KR20010101790A - (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물 - Google Patents

(ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물 Download PDF

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Publication number
KR20010101790A
KR20010101790A KR1020017009914A KR20017009914A KR20010101790A KR 20010101790 A KR20010101790 A KR 20010101790A KR 1020017009914 A KR1020017009914 A KR 1020017009914A KR 20017009914 A KR20017009914 A KR 20017009914A KR 20010101790 A KR20010101790 A KR 20010101790A
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KR
South Korea
Prior art keywords
drug
isoenzyme
inhibitor
inducer
substrate
Prior art date
Application number
KR1020017009914A
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English (en)
Korean (ko)
Inventor
알리 라자
존 스투어트 피어스
호워드 제라드 후췬손
데니스 쉬네크
타카히코 바바
아키라 토우취
요쉬타카 야마구취
Original Assignee
시오노기 세이야꾸 가부시키가이샤
다비드 에 질레스
아스트라제네카 아베
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20010101790(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9902593.4A external-priority patent/GB9902593D0/en
Priority claimed from GBGB9921064.3A external-priority patent/GB9921064D0/en
Priority claimed from GBGB9921063.5A external-priority patent/GB9921063D0/en
Application filed by 시오노기 세이야꾸 가부시키가이샤, 다비드 에 질레스, 아스트라제네카 아베 filed Critical 시오노기 세이야꾸 가부시키가이샤
Publication of KR20010101790A publication Critical patent/KR20010101790A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020017009914A 1999-02-06 2000-02-01 (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물 KR20010101790A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9902593.4 1999-02-06
GBGB9902593.4A GB9902593D0 (en) 1999-02-06 1999-02-06 Drug combinations
GB9921063.5 1999-09-08
GBGB9921064.3A GB9921064D0 (en) 1999-09-08 1999-09-08 Drug combination
GBGB9921063.5A GB9921063D0 (en) 1999-09-08 1999-09-08 Therapy
GB9921064.3 1999-09-08
PCT/GB2000/000278 WO2000045817A1 (en) 1999-02-06 2000-02-01 Drug combinations comprising (e) -7 - [4 -(4 -fluorophenyl) -6 - isopropyl -2 - [methyl (methylsulfonyl) amino] pyrimidin -5 -yl] (3r,5s) -3,5 - dihydroxyhept -6 - enoic acid and an inhibitor, inducer or substrate of p450 isoenzyme 3a4

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067021986A Division KR20060117381A (ko) 1999-02-06 2000-02-01 (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물

Publications (1)

Publication Number Publication Date
KR20010101790A true KR20010101790A (ko) 2001-11-14

Family

ID=27269637

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020017009914A KR20010101790A (ko) 1999-02-06 2000-02-01 (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물
KR1020067021986A KR20060117381A (ko) 1999-02-06 2000-02-01 (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020067021986A KR20060117381A (ko) 1999-02-06 2000-02-01 (ｅ)-7-[4-(4-플루오로페닐)-6-이소프로필-2-[메틸(메틸술포닐)아미노]피리미딘-5-일](3ｒ,5ｓ)-3,5-디히드록시헵트-6-엔산 및 ｐ450 이소효소 3ａ4의 억제제, 유도제 또는기질을 함유하는 약물 조합물

Country Status (29)

