IL124747A - Process for producing captopril - Google Patents

Process for producing captopril

Info

Publication number
IL124747A
IL124747A IL12474797A IL12474797A IL124747A IL 124747 A IL124747 A IL 124747A IL 12474797 A IL12474797 A IL 12474797A IL 12474797 A IL12474797 A IL 12474797A IL 124747 A IL124747 A IL 124747A
Authority
IL
Israel
Prior art keywords
aqueous medium
hydrolysis reaction
producing captopril
captopril
producing
Prior art date
Application number
IL12474797A
Other languages
English (en)
Other versions
IL124747A0 (en
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Publication of IL124747A0 publication Critical patent/IL124747A0/xx
Publication of IL124747A publication Critical patent/IL124747A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
IL12474797A 1996-10-11 1997-10-13 Process for producing captopril IL124747A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28934096A JP3980684B2 (ja) 1996-10-11 1996-10-11 高品質カプトプリルの簡便な製造方法
PCT/JP1997/003655 WO1998016509A1 (fr) 1996-10-11 1997-10-13 Procede simplifie pour produire du captotril de qualite superieure

Publications (2)

Publication Number Publication Date
IL124747A0 IL124747A0 (en) 1999-01-26
IL124747A true IL124747A (en) 2003-05-29

Family

ID=17741941

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12474797A IL124747A (en) 1996-10-11 1997-10-13 Process for producing captopril

Country Status (14)

Country Link
US (1) US6187932B1 (xx)
EP (1) EP0889031B1 (xx)
JP (1) JP3980684B2 (xx)
KR (1) KR19990072045A (xx)
AT (1) ATE231125T1 (xx)
CA (1) CA2249543A1 (xx)
DE (1) DE69718450T2 (xx)
ES (1) ES2191200T3 (xx)
HR (1) HRP970536A2 (xx)
HU (1) HUP0000199A3 (xx)
IL (1) IL124747A (xx)
IN (1) IN183229B (xx)
SI (1) SI9720012A (xx)
WO (1) WO1998016509A1 (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107652215A (zh) * 2017-09-19 2018-02-02 重庆西南制药二厂有限责任公司 一种卡托普利的制备方法
CN110950792A (zh) * 2019-12-11 2020-04-03 华中药业股份有限公司 一种卡托普利的改进制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538363A (en) * 1978-09-13 1980-03-17 Yoshitomi Pharmaceut Ind Ltd Preparation of optically active n-mercaptoacyl-imino acid
US4297282A (en) * 1979-03-02 1981-10-27 Sumitomo Chemical Company, Limited Resolution of mercaptopropionic acids
US5026873A (en) * 1989-11-06 1991-06-25 E. R. Squibb & Sons, Inc. Process for direct isolation of captopril
JP2896818B2 (ja) * 1991-04-02 1999-05-31 三菱レイヨン株式会社 Ｌ−プロリン誘導体の製造法
JPH05221966A (ja) * 1992-02-18 1993-08-31 Mitsubishi Rayon Co Ltd Ｌ−プロリン誘導体の製造方法
HU211101B (en) * 1992-03-13 1995-10-30 Egyt Gyogyszervegyeszeti Gyar Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid
US5387697A (en) * 1994-06-13 1995-02-07 Merck & Co., Inc. Process for the preparation of 1-[3-acetylthio-2(s)-methylpropanoyl]-l-proline
JPH09157251A (ja) 1995-10-06 1997-06-17 Kanegafuchi Chem Ind Co Ltd Ｎ−（Ｄ−α−メチル−β−メルカプトプロピオニル）−Ｌ−プロリン及び該中間体の製造方法

Also Published As

Publication number Publication date
CA2249543A1 (en) 1998-04-23
SI9720012A (sl) 1998-12-31
JP3980684B2 (ja) 2007-09-26
ATE231125T1 (de) 2003-02-15
JPH10114740A (ja) 1998-05-06
HUP0000199A3 (en) 2001-12-28
EP0889031B1 (en) 2003-01-15
HUP0000199A2 (hu) 2000-06-28
ES2191200T3 (es) 2003-09-01
DE69718450D1 (de) 2003-02-20
US6187932B1 (en) 2001-02-13
WO1998016509A1 (fr) 1998-04-23
IL124747A0 (en) 1999-01-26
HRP970536A2 (en) 1998-08-31
DE69718450T2 (de) 2003-11-20
KR19990072045A (ko) 1999-09-27
EP0889031A1 (en) 1999-01-07
EP0889031A4 (en) 2000-03-22
IN183229B (xx) 1999-10-09

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees