HUP0000199A2 - Eljárás nagytisztaságú kaptopril előállítására - Google Patents
Eljárás nagytisztaságú kaptopril előállításáraInfo
- Publication number
- HUP0000199A2 HUP0000199A2 HU0000199A HUP0000199A HUP0000199A2 HU P0000199 A2 HUP0000199 A2 HU P0000199A2 HU 0000199 A HU0000199 A HU 0000199A HU P0000199 A HUP0000199 A HU P0000199A HU P0000199 A2 HUP0000199 A2 HU P0000199A2
- Authority
- HU
- Hungary
- Prior art keywords
- captopril
- purity
- simple process
- producing high
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- FAKRSMQSSFJEIM-RQJHMYQMSA-N captopril Chemical compound SC[C@@H](C)C(=O)N1CCC[C@H]1C(O)=O FAKRSMQSSFJEIM-RQJHMYQMSA-N 0.000 title 1
- 229960000830 captopril Drugs 0.000 title 1
- 239000012736 aqueous medium Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical compound OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
A találmány tárgyát eljárás képezi az (1) képletű kaptőprilelőállítására. A találmány szerint a (2) általánős képletűszűbsztrátűmvegyü-letet hidrőlízises reakciónak vetik alá vizesközegben az RCO csőpőrt eltávőlítása céljából, majd a kapőttvegyületet izőlálják. A hidrőlízises reakciót vizes közegbenfőlytatják le erős sav jelenlétében legfeljebb 1 pH-értéken éslegalább 40 řC hőmérsékleten. (1) (2) ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP28934096A JP3980684B2 (ja) | 1996-10-11 | 1996-10-11 | 高品質カプトプリルの簡便な製造方法 |
PCT/JP1997/003655 WO1998016509A1 (fr) | 1996-10-11 | 1997-10-13 | Procede simplifie pour produire du captotril de qualite superieure |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0000199A2 true HUP0000199A2 (hu) | 2000-06-28 |
HUP0000199A3 HUP0000199A3 (en) | 2001-12-28 |
Family
ID=17741941
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0000199A HUP0000199A3 (en) | 1996-10-11 | 1997-10-13 | Simple process for producing high-purity captopril |
Country Status (14)
Country | Link |
---|---|
US (1) | US6187932B1 (hu) |
EP (1) | EP0889031B1 (hu) |
JP (1) | JP3980684B2 (hu) |
KR (1) | KR19990072045A (hu) |
AT (1) | ATE231125T1 (hu) |
CA (1) | CA2249543A1 (hu) |
DE (1) | DE69718450T2 (hu) |
ES (1) | ES2191200T3 (hu) |
HR (1) | HRP970536A2 (hu) |
HU (1) | HUP0000199A3 (hu) |
IL (1) | IL124747A (hu) |
IN (1) | IN183229B (hu) |
SI (1) | SI9720012A (hu) |
WO (1) | WO1998016509A1 (hu) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107652215A (zh) * | 2017-09-19 | 2018-02-02 | 重庆西南制药二厂有限责任公司 | 一种卡托普利的制备方法 |
CN110950792A (zh) * | 2019-12-11 | 2020-04-03 | 华中药业股份有限公司 | 一种卡托普利的改进制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5538363A (en) * | 1978-09-13 | 1980-03-17 | Yoshitomi Pharmaceut Ind Ltd | Preparation of optically active n-mercaptoacyl-imino acid |
US4297282A (en) * | 1979-03-02 | 1981-10-27 | Sumitomo Chemical Company, Limited | Resolution of mercaptopropionic acids |
US5026873A (en) * | 1989-11-06 | 1991-06-25 | E. R. Squibb & Sons, Inc. | Process for direct isolation of captopril |
JP2896818B2 (ja) * | 1991-04-02 | 1999-05-31 | 三菱レイヨン株式会社 | L−プロリン誘導体の製造法 |
JPH05221966A (ja) * | 1992-02-18 | 1993-08-31 | Mitsubishi Rayon Co Ltd | L−プロリン誘導体の製造方法 |
HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
US5387697A (en) * | 1994-06-13 | 1995-02-07 | Merck & Co., Inc. | Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline |
JPH09157251A (ja) | 1995-10-06 | 1997-06-17 | Kanegafuchi Chem Ind Co Ltd | N−(D−α−メチル−β−メルカプトプロピオニル)−L−プロリン及び該中間体の製造方法 |
-
1996
- 1996-10-11 JP JP28934096A patent/JP3980684B2/ja not_active Expired - Lifetime
-
1997
- 1997-10-07 IN IN1885CA1997 patent/IN183229B/en unknown
- 1997-10-08 HR HRHEI-8-289340A patent/HRP970536A2/hr not_active Application Discontinuation
- 1997-10-13 DE DE69718450T patent/DE69718450T2/de not_active Expired - Fee Related
- 1997-10-13 ES ES97943179T patent/ES2191200T3/es not_active Expired - Lifetime
- 1997-10-13 US US09/077,747 patent/US6187932B1/en not_active Expired - Fee Related
- 1997-10-13 HU HU0000199A patent/HUP0000199A3/hu unknown
- 1997-10-13 KR KR1019980704339A patent/KR19990072045A/ko not_active Application Discontinuation
- 1997-10-13 WO PCT/JP1997/003655 patent/WO1998016509A1/ja not_active Application Discontinuation
- 1997-10-13 SI SI9720012A patent/SI9720012A/sl not_active IP Right Cessation
- 1997-10-13 AT AT97943179T patent/ATE231125T1/de not_active IP Right Cessation
- 1997-10-13 CA CA002249543A patent/CA2249543A1/en not_active Abandoned
- 1997-10-13 IL IL12474797A patent/IL124747A/xx not_active IP Right Cessation
- 1997-10-13 EP EP97943179A patent/EP0889031B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2249543A1 (en) | 1998-04-23 |
SI9720012A (sl) | 1998-12-31 |
JP3980684B2 (ja) | 2007-09-26 |
ATE231125T1 (de) | 2003-02-15 |
JPH10114740A (ja) | 1998-05-06 |
HUP0000199A3 (en) | 2001-12-28 |
EP0889031B1 (en) | 2003-01-15 |
ES2191200T3 (es) | 2003-09-01 |
DE69718450D1 (de) | 2003-02-20 |
US6187932B1 (en) | 2001-02-13 |
WO1998016509A1 (fr) | 1998-04-23 |
IL124747A0 (en) | 1999-01-26 |
IL124747A (en) | 2003-05-29 |
HRP970536A2 (en) | 1998-08-31 |
DE69718450T2 (de) | 2003-11-20 |
KR19990072045A (ko) | 1999-09-27 |
EP0889031A1 (en) | 1999-01-07 |
EP0889031A4 (en) | 2000-03-22 |
IN183229B (hu) | 1999-10-09 |
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