Country Link
US (3) US6982157B1 (cs)
EP (1) EP1185274B1 (cs)
JP (2) JP2002536331A (cs)
KR (2) KR20010101790A (cs)
CN (1) CN1165310C (cs)
AR (1) AR029333A1 (cs)
AT (1) ATE282415T1 (cs)
AU (1) AU767304B2 (cs)
BR (1) BR0007999A (cs)
CA (1) CA2358632C (cs)
CZ (1) CZ301296B6 (cs)
DE (1) DE60015965T2 (cs)
EE (1) EE04929B1 (cs)
EG (1) EG23858A (cs)
ES (1) ES2232418T3 (cs)
GB (1) GB0000710D0 (cs)
HK (1) HK1041817A1 (cs)
ID (1) ID30485A (cs)
IL (1) IL144715A0 (cs)
IS (1) IS2337B (cs)
MX (1) MXPA01007905A (cs)
MY (1) MY130606A (cs)
NO (1) NO320745B1 (cs)
NZ (1) NZ512982A (cs)
PL (1) PL198034B1 (cs)
PT (1) PT1185274E (cs)
TR (1) TR200102228T2 (cs)
TW (1) TWI282738B (cs)
WO (1) WO2000045817A1 (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
DE19944803A1 (de) * 1999-09-20 2001-03-29 Bayer Ag Kombination von Dihydropyridinverbindungen und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln
GB0001621D0 (en) * 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
US9173847B2 (en) 2003-10-10 2015-11-03 Veloxis Pharmaceuticals A/S Tablet comprising a fibrate
US7658944B2 (en) 2003-10-10 2010-02-09 Lifecycle Pharma A/S Solid dosage form comprising a fibrate
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1786414A4 (en) 2004-08-06 2008-04-09 Transform Pharmaceuticals Inc NEW PHARMACEUTICAL STATIN COMPOSITIONS AND RELEVANT TREATMENT PROCEDURES
WO2007005941A2 (en) 2005-07-05 2007-01-11 President And Fellows Of Harvard College Liver targeted conjugates
CN101330919B (zh) * 2005-12-20 2012-12-05 力奇制药公司 包含(e)-7-[4-(4-氟苯基)-6-异丙基-2-[甲基(甲磺酰基)氨基]嘧啶-5-基]-(3r,5s)-3,5-二羟基庚-6-烯酸的药物组合物
US20080109252A1 (en) * 2006-11-08 2008-05-08 Lafountain Andrea Predicting patient compliance with medical treatment
US20120130202A1 (en) * 2010-11-24 2012-05-24 Fujitsu Limited Diagnosis and Monitoring of Musculoskeletal Pathologies
CA3103616A1 (en) * 2018-06-14 2019-12-19 Astrazeneca Uk Limited Methods for lowering blood pressure with a dihydropyridine-type calcium channel blocker pharmaceutical composition
JP2022542004A (ja) 2019-07-31 2022-09-29 インタス ファーマシューティカルズ リミテッド ＨＭＧ－ＣｏＡレダクターゼ阻害剤及びフェノフィブラートを含む医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2627696B1 (fr) * 1988-02-26 1991-09-13 Fournier Innovation Synergie Nouvelle forme galenique du fenofibrate
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
DK0521417T3 (da) * 1991-07-02 1995-03-27 Benckiser Gmbh Joh A Sammenklappelig forrådsflaske
JP3852621B2 (ja) * 1992-01-21 2006-12-06 あすか製薬株式会社 血管内皮細胞機能改善剤
FR2730231B1 (fr) * 1995-02-02 1997-04-04 Fournier Sca Lab Association de fenofibrate et de vitamine e, utilisation en therapeutique
AU1289899A (en) * 1997-10-31 1999-05-24 Arch Development Corporation Methods and compositions for regulation of 5-alpha reductase activity

Also Published As

Publication number Publication date
IS6009A (is) 2001-07-17
IL144715A0 (en) 2002-06-30
EG23858A (en) 2007-11-18
GB0000710D0 (en) 2000-03-08
ID30485A (id) 2001-12-13
CN1338936A (zh) 2002-03-06
MXPA01007905A (es) 2003-06-04
US20060040969A1 (en) 2006-02-23
TWI282738B (en) 2007-06-21
AU767304B2 (en) 2003-11-06
NZ512982A (en) 2003-08-29
EP1185274B1 (en) 2004-11-17
PL364780A1 (en) 2004-12-13
PT1185274E (pt) 2005-03-31
NO20013811L (no) 2001-10-02
NO320745B1 (no) 2006-01-23
DE60015965T2 (de) 2006-01-05
EE200100406A (et) 2002-10-15
HK1041817A1 (en) 2002-07-26
WO2000045817A1 (en) 2000-08-10
US20090042911A1 (en) 2009-02-12
DE60015965D1 (de) 2004-12-23
CN1165310C (zh) 2004-09-08
CA2358632A1 (en) 2000-08-10
TR200102228T2 (tr) 2002-03-21
CZ20012844A3 (cs) 2001-11-14
ATE282415T1 (de) 2004-12-15
JP2002536331A (ja) 2002-10-29
PL198034B1 (pl) 2008-05-30
ES2232418T3 (es) 2005-06-01
CZ301296B6 (cs) 2010-01-06
CA2358632C (en) 2008-10-28
NO20013811D0 (no) 2001-08-03
EE04929B1 (et) 2007-12-17
AR029333A1 (es) 2003-06-25
EP1185274A1 (en) 2002-03-13
IS2337B (is) 2008-02-15
JP2007277267A (ja) 2007-10-25
US6982157B1 (en) 2006-01-03
AU2121800A (en) 2000-08-25
BR0007999A (pt) 2001-11-06
MY130606A (en) 2007-07-31
KR20060117381A (ko) 2006-11-16

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