KR20040030388A - 폴리아크릴레이트와 폴리아민염의 2상 접착 매트릭스로구성되는 의약용 감압 접착제 - Google Patents
폴리아크릴레이트와 폴리아민염의 2상 접착 매트릭스로구성되는 의약용 감압 접착제 Download PDFInfo
- Publication number
- KR20040030388A KR20040030388A KR10-2003-7001030A KR20037001030A KR20040030388A KR 20040030388 A KR20040030388 A KR 20040030388A KR 20037001030 A KR20037001030 A KR 20037001030A KR 20040030388 A KR20040030388 A KR 20040030388A
- Authority
- KR
- South Korea
- Prior art keywords
- sensitive adhesive
- pressure sensitive
- adhesive
- polyacrylate
- active ingredient
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/08—Homopolymers or copolymers of acrylic acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/58—Adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/14—Polymer mixtures characterised by other features containing polymeric additives characterised by shape
- C08L2205/18—Spheres
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
- C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
- C08L2666/04—Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- C08L33/04—Homopolymers or copolymers of esters
- C08L33/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical
- C08L33/062—Copolymers with monomers not covered by C08L33/06
- C08L33/064—Copolymers with monomers not covered by C08L33/06 containing anhydride, COOH or COOM groups, with M being metal or onium-cation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
- Y10T428/2839—Web or sheet containing structurally defined element or component and having an adhesive outermost layer with release or antistick coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
- Y10T428/2852—Adhesive compositions
- Y10T428/2878—Adhesive compositions including addition polymer from unsaturated monomer
- Y10T428/2887—Adhesive compositions including addition polymer from unsaturated monomer including nitrogen containing polymer [e.g., polyacrylonitrile, polymethacrylonitrile, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/28—Web or sheet containing structurally defined element or component and having an adhesive outermost layer
- Y10T428/2852—Adhesive compositions
- Y10T428/2878—Adhesive compositions including addition polymer from unsaturated monomer
- Y10T428/2891—Adhesive compositions including addition polymer from unsaturated monomer including addition polymer from alpha-beta unsaturated carboxylic acid [e.g., acrylic acid, methacrylic acid, etc.] Or derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Materials For Medical Uses (AREA)
- Adhesive Tapes (AREA)
Abstract
Description
Claims (14)
- 폴리아크릴레이트와 중성 폴리아민염을 기재로 하는 의약용 감압 접착제로서, 하기의 두 중합체 성분 A와 B로 된 감압 접착 매트릭스를 가짐을 특징으로 하는 감압 접착제.- 중합체 성분 A는 중화된 카복실기를 함유하는 폴리아크릴레이트 감압 접착제이며,- 중합체 성분 B는 아미노기를 함유하는 폴리아크릴레이트 공중합체를 산과 반응시켜 얻어진 중성 폴리아민염임.- 중합체 성분 B는 중합체 성분 A에 분산되어 있으며, 이 두 성분은 2상을 형성함.
- 제1항에 있어서,아미노기 함유 폴리아크릴레이트와 반응시키는 산으로서, 불포화 지방산류 및 디카복실산류로 이루어진 군에서 선택한 산 또는 이들 산의 혼합물을 사용함을 특징으로 하는 감압 접착제.
- 제1항 또는 제2항에 있어서,아미노기 함유 폴리아크릴레이트는 중성 메타크릴산 에스테르와 디메틸아미노에틸메타크릴레이트의 폴리(메트)아크릴레이트 공중합체임을 특징으로 하는 감압접착제.
- 제1항 내지 제3항 중 어느 한 항에 있어서,카복실기 함유 폴리아크릴레이트 접착제는 그 안에 중합된 아크릴산 또는 메타크릴산을 적어도 3몰% 함유함을 특징으로 하는 감압 접착제.
- 제1항 내지 제4항 중 어느 한 항에 있어서,폴리아크릴레이트 감압 접착제의 카복실기를 가성 알칼리 용액, 바람직하게는 NaOH 또는 KOH로 중화시킴을 특징으로 하는 감압 접착제.
- 제1항 내지 제5항 중 어느 한 항에 있어서,성분 A 및 B가 각각의 경우 중량으로, 0.5:1∼50:1의 비율, 바람직하게는 1:1∼10:1의 비율로 분산되어 있음을 특징으로 하는 감압 접착제.
- 제1항 내지 제6항 중 어느 한 항에 있어서,중화된 카복실기 함유 폴리아크릴레이트 접착제는 금속 킬레이트, 바람직하게는 알루미늄 아세틸아세토네이트의 첨가에 의해 가교됨을 특징으로 하는 감압 접착제.
- 제1항 내지 제7항 중 어느 한 항에 있어서,두 중합체 성분 중 적어도 하나는, 바람직하게는, 두 성분 모두 활성성분을 용해 또는 현탁된 형태로 함유함을 특징으로 하는 감압 접착제.
- 제8항에 있어서,- 2상의 중화된 감압 접착제를 60∼95중량% (이들 중, 중합체 성분 A는 그 안에 중화된 아크릴산 또는 메타크릴산 공중합체를 3몰% 갖는 중화된 폴리아크릴레이트 공중합체이고, 중합체 성분 B는 중성 메타크리산 에스테르와 디메틸아미노에틸 메타크릴레이트의 폴리(메트)아크릴레이트 공중합체를 변환시켜 얻어진 중성 폴리아민염임); 및- 활성성분을 상기 2상 감압 접착제내에 용해 또는 분산된 상태로 1∼20 중량% 함유함을 특징으로 하는 갑압 접착제.
- 제8항 또는 제9항에 있어서,중합체 성분 중에 용해 또는 현탁되어 있는 하나 이상의 침투-증강제를 바람직하게는 5∼20중량%를 함유함을 특징으로 하는 감압 접착제.
- 활성성분 비투과 지지층, 중합체 매트릭스를 기제로 하는 활성성분 함유 저장소 및 분리형 보호층을 갖는 플라스터 형태의 경피 치료 시스템으로서, 활성성분 함유 저장소가 제1항 내지 제10항 중 어느 한 항 기재의 감압 접착제를 함유함을 특징으로 하는 경피 치료 시스템.
- 접착 드레싱, 고정 플라스터, 접착 플라스터, 상처 플라스터 또는 자기 접착성 전극의 제조를 위한, 제1항 내지 제7항 중 어느 한 항 기재의 감압 접착제의 용도.
- 약제 활성성분의 경피 투여용 활성성분 함유 플라스터의 제조를 위한, 제1항 내지 제10항 중 어느 한 항 기재의 감압 접착제의 용도.
- 제13항에 있어서,활성성분 함유 플라스터가 산성 또는 염기성 약제 성분 또는 약제학적으로 허용가능한 그들의 염을 함유함을 특징으로 하는 감압 접착제의 용도.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10035891A DE10035891A1 (de) | 2000-07-24 | 2000-07-24 | Medizinischer Haftkleber mit einer zweiphasigen Klebermatrix aus Polyacrylaten und Polyaminsalzen |
DE10035891.8 | 2000-07-24 | ||
PCT/EP2001/007982 WO2002008352A1 (de) | 2000-07-24 | 2001-07-11 | Medizinischer haftkleber mit einer zweiphasigen klebermatrix aus polyacrylaten und polyaminsalzen |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20040030388A true KR20040030388A (ko) | 2004-04-09 |
KR100660584B1 KR100660584B1 (ko) | 2006-12-21 |
Family
ID=7649960
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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KR1020037001030A KR100660584B1 (ko) | 2000-07-24 | 2001-07-11 | 폴리아크릴레이트와 폴리아민염의 2상 접착 매트릭스로구성되는 의약용 감압 접착제 |
Country Status (8)
Country | Link |
---|---|
US (1) | US6936661B2 (ko) |
EP (1) | EP1305378B1 (ko) |
JP (1) | JP4663209B2 (ko) |
KR (1) | KR100660584B1 (ko) |
AT (1) | ATE310061T1 (ko) |
DE (2) | DE10035891A1 (ko) |
ES (1) | ES2253408T3 (ko) |
WO (1) | WO2002008352A1 (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101087346B1 (ko) | 2004-02-19 | 2011-11-25 | 에스케이케미칼주식회사 | 자기발열체용 피부 점착성 조성물 및 이것이 부착된자기발열체 |
ITMI20041628A1 (it) * | 2004-08-06 | 2004-11-06 | Bouty S P A | Sistema terapeutico a rilascio controllato per uso topico transdermico |
US7976951B2 (en) | 2006-11-14 | 2011-07-12 | Momentive Performance Materials Inc. | Laminate containing an adhesive-forming composition |
US7829116B2 (en) | 2006-11-14 | 2010-11-09 | Momentive Performance Materials Inc. | Adhesive-forming composition and blend of adhesives obtained therefrom |
CA2714559A1 (en) * | 2007-08-27 | 2009-03-05 | Jaymore Enterprises Limited | Catheter clip |
GB0809905D0 (en) * | 2008-06-02 | 2008-07-09 | Secr Defence | A Transdermal drug delivery device |
PL2285362T3 (pl) * | 2008-06-19 | 2017-12-29 | Lts Lohmann Therapie-Systeme Ag | Kompozycja do przezskórnego dostarczania kationowych substancji czynnych |
US8366600B2 (en) * | 2008-06-19 | 2013-02-05 | Nupathe Inc. | Polyamine enhanced formulations for triptan compound iontophoresis |
UA103851C2 (en) | 2010-04-30 | 2013-11-25 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Propylaminoindan transdermal composition |
EP2688561B1 (en) | 2011-03-24 | 2018-08-22 | Teikoku Pharma USA, Inc. | Transdermal compositions comprising an active agent layer and an active agent conversion layer |
EP2776020B1 (en) | 2011-11-09 | 2019-09-11 | Teikoku Seiyaku Co., Ltd. | Methods for the treatment of skin neoplasms |
EA031621B1 (ru) | 2012-11-02 | 2019-01-31 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Трансдермальная композиция на основе пропиниламиноиндана, содержащий такие композиции набор и способ доставки пропиниламиноиндана |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2693212B2 (ja) * | 1989-03-28 | 1997-12-24 | 日東電工株式会社 | 疾患治療用テープ製剤 |
DE3924393A1 (de) * | 1989-07-24 | 1991-01-31 | Roehm Gmbh | Wasserloeslicher druckempfindlicher hauthaftkleber, dessen verwendung und damit ausgeruestete mittel |
JP3046346B2 (ja) * | 1990-03-12 | 2000-05-29 | 昭和電工株式会社 | 外用剤基剤又は補助剤とそれを含有する人又は動物の外用剤 |
US5977242A (en) * | 1992-11-24 | 1999-11-02 | Konishi Co., Ltd. | Two-part emulsion adhesive |
JPH06322342A (ja) | 1993-05-12 | 1994-11-22 | Konishi Kk | 二液型接着剤組成物 |
DE4429791C2 (de) * | 1994-08-23 | 1997-04-24 | Lohmann Therapie Syst Lts | Medizinischer Haftkleber auf Basis von Polyacrylaten und dessen Verwendung |
JPH09143061A (ja) * | 1995-11-20 | 1997-06-03 | Showa Denko Kk | 鎮痛剤用経皮吸収製剤 |
DE19918105C1 (de) | 1999-04-22 | 2000-09-21 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einem stark wirksamen Neuroleptikum |
-
2000
- 2000-07-24 DE DE10035891A patent/DE10035891A1/de not_active Withdrawn
-
2001
- 2001-07-11 DE DE50108099T patent/DE50108099D1/de not_active Expired - Lifetime
- 2001-07-11 US US10/333,783 patent/US6936661B2/en not_active Expired - Lifetime
- 2001-07-11 WO PCT/EP2001/007982 patent/WO2002008352A1/de active IP Right Grant
- 2001-07-11 AT AT01956526T patent/ATE310061T1/de not_active IP Right Cessation
- 2001-07-11 ES ES01956526T patent/ES2253408T3/es not_active Expired - Lifetime
- 2001-07-11 KR KR1020037001030A patent/KR100660584B1/ko active IP Right Grant
- 2001-07-11 JP JP2002514243A patent/JP4663209B2/ja not_active Expired - Fee Related
- 2001-07-11 EP EP01956526A patent/EP1305378B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100660584B1 (ko) | 2006-12-21 |
DE10035891A1 (de) | 2002-02-14 |
EP1305378B1 (de) | 2005-11-16 |
JP2004504409A (ja) | 2004-02-12 |
ATE310061T1 (de) | 2005-12-15 |
EP1305378A1 (de) | 2003-05-02 |
ES2253408T3 (es) | 2006-06-01 |
US6936661B2 (en) | 2005-08-30 |
US20040010054A1 (en) | 2004-01-15 |
WO2002008352A1 (de) | 2002-01-31 |
JP4663209B2 (ja) | 2011-04-06 |
DE50108099D1 (de) | 2005-12-22 |
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