ZA200105165B - Treatment and prevention of reactive oxygen metabolite-mediated cellular damage. - Google Patents

Treatment and prevention of reactive oxygen metabolite-mediated cellular damage.

Info

Publication number
ZA200105165B
ZA200105165B ZA200105165A ZA200105165A ZA200105165B ZA 200105165 B ZA200105165 B ZA 200105165B ZA 200105165 A ZA200105165 A ZA 200105165A ZA 200105165 A ZA200105165 A ZA 200105165A ZA 200105165 B ZA200105165 B ZA 200105165B
Authority
ZA
South Africa
Prior art keywords
reactive oxygen
prevention
treatment
roms
cellular damage
Prior art date
Application number
ZA200105165A
Other languages
English (en)
Inventor
Kristoffer Hellstrand
Svante Hermodsson
Kurt R Gehlsen
Original Assignee
Maxim Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxim Pharm Inc filed Critical Maxim Pharm Inc
Publication of ZA200105165B publication Critical patent/ZA200105165B/xx

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/417—Imidazole-alkylamines, e.g. histamine, phentolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA200105165A 1999-01-08 2001-06-22 Treatment and prevention of reactive oxygen metabolite-mediated cellular damage. ZA200105165B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/227,455 US6242473B1 (en) 1999-01-08 1999-01-08 Treatment and prevention of reactive oxygen metabolite-mediated cellular damage

Publications (1)

Publication Number Publication Date
ZA200105165B true ZA200105165B (en) 2002-06-12

Family

ID=22853182

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200105165A ZA200105165B (en) 1999-01-08 2001-06-22 Treatment and prevention of reactive oxygen metabolite-mediated cellular damage.

Country Status (16)

Country Link
US (6) US6242473B1 (enExample)
EP (2) EP1410798A3 (enExample)
JP (1) JP2002534384A (enExample)
KR (1) KR20010101416A (enExample)
CN (1) CN1203851C (enExample)
AT (1) ATE275954T1 (enExample)
AU (1) AU768526B2 (enExample)
CA (1) CA2358851A1 (enExample)
DE (1) DE60013764T2 (enExample)
ES (1) ES2228453T3 (enExample)
HK (1) HK1040923B (enExample)
IL (1) IL143970A0 (enExample)
PT (1) PT1140077E (enExample)
TW (1) TWI248816B (enExample)
WO (1) WO2000040241A2 (enExample)
ZA (1) ZA200105165B (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8586298A (en) * 1997-07-25 1999-02-16 University Of Massachusetts Designed protein pores as components for biosensors
US20030083231A1 (en) * 1998-11-24 2003-05-01 Ahlem Clarence N. Blood cell deficiency treatment method
US6270781B1 (en) * 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US7341717B2 (en) * 2001-04-13 2008-03-11 Gpc Biotech Ag Therapeutic targets for treatment of HCV infections, methods of treating HCV infections and compounds useful therefor
CA2443525A1 (en) * 2001-04-13 2002-10-24 Axxima Pharmaceuticals Ag Human cellular protein gastrointestinal glutathione peroxidase as target for medical intervention against hepatitis c virus infections
DE60229371D1 (de) * 2001-05-02 2008-11-27 Brni Neurosciences Inst Kohlensäureanhydrase-aktivatoren zur verbesserung der lern- und gedächtnisleistung
KR20040058192A (ko) * 2001-10-19 2004-07-03 맥심 파마수티컬즈 인크. 간 질환 치료용으로서의 히스타민 용도
NZ532074A (en) * 2001-11-06 2006-02-24 Maxim Pharm Inc Compositions for the treatment of infectious diseases
JP2006512279A (ja) * 2002-03-29 2006-04-13 マキシム ファーマシューティカルス，インコーポレイテッド 眼内損傷を治療および予防するためのｒｏｍ生成および放出阻害剤の使用
AU2003239418B2 (en) * 2002-05-08 2008-01-31 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
US6932804B2 (en) 2003-01-21 2005-08-23 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
US20040106896A1 (en) * 2002-11-29 2004-06-03 The Regents Of The University Of California System and method for forming a non-ablative cardiac conduction block
AU2003233147B2 (en) 2002-05-13 2008-03-06 Arexis Ab Autoimmune conditions and NADPH oxidase defects
US20070003552A1 (en) * 2002-07-09 2007-01-04 Gebbink Martijn F B Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
EP1380290A1 (en) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-beta structure pathway and its therapeutic relevance
US20040057983A1 (en) 2002-09-25 2004-03-25 David Schmidt Biomolecular wearable apparatus
US7317950B2 (en) * 2002-11-16 2008-01-08 The Regents Of The University Of California Cardiac stimulation system with delivery of conductive agent
US20060198904A1 (en) * 2002-11-20 2006-09-07 Istvan Boldogh Methods for inhibiting allergic inflammation and other responses initiated by pollens, molds, and other non-animal derived allergens
GB0308382D0 (en) * 2003-04-10 2003-05-21 Univ Cambridge Tech Therapeutic methods and means
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
WO2005060960A2 (en) * 2003-12-11 2005-07-07 Maxim Pharmaceuticals, Inc. Use of histamine to treat bone disease
TW201207390A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
EP1602926A1 (en) 2004-06-04 2005-12-07 University of Geneva Novel means and methods for the treatment of hearing loss and phantom hearing
US20090202980A1 (en) * 2005-03-21 2009-08-13 Crossbeta Biosciences B.V. Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
US20080249606A1 (en) * 2005-07-13 2008-10-09 Martijn Frans Ben Gerard Gebbink Methods for Determining the Effect of a Treatment on the Cross-Beta Structure Content of a Protein; Selection of Treatments and Uses Thereof
US8114832B2 (en) * 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
WO2007008072A2 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. CROSS-ß STRUCTURE BINDING COMPOUNDS
WO2007041230A2 (en) * 2005-09-30 2007-04-12 Omp, Inc. Stable ascorbic acid compositions
JP2009084155A (ja) * 2006-01-16 2009-04-23 Kanazawa Univ レビー小体病治療薬及びレビー小体病予防薬
US8999933B2 (en) * 2006-01-18 2015-04-07 Biolitec Pharma Marketing Ltd Photodynamic cosmetic procedure and healing method
US7825099B2 (en) 2006-01-20 2010-11-02 Quark Pharmaceuticals, Inc. Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
US20070269534A1 (en) * 2006-02-02 2007-11-22 Ramirez Jose E Methods of treating skin to enhance therapeutic treatment thereof
US20070178058A1 (en) * 2006-02-02 2007-08-02 Ramirez Jose E Methods of using stable ascorbic acid compositions
WO2007108675A1 (en) * 2006-03-17 2007-09-27 Crossbeta Biosciences B.V. Methods of binding of cross-beta structures by chaperones
EP2058001A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Enhancement of immunogenicity of antigens
EP2058000A1 (en) * 2007-11-08 2009-05-13 Crossbeta Biosciences B.V. Immunogenic compositions capable of activating T cells
US8602961B2 (en) 2008-05-15 2013-12-10 Lifewave Products Llc Apparatus and method of stimulating elevation of glutathione levels in a subject
TW201029676A (en) * 2009-02-05 2010-08-16 Yuk Kwan Liu Formulation for the treatment of hypoxia and related disorders
WO2010121081A1 (en) 2009-04-15 2010-10-21 Bmg Pharma Llc Mineral salt-sulfonic acid compositions and methods of use
US20140121256A1 (en) * 2012-10-26 2014-05-01 Beech Tree Labs, Inc. Method of treating muscular weakness comprising administering a composition comprising an effective amount of histamine and/or serotonin
EP4340838A4 (en) * 2021-05-19 2025-04-16 Alberto Paz ORALLY ADMINISTERED COMPOSITIONS FOR CANCER TREATMENT

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636202A (en) * 1968-02-12 1972-01-18 Lewis A Klein Treatment of rheumatoid arthritis and related diseases
SU512764A1 (ru) * 1972-02-24 1976-05-05 Войсковая Часть 64688 Средство дл профилактики атеросклероза "аэровит"
US3898325A (en) * 1973-09-19 1975-08-05 American Lipids Corp Method and preparations for relieving pain and producing analgesia
US4704273A (en) * 1982-05-17 1987-11-03 Mcmichael John Methods and materials for treatment of rheumatoid arthritis
DE3239870A1 (de) * 1982-10-27 1984-05-03 Gert Dr.med. 8000 München Baumann Arzneimittel zur behandlung von chronischem und akutem herzversagen
US5268291A (en) 1983-01-19 1993-12-07 Genentech, Inc. Human t-PA production using vectors coding for DHFR protein
US4573996A (en) 1984-01-03 1986-03-04 Jonergin, Inc. Device for the administration of an active agent to the skin or mucosa
IL74222A (en) * 1984-02-06 1988-07-31 Lilly Co Eli 6-substituted-4-dialkylamino tetrahydrobenz(c,d)indoles,their preparation and pharmaceutical compositions comprising them
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
JPH0717504B2 (ja) * 1985-03-09 1995-03-01 美浜 久春 血栓症予防及び治療用組成物
US5288497A (en) 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US5122127A (en) 1985-05-01 1992-06-16 University Of Utah Apparatus and methods for use in administering medicaments by direct medicament contact to mucosal tissues
US4843096A (en) * 1985-06-26 1989-06-27 Stiefel Laboratories, Inc. Treatment of acne
SU1394134A1 (ru) * 1986-02-27 1988-05-07 Тернопольский государственный медицинский институт Способ исследовани секреторной функции желудка
DE3616923A1 (de) * 1986-05-20 1987-11-26 Nattermann A & Cie Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on
JPS6396123A (ja) * 1986-10-13 1988-04-27 Kuraray Co Ltd ビタミンａ酸亜鉛塩を含有する抗炎症剤
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
US4886665A (en) * 1987-03-11 1989-12-12 Arcopharma Ltd. Compositions of oats and nettle extracts to be used as a food additive or pharmaceutical preparation in human health care
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
DE3720493A1 (de) * 1987-06-20 1989-01-26 Nattermann A & Cie Arzneizubereitungen mit mikronisierten ebselen-kristallen
US4943435A (en) 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
US4839174A (en) 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
US5284647A (en) 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5094953A (en) 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5214156A (en) * 1988-03-25 1993-05-25 The Upjohn Company Therapeutically useful tetralin derivatives
US5674706A (en) * 1988-05-06 1997-10-07 Chiron Corporation High level expression of proteins in yeast
DE3821392A1 (de) * 1988-06-24 1989-12-28 Nattermann A & Cie Neue pharmazeutische verwendung von 2-phenyl-1,2-benzisoselenazol-3(2h)-on (ebselen)
DE3831888A1 (de) * 1988-09-20 1990-03-29 Troponwerke Gmbh & Co Kg Arzneimittel zur behandlung von apoplexia cerebri
US4908213A (en) 1989-02-21 1990-03-13 Schering Corporation Transdermal delivery of nicotine
CA1335106C (en) * 1989-02-27 1995-04-04 John Mehnert Schaus Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
IT1230140B (it) * 1989-05-03 1991-10-14 Fidia Spa Derivati della serina, loro processo di preparazione e impiego in terapia umana
US5637479A (en) * 1989-06-23 1997-06-10 The Trustees Of The University Of Pennsylvania Method of modulating DNA binding activity of recombinant α-1 antichymotrypsin and other serine protease inhibitors
US5674708A (en) * 1989-06-23 1997-10-07 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having elastase inhibitory activity
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US5134154A (en) * 1989-10-20 1992-07-28 Merrell Dow Pharmaceuticals Inc. Phenoxy-heterocyclic compounds
JPH0725786A (ja) * 1990-05-16 1995-01-27 Univ Rockefeller アルツハイマー病を伴うアミロイドーシスの治療
US5215965A (en) * 1990-10-02 1993-06-01 John Lezdey Treatment of inflammation
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
DE4039631A1 (de) * 1990-12-12 1992-06-17 Troponwerke Gmbh & Co Kg Neuroprotektive kombination
US5679337A (en) 1991-06-14 1997-10-21 Professional Pharmaceutical, Inc. Method and composition for topical treatment of Aphthous stomatitis histamine using phosphate as active ingredient
DE69231536T2 (de) 1991-08-26 2001-06-13 Abbott Laboratories, Abbott Park Verbindungen und methoden zur sublingualen oder buccalen verabreichung von therapeutischen agentien
JPH05163160A (ja) * 1991-12-13 1993-06-29 Snow Brand Milk Prod Co Ltd 免疫低下に伴う感染症の予防及び治療用栄養剤
GB9200623D0 (en) * 1992-01-13 1992-03-11 Bayer Ag Benzofuranyl and thiophenyl-methylthio-alkanecarboxylic acid derivatives
US5244916A (en) * 1992-01-31 1993-09-14 The Scripps Research Institute Inhibition of respiratory burst using posttranslational modification inhibitors
CZ188394A3 (en) * 1992-02-07 1996-02-14 Albert M Kligman Pharmaceutical preparation for the control of inflammatory dermatose cleaning and the use of corticosteroidal matter in combination with a retoidal matter for preparing such preparations
JPH05213763A (ja) * 1992-02-10 1993-08-24 Sanwa Kagaku Kenkyusho Co Ltd 易吸収活性化カルシウム製剤
US5219888A (en) * 1992-03-31 1993-06-15 American Cyanamid Company Use of retinoids for the treatment of coronary artery disease
CA2075517C (en) 1992-04-01 1997-03-11 John Wick Transdermal patch incorporating a polymer film incorporated with an active agent
SE513429C2 (sv) 1992-06-03 2000-09-11 Syntello Inc Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer
WO1993024635A1 (en) 1992-06-03 1993-12-09 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
IT1260155B (it) * 1992-08-03 1996-03-28 Fidia Spa Uso terapeutico della fosforil-l-serina-n-acil-sfingosina
US5773457A (en) * 1995-02-15 1998-06-30 Cesar Roberto Dias Nahoum Compositions
US5376633A (en) * 1992-09-30 1994-12-27 Lezdey; John Method for deactivating viruses in blood component containers
US5834509A (en) * 1992-12-07 1998-11-10 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
FR2699821A1 (fr) * 1992-12-24 1994-07-01 Pichot Eric Traitement homéopathique préventif des maladies cardio-vasculaires (athérome, athérothrombomatose, infarctus du myocarde).
US5474527A (en) 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5686436A (en) * 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
US5457129A (en) * 1993-05-17 1995-10-10 Research Development Foundation Inhibition of nitric oxide production by retinoic acid
EP0703917A1 (en) * 1993-06-17 1996-04-03 Novartis AG Indolocarbazole compound useful as proteinkinase c inhibitor
US5549906A (en) 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
US5726155A (en) 1993-08-02 1998-03-10 The Scripps Research Institute Regulation of oxidative burst using LMWG-derived peptides and analogs
JP3193205B2 (ja) * 1993-08-09 2001-07-30 日本臓器製薬株式会社 好酸球増多抑制剤
DE4329776A1 (de) * 1993-09-03 1995-03-09 Sandoz Ag Naphthoxazine, ihre Herstellung und Verwendung
CA2133855A1 (en) * 1993-10-11 1995-04-12 Marco Baroni Heteroarylpiperidines, process for their preparation and pharmaceutical compositions in which they are present
GB9325395D0 (en) * 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
GB2285047B (en) * 1993-12-21 1998-04-15 Yamanouchi U K Ltd Polypeptides which inhibit the NADPH oxidase complex
US5399562A (en) * 1994-02-04 1995-03-21 G. D. Searle & Co. Indolones useful as serotonergic agents
WO1995026953A1 (en) * 1994-03-30 1995-10-12 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compound and use thereof as medicine
JPH07313180A (ja) * 1994-05-19 1995-12-05 Mercian Corp 新規ポリエン化合物
AU2880595A (en) * 1994-07-06 1996-01-25 Bo Arne Hofmann Use of pharmaceutical agents for restoring, alleviation, or treatment of immunodeficiency, including the alleviation or treatment of the immune dysfunction related to infection with human immunodeficiency viruses (hiv) or related viruses
CA2196756A1 (en) 1994-08-08 1996-02-22 Jan Urban Kristoffer Hellstrand Enhanced activation of natural killer cells using an nk cell activator and a hydrogen peroxide scavenger or inhibitor
GB9416921D0 (en) * 1994-08-22 1994-10-12 Conway Gitta C A nutritional preparation
US5502080A (en) * 1994-11-01 1996-03-26 Hitzig; Pietr Combined use of dopamine and serotonin agonists in the treatment of allergic disorders
FR2727682A1 (fr) * 1994-12-02 1996-06-07 Pf Medicament Nouveaux derives de 3,5-dioxo-(2h,4h)-1,2,4-triazines, leur preparation et leur application a titre de medicament
US5804203A (en) 1994-12-21 1998-09-08 Cosmederm Technologies Topical product formulations containing strontium for reducing skin irritation
US5489611A (en) * 1995-02-10 1996-02-06 Warner-Lambert Company Method for lowering plasma levels of lipoprotein (a)
US5830453A (en) * 1995-05-19 1998-11-03 Emory University Use of IL-13 to induce 15-lipoxygenase
US5637497A (en) * 1995-06-28 1997-06-10 Alcon Laboratories, Inc. Apparatus and method for cleaning and disinfecting contact lenses
FR2739777B1 (fr) * 1995-10-11 1997-11-14 Cird Galderma Ligand antagoniste rar-gamma ou agoniste rar-alpha en tant qu'inhibiteur d'apoptose
US5763496A (en) * 1995-11-27 1998-06-09 The Research Foundation Of State University Of New York Prevention of atherosclerosis using NADPH oxidase inhibitors
BR9509985A (pt) * 1995-12-12 1998-11-03 Omeros Med Sys Inc Solução para irrigação e método para inibição de dor inflamação e esparmo
US5597585A (en) * 1995-12-26 1997-01-28 Williams; Andrew H. Vitamin/mineral composition
AU2611297A (en) * 1996-04-12 1997-11-07 Eli Lilly And Company Bisindoles for treating pain or nociception
US5961969A (en) * 1996-05-14 1999-10-05 Maxim Pharmaceuticals, Inc. Stable circulating histamine levels
US6071942A (en) * 1996-05-14 2000-06-06 Maxim Pharmaceuticals, Inc. Elevation of circulating blood histamine levels
AU2434297A (en) * 1996-05-23 1997-12-09 Alcon Laboratories, Inc. The use of 5-ht1b/1d agonists to treat ocular pain
TW336325B (en) * 1996-05-24 1998-07-11 Electrocopper Products Ltd Copper wire and process for making copper wire
US5780440A (en) * 1996-06-17 1998-07-14 Protease Sciences Inc. Treatment of pulmonary disease with protease inhibitors
US5939460A (en) 1996-07-08 1999-08-17 Idun Pharmaceuticals, Inc. Method of inhibiting NADPH oxidase
JPH10120700A (ja) * 1996-10-17 1998-05-12 Takeda Chem Ind Ltd ヒスタミン産生増大因子およびその用途
WO1998031384A1 (en) * 1997-01-22 1998-07-23 The Wistar Institute Of Anatomy & Biology Methods and compositions using interleukin-13 for enhancing immune responses
CN1217698C (zh) * 1998-08-24 2005-09-07 马克西姆药品公司 应用h2受体激动剂和其它t细胞活化剂激活和保护t细胞(cd4+和cd8+)
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6270781B1 (en) * 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors

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AU768526B2 (en) 2003-12-18
EP1140077B1 (en) 2004-09-15
US20010023256A1 (en) 2001-09-20
ATE275954T1 (de) 2004-10-15
US20020150565A1 (en) 2002-10-17
ES2228453T3 (es) 2005-04-16
US6462067B1 (en) 2002-10-08
CN1203851C (zh) 2005-06-01
CN1342079A (zh) 2002-03-27
JP2002534384A (ja) 2002-10-15
CA2358851A1 (en) 2000-07-13
KR20010101416A (ko) 2001-11-14
IL143970A0 (en) 2002-04-21
DE60013764T2 (de) 2005-09-29
EP1140077A2 (en) 2001-10-10
WO2000040241A3 (en) 2000-11-30
DE60013764D1 (de) 2004-10-21
US6407133B2 (en) 2002-06-18
TWI248816B (en) 2006-02-11
HK1040923A1 (en) 2002-06-28
PT1140077E (pt) 2005-01-31
EP1410798A2 (en) 2004-04-21
US6730692B2 (en) 2004-05-04
US6242473B1 (en) 2001-06-05
HK1040923B (en) 2005-04-01
US20030017145A1 (en) 2003-01-23
US20040191239A1 (en) 2004-09-30

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