KR20000049210A - 치환된 트리시클릭류 - Google Patents
치환된 트리시클릭류 Download PDFInfo
- Publication number
- KR20000049210A KR20000049210A KR1019990703309A KR19997003309A KR20000049210A KR 20000049210 A KR20000049210 A KR 20000049210A KR 1019990703309 A KR1019990703309 A KR 1019990703309A KR 19997003309 A KR19997003309 A KR 19997003309A KR 20000049210 A KR20000049210 A KR 20000049210A
- Authority
- KR
- South Korea
- Prior art keywords
- arthritis
- phenyl
- alkyl
- benzyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2984996P | 1996-10-30 | 1996-10-30 | |
| US60/029,849 | 1996-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20000049210A true KR20000049210A (ko) | 2000-07-25 |
Family
ID=21851210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019990703309A Ceased KR20000049210A (ko) | 1996-10-30 | 1997-10-23 | 치환된 트리시클릭류 |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0839806B1 (enExample) |
| JP (1) | JP2001503055A (enExample) |
| KR (1) | KR20000049210A (enExample) |
| CN (1) | CN1233176A (enExample) |
| AR (1) | AR010050A1 (enExample) |
| AT (1) | ATE244703T1 (enExample) |
| AU (1) | AU734096B2 (enExample) |
| BR (1) | BR9713261A (enExample) |
| CA (1) | CA2269203A1 (enExample) |
| CO (1) | CO4920250A1 (enExample) |
| CZ (1) | CZ136899A3 (enExample) |
| DE (1) | DE69723393T2 (enExample) |
| DK (1) | DK0839806T3 (enExample) |
| EA (1) | EA003992B1 (enExample) |
| ES (1) | ES2202560T3 (enExample) |
| ID (1) | ID18685A (enExample) |
| IL (1) | IL129481A0 (enExample) |
| NO (1) | NO314899B1 (enExample) |
| NZ (1) | NZ335246A (enExample) |
| PE (1) | PE10999A1 (enExample) |
| PL (1) | PL332896A1 (enExample) |
| PT (1) | PT839806E (enExample) |
| TR (1) | TR199900956T2 (enExample) |
| TW (1) | TW513428B (enExample) |
| WO (1) | WO1998018464A1 (enExample) |
| YU (1) | YU19299A (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2301586A1 (en) * | 1997-08-28 | 1999-03-04 | William Louis Macias | Method for treatment of non-rheumatoid arthritis |
| HUP0102981A3 (en) | 1998-03-31 | 2002-10-28 | Shionogi & Co | Pyrrolo[1,2-a]pyrazine derivatives and pharmaceutical compositions thereof |
| IL129484A0 (en) * | 1998-04-17 | 2000-02-29 | Lilly Co Eli | Substituted tricyclics |
| DZ2769A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Composés tricycliques substitués. |
| TR200003194T2 (tr) | 1998-05-01 | 2001-03-21 | Eli Lilly And Company | Hastalık tedavisine mahsus sPLA2 önleyici bileşikler |
| KR20010034881A (ko) | 1998-05-21 | 2001-04-25 | 시오노 요시히코 | ｓＰＬＡ2 억제 효과를 갖는 피롤로[1,2-ｂ]피리다진 유도체 |
| ATE329619T1 (de) | 1998-10-14 | 2006-07-15 | Shionogi & Co | Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden |
| US6448284B1 (en) * | 1998-12-22 | 2002-09-10 | Eli Lilly And Company | Substituted tricyclics |
| AU6015600A (en) | 1999-07-19 | 2001-02-05 | Shionogi & Co., Ltd. | Tricyclic compounds having spla2-inhibitory activities |
| US6673781B1 (en) | 1999-08-02 | 2004-01-06 | Shionogi & Co., Ltd. | Tricyclic compounds having sPLA2-inhibitory activities |
| US6787545B1 (en) | 1999-08-23 | 2004-09-07 | Shiongi & Co., Ltd. | Pyrrolotriazine derivatives having spla2-inhibitory activities |
| MY125942A (en) | 1999-09-07 | 2006-09-29 | Upjohn Co | Aminoalkoxy carbazoles for the treatment of cns diseases |
| US6756376B1 (en) | 1999-11-15 | 2004-06-29 | Shionogi & Co., Ltd. | Tricyclic azaindolizine derivatives having an sPLA2-inhibitory activities |
| WO2001049323A1 (en) * | 2000-01-06 | 2001-07-12 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
| JPWO2002000621A1 (ja) | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | Ｘ型ｓＰＬＡ２阻害作用を有する化合物 |
| WO2002000256A1 (fr) | 2000-06-29 | 2002-01-03 | Shionogi & Co., Ltd. | Remedes contre la cirrhose |
| US6872743B2 (en) | 2000-12-18 | 2005-03-29 | Eli Lilly And Company | sPLA2 inhibitors |
| TWI314457B (enExample) | 2001-03-19 | 2009-09-11 | Shionogi & Co | |
| AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
| US8329913B2 (en) | 2004-10-29 | 2012-12-11 | Zeria Pharmaceutical Co., Ltd. | Carbazole derivative, solvate thereof, or pharmaceutically acceptable salt thereof |
| ES2924728T3 (es) | 2015-06-15 | 2022-10-10 | Raziel Therapeutics Ltd | Derivados de carbazol para el tratamiento de enfermedades fibróticas, así como de síntomas y afecciones relacionados con las mismas |
| CN112409493B (zh) * | 2020-08-12 | 2022-09-30 | 浙江工业大学 | 一种重组融合酶及其在乙醛酸甲酯合成中的应用 |
| US12440370B2 (en) | 2020-10-21 | 2025-10-14 | Purewick Corporation | Apparatus with compressible casing for receiving discharged urine |
| US12208031B2 (en) | 2020-10-21 | 2025-01-28 | Purewick Corporation | Adapters for fluid collection devices |
| US12257174B2 (en) | 2020-10-21 | 2025-03-25 | Purewick Corporation | Fluid collection assemblies including at least one of a protrusion or at least one expandable material |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3479391A (en) * | 1966-10-03 | 1969-11-18 | Squibb & Sons Inc | Delta**3,14-17alpha-hydroxy-norprogesterone and esters |
| US3939177A (en) * | 1972-11-22 | 1976-02-17 | Sterling Drug Inc. | 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles |
| US3979391A (en) * | 1972-11-22 | 1976-09-07 | Sterling Drug Inc. | 1,2,3,4-Tetrahydrocarbazoles |
| US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
| IL109309A (en) * | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
| IL109311A0 (en) * | 1993-04-16 | 1994-07-31 | Lilly Co Eli | 1H-indole-3-acetamide sPla2 inhibitors |
-
1997
- 1997-10-23 KR KR1019990703309A patent/KR20000049210A/ko not_active Ceased
- 1997-10-23 CZ CZ991368A patent/CZ136899A3/cs unknown
- 1997-10-23 CN CN97198834A patent/CN1233176A/zh active Pending
- 1997-10-23 IL IL12948197A patent/IL129481A0/xx unknown
- 1997-10-23 BR BR9713261-6A patent/BR9713261A/pt unknown
- 1997-10-23 TR TR1999/00956T patent/TR199900956T2/xx unknown
- 1997-10-23 NZ NZ335246A patent/NZ335246A/en unknown
- 1997-10-23 JP JP10520585A patent/JP2001503055A/ja active Pending
- 1997-10-23 CA CA002269203A patent/CA2269203A1/en not_active Abandoned
- 1997-10-23 EA EA199900305A patent/EA003992B1/ru not_active IP Right Cessation
- 1997-10-23 PL PL97332896A patent/PL332896A1/xx unknown
- 1997-10-23 YU YU19299A patent/YU19299A/sh unknown
- 1997-10-23 AU AU51494/98A patent/AU734096B2/en not_active Ceased
- 1997-10-23 WO PCT/US1997/019183 patent/WO1998018464A1/en not_active Ceased
- 1997-10-24 PE PE1997000950A patent/PE10999A1/es not_active Application Discontinuation
- 1997-10-27 ID IDP973534A patent/ID18685A/id unknown
- 1997-10-28 AR ARP970104997A patent/AR010050A1/es active IP Right Grant
- 1997-10-28 CO CO97063171A patent/CO4920250A1/es unknown
- 1997-10-29 EP EP97308645A patent/EP0839806B1/en not_active Expired - Lifetime
- 1997-10-29 PT PT97308645T patent/PT839806E/pt unknown
- 1997-10-29 AT AT97308645T patent/ATE244703T1/de active
- 1997-10-29 ES ES97308645T patent/ES2202560T3/es not_active Expired - Lifetime
- 1997-10-29 DE DE69723393T patent/DE69723393T2/de not_active Expired - Lifetime
- 1997-10-29 DK DK97308645T patent/DK0839806T3/da active
- 1997-10-30 TW TW086116217A patent/TW513428B/zh not_active IP Right Cessation
-
1999
- 1999-04-16 NO NO19991831A patent/NO314899B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT839806E (pt) | 2003-11-28 |
| NO991831L (no) | 1999-06-21 |
| PE10999A1 (es) | 1999-02-10 |
| DE69723393T2 (de) | 2004-06-09 |
| ES2202560T3 (es) | 2004-04-01 |
| EP0839806B1 (en) | 2003-07-09 |
| EA199900305A1 (ru) | 1999-12-29 |
| NO991831D0 (no) | 1999-04-16 |
| NZ335246A (en) | 2001-09-28 |
| ATE244703T1 (de) | 2003-07-15 |
| CO4920250A1 (es) | 2000-05-29 |
| AR010050A1 (es) | 2000-05-17 |
| NO314899B1 (no) | 2003-06-10 |
| TR199900956T2 (xx) | 1999-07-21 |
| DK0839806T3 (da) | 2003-10-27 |
| CA2269203A1 (en) | 1998-05-07 |
| AU5149498A (en) | 1998-05-22 |
| EP0839806A1 (en) | 1998-05-06 |
| EA003992B1 (ru) | 2003-12-25 |
| BR9713261A (pt) | 2000-03-28 |
| YU19299A (sh) | 2000-03-21 |
| WO1998018464A1 (en) | 1998-05-07 |
| TW513428B (en) | 2002-12-11 |
| IL129481A0 (en) | 2000-02-29 |
| CN1233176A (zh) | 1999-10-27 |
| ID18685A (id) | 1998-04-30 |
| JP2001503055A (ja) | 2001-03-06 |
| PL332896A1 (en) | 1999-10-25 |
| AU734096B2 (en) | 2001-06-07 |
| CZ136899A3 (cs) | 1999-09-15 |
| DE69723393D1 (de) | 2003-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 19990416 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20020528 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20040831 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20050223 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20040831 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |