KR19990072045A - 고품질카프토프릴의간편한제조방법 - Google Patents

고품질카프토프릴의간편한제조방법 Download PDF

Info

Publication number
KR19990072045A
KR19990072045A KR1019980704339A KR19980704339A KR19990072045A KR 19990072045 A KR19990072045 A KR 19990072045A KR 1019980704339 A KR1019980704339 A KR 1019980704339A KR 19980704339 A KR19980704339 A KR 19980704339A KR 19990072045 A KR19990072045 A KR 19990072045A
Authority
KR
South Korea
Prior art keywords
formula
captopril
compound
reaction
aqueous medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019980704339A
Other languages
English (en)
Korean (ko)
Inventor
고이찌 기노시따
후미히꼬 가노우
다까히로 오꾸보
야스요시 우에다
Original Assignee
후루타 다케시
가네가후치 가가쿠고교 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 후루타 다케시, 가네가후치 가가쿠고교 가부시키가이샤 filed Critical 후루타 다케시
Publication of KR19990072045A publication Critical patent/KR19990072045A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
KR1019980704339A 1996-10-11 1997-10-13 고품질카프토프릴의간편한제조방법 Ceased KR19990072045A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP28934096A JP3980684B2 (ja) 1996-10-11 1996-10-11 高品質カプトプリルの簡便な製造方法
JP96-289340 1996-10-11
PCT/JP1997/003655 WO1998016509A1 (en) 1996-10-11 1997-10-13 Simple process for producing high-quality captopril

Publications (1)

Publication Number Publication Date
KR19990072045A true KR19990072045A (ko) 1999-09-27

Family

ID=17741941

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019980704339A Ceased KR19990072045A (ko) 1996-10-11 1997-10-13 고품질카프토프릴의간편한제조방법

Country Status (14)

Country Link
US (1) US6187932B1 (enExample)
EP (1) EP0889031B1 (enExample)
JP (1) JP3980684B2 (enExample)
KR (1) KR19990072045A (enExample)
AT (1) ATE231125T1 (enExample)
CA (1) CA2249543A1 (enExample)
DE (1) DE69718450T2 (enExample)
ES (1) ES2191200T3 (enExample)
HR (1) HRP970536A2 (enExample)
HU (1) HUP0000199A3 (enExample)
IL (1) IL124747A (enExample)
IN (1) IN183229B (enExample)
SI (1) SI9720012A (enExample)
WO (1) WO1998016509A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652215A (zh) * 2017-09-19 2018-02-02 重庆西南制药二厂有限责任公司 一种卡托普利的制备方法
CN110950792A (zh) * 2019-12-11 2020-04-03 华中药业股份有限公司 一种卡托普利的改进制备方法
CN116655512A (zh) * 2023-05-31 2023-08-29 江苏阿尔法药业股份有限公司 一种卡托普利的制备工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538363A (en) * 1978-09-13 1980-03-17 Yoshitomi Pharmaceut Ind Ltd Preparation of optically active n-mercaptoacyl-imino acid
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
JP2896818B2 (ja) * 1991-04-02 1999-05-31 三菱レイヨン株式会社 Ｌ−プロリン誘導体の製造法
JPH05221966A (ja) * 1992-02-18 1993-08-31 Mitsubishi Rayon Co Ltd Ｌ−プロリン誘導体の製造方法
HU211101B (en) * 1992-03-13 1995-10-30 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid
US5387697A (en) * 1994-06-13 1995-02-07 Merck & Co., Inc. Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JPH09157251A (ja) 1995-10-06 1997-06-17 Kanegafuchi Chem Ind Co Ltd Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法

Also Published As

Publication number Publication date
EP0889031A4 (en) 2000-03-22
EP0889031A1 (en) 1999-01-07
IN183229B (enExample) 1999-10-09
JPH10114740A (ja) 1998-05-06
WO1998016509A1 (en) 1998-04-23
IL124747A (en) 2003-05-29
SI9720012A (sl) 1998-12-31
HUP0000199A2 (hu) 2000-06-28
DE69718450D1 (de) 2003-02-20
EP0889031B1 (en) 2003-01-15
CA2249543A1 (en) 1998-04-23
HUP0000199A3 (en) 2001-12-28
ATE231125T1 (de) 2003-02-15
JP3980684B2 (ja) 2007-09-26
IL124747A0 (en) 1999-01-26
HRP970536A2 (en) 1998-08-31
DE69718450T2 (de) 2003-11-20
ES2191200T3 (es) 2003-09-01
US6187932B1 (en) 2001-02-13

Similar Documents

Publication Publication Date Title
EP1377544B1 (en) Purification of 2-nitro-4-methylsulphonylbenzoic acid
JP4322621B2 (ja) ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
EP0802182B1 (en) PROCESS FOR PRODUCING N-(D-alpha-METHYL-beta-MERCAPTOPROPIONYL)-L-PROLINE AND INTERMEDIATES THEREOF
KR19990072045A (ko) 고품질카프토프릴의간편한제조방법
US5118840A (en) Method of crystallizing phenylalanine
JP2957273B2 (ja) ７―クロル―キノリン―８―カルボン酸の精製方法
EP0021644B1 (en) A salt of 3-thienylmalonic acid and a process for the preparation of 3-thienylmalonic acid
JPH0710835A (ja) Ｌ−プロリン誘導体の精製法
JP3815064B2 (ja) １−（４−クロロベンゾイル）−５−メトキシ−２−メチルインドール−３−酢酸の精製方法
JP4453247B2 (ja) ３，３−ジメチルシクロプロパン−１，２−ジカルボン酸無水物の精製方法
US6320072B1 (en) Method for isolation of n-protected s-phenylcysteine
JPH01143847A (ja) ３−（３，５−ジ第３級ブチル−４−ヒドロキシフェニル）プロピオン酸エステルの分離精製法
KR20000013423A (ko) 무정형 세푸록심 악세틸의 합성방법
CH637967A5 (fr) Produit d'addition du n,n-dimethylacetamide et d'un derive d'un acide cephem-4-carboxylique et procede de sa preparation.
JPH0623149B2 (ja) 高純度ｎ−アセチル−ｄｌ−アミノ酸の製造方法
JPH0680628A (ja) Ｎ−（Ｄ−α−アルキル−β−メルカプトプロピオニル）−Ｌ−プロリンの精製法
WO2000068205A1 (en) Process for obtaining a hydroxamic acid
JPH11100363A (ja) アミノ基が保護された（２ｓ，３ｒ）−１−ハロ−２−ヒドロキシ−３−アミノ−４−フェニルチオブタン又はその光学対掌体の精製、単離方法
JP2000186069A (ja) Ｎ―保護―ｓ―フェニルシステインの単離方法
EP1275642A1 (en) Process for crystallization of 2-acetylthio-3-phenyl-propionic acid
MXPA00009168A (en) Method for isolation of n-protected s-phenylcysteine

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 19980610

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20021007

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20041130

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20050325

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20041130

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I