) | 2009-08-26 |
| US20080182891A1 (en) | 2008-07-31 |
| US20060258714A1 (en) | 2006-11-16 |
| JP2008538576A (ja) | 2008-10-30 |
| WO2006116165A1 (en) | 2006-11-02 |
| CN101203505A (zh) | 2008-06-18 |
| MX2007013163A (es) | 2008-01-21 |
| IL186837A0 (en) | 2008-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR20080008378A (ko) | 크로만 및 크로멘 유도체 및 이의 용도 | |
| KR20080009295A (ko) | 벤조디옥산 및 벤조디옥솔란 유도체 및 이의 용도 | |
| US7368477B2 (en) | Benzofuranyl alkanamine derivatives and uses thereof | |
| US20060258739A1 (en) | Dihydrobenzofuran derivatives and uses therof | |
| CA2604916A1 (en) | Dihydrobenzofuran derivatives and uses thereof | |
| JP2007509174A (ja) | ５ｈｔ２ｃアゴニストとしてのジヒドロベンゾフラニルアルカンアミン誘導体 | |
| WO2008052086A1 (en) | Benzodioxane derivatives and uses thereof | |
| EP2470520A1 (en) | Chromone derivatives, a process for their preparation and their therapeutic applications | |
| US20100035871A1 (en) | Benzoxazine derivatives and uses thereof | |
| US20100160411A1 (en) | Benzoxathiine and benzoxathiole derivatives and uses thereof | |
| WO2008052087A1 (en) | Chromane derivatives and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |