KR20010101416A - 반응성 산소 대사물 매개성 세포 손상의 치료법 및 예방법 - Google Patents
반응성 산소 대사물 매개성 세포 손상의 치료법 및 예방법 Download PDFInfo
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- KR20010101416A KR20010101416A KR1020017008621A KR20017008621A KR20010101416A KR 20010101416 A KR20010101416 A KR 20010101416A KR 1020017008621 A KR1020017008621 A KR 1020017008621A KR 20017008621 A KR20017008621 A KR 20017008621A KR 20010101416 A KR20010101416 A KR 20010101416A
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Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999005167A1 (en) * | 1997-07-25 | 1999-02-04 | University Of Massachusetts | Designed protein pores as components for biosensors |
| US20030083231A1 (en) * | 1998-11-24 | 2003-05-01 | Ahlem Clarence N. | Blood cell deficiency treatment method |
| US6270781B1 (en) * | 1999-01-08 | 2001-08-07 | Maxim Pharmaceuticals, Inc. | Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors |
| US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
| US7341717B2 (en) * | 2001-04-13 | 2008-03-11 | Gpc Biotech Ag | Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor |
| WO2002084294A2 (en) * | 2001-04-13 | 2002-10-24 | Axxima Pharmaceuticals Ag | Gastrointestinal glutathione peroxidase in hepatitis c virus infections |
| US20040235889A1 (en) * | 2001-05-02 | 2004-11-25 | Miao-Kun Sun | Carbonic anhydrase activator for enhancing learning and memory |
| EP1435984A1 (en) * | 2001-10-19 | 2004-07-14 | Maxim Pharmaceuticals, Inc. | Use of histamine to treat liver disease |
| US20030149090A1 (en) * | 2001-11-06 | 2003-08-07 | Gehlsen Kurt R. | Compositions for the treatment of infectious diseases |
| JP2006512279A (ja) * | 2002-03-29 | 2006-04-13 | マキシム ファーマシューティカルス,インコーポレイテッド | 眼内損傷を治療および予防するためのrom生成および放出阻害剤の使用 |
| US20040106896A1 (en) * | 2002-11-29 | 2004-06-03 | The Regents Of The University Of California | System and method for forming a non-ablative cardiac conduction block |
| EP1503819A4 (en) * | 2002-05-08 | 2007-07-25 | Univ California | SYSTEM AND METHOD FOR PRODUCING A NON-ABSORBENT HEADLINE BLOCK |
| US6932804B2 (en) | 2003-01-21 | 2005-08-23 | The Regents Of The University Of California | System and method for forming a non-ablative cardiac conduction block |
| JP4578235B2 (ja) | 2002-05-13 | 2010-11-10 | アレクシス・アクチボラゲット | 自己免疫状態およびnadphオキシダーゼ欠損 |
| US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
| EP1380290A1 (en) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-beta structure pathway and its therapeutic relevance |
| US20040057983A1 (en) | 2002-09-25 | 2004-03-25 | David Schmidt | Biomolecular wearable apparatus |
| US7317950B2 (en) * | 2002-11-16 | 2008-01-08 | The Regents Of The University Of California | Cardiac stimulation system with delivery of conductive agent |
| US20060198904A1 (en) * | 2002-11-20 | 2006-09-07 | Istvan Boldogh | Methods for inhibiting allergic inflammation and other responses initiated by pollens, molds, and other non-animal derived allergens |
| GB0308382D0 (en) * | 2003-04-10 | 2003-05-21 | Univ Cambridge Tech | Therapeutic methods and means |
| US7290197B2 (en) * | 2003-06-03 | 2007-10-30 | Quantum Corporation | Correcting data using redundancy blocks |
| US20050171192A1 (en) * | 2003-12-11 | 2005-08-04 | Gehlsen Kurt R. | Use of histamine to treat bone disease |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| EP1602926A1 (en) | 2004-06-04 | 2005-12-07 | University of Geneva | Novel means and methods for the treatment of hearing loss and phantom hearing |
| US20090202980A1 (en) * | 2005-03-21 | 2009-08-13 | Crossbeta Biosciences B.V. | Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation |
| EP1907864A2 (en) * | 2005-07-13 | 2008-04-09 | Crossbeta Biosciences B.V. | METHODS FOR DETERMINING THE EFFECT OF A TREATMENT ON THE CROSS-ß STRUCTURE CONTENT OF A PROTEIN; SELECTION OF TREATMENTS AND USES THEREOF |
| ATE554394T1 (de) | 2005-07-13 | 2012-05-15 | Crossbeta Biosciences Bv | Cross-beta-struktur-bindende verbindungen |
| US8114832B2 (en) * | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
| CA2623725A1 (en) * | 2005-09-30 | 2007-04-12 | Omp, Inc. | Stable ascorbic acid compositions |
| JP2009084155A (ja) * | 2006-01-16 | 2009-04-23 | Kanazawa Univ | レビー小体病治療薬及びレビー小体病予防薬 |
| US8999933B2 (en) * | 2006-01-18 | 2015-04-07 | Biolitec Pharma Marketing Ltd | Photodynamic cosmetic procedure and healing method |
| US7825099B2 (en) | 2006-01-20 | 2010-11-02 | Quark Pharmaceuticals, Inc. | Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes |
| US20070178058A1 (en) * | 2006-02-02 | 2007-08-02 | Ramirez Jose E | Methods of using stable ascorbic acid compositions |
| US20070269534A1 (en) * | 2006-02-02 | 2007-11-22 | Ramirez Jose E | Methods of treating skin to enhance therapeutic treatment thereof |
| US20100015126A1 (en) * | 2006-03-17 | 2010-01-21 | Martijn Frans Ben Gerard Gebbink | Methods of Binding of Cross-Beta Structures By Chaperones |
| EP2058000A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Immunogenic compositions capable of activating T cells |
| EP2058001A1 (en) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Enhancement of immunogenicity of antigens |
| US8602961B2 (en) | 2008-05-15 | 2013-12-10 | Lifewave Products Llc | Apparatus and method of stimulating elevation of glutathione levels in a subject |
| WO2010089712A2 (en) * | 2009-02-05 | 2010-08-12 | Lui, Jacqueline, C. | Formulation for the treatment of hypoxia and related disorders |
| EP3406244B1 (en) | 2009-04-15 | 2023-06-07 | BMG Pharma S.p.A. | Compositions comprising zinc gluconate and taurine for mucosal or dermal disorders |
| WO2014066672A1 (en) * | 2012-10-26 | 2014-05-01 | Beech Tree Labs, Inc. | Method of treating muscular weakness comprising administering a composition comprising an effective amount of histamine and/or serotonin |
| EP4340838A4 (en) * | 2021-05-19 | 2025-04-16 | Alberto Paz | ORALLY ADMINISTERED COMPOSITIONS FOR CANCER TREATMENT |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3636202A (en) * | 1968-02-12 | 1972-01-18 | Lewis A Klein | Treatment of rheumatoid arthritis and related diseases |
| SU512764A1 (ru) * | 1972-02-24 | 1976-05-05 | Войсковая Часть 64688 | Средство дл профилактики атеросклероза "аэровит" |
| US3898325A (en) * | 1973-09-19 | 1975-08-05 | American Lipids Corp | Method and preparations for relieving pain and producing analgesia |
| US4704273A (en) * | 1982-05-17 | 1987-11-03 | Mcmichael John | Methods and materials for treatment of rheumatoid arthritis |
| DE3239870A1 (de) * | 1982-10-27 | 1984-05-03 | Gert Dr.med. 8000 München Baumann | Arzneimittel zur behandlung von chronischem und akutem herzversagen |
| US5268291A (en) | 1983-01-19 | 1993-12-07 | Genentech, Inc. | Human t-PA production using vectors coding for DHFR protein |
| US4573996A (en) | 1984-01-03 | 1986-03-04 | Jonergin, Inc. | Device for the administration of an active agent to the skin or mucosa |
| IL74222A (en) * | 1984-02-06 | 1988-07-31 | Lilly Co Eli | 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them |
| US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| JPH0717504B2 (ja) * | 1985-03-09 | 1995-03-01 | 美浜 久春 | 血栓症予防及び治療用組成物 |
| US5288497A (en) | 1985-05-01 | 1994-02-22 | The University Of Utah | Compositions of oral dissolvable medicaments |
| US5122127A (en) | 1985-05-01 | 1992-06-16 | University Of Utah | Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues |
| US4843096A (en) * | 1985-06-26 | 1989-06-27 | Stiefel Laboratories, Inc. | Treatment of acne |
| SU1394134A1 (ru) * | 1986-02-27 | 1988-05-07 | Тернопольский государственный медицинский институт | Способ исследовани секреторной функции желудка |
| DE3616923A1 (de) * | 1986-05-20 | 1987-11-26 | Nattermann A & Cie | Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on |
| JPS6396123A (ja) * | 1986-10-13 | 1988-04-27 | Kuraray Co Ltd | ビタミンa酸亜鉛塩を含有する抗炎症剤 |
| US5166134A (en) * | 1986-12-24 | 1992-11-24 | John Lezdey | Treatment of allergic rhinitis |
| US4886665A (en) * | 1987-03-11 | 1989-12-12 | Arcopharma Ltd. | Compositions of oats and nettle extracts to be used as a food additive or pharmaceutical preparation in human health care |
| US5312325A (en) | 1987-05-28 | 1994-05-17 | Drug Delivery Systems Inc | Pulsating transdermal drug delivery system |
| DE3720493A1 (de) * | 1987-06-20 | 1989-01-26 | Nattermann A & Cie | Arzneizubereitungen mit mikronisierten ebselen-kristallen |
| US4943435A (en) | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
| US4839174A (en) | 1987-10-05 | 1989-06-13 | Pharmetrix Corporation | Novel transdermal nicotine patch |
| US5284647A (en) | 1988-03-18 | 1994-02-08 | Schering Aktiengesellschaft | Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them |
| US5094953A (en) | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
| US5214156A (en) * | 1988-03-25 | 1993-05-25 | The Upjohn Company | Therapeutically useful tetralin derivatives |
| US5674706A (en) * | 1988-05-06 | 1997-10-07 | Chiron Corporation | High level expression of proteins in yeast |
| DE3821392A1 (de) * | 1988-06-24 | 1989-12-28 | Nattermann A & Cie | Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on (ebselen) |
| DE3831888A1 (de) * | 1988-09-20 | 1990-03-29 | Troponwerke Gmbh & Co Kg | Arzneimittel zur behandlung von apoplexia cerebri |
| US4908213A (en) | 1989-02-21 | 1990-03-13 | Schering Corporation | Transdermal delivery of nicotine |
| CA1335106C (en) * | 1989-02-27 | 1995-04-04 | John Mehnert Schaus | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes |
| IT1230140B (it) * | 1989-05-03 | 1991-10-14 | Fidia Spa | Derivati della serina, loro processo di preparazione e impiego in terapia umana |
| US5674708A (en) * | 1989-06-23 | 1997-10-07 | Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin analogues having elastase inhibitory activity |
| US5637479A (en) * | 1989-06-23 | 1997-06-10 | The Trustees Of The University Of Pennsylvania | Method of modulating DNA binding activity of recombinant α-1 antichymotrypsin and other serine protease inhibitors |
| US5723316A (en) * | 1989-06-23 | 1998-03-03 | Trustees Of The University Of Pennsylvania | α-1-antichymotrypsin analogues having chymase inhibiting activity |
| US5134154A (en) * | 1989-10-20 | 1992-07-28 | Merrell Dow Pharmaceuticals Inc. | Phenoxy-heterocyclic compounds |
| JPH0725786A (ja) * | 1990-05-16 | 1995-01-27 | Univ Rockefeller | アルツハイマー病を伴うアミロイドーシスの治療 |
| US5215965A (en) * | 1990-10-02 | 1993-06-01 | John Lezdey | Treatment of inflammation |
| US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| DE4039631A1 (de) * | 1990-12-12 | 1992-06-17 | Troponwerke Gmbh & Co Kg | Neuroprotektive kombination |
| US5679337A (en) | 1991-06-14 | 1997-10-21 | Professional Pharmaceutical, Inc. | Method and composition for topical treatment of Aphthous stomatitis histamine using phosphate as active ingredient |
| CA2103163C (en) | 1991-08-26 | 1998-10-20 | Mou-Ying Fu Lu | Compositions and methods for the sublingual or buccal administration of therapeutic agents |
| JPH05163160A (ja) * | 1991-12-13 | 1993-06-29 | Snow Brand Milk Prod Co Ltd | 免疫低下に伴う感染症の予防及び治療用栄養剤 |
| GB9200623D0 (en) * | 1992-01-13 | 1992-03-11 | Bayer Ag | Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives |
| US5244916A (en) * | 1992-01-31 | 1993-09-14 | The Scripps Research Institute | Inhibition of respiratory burst using posttranslational modification inhibitors |
| EP0625045A4 (en) * | 1992-02-07 | 1995-01-18 | Albert M Kligman | METHOD FOR TREATING FLAMMABLE DERMATOS. |
| JPH05213763A (ja) * | 1992-02-10 | 1993-08-24 | Sanwa Kagaku Kenkyusho Co Ltd | 易吸収活性化カルシウム製剤 |
| US5219888A (en) * | 1992-03-31 | 1993-06-15 | American Cyanamid Company | Use of retinoids for the treatment of coronary artery disease |
| CA2075517C (en) | 1992-04-01 | 1997-03-11 | John Wick | Transdermal patch incorporating a polymer film incorporated with an active agent |
| SE513429C2 (sv) | 1992-06-03 | 2000-09-11 | Syntello Inc | Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer |
| DK0786257T3 (da) | 1992-06-03 | 2003-10-06 | Genentech Inc | Glycolyseringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
| IT1260155B (it) * | 1992-08-03 | 1996-03-28 | Fidia Spa | Uso terapeutico della fosforil-l-serina-n-acil-sfingosina |
| US5773457A (en) * | 1995-02-15 | 1998-06-30 | Cesar Roberto Dias Nahoum | Compositions |
| US5376633A (en) * | 1992-09-30 | 1994-12-27 | Lezdey; John | Method for deactivating viruses in blood component containers |
| US5834509A (en) * | 1992-12-07 | 1998-11-10 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| FR2699821A1 (fr) * | 1992-12-24 | 1994-07-01 | Pichot Eric | Traitement homéopathique préventif des maladies cardio-vasculaires (athérome, athérothrombomatose, infarctus du myocarde). |
| US5474527A (en) | 1993-03-29 | 1995-12-12 | Bettinger; David S. | Positive displacement transdermal system |
| US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
| US5457129A (en) * | 1993-05-17 | 1995-10-10 | Research Development Foundation | Inhibition of nitric oxide production by retinoic acid |
| AU7000094A (en) * | 1993-06-17 | 1995-01-17 | Ciba-Geigy Ag | Indolocarbazole compound useful as proteinkinase c inhibitor |
| US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
| US5726155A (en) | 1993-08-02 | 1998-03-10 | The Scripps Research Institute | Regulation of oxidative burst using LMWG-derived peptides and analogs |
| JP3193205B2 (ja) * | 1993-08-09 | 2001-07-30 | 日本臓器製薬株式会社 | 好酸球増多抑制剤 |
| DE4329776A1 (de) * | 1993-09-03 | 1995-03-09 | Sandoz Ag | Naphthoxazine, ihre Herstellung und Verwendung |
| US5502063A (en) * | 1993-10-11 | 1996-03-26 | Sanofi | 1-halopyridin-4-amino-4-alkylpiperidines |
| GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
| GB2285047B (en) * | 1993-12-21 | 1998-04-15 | Yamanouchi U K Ltd | Polypeptides which inhibit the NADPH oxidase complex |
| US5399562A (en) * | 1994-02-04 | 1995-03-21 | G. D. Searle & Co. | Indolones useful as serotonergic agents |
| EP0774460A1 (en) * | 1994-03-30 | 1997-05-21 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compound and use thereof as medicine |
| JPH07313180A (ja) * | 1994-05-19 | 1995-12-05 | Mercian Corp | 新規ポリエン化合物 |
| WO1996001107A1 (en) * | 1994-07-06 | 1996-01-18 | Bo Arne Hofmann | Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses |
| CA2196756A1 (en) | 1994-08-08 | 1996-02-22 | Jan Urban Kristoffer Hellstrand | Enhanced activation of natural killer cells using an nk cell activator and a hydrogen peroxide scavenger or inhibitor |
| GB9416921D0 (en) * | 1994-08-22 | 1994-10-12 | Conway Gitta C | A nutritional preparation |
| US5502080A (en) * | 1994-11-01 | 1996-03-26 | Hitzig; Pietr | Combined use of dopamine and serotonin agonists in the treatment of allergic disorders |
| FR2727682A1 (fr) * | 1994-12-02 | 1996-06-07 | Pf Medicament | Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament |
| JPH10510540A (ja) * | 1994-12-12 | 1998-10-13 | オメロス メディカル システムズ,インコーポレーテッド | 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法 |
| US5804203A (en) | 1994-12-21 | 1998-09-08 | Cosmederm Technologies | Topical product formulations containing strontium for reducing skin irritation |
| US5489611A (en) * | 1995-02-10 | 1996-02-06 | Warner-Lambert Company | Method for lowering plasma levels of lipoprotein (a) |
| US5830453A (en) * | 1995-05-19 | 1998-11-03 | Emory University | Use of IL-13 to induce 15-lipoxygenase |
| US5637497A (en) * | 1995-06-28 | 1997-06-10 | Alcon Laboratories, Inc. | Apparatus and method for cleaning and disinfecting contact lenses |
| FR2739777B1 (fr) * | 1995-10-11 | 1997-11-14 | Cird Galderma | Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose |
| US5763496A (en) * | 1995-11-27 | 1998-06-09 | The Research Foundation Of State University Of New York | Prevention of atherosclerosis using NADPH oxidase inhibitors |
| US5597585A (en) * | 1995-12-26 | 1997-01-28 | Williams; Andrew H. | Vitamin/mineral composition |
| WO1997038692A1 (en) * | 1996-04-12 | 1997-10-23 | Eli Lilly And Company | Bisindoles for treating pain or nociception |
| US6071942A (en) * | 1996-05-14 | 2000-06-06 | Maxim Pharmaceuticals, Inc. | Elevation of circulating blood histamine levels |
| US5961969A (en) * | 1996-05-14 | 1999-10-05 | Maxim Pharmaceuticals, Inc. | Stable circulating histamine levels |
| WO1997044062A1 (en) * | 1996-05-23 | 1997-11-27 | Alcon Laboratories, Inc. | The use of 5-ht1b/1d agonists to treat ocular pain |
| TW336325B (en) * | 1996-05-24 | 1998-07-11 | Electrocopper Products Ltd | Copper wire and process for making copper wire |
| US5780440A (en) * | 1996-06-17 | 1998-07-14 | Protease Sciences Inc. | Treatment of pulmonary disease with protease inhibitors |
| US5939460A (en) * | 1996-07-08 | 1999-08-17 | Idun Pharmaceuticals, Inc. | Method of inhibiting NADPH oxidase |
| JPH10120700A (ja) * | 1996-10-17 | 1998-05-12 | Takeda Chem Ind Ltd | ヒスタミン産生増大因子およびその用途 |
| WO1998031384A1 (en) * | 1997-01-22 | 1998-07-23 | The Wistar Institute Of Anatomy & Biology | Methods and compositions using interleukin-13 for enhancing immune responses |
| CN1217698C (zh) * | 1998-08-24 | 2005-09-07 | 马克西姆药品公司 | 应用h2受体激动剂和其它t细胞活化剂激活和保护t细胞(cd4+和cd8+) |
| US6270781B1 (en) * | 1999-01-08 | 2001-08-07 | Maxim Pharmaceuticals, Inc. | Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors |
| US6242473B1 (en) * | 1999-01-08 | 2001-06-05 | Maxim Pharmaceuticals, Inc. | Treatment and prevention of reactive oxygen metabolite-mediated cellular damage |
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1999
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- 1999-08-26 TW TW088114611A patent/TWI248816B/zh active
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2000
- 2000-01-07 DE DE60013764T patent/DE60013764T2/de not_active Expired - Fee Related
- 2000-01-07 CN CNB008045828A patent/CN1203851C/zh not_active Expired - Fee Related
- 2000-01-07 HK HK02102711.2A patent/HK1040923B/en not_active IP Right Cessation
- 2000-01-07 AT AT00902340T patent/ATE275954T1/de not_active IP Right Cessation
- 2000-01-07 EP EP00902340A patent/EP1140077B1/en not_active Expired - Lifetime
- 2000-01-07 CA CA002358851A patent/CA2358851A1/en not_active Abandoned
- 2000-01-07 ES ES00902340T patent/ES2228453T3/es not_active Expired - Lifetime
- 2000-01-07 IL IL14397000A patent/IL143970A0/xx unknown
- 2000-01-07 EP EP03026944A patent/EP1410798A3/en not_active Withdrawn
- 2000-01-07 AU AU24075/00A patent/AU768526B2/en not_active Ceased
- 2000-01-07 JP JP2000591998A patent/JP2002534384A/ja active Pending
- 2000-01-07 KR KR1020017008621A patent/KR20010101416A/ko not_active Ceased
- 2000-01-07 WO PCT/US2000/000314 patent/WO2000040241A2/en not_active Ceased
- 2000-01-07 PT PT00902340T patent/PT1140077E/pt unknown
- 2000-11-06 US US09/707,343 patent/US6462067B1/en not_active Expired - Fee Related
-
2001
- 2001-04-12 US US09/833,896 patent/US6407133B2/en not_active Expired - Fee Related
- 2001-06-22 ZA ZA200105165A patent/ZA200105165B/xx unknown
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2002
- 2002-06-11 US US10/171,018 patent/US6730692B2/en not_active Expired - Lifetime
- 2002-09-19 US US10/251,420 patent/US20030017145A1/en not_active Abandoned
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2004
- 2004-04-07 US US10/819,594 patent/US20040191239A1/en not_active Abandoned
Also Published As
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|---|---|
| HK1040923A1 (en) | 2002-06-28 |
| US20020150565A1 (en) | 2002-10-17 |
| ES2228453T3 (es) | 2005-04-16 |
| AU768526B2 (en) | 2003-12-18 |
| EP1140077A2 (en) | 2001-10-10 |
| ZA200105165B (en) | 2002-06-12 |
| US20010023256A1 (en) | 2001-09-20 |
| EP1410798A3 (en) | 2004-10-13 |
| EP1410798A2 (en) | 2004-04-21 |
| WO2000040241A3 (en) | 2000-11-30 |
| CN1203851C (zh) | 2005-06-01 |
| CN1342079A (zh) | 2002-03-27 |
| US6730692B2 (en) | 2004-05-04 |
| US6407133B2 (en) | 2002-06-18 |
| US6242473B1 (en) | 2001-06-05 |
| PT1140077E (pt) | 2005-01-31 |
| US20040191239A1 (en) | 2004-09-30 |
| HK1040923B (en) | 2005-04-01 |
| JP2002534384A (ja) | 2002-10-15 |
| EP1140077B1 (en) | 2004-09-15 |
| DE60013764T2 (de) | 2005-09-29 |
| CA2358851A1 (en) | 2000-07-13 |
| DE60013764D1 (de) | 2004-10-21 |
| US6462067B1 (en) | 2002-10-08 |
| AU2407500A (en) | 2000-07-24 |
| WO2000040241A2 (en) | 2000-07-13 |
| US20030017145A1 (en) | 2003-01-23 |
| TWI248816B (en) | 2006-02-11 |
| ATE275954T1 (de) | 2004-10-15 |
| IL143970A0 (en) | 2002-04-21 |
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