DE69517832D1 - Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen - Google Patents

Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen

Info

Publication number
DE69517832D1
DE69517832D1 DE69517832T DE69517832T DE69517832D1 DE 69517832 D1 DE69517832 D1 DE 69517832D1 DE 69517832 T DE69517832 T DE 69517832T DE 69517832 T DE69517832 T DE 69517832T DE 69517832 D1 DE69517832 D1 DE 69517832D1
Authority
DE
Germany
Prior art keywords
preparation
tetrazolyl compound
tetrazolyl compounds
tetrazolyl
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69517832T
Other languages
English (en)
Other versions
DE69517832T2 (de
Inventor
Yasushi Shida
Kokichi Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69517832D1 publication Critical patent/DE69517832D1/de
Application granted granted Critical
Publication of DE69517832T2 publication Critical patent/DE69517832T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DE69517832T 1994-01-28 1995-01-26 Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen Expired - Lifetime DE69517832T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP823394 1994-01-28

Publications (2)

Publication Number Publication Date
DE69517832D1 true DE69517832D1 (de) 2000-08-17
DE69517832T2 DE69517832T2 (de) 2000-11-09

Family

ID=11687442

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517832T Expired - Lifetime DE69517832T2 (de) 1994-01-28 1995-01-26 Ein Verfahren zur Herstellung von Tetrazolyl-Verbindungen

Country Status (9)

Country Link
US (2) US5578733A (de)
EP (1) EP0668272B1 (de)
AT (1) ATE194603T1 (de)
CA (1) CA2141175C (de)
DE (1) DE69517832T2 (de)
DK (1) DK0668272T3 (de)
ES (1) ES2147798T3 (de)
GR (1) GR3034464T3 (de)
PT (1) PT668272E (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE416784T1 (de) 2000-12-01 2008-12-15 Takeda Pharmaceutical Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
EP1482896A4 (de) * 2002-03-01 2005-11-23 Merck & Co Inc Aminoalkylphosphonate und verwandte verbindungen als edg-rezeptor-agonisten
DE602004013405T2 (de) * 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
AU2003230193A1 (en) * 2003-03-27 2004-10-18 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
EP1556363A2 (de) 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Verfahren zur herstellung von valsartan und zwischenprodukte davon
CZ297016B6 (cs) * 2003-08-27 2006-08-16 Zentiva, A.S. Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím
US7098342B2 (en) * 2003-10-16 2006-08-29 Teva Pharmaceutical Industries Ltd. Preparation of candesartan cilexetil
WO2005051928A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
EP1713795A2 (de) * 2004-02-11 2006-10-25 Teva Pharmaceutical Industries Ltd. Candesartan-cilexetil-polymorphe
KR20090029310A (ko) * 2004-05-05 2009-03-20 테바 파마슈티컬 인더스트리즈 리미티드 순도가 높은 칸데사르탄 실렉세틸의 제조
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
EP1655298A1 (de) * 2004-11-03 2006-05-10 LEK Pharmaceuticals d.d. Krystalline Polymorpheme Formen von Candesartan Cilexetil
EP1812423A1 (de) 2004-11-11 2007-08-01 LEK Pharmaceuticals D.D. Verfahren zur synthese von tetrazolen
EP1836195A2 (de) * 2005-01-14 2007-09-26 Teva Pharmaceutical Industries Ltd Herstellung von rohem candesartan-cilexetil
EP1763525A2 (de) * 2005-05-10 2007-03-21 Teva Pharmaceutical Industries Ltd. Stabiles mikronisiertes candesartan-cilexetil und herstellungsverfahren
EP1896455A2 (de) 2005-06-06 2008-03-12 Medichem, S.A. Verfahren zur herstellung von tetrazolylverbindungen
EP1816131A1 (de) * 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur Herstellung von Olmesartan Medoxomil
CA2616466A1 (en) * 2005-07-29 2007-02-15 Krka Process for the preparation of olmesartan medoxomil
SI22127A (sl) 2005-10-07 2007-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo kandesartan cileksetila
CZ299265B6 (cs) * 2005-10-20 2008-05-28 Zentiva, A. S. Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu)
ITTO20060560A1 (it) * 2006-07-27 2008-01-28 S I M S S R L Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii
WO2008012372A1 (en) * 2006-07-28 2008-01-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of candesartan cilexetil form i
US20100210852A1 (en) * 2007-07-11 2010-08-19 Alembic Limited Process for the preparation of candesartan cilexetil
EP2432777A1 (de) 2009-05-20 2012-03-28 Ranbaxy Laboratories Limited Verfahren zur herstellung von olmesartan-medoxomil
WO2011080684A1 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Process for the preparation of candesartan cilexetil
WO2011092666A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
KR101251741B1 (ko) 2010-12-16 2013-04-05 동화약품주식회사 칸데사르탄실렉세틸의 개선된 제조방법
CN103396408A (zh) * 2013-08-13 2013-11-20 河南华商药业有限公司 坎地沙坦酯中杂质b的制备方法
CN109776503A (zh) * 2019-01-30 2019-05-21 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法
CN109851612A (zh) * 2019-01-30 2019-06-07 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法
CN109627234A (zh) * 2019-01-30 2019-04-16 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
TW209213B (de) * 1991-08-21 1993-07-11 Yamanouchi Pharma Co Ltd
IL103020A (en) * 1991-09-10 1998-10-30 Tanabe Seiyaku Co History of acid 3) 1, '1 in biphenyl 4 Methyl (4,5,6,7 tetrahydro H3 imidazo] C 4,5 [pyridine 4 carboxylic acid, preparation and pharmaceutical preparations containing them
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
EP0550313A1 (de) * 1991-12-30 1993-07-07 Synthelabo 2-(Tetranol-5-yl)-(1,1'-Biphenyl)derivate, ihre Herstellung und Anwendung als Zwischenverbindungen
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
DK0668272T3 (da) 2000-09-18
CA2141175C (en) 2006-12-12
ES2147798T3 (es) 2000-10-01
ATE194603T1 (de) 2000-07-15
DE69517832T2 (de) 2000-11-09
GR3034464T3 (en) 2000-12-29
US5763619A (en) 1998-06-09
EP0668272B1 (de) 2000-07-12
CA2141175A1 (en) 1995-07-29
EP0668272A2 (de) 1995-08-23
EP0668272A3 (de) 1995-08-30
US5578733A (en) 1996-11-26
PT668272E (pt) 2000-10-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP