GB2285047B - Polypeptides which inhibit the NADPH oxidase complex - Google Patents

Polypeptides which inhibit the NADPH oxidase complex

Info

Publication number
GB2285047B
GB2285047B GB9424674A GB9424674A GB2285047B GB 2285047 B GB2285047 B GB 2285047B GB 9424674 A GB9424674 A GB 9424674A GB 9424674 A GB9424674 A GB 9424674A GB 2285047 B GB2285047 B GB 2285047B
Authority
GB
United Kingdom
Prior art keywords
polypeptides
inhibit
nadph oxidase
oxidase complex
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB9424674A
Other versions
GB9424674D0 (en
GB2285047A (en
Inventor
Yasuaki Shimizu
Michael Derek Waterfield
Ivan Tarasovich Gout
Peter Michael Finan
Stuart Kellie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Institute for Cancer Research London
Astellas Pharma Europe Ltd
Ludwig Institute for Cancer Research New York
Original Assignee
Ludwig Institute for Cancer Research London
Yamanouchi UK Ltd
Ludwig Institute for Cancer Research New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939326083A external-priority patent/GB9326083D0/en
Priority claimed from GB9400248A external-priority patent/GB9400248D0/en
Application filed by Ludwig Institute for Cancer Research London, Yamanouchi UK Ltd, Ludwig Institute for Cancer Research New York filed Critical Ludwig Institute for Cancer Research London
Priority to GB9424674A priority Critical patent/GB2285047B/en
Publication of GB9424674D0 publication Critical patent/GB9424674D0/en
Publication of GB2285047A publication Critical patent/GB2285047A/en
Application granted granted Critical
Publication of GB2285047B publication Critical patent/GB2285047B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
GB9424674A 1993-12-21 1994-12-07 Polypeptides which inhibit the NADPH oxidase complex Expired - Fee Related GB2285047B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9424674A GB2285047B (en) 1993-12-21 1994-12-07 Polypeptides which inhibit the NADPH oxidase complex

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939326083A GB9326083D0 (en) 1993-12-21 1993-12-21 Polypeptides which inhibit the nadph oxidase complex
GB9400248A GB9400248D0 (en) 1994-01-07 1994-01-07 Polypeptides which inhibit NADPH oxidise complex
GB9424674A GB2285047B (en) 1993-12-21 1994-12-07 Polypeptides which inhibit the NADPH oxidase complex

Publications (3)

Publication Number Publication Date
GB9424674D0 GB9424674D0 (en) 1995-02-01
GB2285047A GB2285047A (en) 1995-06-28
GB2285047B true GB2285047B (en) 1998-04-15

Family

ID=27266996

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9424674A Expired - Fee Related GB2285047B (en) 1993-12-21 1994-12-07 Polypeptides which inhibit the NADPH oxidase complex

Country Status (1)

Country Link
GB (1) GB2285047B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2311067B (en) * 1996-01-08 2000-03-29 Yamanouchi U K Ltd Proline rich peptides derived from the rasgap-associated protein P62
US6133233A (en) * 1997-02-18 2000-10-17 Kansas State University Research Foundation Peptide modulation of reperfusion injury
US5856139A (en) * 1997-03-11 1999-01-05 Incyte Pharmaceuticals, Inc. Proline-rich acidic protein
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
WO2001042453A1 (en) * 1999-12-06 2001-06-14 Biomolecular Engineering Research Institute Structural coordinate and nmr chemical shift of protein and utilization thereof
US6489149B1 (en) * 2001-03-29 2002-12-03 Pe Corporation (Ny) Isolated human NADPH oxidase, nucleic acid molecules encoding said proteins, and uses thereof
EP1281962A1 (en) * 2001-07-30 2003-02-05 Warner-Lambert Company Method for the screening of compounds that inhibit the interaction between a proline-rich peptide and an SH3 domain comprising peptide
EP1281963A3 (en) * 2001-07-30 2003-03-19 Warner-Lambert Company Method for the screening of compounds that inhibit the interaction between a proline-rich peptide and a SH3 domain comprising peptide
EP1509618B1 (en) 2002-05-13 2008-08-20 Arexis AB Autoimmune conditions and nadph oxidase defects
EP2752196A1 (en) * 2013-01-03 2014-07-09 Université Bordeaux Segalen Selective nox-1 inhibitor peptides and uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014749A1 (en) * 1992-01-31 1993-08-05 The Scripps Research Institute Inhibition of respiratory burst using posttranslational modification inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993014749A1 (en) * 1992-01-31 1993-08-05 The Scripps Research Institute Inhibition of respiratory burst using posttranslational modification inhibitors

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Mol.Cell.Biol. 1990,10(10),5388-5396 *
Nature 1993,363,83-85 *
Science 1993,259,1157-1161 *

Also Published As

Publication number Publication date
GB9424674D0 (en) 1995-02-01
GB2285047A (en) 1995-06-28

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20011207