KR20070105812A - 케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및 이의 용도 - Google Patents
케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및 이의 용도 Download PDFInfo
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- KR20070105812A KR20070105812A KR1020060067626A KR20060067626A KR20070105812A KR 20070105812 A KR20070105812 A KR 20070105812A KR 1020060067626 A KR1020060067626 A KR 1020060067626A KR 20060067626 A KR20060067626 A KR 20060067626A KR 20070105812 A KR20070105812 A KR 20070105812A
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- extract
- methanol
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- compound
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- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- YGSFNCRAZOCNDJ-UHFFFAOYSA-N propan-2-one Chemical compound CC(C)=O.CC(C)=O YGSFNCRAZOCNDJ-UHFFFAOYSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 230000003595 spectral effect Effects 0.000 description 1
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- 230000004763 spore germination Effects 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/302—Foods, ingredients or supplements having a functional effect on health having a modulating effect on age
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
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- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
추출물과 분획 | RC50 2 )(㎍/㎖) |
MeOH 추출물 | 599 |
헥산 분획 | 755 |
EtOAc 분획 | 294 |
BuOH 분획 | 441 |
수층 분획 | 1992 |
1) 1,1-diphenyl-2-picryl-hydrazyl 2) Amount required for 50% reduction of DPPH after 30 min. |
균주 용매 | 케나프 잎 추출물(㎍/㎕) | ||||
Staphylococus aureus | E. coli | Salmonella tyhimurium | Klebsiella pneumoniae | Bacillus subtilis | |
MeOH | > 1000 | 500 | 125 | 500 | 1000 |
Hexane | 250 | 125 | 125 | 250 | 500 |
EtOAC | 500 | 125 | 125 | 250 | 500 |
BuOH | > 1000 | 1000 | 500 | 500 | 500 |
Water | > 1000 | 500 | 125 | 500 | 500 |
Claims (5)
- 케나프(Hibiscus cannabbinus L., Malvaceae) 추출물을 유효성분으로 함유하는 것을 특징으로 하는 식품 및 약학적 조성물.
- 제 1 항에 있어서, 상기 추출물의 추출용매가 물, 지방족 알콜 또는 알콜 수용액, 헥산, 클로로포름 및 에틸아세테이트 중에서 선택된 것임을 특징으로 하는 식품 및 약학적 조성물.
- 1) 케나프(Hibiscus cannabbinus L., Malvaceae) 잎 부위를 메탄올로 추출하여 메탄올 조추출물을 수득하는 단계;2) 상기 메탄올 조추출물을 물, 지방족 알콜, 알콜 수용액, 헥산, 클로로포름, 에틸아세테이트 중에서 선택된 용매로 추출하여 물층 및 유기층을 수득하는 단계;3) 상기 물층 및 유기층을 순상 실리카 크로마토그래피 컬럼에 흡착시킨 후, 톨루엔, 아세톤 및 메탄올 혼합물의 비율을 톨루엔과 아세톤 및 아세톤과 메탄올의 비율을 변화시키면서 용출시켜, 항균 및 항산화 활성이 확인된 분을 수득하는 단계;4) 상기 분획을 2차 순상 실리카 크로마토그래피 컬럼에 흡착시킨 후, 물과 메탄올(10 : 0 ~ 5 : 5)의 비율로 변화시키면서 용출시켜 활성 분획을 수득하는 단계;5) 상기 분획을 40 % 메탄올을 용매를 사용하여 겔 필터 크로마토그래피(Sephadex LH-20)를 실시하여 정제하는 단계;6) 상기 정제된 분획을 최종적으로 재결정 방법 및 고속 액체크로마토그래피(HPLC)를 이용하여 단일 활성 화합물을 정제하는 단계를 포함하는 것을 특징으로 하는 케나프(Hibiscus cannabbinus L., Malvaceae) 로부터 다음 화학식 1로 표시되는 화합물의 분리방법.[화학식 1]
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KR1020070095740A KR100835710B1 (ko) | 2006-04-27 | 2007-09-20 | 케나프 추출물과 이로부터 분리된 신규 캠프페롤 화합물 및이의 식품으로의 용도 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105193882A (zh) * | 2015-10-30 | 2015-12-30 | 中国科学院昆明植物研究所 | 红麻提取物及其化妆品组合物和其应用 |
CN109258648A (zh) * | 2018-10-25 | 2019-01-25 | 黑龙江工业学院 | 一种食品机械用杀菌剂组合物 |
KR20210013949A (ko) * | 2019-07-29 | 2021-02-08 | (주)케나프 | 케나프 종자 추출물을 유효성분으로 함유하는 항균용 조성물 |
KR20220104352A (ko) * | 2021-01-18 | 2022-07-26 | 강원대학교산학협력단 | 항균 활성이 증진된 케나프 전해수 추출물의 제조방법 및 이의 용도 |
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MY162712A (en) | 2008-12-04 | 2017-07-14 | Univ Putra Malaysia | A supercritical fluid extraction process of kenaf seeds |
KR101025160B1 (ko) | 2010-04-23 | 2011-03-31 | 강원대학교산학협력단 | 항염증 및 면역증강을 위한 조성물 |
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JP3091757B1 (ja) | 2000-01-21 | 2000-09-25 | 有限会社竜宮 | ケナフ茶およびケナフ茶包装製品 |
KR100429406B1 (ko) * | 2002-02-15 | 2004-04-29 | 정해영 | 솔잎유래의 항산화물질 및 그 분리방법 |
KR20050081595A (ko) * | 2004-02-16 | 2005-08-19 | 한국 메디텍 제약 주식회사 | 캄페롤을 유효성분으로 함유하는 골다공증치료제 |
KR20050105910A (ko) * | 2004-05-03 | 2005-11-08 | 박근형 | 쿼서틴 3-O-α-L-람노시드, 캠페롤3-O-α-L-람노피라노시드, 캠페롤 3,7-O-α-L-디람노시드,카페인, 캠페롤3-O-α-L-람노실(1→6)-O-β-D-글루코실(1→2)-O-β-D-글루코시드, 그리고 캠페롤3-O-α-L-람노시드-7-O-[β-D-글루코실-(1→3)-α-L-람노시드] 등의 천연항산화물질을 포함하여 항산화 기능을 갖는헛개나무 추출물 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105193882A (zh) * | 2015-10-30 | 2015-12-30 | 中国科学院昆明植物研究所 | 红麻提取物及其化妆品组合物和其应用 |
CN109258648A (zh) * | 2018-10-25 | 2019-01-25 | 黑龙江工业学院 | 一种食品机械用杀菌剂组合物 |
KR20210013949A (ko) * | 2019-07-29 | 2021-02-08 | (주)케나프 | 케나프 종자 추출물을 유효성분으로 함유하는 항균용 조성물 |
KR20220104352A (ko) * | 2021-01-18 | 2022-07-26 | 강원대학교산학협력단 | 항균 활성이 증진된 케나프 전해수 추출물의 제조방법 및 이의 용도 |
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KR20070111409A (ko) | 2007-11-21 |
KR100835710B1 (ko) | 2008-06-09 |
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