ES2147798T3 - Un procedimiento para la produccion de compuestos de tetrazolilo. - Google Patents

Un procedimiento para la produccion de compuestos de tetrazolilo.

Info

Publication number
ES2147798T3
ES2147798T3 ES95101055T ES95101055T ES2147798T3 ES 2147798 T3 ES2147798 T3 ES 2147798T3 ES 95101055 T ES95101055 T ES 95101055T ES 95101055 T ES95101055 T ES 95101055T ES 2147798 T3 ES2147798 T3 ES 2147798T3
Authority
ES
Spain
Prior art keywords
procedure
production
tetrazolyl compounds
tetrazolyl compound
tetrazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95101055T
Other languages
English (en)
Inventor
Yasushi Shida
Kokichi Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2147798T3 publication Critical patent/ES2147798T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA EXTRAER UN GRUPO PROTECTOR DE UN COMPUESTO DE TETRAZOLILO N-PROTEGIDO, QUE COMPRENDE LA REACCION DEL CITADO COMPUESTO DE TETRAZOLIL N-PROTEGIDO CON UN ACIDO MINERAL, EN CONDICIONES SUSTANCIALMENTE ANHIDRAS, EN PRESENCIA DE UN ALCOHOL, ASEGURANDO UN RESULTADO DE ALTA REACCION DEL COMPUESTO DE TETRATROZILO PRODUCIDO.
ES95101055T 1994-01-28 1995-01-26 Un procedimiento para la produccion de compuestos de tetrazolilo. Expired - Lifetime ES2147798T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP823394 1994-01-28

Publications (1)

Publication Number Publication Date
ES2147798T3 true ES2147798T3 (es) 2000-10-01

Family

ID=11687442

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95101055T Expired - Lifetime ES2147798T3 (es) 1994-01-28 1995-01-26 Un procedimiento para la produccion de compuestos de tetrazolilo.

Country Status (9)

Country Link
US (2) US5578733A (es)
EP (1) EP0668272B1 (es)
AT (1) ATE194603T1 (es)
CA (1) CA2141175C (es)
DE (1) DE69517832T2 (es)
DK (1) DK0668272T3 (es)
ES (1) ES2147798T3 (es)
GR (1) GR3034464T3 (es)
PT (1) PT668272E (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1346722B1 (en) 2000-12-01 2008-12-10 Takeda Pharmaceutical Company Limited Method for producing preparation containing bioactive substance
CA2466659A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticancer agents
JP2005531508A (ja) * 2002-03-01 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
DE602004013405T2 (de) * 2003-03-17 2009-05-07 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
AU2003230193A1 (en) 2003-03-27 2004-10-18 Hetero Drugs Limited Novel crystalline forms of candesartan cilexetil
WO2004094391A2 (en) 2003-04-21 2004-11-04 Teva Pharmaceutical Industries Ltd. Process for the preparation of valsartan and intermediates thereof
CZ297016B6 (cs) * 2003-08-27 2006-08-16 Zentiva, A.S. Zpusob odstranování trifenylmethanové chránicí skupiny z 1-trityl-5-(4'-subst. aminomethyl-1,1' -bifenyl-2-yl)-1H-tetrazolu a zpusob výroby draselné soli losartanu, irbesartanu a valsartanu s jeho pouzitím
PT1685126E (pt) * 2003-10-16 2007-04-30 Teva Pharma Preparação de candesartan cilexetil
WO2005051928A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Process for production of tetrazolyl compounds
WO2005077941A2 (en) 2004-02-11 2005-08-25 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
KR100908308B1 (ko) * 2004-05-05 2009-07-17 테바 파마슈티컬 인더스트리즈 리미티드 순도가 높은 칸데사르탄 실렉세틸의 제조
WO2005123720A1 (en) * 2004-06-18 2005-12-29 Ranbaxy Laboratories Limited Fine particles of the angiotensin ii antagonist candesartan cilexetil and process for production thereof
EP1655298A1 (en) * 2004-11-03 2006-05-10 LEK Pharmaceuticals d.d. Novel polymorph forms of candesartan cilexetil
EP1812423A1 (en) 2004-11-11 2007-08-01 LEK Pharmaceuticals D.D. Process for the synthesis of tetrazoles
JP2007527925A (ja) * 2005-01-14 2007-10-04 テバ ファーマシューティカル インダストリーズ リミティド 粗カンデサルタンシレキセチルの調製
US20070082055A1 (en) * 2005-05-10 2007-04-12 Ziv Kurgan Stable micronized candesartan cilexetil and methods for preparing thereof
WO2007074399A2 (en) 2005-06-06 2007-07-05 Medichem, S.A. Process for the preparation of tetrazolyl compounds
EP1816131A1 (en) * 2006-02-06 2007-08-08 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of olmesartan medoxomil
US7943779B2 (en) 2005-07-29 2011-05-17 Krka Process for the preparation of olmesartan medoxomil
SI22127A (sl) 2005-10-07 2007-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo kandesartan cileksetila
CZ299265B6 (cs) * 2005-10-20 2008-05-28 Zentiva, A. S. Zpusob výroby 1-(cyklohexyloxykarbonyloxy)ethyl-2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)bifenyl-4-yl]methyl]benzimidazol-7-karboxylátu (candesartan cilexetilu)
ITTO20060560A1 (it) * 2006-07-27 2008-01-28 S I M S S R L Composti intermedi per la preparazione di antagonisti dell¿angiotensina ii
WO2008012372A1 (en) * 2006-07-28 2008-01-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of candesartan cilexetil form i
EP2170868A1 (en) * 2007-07-11 2010-04-07 Alembic Limited An improved process for the preparation of candesartan cilexetil
KR20120046115A (ko) 2009-05-20 2012-05-09 랜박시 래보러터리스 리미티드 올메사르탄 메독소밀의 제조 방법
WO2011080684A1 (en) 2009-12-31 2011-07-07 Ranbaxy Laboratories Limited Process for the preparation of candesartan cilexetil
WO2011092666A1 (en) 2010-01-29 2011-08-04 Ranbaxy Laboratories Limited An improved process for the preparation of candesartan cilexetil, polymorphic forms of n-trityl candesartan and their uses thereof
KR101251741B1 (ko) 2010-12-16 2013-04-05 동화약품주식회사 칸데사르탄실렉세틸의 개선된 제조방법
CN103396408A (zh) * 2013-08-13 2013-11-20 河南华商药业有限公司 坎地沙坦酯中杂质b的制备方法
CN109851612A (zh) * 2019-01-30 2019-06-07 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法
CN109776503A (zh) * 2019-01-30 2019-05-21 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法
CN109627234A (zh) * 2019-01-30 2019-04-16 浙江省食品药品检验研究院 一种坎地沙坦酯晶体及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
TW209213B (es) * 1991-08-21 1993-07-11 Yamanouchi Pharma Co Ltd
CA2077419C (en) * 1991-09-10 1998-08-25 Yasushi Honma Imidazopyridine derivatives and process for preparation thereof
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
DE4212748A1 (de) * 1992-04-16 1993-10-21 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
GR3034464T3 (en) 2000-12-29
EP0668272B1 (en) 2000-07-12
US5763619A (en) 1998-06-09
EP0668272A3 (en) 1995-08-30
US5578733A (en) 1996-11-26
PT668272E (pt) 2000-10-31
CA2141175C (en) 2006-12-12
CA2141175A1 (en) 1995-07-29
DE69517832D1 (de) 2000-08-17
EP0668272A2 (en) 1995-08-23
DE69517832T2 (de) 2000-11-09
DK0668272T3 (da) 2000-09-18
ATE194603T1 (de) 2000-07-15

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